AU2006245770A1 - Combination of the PDE4 inhibitor roflumilast and a tetrahydrobiopterin derivative - Google Patents
Combination of the PDE4 inhibitor roflumilast and a tetrahydrobiopterin derivative Download PDFInfo
- Publication number
- AU2006245770A1 AU2006245770A1 AU2006245770A AU2006245770A AU2006245770A1 AU 2006245770 A1 AU2006245770 A1 AU 2006245770A1 AU 2006245770 A AU2006245770 A AU 2006245770A AU 2006245770 A AU2006245770 A AU 2006245770A AU 2006245770 A1 AU2006245770 A1 AU 2006245770A1
- Authority
- AU
- Australia
- Prior art keywords
- roflumilast
- acceptable salt
- combination product
- amount
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103938.6 | 2005-05-11 | ||
| EP05103938 | 2005-05-11 | ||
| PCT/EP2006/062117 WO2006120176A2 (en) | 2005-05-11 | 2006-05-08 | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2006245770A1 true AU2006245770A1 (en) | 2006-11-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2006245770A Abandoned AU2006245770A1 (en) | 2005-05-11 | 2006-05-08 | Combination of the PDE4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080221111A1 (https=) |
| EP (1) | EP1940392A2 (https=) |
| JP (1) | JP2008540486A (https=) |
| KR (1) | KR20080005601A (https=) |
| CN (1) | CN101171005A (https=) |
| AU (1) | AU2006245770A1 (https=) |
| BR (1) | BRPI0612796A2 (https=) |
| CA (1) | CA2607331A1 (https=) |
| EA (1) | EA200702358A1 (https=) |
| IL (1) | IL186804A0 (https=) |
| MX (1) | MX2007013766A (https=) |
| NO (1) | NO20076206L (https=) |
| WO (1) | WO2006120176A2 (https=) |
| ZA (1) | ZA200708776B (https=) |
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| JP2009518415A (ja) * | 2005-12-05 | 2009-05-07 | バイオマリン ファーマシューティカル インコーポレイテッド | 疾患の処置のための方法および組成物 |
| US20100009997A1 (en) * | 2007-01-12 | 2010-01-14 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiarty disorder with a bh4 derivative prodrug |
| AU2008313660B2 (en) | 2007-10-19 | 2013-11-07 | Boehringer Ingelheim International Gmbh | Substituted piperidino-dihydrothienopyrimidines |
| US20110144117A1 (en) * | 2008-08-12 | 2011-06-16 | Orpha Swiss Gmbh | Pharmaceutical Dosage Form Containing Tetrahydrobiopterin |
| HUE025547T2 (en) | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| JP5629274B2 (ja) | 2009-02-26 | 2014-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ブラジキニンｂ１アンタゴニストとしての化合物 |
| WO2010097373A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
| WO2010097374A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
| CN102781916B (zh) | 2010-02-23 | 2014-06-25 | 贝林格尔.英格海姆国际有限公司 | 作为缓激肽b1拮抗剂的化合物 |
| EP2562176B1 (en) | 2010-04-22 | 2018-08-15 | Nihon University | Medicinal agent and beverage/food for preventing cerebral dysfunction and improving same |
| CN102274222B (zh) * | 2011-08-18 | 2013-04-10 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特药物组合物及其制备方法 |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| US9303038B2 (en) | 2011-09-06 | 2016-04-05 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological diseases |
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| US9273061B2 (en) | 2012-05-10 | 2016-03-01 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
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| US9403857B2 (en) | 2012-05-10 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| WO2013167999A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurologic diseases |
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| US9498461B2 (en) | 2012-05-23 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| US9492409B2 (en) | 2012-05-23 | 2016-11-15 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| AU2013264820A1 (en) | 2012-05-23 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for treatment of mucositis |
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| US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| US5830461A (en) * | 1992-11-25 | 1998-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for promoting wound healing and treating transplant-associated vasculopathy |
| ES2176252T3 (es) * | 1993-07-02 | 2002-12-01 | Altana Pharma Ag | Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. |
| DE4418097A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
| DE69725721T3 (de) * | 1996-08-30 | 2007-10-31 | Daiichi Asubio Pharma Co., Ltd. | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind |
| SE0000307D0 (sv) * | 2000-01-31 | 2000-01-31 | Univ Zuerich | Method and formulation för treatment of vasoconstriction |
| US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
| US20070049599A1 (en) * | 2003-10-31 | 2007-03-01 | Altana Pharma Ag | Use of bh4 for the treatment of respiratory diseases |
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- 2006-05-08 CN CNA2006800148286A patent/CN101171005A/zh active Pending
- 2006-05-08 EP EP06755065A patent/EP1940392A2/en not_active Withdrawn
- 2006-05-08 CA CA002607331A patent/CA2607331A1/en not_active Abandoned
- 2006-05-08 WO PCT/EP2006/062117 patent/WO2006120176A2/en not_active Ceased
- 2006-05-08 BR BRPI0612796-7A patent/BRPI0612796A2/pt not_active IP Right Cessation
- 2006-05-08 MX MX2007013766A patent/MX2007013766A/es not_active Application Discontinuation
- 2006-05-08 EA EA200702358A patent/EA200702358A1/ru unknown
- 2006-05-08 US US11/919,742 patent/US20080221111A1/en not_active Abandoned
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| IL186804A0 (en) | 2008-06-05 |
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| NO20076206L (no) | 2007-12-11 |
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| EA200702358A1 (ru) | 2008-04-28 |
| JP2008540486A (ja) | 2008-11-20 |
| KR20080005601A (ko) | 2008-01-14 |
| WO2006120176A2 (en) | 2006-11-16 |
| BRPI0612796A2 (pt) | 2010-11-30 |
| CA2607331A1 (en) | 2006-11-16 |
| WO2006120176A3 (en) | 2007-04-19 |
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