AU2007250086B2 - Electrochemical test sensor with reduced sample volume - Google Patents
Electrochemical test sensor with reduced sample volume Download PDFInfo
- Publication number
- AU2007250086B2 AU2007250086B2 AU2007250086A AU2007250086A AU2007250086B2 AU 2007250086 B2 AU2007250086 B2 AU 2007250086B2 AU 2007250086 A AU2007250086 A AU 2007250086A AU 2007250086 A AU2007250086 A AU 2007250086A AU 2007250086 B2 AU2007250086 B2 AU 2007250086B2
- Authority
- AU
- Australia
- Prior art keywords
- test sensor
- electrochemical test
- counter electrode
- lid
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000840 electrochemical analysis Methods 0.000 title claims abstract description 115
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 68
- 238000012360 testing method Methods 0.000 claims abstract description 65
- 239000012530 fluid Substances 0.000 claims abstract description 62
- 239000012491 analyte Substances 0.000 claims abstract description 56
- 108090000790 Enzymes Proteins 0.000 claims abstract description 21
- 102000004190 Enzymes Human genes 0.000 claims abstract description 21
- 125000006850 spacer group Chemical group 0.000 claims description 50
- 238000000034 method Methods 0.000 description 83
- 239000002585 base Substances 0.000 description 64
- 230000008569 process Effects 0.000 description 43
- 229940088598 enzyme Drugs 0.000 description 18
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- 239000008103 glucose Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 9
- -1 poly(ethylene oxide) Polymers 0.000 description 6
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 5
- 108010015776 Glucose oxidase Proteins 0.000 description 5
- 239000004366 Glucose oxidase Substances 0.000 description 5
- 229940116332 glucose oxidase Drugs 0.000 description 5
- 235000019420 glucose oxidase Nutrition 0.000 description 5
- 210000001124 body fluid Anatomy 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
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- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 210000003722 extracellular fluid Anatomy 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
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- 238000012544 monitoring process Methods 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
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- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- RRKGBEPNZRCDAP-UHFFFAOYSA-N [C].[Ag] Chemical compound [C].[Ag] RRKGBEPNZRCDAP-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminum chloride Substances Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
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- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79879706P | 2006-05-08 | 2006-05-08 | |
| US60/798,797 | 2006-05-08 | ||
| PCT/US2007/010614 WO2007133457A2 (en) | 2006-05-08 | 2007-05-03 | Electrochemical test sensor with reduced sample volume |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2007250086A1 AU2007250086A1 (en) | 2007-11-22 |
| AU2007250086B2 true AU2007250086B2 (en) | 2013-07-18 |
Family
ID=38694394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007250086A Ceased AU2007250086B2 (en) | 2006-05-08 | 2007-05-03 | Electrochemical test sensor with reduced sample volume |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8617367B2 (enExample) |
| EP (1) | EP2018556A2 (enExample) |
| JP (4) | JP5460313B2 (enExample) |
| KR (1) | KR101361888B1 (enExample) |
| CN (2) | CN103399069B (enExample) |
| AU (1) | AU2007250086B2 (enExample) |
| BR (1) | BRPI0711337A2 (enExample) |
| CA (1) | CA2650949C (enExample) |
| CO (1) | CO6141495A2 (enExample) |
| MX (1) | MX2008014251A (enExample) |
| NO (1) | NO20085094L (enExample) |
| RU (1) | RU2475731C2 (enExample) |
| TW (1) | TWI408366B (enExample) |
| WO (1) | WO2007133457A2 (enExample) |
| ZA (1) | ZA200809649B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0637244B2 (ja) | 1985-03-20 | 1994-05-18 | 住友重機械工業株式会社 | フオ−ク上の荷の幅寄せ装置 |
| WO2009076271A2 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Wear-resistant electrochemical test sensor and method of forming the same |
| JP5405916B2 (ja) * | 2008-06-24 | 2014-02-05 | パナソニック株式会社 | バイオセンサ、その製造方法、及びそれを備える検出システム |
| WO2010116624A1 (ja) * | 2009-04-07 | 2010-10-14 | パナソニック株式会社 | センサチップとこれを用いる測定器及び血液検査装置 |
| US20110186428A1 (en) * | 2010-01-29 | 2011-08-04 | Roche Diagnostics Operations, Inc. | Electrode arrangements for biosensors |
| JP5102334B2 (ja) * | 2010-06-25 | 2012-12-19 | 日本電波工業株式会社 | 感知装置 |
| US9086338B2 (en) | 2010-06-25 | 2015-07-21 | Nihon Dempa Kogyo Co., Ltd. | Sensing device |
| US20120048746A1 (en) * | 2010-08-30 | 2012-03-01 | Cilag Gmbh International | Analyte test strip with electrically distinguishable divided electrode |
| JP5953301B2 (ja) * | 2011-06-16 | 2016-07-20 | パナソニックヘルスケアホールディングス株式会社 | センサおよびこれを備えたセンサシステム |
| EP2827140A1 (en) * | 2012-03-15 | 2015-01-21 | Murata Manufacturing Co., Ltd. | Method for manufacturing biosensor |
| KR20140066377A (ko) * | 2012-11-23 | 2014-06-02 | 삼성전자주식회사 | 바이오 센서 |
| US9097659B2 (en) * | 2013-03-14 | 2015-08-04 | Bayer Healthcare Llc | Maintaining electrode function during manufacture with a protective layer |
| US10041901B2 (en) | 2013-03-15 | 2018-08-07 | Roche Diabetes Care, Inc. | Electrode configuration for a biosensor |
| JP6700246B2 (ja) | 2014-07-09 | 2020-05-27 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドＳｉｅｍｅｎｓ Ｈｅａｌｔｈｃａｒｅ Ｄｉａｇｎｏｓｔｉｃｓ Ｉｎｃ． | 少量試料検知装置 |
| BR112017005121A2 (pt) | 2014-09-23 | 2018-07-31 | Tearlab Res Inc | sistemas e métodos para integração de coleta de lágrima microfluídica e análise de fluxo lateral de analitos de interesse. |
| TWI638158B (zh) * | 2017-03-29 | 2018-10-11 | 泰博科技股份有限公司 | 電化學生物感測試紙及其製造方法 |
| KR102197061B1 (ko) * | 2017-10-23 | 2020-12-30 | 주식회사 비바이오 | 커피링 효과에 강인한 바이오센서 |
| CN109116029A (zh) * | 2018-07-21 | 2019-01-01 | 福建医科大学 | 一种基于喷墨打印技术可控性制作纸基微流控芯片用于葡萄糖定量检测的方法 |
| CN109557151A (zh) * | 2019-01-15 | 2019-04-02 | 中国电子科技集团公司第四十九研究所 | 基于陶瓷共烧工艺的传感单元、含有该传感单元的电化学气体传感器及传感单元的制造方法 |
| WO2020261086A1 (en) | 2019-06-28 | 2020-12-30 | 3M Innovative Properties Company | Articles having conformal layers and methods of making same |
| US11726054B2 (en) * | 2020-11-24 | 2023-08-15 | Ascensia Diabetes Care Holdings Ag | NFC-enabled test sensors, systems and methods using the same |
| EP4116705A1 (en) * | 2021-07-05 | 2023-01-11 | ARKRAY, Inc. | Biosensor |
| US20240342711A1 (en) | 2021-09-30 | 2024-10-17 | 3M Innovative Properties Company | Small volume fluidic devices |
| TWI803996B (zh) * | 2021-10-06 | 2023-06-01 | 立寶光電股份有限公司 | 檢測試片及電極製造方法 |
| US20250052712A1 (en) * | 2021-12-07 | 2025-02-13 | Analog Devices International Unlimited Company | Sensor assembly and method of manufacture |
| KR20240001383A (ko) * | 2022-06-27 | 2024-01-03 | 주식회사 동운아나텍 | 검체 측정을 위한 바이오 센서 스트립, 그 전극 구조 및 이를 이용한 검체 측정 방법 |
Citations (3)
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| WO2003097866A1 (en) * | 2002-05-20 | 2003-11-27 | Infopia Co., Ltd. | Biosensor |
| US20040096928A1 (en) * | 2001-11-14 | 2004-05-20 | Miwa Hasegawa | Biosensor |
| US20040222092A1 (en) * | 1999-08-02 | 2004-11-11 | Musho Matthew K. | Electrochemical-sensor design |
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| BRPI0507378A (pt) * | 2004-02-06 | 2007-07-10 | Bayer Healthcare Llc | sensor para teste de fluido tendo suspiros para direcionar fluxo de fluido |
| JP4814110B2 (ja) | 2004-02-06 | 2011-11-16 | バイエル・ヘルスケア・エルエルシー | 電気化学的バイオセンサ |
| MX2007001770A (es) | 2004-08-13 | 2007-08-07 | Egomedical Technologies Ag | Sistema de prueba de analitos para determinar la concentracion de un analito en un fluido fisiologico o acuoso. |
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2007
- 2007-05-03 WO PCT/US2007/010614 patent/WO2007133457A2/en not_active Ceased
- 2007-05-03 CN CN201310285464.7A patent/CN103399069B/zh active Active
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- 2007-05-03 CN CN200780023668.6A patent/CN101479600B/zh active Active
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2008
- 2008-11-12 ZA ZA200809649A patent/ZA200809649B/xx unknown
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| US20040222092A1 (en) * | 1999-08-02 | 2004-11-11 | Musho Matthew K. | Electrochemical-sensor design |
| US20040096928A1 (en) * | 2001-11-14 | 2004-05-20 | Miwa Hasegawa | Biosensor |
| WO2003097866A1 (en) * | 2002-05-20 | 2003-11-27 | Infopia Co., Ltd. | Biosensor |
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