AU2007206877A1 - A solid lyophilized taxane composition, a method for preparing said solid composition, a pharmaceutical formulation and a kit for said formulation - Google Patents
A solid lyophilized taxane composition, a method for preparing said solid composition, a pharmaceutical formulation and a kit for said formulation Download PDFInfo
- Publication number
- AU2007206877A1 AU2007206877A1 AU2007206877A AU2007206877A AU2007206877A1 AU 2007206877 A1 AU2007206877 A1 AU 2007206877A1 AU 2007206877 A AU2007206877 A AU 2007206877A AU 2007206877 A AU2007206877 A AU 2007206877A AU 2007206877 A1 AU2007206877 A1 AU 2007206877A1
- Authority
- AU
- Australia
- Prior art keywords
- taxane
- composition
- procedure
- lyophilisation
- solid composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940123237 Taxane Drugs 0.000 title claims description 151
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title claims description 132
- 239000000203 mixture Substances 0.000 title claims description 100
- 239000008247 solid mixture Substances 0.000 title claims description 62
- 238000000034 method Methods 0.000 title claims description 58
- 238000009472 formulation Methods 0.000 title claims description 41
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 12
- 239000007787 solid Substances 0.000 title description 17
- 238000004108 freeze drying Methods 0.000 claims description 85
- 239000000243 solution Substances 0.000 claims description 63
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 59
- 239000003960 organic solvent Substances 0.000 claims description 59
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- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
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- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
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- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960000699 terbinafine hydrochloride Drugs 0.000 description 1
- VQMNWIMYFHHFMC-UHFFFAOYSA-N tert-butyl 4-hydroxyindole-1-carboxylate Chemical compound C1=CC=C2N(C(=O)OC(C)(C)C)C=CC2=C1O VQMNWIMYFHHFMC-UHFFFAOYSA-N 0.000 description 1
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- HWAAPJPFZPHHBC-FGJQBABTSA-N tirofiban hydrochloride Chemical compound O.Cl.C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 HWAAPJPFZPHHBC-FGJQBABTSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP06100208 | 2006-01-20 | ||
| AR20060100208A AR054215A1 (es) | 2006-01-20 | 2006-01-20 | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
| PCT/ES2007/070013 WO2007082979A1 (es) | 2006-01-20 | 2007-01-19 | Una composición sólida de taxano liofilizada, un procedimiento para preparar dicha composición sólida, una formulación farmacéutica y un conjunto (kit) de dicha formulación |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2007206877A1 true AU2007206877A1 (en) | 2007-07-26 |
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| AU2007206877A Abandoned AU2007206877A1 (en) | 2006-01-20 | 2007-01-19 | A solid lyophilized taxane composition, a method for preparing said solid composition, a pharmaceutical formulation and a kit for said formulation |
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| Country | Link |
|---|---|
| US (2) | US20090215883A1 (enExample) |
| EP (2) | EP1994925A4 (enExample) |
| JP (2) | JP2009523770A (enExample) |
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| AU (1) | AU2007206877A1 (enExample) |
| BR (2) | BRPI0706931A2 (enExample) |
| CA (2) | CA2637893A1 (enExample) |
| GT (2) | GT200800146A (enExample) |
| MX (2) | MX2008009358A (enExample) |
| NZ (2) | NZ569783A (enExample) |
| PE (2) | PE20070945A1 (enExample) |
| RU (1) | RU2429837C2 (enExample) |
| UY (2) | UY30100A1 (enExample) |
| WO (2) | WO2007082978A1 (enExample) |
| ZA (2) | ZA200805704B (enExample) |
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| US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
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| US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
| US8425459B2 (en) * | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
| US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
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| US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
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| US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
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| CA2683712A1 (en) * | 2007-04-20 | 2009-01-15 | Sun Pharmaceutical Industries Limited | Pharmaceutical compositions |
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| CN101677987A (zh) * | 2007-06-22 | 2010-03-24 | 赛多斯有限责任公司 | 不含吐温80的多西他赛的增溶制剂 |
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-
2006
- 2006-01-20 AR AR20060100208A patent/AR054215A1/es unknown
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2007
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- 2007-01-18 JP JP2008550785A patent/JP2009523770A/ja active Pending
- 2007-01-18 BR BRPI0706931-6A patent/BRPI0706931A2/pt not_active IP Right Cessation
- 2007-01-18 CA CA002637893A patent/CA2637893A1/en not_active Abandoned
- 2007-01-18 US US12/161,625 patent/US20090215883A1/en not_active Abandoned
- 2007-01-18 NZ NZ569783A patent/NZ569783A/en not_active IP Right Cessation
- 2007-01-18 MX MX2008009358A patent/MX2008009358A/es unknown
- 2007-01-18 RU RU2008133761/15A patent/RU2429837C2/ru not_active IP Right Cessation
- 2007-01-18 EP EP07712569A patent/EP1994925A4/en not_active Withdrawn
- 2007-01-19 UY UY30100A patent/UY30100A1/es not_active Application Discontinuation
- 2007-01-19 WO PCT/ES2007/070013 patent/WO2007082979A1/es not_active Ceased
- 2007-01-19 ZA ZA200805704A patent/ZA200805704B/xx unknown
- 2007-01-19 JP JP2008550786A patent/JP2009523771A/ja not_active Abandoned
- 2007-01-19 PE PE2007000062A patent/PE20070945A1/es not_active Application Discontinuation
- 2007-01-19 NZ NZ569968A patent/NZ569968A/en not_active IP Right Cessation
- 2007-01-19 MX MX2008009357A patent/MX2008009357A/es not_active Application Discontinuation
- 2007-01-19 AU AU2007206877A patent/AU2007206877A1/en not_active Abandoned
- 2007-01-19 EP EP07712570A patent/EP1982699A1/en not_active Withdrawn
- 2007-01-19 BR BRPI0706932-4A patent/BRPI0706932A2/pt not_active IP Right Cessation
- 2007-01-19 UY UY30099A patent/UY30099A1/es not_active Application Discontinuation
- 2007-01-19 US US12/161,609 patent/US20090215882A1/en not_active Abandoned
- 2007-01-19 CA CA002638034A patent/CA2638034A1/en not_active Abandoned
- 2007-01-19 PE PE2007000063A patent/PE20071243A1/es not_active Application Discontinuation
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2008
- 2008-07-09 ZA ZA200805989A patent/ZA200805989B/xx unknown
- 2008-07-18 GT GT200800146A patent/GT200800146A/es unknown
- 2008-07-18 GT GT200800145A patent/GT200800145A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2637893A1 (en) | 2007-07-26 |
| JP2009523771A (ja) | 2009-06-25 |
| WO2007082979A1 (es) | 2007-07-26 |
| CA2638034A1 (en) | 2007-07-26 |
| UY30100A1 (es) | 2008-09-02 |
| EP1994925A1 (en) | 2008-11-26 |
| ZA200805989B (en) | 2009-05-27 |
| BRPI0706931A2 (pt) | 2011-04-19 |
| PE20070945A1 (es) | 2007-10-07 |
| GT200800146A (es) | 2008-12-15 |
| BRPI0706932A2 (pt) | 2011-04-19 |
| WO2007082978A1 (es) | 2007-07-26 |
| ZA200805704B (en) | 2009-11-25 |
| GT200800145A (es) | 2009-07-21 |
| NZ569968A (en) | 2011-07-29 |
| WO2007082978B1 (es) | 2007-09-07 |
| AR054215A1 (es) | 2007-06-13 |
| AU2007206876A1 (en) | 2007-07-26 |
| US20090215883A1 (en) | 2009-08-27 |
| EP1994925A4 (en) | 2013-01-23 |
| JP2009523770A (ja) | 2009-06-25 |
| MX2008009358A (es) | 2008-09-10 |
| UY30099A1 (es) | 2008-09-02 |
| RU2008133761A (ru) | 2010-02-27 |
| NZ569783A (en) | 2011-04-29 |
| PE20071243A1 (es) | 2008-02-03 |
| EP1982699A1 (en) | 2008-10-22 |
| US20090215882A1 (en) | 2009-08-27 |
| MX2008009357A (es) | 2008-09-10 |
| RU2429837C2 (ru) | 2011-09-27 |
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