AU2006266755B2 - Compositions ameliorating a reduced diurnal activity and/or depressive symptoms - Google Patents
Compositions ameliorating a reduced diurnal activity and/or depressive symptoms Download PDFInfo
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- AU2006266755B2 AU2006266755B2 AU2006266755A AU2006266755A AU2006266755B2 AU 2006266755 B2 AU2006266755 B2 AU 2006266755B2 AU 2006266755 A AU2006266755 A AU 2006266755A AU 2006266755 A AU2006266755 A AU 2006266755A AU 2006266755 B2 AU2006266755 B2 AU 2006266755B2
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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| JP2005191506A JP5967855B2 (ja) | 2005-06-30 | 2005-06-30 | 日中活動量の低下および／又はうつ症状の改善作用を有する組成物 |
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| AU (1) | AU2006266755B2 (zh) |
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| RU (1) | RU2463047C2 (zh) |
| WO (1) | WO2007004689A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009002145A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Lipid composition for improving function of brain functioning |
| WO2009002148A1 (en) | 2007-06-27 | 2008-12-31 | N.V. Nutricia | Food composition for prodromal dementia patients |
| NZ599748A (en) | 2007-06-26 | 2013-11-29 | Nutricia Nv | Improving memory in subjects with mini-mental state examination of 24-26 |
| WO2009002146A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Supporting activities of daily living |
| US8343753B2 (en) | 2007-11-01 | 2013-01-01 | Wake Forest University School Of Medicine | Compositions, methods, and kits for polyunsaturated fatty acids from microalgae |
| US8282965B2 (en) | 2007-12-20 | 2012-10-09 | N.V. Nutricia | Liquid nucleotides/nucleosides-containing product |
| JP2011136948A (ja) * | 2009-12-28 | 2011-07-14 | Nisshin Oillio Group Ltd | うつ病又はうつ状態の予防又は治療用油脂組成物 |
| US9549937B2 (en) | 2013-12-05 | 2017-01-24 | Burvia, LLC. | Composition containing phospholipid-DHA and folate |
| US9610302B2 (en) | 2013-12-05 | 2017-04-04 | Buriva, LLC. | Composition containing phospholipid-DHA and B vitamins |
| US9216199B2 (en) | 2013-12-05 | 2015-12-22 | Buriva, LLC | Nutritional supplement containing phospholipid-DHA derived from eggs |
| US9233114B2 (en) | 2013-12-05 | 2016-01-12 | Buriva, LLC | Dietary supplement containing phospholipid-DHA derived from eggs |
| WO2019149822A1 (en) * | 2018-02-02 | 2019-08-08 | Societe Des Produits Nestle S.A. | Stabilizing omega-3 fatty acids with bran |
| KR102430080B1 (ko) | 2019-06-04 | 2022-08-04 | 경북대학교 산학협력단 | 메틸 갈레이트 및 틸로신을 포함하는 항균용 조성물 |
| EP4129405A4 (en) * | 2020-04-01 | 2024-04-24 | Suntory Holdings Ltd | COMPOSITION TO IMPROVE FRIENDLINESS AND/OR EMPATHIC CAPACITY |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998050052A1 (fr) * | 1997-05-06 | 1998-11-12 | Institut De Recherche Biologique S.A. | Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique |
| WO2002002105A1 (en) * | 2000-06-29 | 2002-01-10 | Laxdale Limited | Therapeutic combinations of fatty acids |
| WO2004028529A1 (en) * | 2002-09-24 | 2004-04-08 | Suntory Limited | Composition with effects of decline prevention, improvement or enhancement of normal responses of cognitive abilities of a healthy person |
| EP1419768A1 (en) * | 2001-08-02 | 2004-05-19 | Suntory Limited | Compositions having effects of preventing or ameliorating conditions or diseases caused by brain hypofunction |
| WO2004084882A1 (en) * | 2003-03-27 | 2004-10-07 | Suntory Limited | Use of arachidonic acid for normalization of infradian rhythm |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1112820A (en) | 1967-04-28 | 1968-05-08 | Standard Telephones Cables Ltd | Improvements in or relating to electrical storage systems |
| US4668704A (en) * | 1982-08-09 | 1987-05-26 | Regents Of The University Of California | Method for protecting and healing gastro-duodenal mucosa and the liver of mammals |
| US4526902A (en) | 1983-10-24 | 1985-07-02 | Century Laboratories, Inc. | Combined fatty acid composition for treatment or prophylaxis of thrombo-embolic conditions |
| GB8601915D0 (en) | 1986-01-27 | 1986-03-05 | Efamol Ltd | Pharmaceutical compositions |
| JPS63297342A (ja) | 1987-05-28 | 1988-12-05 | Nisshin Oil Mills Ltd:The | 合成油脂ならびにこれを含有する脂肪乳剤輸液および経腸栄養剤 |
| US5198468A (en) * | 1987-06-24 | 1993-03-30 | Efamol Holdings Plc | Essential fatty acid composition |
| US5658767A (en) | 1991-01-24 | 1997-08-19 | Martek Corporation | Arachidonic acid and methods for the production and use thereof |
| GB9224809D0 (en) | 1992-11-26 | 1993-01-13 | Scotia Holdings Plc | Schizophrenia |
| AU673700B2 (en) * | 1993-01-27 | 1996-11-21 | Scotia Holdings Plc | Triglycerides |
| JP3467794B2 (ja) | 1993-03-09 | 2003-11-17 | 日本油脂株式会社 | 学習能向上剤 |
| AU7053494A (en) | 1993-06-04 | 1995-01-03 | Martek Biosciences Corporation | Method of treating coronary vascular disease using docosahexaenoic acid |
| ATE446101T1 (de) | 1993-06-09 | 2009-11-15 | Martek Biosciences Corp | Verwendung von docosahexaensäure zur herstellung eines arzneimittels zur behandlung der senilen demenz und alzheimer-erkrankung |
| ATE167983T1 (de) | 1994-10-05 | 1998-07-15 | Milupa Gmbh & Co Kg | Phospholipidhaltige fettmischung mit lcp- fettsäuren |
| JPH08143454A (ja) | 1994-11-17 | 1996-06-04 | Kanagawa Kagaku Kenkyusho:Kk | 神経成長因子産生増強剤 |
| GB9423625D0 (en) | 1994-11-23 | 1995-01-11 | Scotia Holdings Plc | Fortified fruit juice |
| US5583019A (en) * | 1995-01-24 | 1996-12-10 | Omegatech Inc. | Method for production of arachidonic acid |
| JPH08214891A (ja) | 1995-02-17 | 1996-08-27 | Osaka City | 高度不飽和脂肪酸含有トリグリセリドを含む油脂の製造方法 |
| WO1996040106A2 (en) | 1995-06-07 | 1996-12-19 | Martek Biosciences Corporation | Methods for controlling highly unsaturated fatty acid content in various tissues |
| JPH0923817A (ja) | 1995-07-07 | 1997-01-28 | Nisshin Oil Mills Ltd:The | 油脂含有飲食物 |
| JPH0930962A (ja) | 1995-07-21 | 1997-02-04 | Nisshin Oil Mills Ltd:The | 医療用油脂含有組成物 |
| US6200624B1 (en) | 1996-01-26 | 2001-03-13 | Abbott Laboratories | Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids |
| CN1058845C (zh) | 1996-01-31 | 2000-11-29 | 高世虎 | 强化营养豆奶粉 |
| GB9617847D0 (en) | 1996-08-27 | 1996-10-09 | Scotia Holdings Plc | Fatty acid treatment |
| JP4034370B2 (ja) | 1996-09-27 | 2008-01-16 | 雪印乳業株式会社 | 脳機能改善剤及び栄養組成物 |
| JP4633204B2 (ja) | 1996-10-11 | 2011-02-16 | サントリーホールディングス株式会社 | アラキドン酸含有食用油脂およびそれを含有する食品 |
| FI103856B1 (fi) | 1996-11-15 | 1999-09-30 | Nokia Telecommunications Oy | Dynaaminen kanava-allokointi |
| JPH10155459A (ja) | 1996-11-27 | 1998-06-16 | Suntory Ltd | アスタキサンチン含有飲食物 |
| US6080787A (en) * | 1997-02-21 | 2000-06-27 | Abbott Laboratories | Methods for reducing the incidence of necrotizing enterocolitis |
| US5902807A (en) * | 1997-05-12 | 1999-05-11 | Antti Haapalinna | Method for the treatment of mental illness in mammals and a composition therefor |
| ES2188855T3 (es) * | 1997-07-22 | 2003-07-01 | Nestle Sa | Composicion lipida para formula infantil y procedimiento de preparacion. |
| JP2970804B2 (ja) * | 1997-07-23 | 1999-11-02 | 株式会社フジクラ | 難燃性シート |
| US6225444B1 (en) * | 1998-02-10 | 2001-05-01 | Protarga, Inc. | Neuroprotective peptides and uses thereof |
| JP4175698B2 (ja) | 1998-06-19 | 2008-11-05 | サントリー株式会社 | 新規なトリグリセリド及びそれを含む組成物 |
| AU775421B2 (en) | 1998-10-15 | 2004-07-29 | Dsm Ip Assets B.V. | Pufa supplements |
| GB9916536D0 (en) | 1999-07-14 | 1999-09-15 | Scarista Limited | Nutritional or pharmaceutical compositions |
| JP2001031586A (ja) | 1999-07-14 | 2001-02-06 | Sunstar Inc | 動脈硬化症及び動脈硬化症に起因する疾患の予防又は治療組成物 |
| GB9923738D0 (en) | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US20020019444A1 (en) | 2000-05-08 | 2002-02-14 | Edward Hogestatt | Anandamide and structurally related lipids as vanilloid receptor modulators |
| US7208180B2 (en) * | 2000-05-08 | 2007-04-24 | N.V. Nutricia | Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith |
| US7226916B1 (en) | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
| WO2001091745A2 (en) | 2000-05-30 | 2001-12-06 | The Brigham And Women's Hospital, Inc. | Use of epoxyeicosatrienoic acids in the treatment of cerebrovascular conditions |
| DE60106026T2 (de) | 2000-06-23 | 2006-02-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | 2-arachidonylglycerol (2-ag)-ein hemmer des tumor nekrose faktors-alfa und neuroprotektor des gehirns bei geschlossenen kopfverletzungen |
| CA2424570A1 (en) | 2000-09-07 | 2002-03-14 | University Of Maryland Biotechnology Institute | Use of arachidonic acid for enhanced culturing of fish larvae and broodstock |
| ES2324640T3 (es) | 2001-03-09 | 2009-08-12 | Societe Des Produits Nestle S.A. | Aceite que contiene un o unos acido(s) graso(s) poliin-saturado(s) de cadena larga resultante de una biomasa, procedimiento de preparacion, alimento, composicion nutricional, cosmetica o farmaceutica que lo contiene. |
| GB0111282D0 (en) | 2001-05-09 | 2001-06-27 | Laxdale Ltd | Potentiation of therapeutic effects of fatty acids |
| DK1406641T3 (da) | 2001-06-18 | 2009-05-04 | Neptune Technologies & Bioress | Krillekstrakter til forebyggelse og/eller behandling af cardiovaskulære sygdomme |
| DK1411129T3 (da) | 2001-07-02 | 2010-04-19 | Suntory Holdings Ltd | Fremgangsmåde til fremstilling af fedtstof der omfatter triglycerid indeholdende højumættet fedtsyre |
| WO2003013609A1 (en) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Sustained-release medicines |
| JP2003113120A (ja) | 2001-08-03 | 2003-04-18 | Takeda Chem Ind Ltd | 徐放性医薬 |
| US6689810B2 (en) * | 2001-08-21 | 2004-02-10 | Cellular Sciences, Inc. | Method for treating pulmonary disease states in mammals by altering indigenous in vivo levels of nitric oxide |
| NL1019368C2 (nl) * | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
| BR0309740A (pt) | 2002-05-03 | 2005-02-22 | Pronova Biocare As | Uso de ácido eicosapentaenóico (epa), ácido docosaexaenóico (dha) ou de uma mistura de epa e dha ou de um sal ou derivado farmaceuticamente aceitáveis dos mesmos |
| DK1537221T3 (en) | 2002-09-13 | 2016-02-15 | Suntory Holdings Ltd | PROCEDURE FOR THE PREPARATION OF TRANSFERRED OILS / FATS OR TRIGLYCERIDES |
| GB0221480D0 (en) | 2002-09-16 | 2002-10-23 | Laxdale Ltd | Treatment of anorexia nervosa (AN) and bulimia |
| US20060217368A1 (en) * | 2003-04-18 | 2006-09-28 | Kyowa Hakko Kogyo Co., Ltd. | Drug for nerve regeneration |
| US7964641B2 (en) | 2003-08-18 | 2011-06-21 | Btg International Limited | Treatment of neurodegenerative conditions |
| IL158552A0 (en) | 2003-10-22 | 2004-05-12 | Enzymotec Ltd | Lipids containing omega-3 fatty acids |
| JP4522075B2 (ja) * | 2003-10-29 | 2010-08-11 | サントリーホールディングス株式会社 | 血管の老化に起因する症状あるいは疾患の予防又は改善作用を有する組成物 |
| CA2551882A1 (en) | 2004-01-19 | 2005-08-11 | Martek Biosciences Corporation | Reelin deficiency or dysfunction and methods related thereto |
| JP4868199B2 (ja) | 2004-09-10 | 2012-02-01 | 学校法人鈴鹿医療科学大学 | サルビアノール酸ｂを有効成分とする神経幹細胞増殖剤 |
| JP2006083136A (ja) | 2004-09-17 | 2006-03-30 | Suntory Ltd | ストレスに起因する脳機能の低下およびそれに伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
| JP4993852B2 (ja) | 2004-09-17 | 2012-08-08 | サントリーホールディングス株式会社 | ストレスに起因する行動異常を伴う症状あるいは疾患の予防又は改善作用を有する組成物 |
| JP5697293B2 (ja) | 2005-06-30 | 2015-04-08 | サントリーホールディングス株式会社 | 器質的脳障害に起因する高次脳機能の低下に対する改善作用を有する組成物 |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998050052A1 (fr) * | 1997-05-06 | 1998-11-12 | Institut De Recherche Biologique S.A. | Nouvelle utilisation de phospholipides d'origine animale en therapeutique et/ou dietetique |
| WO2002002105A1 (en) * | 2000-06-29 | 2002-01-10 | Laxdale Limited | Therapeutic combinations of fatty acids |
| EP1419768A1 (en) * | 2001-08-02 | 2004-05-19 | Suntory Limited | Compositions having effects of preventing or ameliorating conditions or diseases caused by brain hypofunction |
| WO2004028529A1 (en) * | 2002-09-24 | 2004-04-08 | Suntory Limited | Composition with effects of decline prevention, improvement or enhancement of normal responses of cognitive abilities of a healthy person |
| WO2004084882A1 (en) * | 2003-03-27 | 2004-10-07 | Suntory Limited | Use of arachidonic acid for normalization of infradian rhythm |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105106191A (zh) | 2015-12-02 |
| RU2463047C2 (ru) | 2012-10-10 |
| EP1896004B1 (en) | 2018-08-15 |
| RU2008103361A (ru) | 2009-08-10 |
| EP1896004A1 (en) | 2008-03-12 |
| US20090226481A1 (en) | 2009-09-10 |
| CN1891214A (zh) | 2007-01-10 |
| WO2007004689A1 (en) | 2007-01-11 |
| CN105878226A (zh) | 2016-08-24 |
| KR101350939B1 (ko) | 2014-01-13 |
| JP2007008861A (ja) | 2007-01-18 |
| CN105106191B (zh) | 2021-09-07 |
| CA2613345A1 (en) | 2007-01-11 |
| KR20080027279A (ko) | 2008-03-26 |
| US9168241B2 (en) | 2015-10-27 |
| AU2006266755A1 (en) | 2007-01-11 |
| JP5967855B2 (ja) | 2016-08-10 |
| CA2613345C (en) | 2016-01-05 |
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