CN101087623B - 用于治疗变态反应和肿瘤细胞增殖的反义寡核苷酸 - Google Patents

用于治疗变态反应和肿瘤细胞增殖的反义寡核苷酸 Download PDF

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CN101087623B
CN101087623B CN2005800448619A CN200580044861A CN101087623B CN 101087623 B CN101087623 B CN 101087623B CN 2005800448619 A CN2005800448619 A CN 2005800448619A CN 200580044861 A CN200580044861 A CN 200580044861A CN 101087623 B CN101087623 B CN 101087623B
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cells
ccr3
oligonucleotide
top004
asm8
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CN101087623A (zh
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K·泽姆祖米
P·伦齐
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Pharmaxis Ltd
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Topigen Pharmaceuticals Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/331—Universal or degenerate base

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  • Wood Science & Technology (AREA)
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  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800448619A 2004-10-29 2005-10-27 用于治疗变态反应和肿瘤细胞增殖的反义寡核苷酸 Expired - Fee Related CN101087623B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62320604P 2004-10-29 2004-10-29
US60/623,206 2004-10-29
PCT/CA2005/001656 WO2006045202A1 (en) 2004-10-29 2005-10-27 Antisense oligonucleotides for treating allergy and neoplastic cell proliferation

Publications (2)

Publication Number Publication Date
CN101087623A CN101087623A (zh) 2007-12-12
CN101087623B true CN101087623B (zh) 2012-09-26

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CN2005800448619A Expired - Fee Related CN101087623B (zh) 2004-10-29 2005-10-27 用于治疗变态反应和肿瘤细胞增殖的反义寡核苷酸

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US (2) US8119790B2 (enExample)
EP (1) EP1812075B1 (enExample)
JP (1) JP5314283B2 (enExample)
CN (1) CN101087623B (enExample)
AU (1) AU2005299218B2 (enExample)
BR (1) BRPI0517387A8 (enExample)
CA (1) CA2584457C (enExample)
ES (1) ES2450929T3 (enExample)
MX (1) MX2007005083A (enExample)
NZ (1) NZ554723A (enExample)
RU (1) RU2416412C2 (enExample)
WO (1) WO2006045202A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2285961A4 (en) 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc OLIGONUCLEOTIDES FOR THE TREATMENT OF INFLAMMATION AND NEOPLASTIC CELL REPRODUCTION
ES2625689T3 (es) 2010-04-29 2017-07-20 Ionis Pharmaceuticals, Inc. Modulación de la expresión de transtiretina
JP2014511181A (ja) * 2011-02-24 2014-05-15 ファーマキシス リミテッド キメラ骨格および２−アミノ−２’−デオキシアデノシンを有するオリゴヌクレオチド阻害剤
US9901079B2 (en) 2011-08-18 2018-02-27 New York University Inhibition of oncogenic kras-induced GM-CSF production and function
WO2015066262A1 (en) * 2013-11-04 2015-05-07 Trustees Of Dartmouth College Methods for preventing toxicity of adoptive cell therapy
HK1255922A1 (zh) 2015-11-04 2019-09-06 Astrazeneca Ab 二肽基肽酶-4和骨膜素作为嗜酸性粒细胞疾病中嗜酸性粒细胞靶向治疗药物临床反应的预测因子

Citations (2)

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WO2003004511A2 (en) * 2001-07-06 2003-01-16 Topigen Pharmaceutique Inc.. Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

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CN101087623A (zh) 2007-12-12
AU2005299218B2 (en) 2012-04-12
EP1812075A4 (en) 2010-04-07
AU2005299218A2 (en) 2008-10-30
RU2007119777A (ru) 2008-12-10
US8119790B2 (en) 2012-02-21
BRPI0517387A (pt) 2008-10-07
AU2005299218A1 (en) 2006-05-04
ES2450929T3 (es) 2014-03-25
MX2007005083A (es) 2007-10-03
CA2584457C (en) 2012-10-23
WO2006045202A1 (en) 2006-05-04
NZ554723A (en) 2009-12-24
EP1812075B1 (en) 2013-12-11
US8202851B2 (en) 2012-06-19
CA2584457A1 (en) 2006-05-04
US20090215861A1 (en) 2009-08-27
EP1812075A1 (en) 2007-08-01
RU2416412C2 (ru) 2011-04-20
BRPI0517387A8 (pt) 2017-07-11
JP2008517953A (ja) 2008-05-29
JP5314283B2 (ja) 2013-10-16
US20120065249A1 (en) 2012-03-15

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Effective date of registration: 20160612

Address after: New South Wales Australia

Patentee after: PHARMAXIS LTD.

Address before: Quebec

Patentee before: Topigen Pharmaceuticals Inc.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20120926

Termination date: 20181027