AU2007207743B2 - Thiazole compounds as protein kinase B (PKB) inhibitors - Google Patents
Thiazole compounds as protein kinase B (PKB) inhibitors Download PDFInfo
- Publication number
- AU2007207743B2 AU2007207743B2 AU2007207743A AU2007207743A AU2007207743B2 AU 2007207743 B2 AU2007207743 B2 AU 2007207743B2 AU 2007207743 A AU2007207743 A AU 2007207743A AU 2007207743 A AU2007207743 A AU 2007207743A AU 2007207743 B2 AU2007207743 B2 AU 2007207743B2
- Authority
- AU
- Australia
- Prior art keywords
- amino
- alkyl
- phenyl
- compound
- thiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75954606P | 2006-01-18 | 2006-01-18 | |
US60/759,546 | 2006-01-18 | ||
PCT/US2007/000871 WO2007084391A2 (en) | 2006-01-18 | 2007-01-11 | Thiazole compounds as protein kinase b ( pkb) inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
AU2007207743A1 AU2007207743A1 (en) | 2007-07-26 |
AU2007207743B2 true AU2007207743B2 (en) | 2010-07-08 |
Family
ID=38180602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2007207743A Ceased AU2007207743B2 (en) | 2006-01-18 | 2007-01-11 | Thiazole compounds as protein kinase B (PKB) inhibitors |
Country Status (21)
Families Citing this family (56)
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KR20080091369A (ko) * | 2006-01-18 | 2008-10-10 | 암젠 인크 | 단백질 키나제 b (pkb) 억제제로서 티아졸 화합물 |
MX2009008775A (es) * | 2007-02-13 | 2010-03-01 | Schering Corp | Agonistas de adrenorreceptores alfa2c funcionalmente selectivos. |
AU2008276512A1 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of PKB |
WO2009011880A2 (en) * | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
EP2303017A4 (en) * | 2008-06-26 | 2011-06-15 | Glaxosmithkline Llc | HAMMER OF ACT ACTIVITY |
US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
EP2326631A4 (en) * | 2008-08-18 | 2012-03-21 | Univ Yale | MODULATORS OF MIF |
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SI3135672T1 (sl) * | 2008-10-10 | 2020-07-31 | Vm Discovery, Inc. | Sestavki in postopki za zdravljenje motenj, bolečin in drugih bolezni povezanih z uporabo alkohola |
MX2011006509A (es) * | 2008-12-19 | 2011-10-19 | Genentech Inc | Compuestos heterociclicos y métodos de uso. |
US20110263647A1 (en) * | 2009-01-15 | 2011-10-27 | Amgen Inc. | Fluoroisoquinoline substituted thiazole compounds and methods of use |
EP2440556A1 (en) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of phosphatidylinositol 3-kinase |
RS56352B2 (sr) | 2009-06-25 | 2023-02-28 | Alkermes Pharma Ireland Ltd | Heterociklična jedinjenja za lečenje neuroloških i psiholoških poremećaja |
ES2530436T3 (es) * | 2009-10-08 | 2015-03-02 | Glaxosmithkline Llc | Combinación |
EP2485593B1 (en) * | 2009-10-08 | 2015-01-07 | GlaxoSmithKline LLC | Combination |
CA2777561A1 (en) * | 2009-10-12 | 2011-04-21 | Glaxosmithkline Llc | Combination |
WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
CA2779574C (en) | 2009-11-05 | 2018-12-18 | Rhizen Pharmaceuticals S.A. | Novel kinase modulators |
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CN102933571A (zh) * | 2010-04-16 | 2013-02-13 | Abbvie公司 | 激酶的酞嗪-(2h)-酮抑制剂 |
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WO2011130921A1 (en) * | 2010-04-23 | 2011-10-27 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
MX365160B (es) | 2011-05-04 | 2019-05-24 | Rhizen Pharmaceuticals Sa | Compuestos novedosos como moduladores de proteína cinasas. |
MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
CN103304468A (zh) * | 2012-03-13 | 2013-09-18 | 华东师范大学 | 一种氧化吲哚的一锅法串联合成方法 |
WO2013146754A1 (ja) * | 2012-03-27 | 2013-10-03 | 塩野義製薬株式会社 | Trpv4阻害活性を有する芳香族複素5員環誘導体 |
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ES2647416T3 (es) | 2012-07-04 | 2017-12-21 | Rhizen Pharmaceuticals S.A. | Inhibidores de PI3K delta selectivos |
JP6417338B2 (ja) | 2013-02-19 | 2018-11-07 | アムジエン・インコーポレーテツド | 癌の治療のためのmdm2阻害剤としてのシス−モルホリノン及び他の化合物 |
MX2015011456A (es) * | 2013-03-13 | 2016-05-31 | Boston Biomedical Inc | Derivados de 3-(arilo o heteroailo) metilenindolino-2-ona como inhibidores de cinasas de la via de las celulas madres cancerosas para el tratamiento del cancer. |
MX2015012427A (es) | 2013-03-14 | 2016-01-12 | Amgen Inc | Compuestos de morfolinona de acido heteroarilo como inhibidores mdm2 para el tratamiento de cancer. |
JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
EA202092456A3 (ru) | 2013-11-11 | 2021-09-30 | Эмджен Инк. | Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака |
SG11201705821XA (en) * | 2015-03-02 | 2017-08-30 | Rigel Pharmaceuticals Inc | TGF-ß INHIBITORS |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
EP3426652B1 (en) * | 2016-03-10 | 2021-12-01 | Astrazeneca AB | Novel inhibitors of phosphatidylinositol 3-kinase gamma |
TW201843139A (zh) | 2017-03-30 | 2018-12-16 | 瑞士商赫孚孟拉羅股份公司 | 作為hpk1之抑制劑的異喹啉 |
JOP20190272A1 (ar) | 2017-05-22 | 2019-11-21 | Amgen Inc | مثبطات kras g12c وطرق لاستخدامها |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
EP4159212A1 (en) | 2017-10-05 | 2023-04-05 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd |
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US11612606B2 (en) | 2018-10-03 | 2023-03-28 | Genentech, Inc. | 8-aminoisoquinoline compounds and uses thereof |
JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
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CN111603466B (zh) * | 2020-06-29 | 2022-07-22 | 江南大学 | 一种乙酮类化合物在制备治疗肿瘤药物中的应用 |
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AU2007207743A1 (en) | 2007-07-26 |
EP1981884B1 (en) | 2012-06-13 |
AR059064A1 (es) | 2008-03-12 |
EP1981884A2 (en) | 2008-10-22 |
TW200738657A (en) | 2007-10-16 |
US8084479B2 (en) | 2011-12-27 |
NO20083572L (no) | 2008-10-17 |
UA91895C2 (en) | 2010-09-10 |
PE20071114A1 (es) | 2008-01-10 |
MY149143A (en) | 2013-07-15 |
BRPI0706621A2 (pt) | 2011-04-05 |
JP5199885B2 (ja) | 2013-05-15 |
ES2389062T3 (es) | 2012-10-22 |
WO2007084391A3 (en) | 2008-03-20 |
US20070173506A1 (en) | 2007-07-26 |
CA2636077C (en) | 2012-01-03 |
IL192751A0 (en) | 2009-02-11 |
US20090270445A1 (en) | 2009-10-29 |
CN101421265A (zh) | 2009-04-29 |
KR20080091369A (ko) | 2008-10-10 |
CA2636077A1 (en) | 2007-07-26 |
CR10211A (es) | 2008-10-03 |
UY30098A1 (es) | 2007-10-31 |
EA200801716A1 (ru) | 2009-04-28 |
JP2009525960A (ja) | 2009-07-16 |
ZA200806386B (en) | 2009-11-25 |
US7514566B2 (en) | 2009-04-07 |
WO2007084391A2 (en) | 2007-07-26 |
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