AU2005299218B2 - Antisense oligonucleotides for treating allergy and neoplastic cell proliferation - Google Patents

Antisense oligonucleotides for treating allergy and neoplastic cell proliferation Download PDF

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Publication number
AU2005299218B2
AU2005299218B2 AU2005299218A AU2005299218A AU2005299218B2 AU 2005299218 B2 AU2005299218 B2 AU 2005299218B2 AU 2005299218 A AU2005299218 A AU 2005299218A AU 2005299218 A AU2005299218 A AU 2005299218A AU 2005299218 B2 AU2005299218 B2 AU 2005299218B2
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AU
Australia
Prior art keywords
cells
oligonucleotide
seq
ccr3
asm8
Prior art date
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Ceased
Application number
AU2005299218A
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English (en)
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AU2005299218A2 (en
AU2005299218A1 (en
Inventor
Paolo Renzi
Khalid Zemzoumi
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Pharmaxis Ltd
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Pharmaxis Ltd
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Publication date
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Publication of AU2005299218A1 publication Critical patent/AU2005299218A1/en
Publication of AU2005299218A2 publication Critical patent/AU2005299218A2/en
Application granted granted Critical
Publication of AU2005299218B2 publication Critical patent/AU2005299218B2/en
Assigned to PHARMAXIS LTD reassignment PHARMAXIS LTD Request for Assignment Assignors: TOPIGEN PHARMACEUTICALS INC.
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/331—Universal or degenerate base

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2005299218A 2004-10-29 2005-10-27 Antisense oligonucleotides for treating allergy and neoplastic cell proliferation Ceased AU2005299218B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62320604P 2004-10-29 2004-10-29
US60/623,206 2004-10-29
PCT/CA2005/001656 WO2006045202A1 (en) 2004-10-29 2005-10-27 Antisense oligonucleotides for treating allergy and neoplastic cell proliferation

Publications (3)

Publication Number Publication Date
AU2005299218A1 AU2005299218A1 (en) 2006-05-04
AU2005299218A2 AU2005299218A2 (en) 2008-10-30
AU2005299218B2 true AU2005299218B2 (en) 2012-04-12

Family

ID=36226992

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005299218A Ceased AU2005299218B2 (en) 2004-10-29 2005-10-27 Antisense oligonucleotides for treating allergy and neoplastic cell proliferation

Country Status (12)

Country Link
US (2) US8119790B2 (enExample)
EP (1) EP1812075B1 (enExample)
JP (1) JP5314283B2 (enExample)
CN (1) CN101087623B (enExample)
AU (1) AU2005299218B2 (enExample)
BR (1) BRPI0517387A8 (enExample)
CA (1) CA2584457C (enExample)
ES (1) ES2450929T3 (enExample)
MX (1) MX2007005083A (enExample)
NZ (1) NZ554723A (enExample)
RU (1) RU2416412C2 (enExample)
WO (1) WO2006045202A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
EP2285961A4 (en) 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc OLIGONUCLEOTIDES FOR THE TREATMENT OF INFLAMMATION AND NEOPLASTIC CELL REPRODUCTION
ES2625689T3 (es) 2010-04-29 2017-07-20 Ionis Pharmaceuticals, Inc. Modulación de la expresión de transtiretina
JP2014511181A (ja) * 2011-02-24 2014-05-15 ファーマキシス リミテッド キメラ骨格および２−アミノ−２’−デオキシアデノシンを有するオリゴヌクレオチド阻害剤
US9901079B2 (en) 2011-08-18 2018-02-27 New York University Inhibition of oncogenic kras-induced GM-CSF production and function
WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
HK1255922A1 (zh) 2015-11-04 2019-09-06 Astrazeneca Ab 二肽基肽酶-4和骨膜素作为嗜酸性粒细胞疾病中嗜酸性粒细胞靶向治疗药物临床反应的预测因子

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1999066037A2 (en) * 1998-06-17 1999-12-23 Recherches Expertises Et Developpement Medicaux Parenz Inc. Antisense oligonucleotides for treating or preventing atopic diseases and neoplastic cell proliferation
WO2003004511A2 (en) * 2001-07-06 2003-01-16 Topigen Pharmaceutique Inc.. Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

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US4880635B1 (en) 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
JPH0825869B2 (ja) 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US4911928A (en) 1987-03-13 1990-03-27 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4917951A (en) 1987-07-28 1990-04-17 Micro-Pak, Inc. Lipid vesicles formed of surfactants and steroids
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FR2734147B1 (fr) 1995-05-19 1997-10-10 Klein Jean Michel Dispositif d'osteosynthese implantable
US6825174B2 (en) 1995-06-07 2004-11-30 East Carolina University Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
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WO1997023244A1 (en) 1995-12-22 1997-07-03 Smithkline Beecham Corporation Use of antisene oligodeoxynucleotides to produce truncated proteins
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ATE346918T1 (de) 1998-06-19 2006-12-15 Univ Mcgill Auf beta-arabinose, und dessen analogen, basierte antisense oligonukleotide
HK1042706A1 (zh) 1998-08-03 2002-08-23 东卡罗来纳大学 低腺苷反义寡核苷酸制剂、组合物、试剂盒及处理
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Publication number Priority date Publication date Assignee Title
WO1999066037A2 (en) * 1998-06-17 1999-12-23 Recherches Expertises Et Developpement Medicaux Parenz Inc. Antisense oligonucleotides for treating or preventing atopic diseases and neoplastic cell proliferation
WO2003004511A2 (en) * 2001-07-06 2003-01-16 Topigen Pharmaceutique Inc.. Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

Also Published As

Publication number Publication date
CN101087623A (zh) 2007-12-12
EP1812075A4 (en) 2010-04-07
AU2005299218A2 (en) 2008-10-30
RU2007119777A (ru) 2008-12-10
US8119790B2 (en) 2012-02-21
BRPI0517387A (pt) 2008-10-07
AU2005299218A1 (en) 2006-05-04
ES2450929T3 (es) 2014-03-25
MX2007005083A (es) 2007-10-03
CA2584457C (en) 2012-10-23
WO2006045202A1 (en) 2006-05-04
NZ554723A (en) 2009-12-24
EP1812075B1 (en) 2013-12-11
US8202851B2 (en) 2012-06-19
CA2584457A1 (en) 2006-05-04
US20090215861A1 (en) 2009-08-27
EP1812075A1 (en) 2007-08-01
RU2416412C2 (ru) 2011-04-20
BRPI0517387A8 (pt) 2017-07-11
JP2008517953A (ja) 2008-05-29
JP5314283B2 (ja) 2013-10-16
CN101087623B (zh) 2012-09-26
US20120065249A1 (en) 2012-03-15

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 25 SEP 2008

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: PHARMAXIS LTD

Free format text: FORMER OWNER WAS: TOPIGEN PHARMACEUTICALS INC.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired