AU2005305210B2 - Opiate intermediates and methods of synthesis - Google Patents

Opiate intermediates and methods of synthesis Download PDF

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Publication number
AU2005305210B2
AU2005305210B2 AU2005305210A AU2005305210A AU2005305210B2 AU 2005305210 B2 AU2005305210 B2 AU 2005305210B2 AU 2005305210 A AU2005305210 A AU 2005305210A AU 2005305210 A AU2005305210 A AU 2005305210A AU 2005305210 B2 AU2005305210 B2 AU 2005305210B2
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AU
Australia
Prior art keywords
formula
compound
alkyl
aryl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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AU2005305210A
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English (en)
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AU2005305210A1 (en
Inventor
Gary L. Cantrell
Daniel P. Magparangalan
Frank W. Moser
Peter Xianqi Wang
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Specgx LLC
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Specgx LLC
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Publication of AU2005305210A1 publication Critical patent/AU2005305210A1/en
Assigned to MALLINCKRODT LLC reassignment MALLINCKRODT LLC Request for Assignment Assignors: MALLINCKRODT INC.
Application granted granted Critical
Publication of AU2005305210B2 publication Critical patent/AU2005305210B2/en
Assigned to SpecGx LLC reassignment SpecGx LLC Request for Assignment Assignors: MALLINCKRODT LLC
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Vacuum Packaging (AREA)
  • Saccharide Compounds (AREA)
AU2005305210A 2004-11-04 2005-10-21 Opiate intermediates and methods of synthesis Expired AU2005305210B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62539704P 2004-11-04 2004-11-04
US60/625,397 2004-11-04
PCT/US2005/038140 WO2006052430A2 (en) 2004-11-04 2005-10-21 Opiate intermediates and methods of synthesis

Publications (2)

Publication Number Publication Date
AU2005305210A1 AU2005305210A1 (en) 2006-05-18
AU2005305210B2 true AU2005305210B2 (en) 2012-01-19

Family

ID=35695757

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005305210A Expired AU2005305210B2 (en) 2004-11-04 2005-10-21 Opiate intermediates and methods of synthesis

Country Status (13)

Country Link
US (1) US7834184B2 (https=)
EP (1) EP1812399B1 (https=)
JP (1) JP2008518910A (https=)
CN (1) CN101052622A (https=)
AT (1) ATE450513T1 (https=)
AU (1) AU2005305210B2 (https=)
CA (1) CA2585698A1 (https=)
DE (1) DE602005018092D1 (https=)
ES (1) ES2336131T3 (https=)
MX (1) MX2007005194A (https=)
PL (1) PL1812399T3 (https=)
PT (1) PT1812399E (https=)
WO (1) WO2006052430A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008073389A2 (en) * 2006-12-12 2008-06-19 Mallinckrodt Inc. Preparation of hexahydroisoquinolines from dihydroisoquinolines
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
WO2011038169A2 (en) 2009-09-24 2011-03-31 Mallinckrodt Inc. One-pot preparation of hexahydroisoquinolines from amides
CN108383788A (zh) * 2018-03-27 2018-08-10 合肥医工医药有限公司 一种二甲啡烷异构体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans

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GB685748A (en) 1949-10-14 1953-01-07 Hoffmann La Roche Improvements in or relating to isoquinoline derivatives
DE1138765B (de) 1954-12-28 1962-10-31 Farmaceutici Italia Verfahren zur Herstellung der Kaffeesaeureester der Chinasaeure
DE1154268B (de) * 1960-01-07 1963-09-12 Bayer Ag Die Verhuetung der elektrostatischen Aufladung bei synthetischen Hochpolymeren
US3438989A (en) * 1967-03-10 1969-04-15 Warner Lambert Pharmaceutical Process for the production of ( ) dihydrothebainone
US3862327A (en) * 1967-11-01 1975-01-21 Uniroyal Inc Substituted phenylethyl sulfites useful for controlling mites
FR2015566A1 (https=) * 1968-08-13 1970-04-30 Basf Ag
US3922285A (en) * 1971-03-26 1975-11-25 Hoffmann La Roche Process for the methylenation of catechols
US3914233A (en) * 1972-10-20 1975-10-21 Hoffmann La Roche 4-Hydroxy-N-substituted morphinan derivatives
HU182087B (en) 1980-01-15 1983-12-28 Mta Kiserleti Orvostudomanyi K Process for preparing an active substance for the selective inhibition of the multiplication of normal cells and of cells in myeloide leukemia
US4727146A (en) 1980-07-03 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Synthesis of chiral 1-benzyl-1,2,3,4-tetra-hydroisoquinolines by asymmetric reduction
US4514569A (en) * 1982-01-28 1985-04-30 Hendrickson James B Synthesis of 1-substituted isoquinolines
US4452601A (en) * 1982-03-19 1984-06-05 Celanese Corporation Process for the thermal stabilization of acrylic fibers and films
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4727504A (en) * 1984-07-05 1988-02-23 The Charles Stark Draper Laboratory, Inc. Interference canceller and signal quantizer
US4737504A (en) 1986-07-25 1988-04-12 Ohio State University Research Foundation 5-fluoro-and 8-fluoro-trimetoquinol compounds and the processes for their preparation
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
US5023342A (en) * 1988-05-26 1991-06-11 Massachusetts Institute Of Technology Cyclic sulfate compounds
US5189200A (en) * 1990-12-21 1993-02-23 Sepracor, Inc. Process for the stereoselective transformation of a diol to an alcohol
GB9127306D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
JPH06247935A (ja) 1993-02-25 1994-09-06 Banyu Pharmaceut Co Ltd ６，７−ジアルコキシ−３，４−ジヒドロイソキノリン−８−オール類、その製造法及び該化合物を用いた６，７−ジアルコキシ−１，２，３，４−テトラヒドロイソキノリン−８−オール類の製造法
US5445164A (en) * 1993-05-11 1995-08-29 Gynetech, Inc. Cervical tissue sampling device
RO117377B1 (ro) * 1993-06-22 2002-02-28 Boots Co Plc Derivati de tetrahidroizochinolina, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament
US5869697A (en) * 1994-05-02 1999-02-09 Council Of Scientific & Industrial Research Process for preparing diltiazem
US6043253A (en) * 1998-03-03 2000-03-28 Merck & Co., Inc. Fused piperidine substituted arylsulfonamides as β3-agonists
KR100295740B1 (ko) * 1998-09-17 2001-11-05 박영구 N-치환된-하이드록시고리화알킬아민유도체의제조방법
DE60042585D1 (de) * 2000-02-29 2009-09-03 Univ Firenze 3-Aza-6,8-dioxabicycloÄ3.2.1Üoctane und Analoga sowie diese enthaltende kombinatorische Bibliotheken
US6593341B2 (en) * 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
US6818766B2 (en) * 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
US6596734B1 (en) * 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HONG, C.Y. et al. 'Preparation of opium alkaloids by palladium catalyzed biscyclizations. Formal total synthesis of morphine', Tetrahedron Letters. 1994, vol. 35, pages 3453-3456 *

Also Published As

Publication number Publication date
AU2005305210A1 (en) 2006-05-18
PL1812399T3 (pl) 2010-05-31
ATE450513T1 (de) 2009-12-15
DE602005018092D1 (de) 2010-01-14
EP1812399A2 (en) 2007-08-01
CA2585698A1 (en) 2006-05-18
US7834184B2 (en) 2010-11-16
PT1812399E (pt) 2010-02-03
ES2336131T3 (es) 2010-04-08
EP1812399B1 (en) 2009-12-02
WO2006052430A3 (en) 2006-08-24
US20080097100A1 (en) 2008-04-24
MX2007005194A (es) 2007-06-20
WO2006052430A2 (en) 2006-05-18
CN101052622A (zh) 2007-10-10
JP2008518910A (ja) 2008-06-05

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Owner name: MALLINCKRODT LLC

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Owner name: SPECGX LLC

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired