AU2005304757A1 - Metabolites of certain (1,4)diazepino(6,7,1-iJ)quinoline derivatives and methods of preparation and use thereof - Google Patents
Metabolites of certain (1,4)diazepino(6,7,1-iJ)quinoline derivatives and methods of preparation and use thereof Download PDFInfo
- Publication number
- AU2005304757A1 AU2005304757A1 AU2005304757A AU2005304757A AU2005304757A1 AU 2005304757 A1 AU2005304757 A1 AU 2005304757A1 AU 2005304757 A AU2005304757 A AU 2005304757A AU 2005304757 A AU2005304757 A AU 2005304757A AU 2005304757 A1 AU2005304757 A1 AU 2005304757A1
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- Prior art keywords
- compound
- dcdq
- salt according
- salt
- hydroxy
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- 238000000034 method Methods 0.000 title claims description 79
- 238000002360 preparation method Methods 0.000 title description 12
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title description 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 159
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 123
- 229930182480 glucuronide Natural products 0.000 claims description 121
- -1 acyl azide Chemical class 0.000 claims description 118
- 150000003839 salts Chemical class 0.000 claims description 95
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- 150000002466 imines Chemical class 0.000 claims description 65
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 45
- 125000000468 ketone group Chemical group 0.000 claims description 40
- 229930194542 Keto Natural products 0.000 claims description 36
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 claims description 31
- 239000000126 substance Substances 0.000 claims description 30
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 27
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 22
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Classifications
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/22—Pteridine radicals
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62533504P | 2004-11-05 | 2004-11-05 | |
| US60/625,335 | 2004-11-05 | ||
| PCT/US2005/040289 WO2006052886A1 (en) | 2004-11-05 | 2005-11-04 | Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005304757A1 true AU2005304757A1 (en) | 2006-05-18 |
Family
ID=36002462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005304757A Abandoned AU2005304757A1 (en) | 2004-11-05 | 2005-11-04 | Metabolites of certain (1,4)diazepino(6,7,1-iJ)quinoline derivatives and methods of preparation and use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060111305A1 (https=) |
| EP (1) | EP1812436A1 (https=) |
| JP (1) | JP2008519056A (https=) |
| KR (1) | KR20070084009A (https=) |
| CN (1) | CN101124225A (https=) |
| AR (1) | AR052227A1 (https=) |
| AU (1) | AU2005304757A1 (https=) |
| BR (1) | BRPI0517100A (https=) |
| CA (1) | CA2586122A1 (https=) |
| CR (1) | CR9092A (https=) |
| GT (1) | GT200500319A (https=) |
| IL (1) | IL182755A0 (https=) |
| MX (1) | MX2007005475A (https=) |
| NO (1) | NO20072165L (https=) |
| PE (1) | PE20060939A1 (https=) |
| RU (1) | RU2007116264A (https=) |
| TW (1) | TW200635926A (https=) |
| WO (1) | WO2006052886A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
| AU2007230997A1 (en) * | 2006-03-24 | 2007-10-04 | Wyeth | Treatment of pain |
| EP1998773A2 (en) * | 2006-03-24 | 2008-12-10 | Wyeth a Corporation of the State of Delaware | New therapeutic combinations for the treatment of depression |
| US20070225278A1 (en) * | 2006-03-24 | 2007-09-27 | Wyeth | Methods for treating cognitive and other disorders |
| CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN111303218B (zh) * | 2020-03-17 | 2021-03-30 | 连江仁泽生物科技有限公司 | 一种马鞭草苷的合成方法及应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3158619A (en) * | 1962-06-14 | 1964-11-24 | Searle & Co | Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
| US3235564A (en) * | 1964-03-27 | 1966-02-15 | Searle & Co | Intermediates to certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
| US3296252A (en) * | 1964-04-02 | 1967-01-03 | Sandoz Ag | Tetracyclic diazepinone compounds |
| US3335134A (en) * | 1964-04-02 | 1967-08-08 | Sandoz Ag | Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones |
| GB1120463A (en) * | 1964-07-06 | 1968-07-17 | Manuf Prod Pharma | Derivatives of 1,3-diazafluoranthene-1-oxide |
| US3329676A (en) * | 1964-11-09 | 1967-07-04 | American Home Prod | Fused 1, 4-diazepine ring systems |
| US3417101A (en) * | 1964-11-09 | 1968-12-17 | American Home Prod | Fused ring compounds |
| US3714149A (en) * | 1969-11-03 | 1973-01-30 | Upjohn Co | Pyridobenzodiazepinones |
| US3914250A (en) * | 1974-08-01 | 1975-10-21 | American Home Prod | 1,4-Diazepino{8 6,5,4-jk{9 carbazoles |
| US4880814A (en) * | 1987-11-13 | 1989-11-14 | Abbott Laboratories | 7-cycloalkyl naphthyridines |
| GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
| JPH02180885A (ja) * | 1988-09-01 | 1990-07-13 | Glaxo Group Ltd | ラクタム誘導体 |
| KR0167346B1 (ko) * | 1989-06-09 | 1999-01-15 | 로버트 에이. 아미테이지 | 중추신경계 활성을 갖는 헤테로사이클릭 아민 |
| NZ314105A (en) * | 1996-02-02 | 1997-12-19 | Sumitomo Pharma | Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring |
| US6380166B1 (en) * | 1999-09-13 | 2002-04-30 | American Home Products Corporation | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols |
| US6761904B2 (en) * | 2000-03-31 | 2004-07-13 | Nycomed Austria Gmbh | Pharmaceutical kit comprising midodrine as active drug substance |
| US6414144B1 (en) * | 2000-11-03 | 2002-07-02 | Wyeth | Process for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi] indole derivatives |
| US6916922B2 (en) * | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
| AR031202A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
| US6759405B2 (en) * | 2000-11-03 | 2004-07-06 | Wyeth | Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
| AR031199A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
| AR031197A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta(b) diazepino(6,7,1-hi)indol |
| US6784172B2 (en) * | 2000-11-03 | 2004-08-31 | Wyeth | Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
| US6503900B2 (en) * | 2000-11-03 | 2003-01-07 | Wyeth | [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives |
| SK7042003A3 (en) * | 2000-12-20 | 2004-07-07 | Bristol Myers Squibb Co | Substituted pyridoindoles as serotonin agonists and antagonists |
| MXPA04001202A (es) * | 2001-08-06 | 2005-02-17 | Pharmacia & Upjhon Company | Ligandos tetraciclicos terapeuticamente utiles. |
| TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
| TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
| WO2004056324A2 (en) * | 2002-12-19 | 2004-07-08 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
| TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
| US20070225278A1 (en) * | 2006-03-24 | 2007-09-27 | Wyeth | Methods for treating cognitive and other disorders |
-
2005
- 2005-11-03 TW TW094138587A patent/TW200635926A/zh unknown
- 2005-11-03 AR ARP050104611A patent/AR052227A1/es unknown
- 2005-11-03 PE PE2005001292A patent/PE20060939A1/es not_active Application Discontinuation
- 2005-11-04 CA CA002586122A patent/CA2586122A1/en not_active Abandoned
- 2005-11-04 EP EP05824172A patent/EP1812436A1/en not_active Withdrawn
- 2005-11-04 BR BRPI0517100-8A patent/BRPI0517100A/pt not_active IP Right Cessation
- 2005-11-04 WO PCT/US2005/040289 patent/WO2006052886A1/en not_active Ceased
- 2005-11-04 JP JP2007540134A patent/JP2008519056A/ja active Pending
- 2005-11-04 MX MX2007005475A patent/MX2007005475A/es unknown
- 2005-11-04 CN CNA2005800449537A patent/CN101124225A/zh active Pending
- 2005-11-04 RU RU2007116264/04A patent/RU2007116264A/ru not_active Application Discontinuation
- 2005-11-04 GT GT200500319A patent/GT200500319A/es unknown
- 2005-11-04 US US11/267,765 patent/US20060111305A1/en not_active Abandoned
- 2005-11-04 AU AU2005304757A patent/AU2005304757A1/en not_active Abandoned
- 2005-11-04 KR KR1020077010287A patent/KR20070084009A/ko not_active Withdrawn
-
2007
- 2007-04-23 IL IL182755A patent/IL182755A0/en unknown
- 2007-04-26 NO NO20072165A patent/NO20072165L/no not_active Application Discontinuation
- 2007-05-02 CR CR9092A patent/CR9092A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812436A1 (en) | 2007-08-01 |
| CN101124225A (zh) | 2008-02-13 |
| CR9092A (es) | 2007-10-23 |
| JP2008519056A (ja) | 2008-06-05 |
| AR052227A1 (es) | 2007-03-07 |
| WO2006052886A1 (en) | 2006-05-18 |
| IL182755A0 (en) | 2007-07-24 |
| NO20072165L (no) | 2007-07-25 |
| WO2006052886A8 (en) | 2007-06-14 |
| BRPI0517100A (pt) | 2008-09-30 |
| GT200500319A (es) | 2006-06-02 |
| PE20060939A1 (es) | 2006-11-10 |
| CA2586122A1 (en) | 2006-05-18 |
| US20060111305A1 (en) | 2006-05-25 |
| RU2007116264A (ru) | 2008-12-10 |
| TW200635926A (en) | 2006-10-16 |
| KR20070084009A (ko) | 2007-08-24 |
| MX2007005475A (es) | 2007-05-24 |
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