AU2005316312B2 - Aminopyrimidine compounds and methods of use - Google Patents

Aminopyrimidine compounds and methods of use Download PDF

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Publication number
AU2005316312B2
AU2005316312B2 AU2005316312A AU2005316312A AU2005316312B2 AU 2005316312 B2 AU2005316312 B2 AU 2005316312B2 AU 2005316312 A AU2005316312 A AU 2005316312A AU 2005316312 A AU2005316312 A AU 2005316312A AU 2005316312 B2 AU2005316312 B2 AU 2005316312B2
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AU
Australia
Prior art keywords
ethyl
ylamino
pyrimidin
dione
thiophen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2005316312A
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English (en)
Other versions
AU2005316312A1 (en
Inventor
Paul Edward Brennan
Frenel Fils Demorin
Gang Liu
Nick A. Paras
Elizabeth Rainbeau
Daniel Martin Retz
Adrian Leonard Smith
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Amgen Inc
Original Assignee
Amgen Inc
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Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU2005316312A1 publication Critical patent/AU2005316312A1/en
Application granted granted Critical
Publication of AU2005316312B2 publication Critical patent/AU2005316312B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AU2005316312A 2004-12-17 2005-12-16 Aminopyrimidine compounds and methods of use Expired AU2005316312B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63660404P 2004-12-17 2004-12-17
US60/636,604 2004-12-17
PCT/US2005/045863 WO2006066172A1 (en) 2004-12-17 2005-12-16 Aminopyrimidine compounds and methods of use

Publications (2)

Publication Number Publication Date
AU2005316312A1 AU2005316312A1 (en) 2006-06-22
AU2005316312B2 true AU2005316312B2 (en) 2009-10-22

Family

ID=36588221

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005316312A Expired AU2005316312B2 (en) 2004-12-17 2005-12-16 Aminopyrimidine compounds and methods of use

Country Status (9)

Country Link
US (2) US7786132B2 (https=)
EP (1) EP1831207B1 (https=)
JP (1) JP4932735B2 (https=)
CN (1) CN101115749B (https=)
AU (1) AU2005316312B2 (https=)
CA (1) CA2590939C (https=)
ES (1) ES2397362T3 (https=)
MX (1) MX2007007032A (https=)
WO (1) WO2006066172A1 (https=)

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US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
JP2013147428A (ja) * 2010-04-27 2013-08-01 Dainippon Sumitomo Pharma Co Ltd 新規２−ヘテロアリール単環ピリミジン誘導体
US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
WO2013119895A1 (en) 2012-02-08 2013-08-15 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
US9566280B2 (en) 2014-01-28 2017-02-14 Massachusetts Institute Of Technology Combination therapies and methods of use thereof for treating cancer
CN104860900A (zh) * 2014-02-25 2015-08-26 中国药科大学 噻唑类化合物、其制备方法及其在制药中的用途
CN105884711A (zh) * 2014-12-16 2016-08-24 中国药科大学 噻唑类化合物、其制备方法及其在制药中的用途
PT3319939T (pt) * 2015-07-08 2025-03-05 Cv6 Therapeutics Ni Ltd Inibidores de desoxiuridina-trifosfatase contendo hidantoína
AU2016296905B2 (en) 2015-07-23 2018-07-05 Centre National De La Recherche Scientifique Use of a combination of Dbait molecule and parp inhibitors to treat cancer
GB201519573D0 (en) 2015-11-05 2015-12-23 King S College London Combination
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PT3494119T (pt) 2016-07-29 2024-12-10 Pgi Drug Discovery Llc Compostos e composições e seus usos
MA45795A (fr) 2016-07-29 2019-06-05 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
WO2018162439A1 (en) 2017-03-08 2018-09-13 Onxeo New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule
CA3070993C (en) 2017-08-02 2025-05-20 Sunovion Pharmaceuticals Inc. ISOCHROMANE COMPOUNDS AND THEIR USES
WO2019025250A1 (en) 2017-08-04 2019-02-07 Basf Se SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI
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CN112125879A (zh) * 2020-09-29 2020-12-25 浙江永太科技股份有限公司 一种卡格列净中间体2-(4-氟苯基)噻吩的制备方法
CN114133337A (zh) * 2020-12-14 2022-03-04 成都泰蓉生物科技有限公司 一种2-取代的赖氨酸的制备方法
KR20230155452A (ko) * 2021-03-09 2023-11-10 바스프 에스이 트리시클릭 살충 화합물
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Also Published As

Publication number Publication date
CN101115749B (zh) 2011-06-22
WO2006066172A1 (en) 2006-06-22
JP4932735B2 (ja) 2012-05-16
JP2008524248A (ja) 2008-07-10
EP1831207A1 (en) 2007-09-12
ES2397362T3 (es) 2013-03-06
EP1831207A4 (en) 2010-09-15
CA2590939A1 (en) 2006-06-22
AU2005316312A1 (en) 2006-06-22
US7786132B2 (en) 2010-08-31
MX2007007032A (es) 2007-07-04
EP1831207B1 (en) 2012-11-14
US20100010014A1 (en) 2010-01-14
CA2590939C (en) 2011-10-18
US20070185133A1 (en) 2007-08-09
US7858785B2 (en) 2010-12-28
CN101115749A (zh) 2008-01-30

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: ADD COINVENTOR RAINBEAU, ELIZABETH

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired