AU2005235133B2 - HMB compositions and uses thereof - Google Patents

HMB compositions and uses thereof Download PDF

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Publication number
AU2005235133B2
AU2005235133B2 AU2005235133A AU2005235133A AU2005235133B2 AU 2005235133 B2 AU2005235133 B2 AU 2005235133B2 AU 2005235133 A AU2005235133 A AU 2005235133A AU 2005235133 A AU2005235133 A AU 2005235133A AU 2005235133 B2 AU2005235133 B2 AU 2005235133B2
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AU
Australia
Prior art keywords
hmb
slurry
protein
pif
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2005235133A
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English (en)
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AU2005235133A1 (en
Inventor
Jeffrey H. Baxter
Pradip. Mukerji
Michael J. Tisdale
Anne C. Voss
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Abbott Laboratories
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Abbott Laboratories
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Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of AU2005235133A1 publication Critical patent/AU2005235133A1/en
Application granted granted Critical
Publication of AU2005235133B2 publication Critical patent/AU2005235133B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
AU2005235133A 2004-03-26 2005-03-14 HMB compositions and uses thereof Ceased AU2005235133B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/810,762 US20050215640A1 (en) 2004-03-26 2004-03-26 HMB compositions and uses thereof
US10/810,762 2004-03-26
PCT/US2005/007951 WO2005102301A2 (en) 2004-03-26 2005-03-14 Hydroxymethylbutyrate compositions and uses thereof

Publications (2)

Publication Number Publication Date
AU2005235133A1 AU2005235133A1 (en) 2005-11-03
AU2005235133B2 true AU2005235133B2 (en) 2010-06-17

Family

ID=34990887

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005235133A Ceased AU2005235133B2 (en) 2004-03-26 2005-03-14 HMB compositions and uses thereof

Country Status (14)

Country Link
US (9) US20050215640A1 (cg-RX-API-DMAC7.html)
EP (3) EP1727534A2 (cg-RX-API-DMAC7.html)
JP (3) JP5145033B2 (cg-RX-API-DMAC7.html)
KR (2) KR20130010912A (cg-RX-API-DMAC7.html)
CN (1) CN101212961A (cg-RX-API-DMAC7.html)
AU (1) AU2005235133B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0509017A (cg-RX-API-DMAC7.html)
CA (2) CA2807787C (cg-RX-API-DMAC7.html)
EC (1) ECSP066873A (cg-RX-API-DMAC7.html)
ES (2) ES2586402T3 (cg-RX-API-DMAC7.html)
IL (1) IL178039A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA06010922A (cg-RX-API-DMAC7.html)
TW (1) TWI369981B (cg-RX-API-DMAC7.html)
WO (1) WO2005102301A2 (cg-RX-API-DMAC7.html)

Families Citing this family (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
PL371081A1 (pl) * 2004-11-08 2006-05-15 Sgp & Sons Ab Preparat farmaceutyczny wpływający na procesy wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt oraz zastosowanie preparatu farmaceutycznego w procesie wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt
CA2632262C (en) * 2005-12-19 2015-04-07 Abbott Laboratories Method of using .beta.-hydroxy-.beta.-methylbutyrate
US9358242B2 (en) * 2007-08-30 2016-06-07 Prelief Inc. Calcium glycerophosphate for treating and preventing respiratory diseases or conditions
US9707241B2 (en) 2008-12-09 2017-07-18 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9770424B2 (en) 2008-12-09 2017-09-26 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9259430B2 (en) 2008-12-09 2016-02-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US11173167B2 (en) 2008-12-09 2021-11-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
PL2381784T3 (pl) * 2008-12-09 2019-01-31 Metabolic Technologies, Inc. Interwencyjny produkt odżywczy w celu poprawy funkcji i siły mięśni
US9539224B2 (en) 2008-12-09 2017-01-10 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
KR20170053733A (ko) 2009-02-24 2017-05-16 리터 파마슈티컬즈 인코오포레이티드 프리바이오틱 제제 및 사용 방법
AU2010241571B2 (en) 2009-04-29 2014-06-26 Amarin Pharmaceuticals Ireland Limited Stable pharmaceutical composition and methods of using same
CN102413825A (zh) 2009-04-29 2012-04-11 阿马里纳股份公司 含有epa和心血管剂的药物组合物以及使用其的方法
WO2010147994A1 (en) 2009-06-15 2010-12-23 Amarin Pharma, Inc. Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
AU2010298222B2 (en) 2009-09-23 2017-01-05 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
CN101704736A (zh) * 2009-10-30 2010-05-12 黄再新 β-羟基-β-甲基丁酸生产过程中氯气逸出时的应急处理方法
US9754437B2 (en) * 2009-11-24 2017-09-05 Pepsico, Inc. Automated beverage formulation
US8335592B2 (en) 2009-11-24 2012-12-18 Pepsico, Inc. Beverage dispensing device
US8490829B2 (en) * 2009-11-24 2013-07-23 Pepsico, Inc. Personalized beverage dispensing device
WO2011075741A1 (en) * 2009-12-18 2011-06-23 Metabolic Technologies, Inc. Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb)
PE20121730A1 (es) * 2010-01-29 2013-01-13 Abbott Lab Liquidos nutricionales envasados asepticamente que comprenden beta-hidroxi-beta-metilbutirato (hmb)
PE20121728A1 (es) * 2010-01-29 2013-01-13 Abbott Lab Polvos nutricionales que comprenden hmb secado por aspersion
CN102711524B (zh) * 2010-01-29 2014-09-10 雅培制药有限公司 包含hmb钙的营养乳剂
CN107080236A (zh) * 2010-01-29 2017-08-22 雅培制药有限公司 包含hmb的塑料包装的营养液
WO2011094544A1 (en) * 2010-01-29 2011-08-04 Abbott Laboratories Nutritional emulsions comprising calcium hmb and soluble protein
US9693577B2 (en) 2010-01-29 2017-07-04 Abbott Laboratories Method of preparing a nutritional powder comprising spray dried HMB
EP3202406A1 (en) 2010-04-28 2017-08-09 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣hmb及可溶性蛋白質之實質上透明營養液
EP2444083A1 (en) * 2010-10-21 2012-04-25 Nestec S.A. Cysteine and food intake
NZ778131A (en) 2010-11-29 2023-03-31 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
JP2014501530A (ja) * 2010-12-22 2014-01-23 アボット・ラボラトリーズ カルシウムベータ−ヒドロキシ−ベータメチルブチレートと共役リノール酸とを含む栄養補助製品
SG191369A1 (en) * 2010-12-27 2013-08-30 Abbott Lab Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate
EP2672843B1 (en) * 2011-02-07 2018-07-11 Abbott Laboratories Nutritional products comprising beta-hydroxy-beta-methylbutyrate
US8715648B2 (en) 2011-02-16 2014-05-06 Pivotal Therapeutics Inc. Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics
US9119826B2 (en) 2011-02-16 2015-09-01 Pivotal Therapeutics, Inc. Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels
US8952000B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events
US8951514B2 (en) 2011-02-16 2015-02-10 Pivotal Therapeutics Inc. Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels
EP2675298A1 (en) 2011-02-17 2013-12-25 Abbott Laboratories Methods for improving brain development and cognitive function using beta-hydroxy-beta-methylbutyrate
CA2829229A1 (en) * 2011-03-31 2012-10-04 Nestec S.A. Nutritional compositions for increasing arginine levels and methods of using same
US8183227B1 (en) 2011-07-07 2012-05-22 Chemo S. A. France Compositions, kits and methods for nutrition supplementation
JP2014525410A (ja) * 2011-08-15 2014-09-29 アボット・ラボラトリーズ Hmb及びその塩を製造する方法
US8168611B1 (en) 2011-09-29 2012-05-01 Chemo S.A. France Compositions, kits and methods for nutrition supplementation
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2775837A4 (en) 2011-11-07 2015-10-28 Amarin Pharmaceuticals Ie Ltd METHODS OF TREATING HYPERTRIGLYCERIDEMIA
AU2013207368A1 (en) 2012-01-06 2014-07-24 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-CRP) in a subject
ES2421187B1 (es) * 2012-02-23 2014-11-26 Abbott Laboratories Metodo para mejorar el desarrollo cerebral y la funcion cognitiva usando beta-hidroxi-beta-metilbutirato
US20150119339A1 (en) * 2012-06-11 2015-04-30 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients
LT3363433T (lt) 2012-06-29 2021-02-25 Amarin Pharmaceuticals Ireland Limited Širdies ir kraujagyslių sistemos sutrikimų rizikos sumažinimo būdas subjektui, gydomam statinais, panaudojant eikozapentaeno rūgšties etilo esterį
US20140037813A1 (en) * 2012-08-02 2014-02-06 Mead Johnson Nutrition Company Nutritional creamer composition
ES2970283T3 (es) * 2012-09-10 2024-05-27 Metabolic Tech Llc Composiciones que comprenden HMB y ATP así como su uso
JP2015529470A (ja) * 2012-09-17 2015-10-08 アボット・ラボラトリーズAbbott Laboratories β−ヒドロキシ−β−メチル酪酸(METHYLBUTRYICACID)含有組成物およびその使用
SG11201502205SA (en) 2012-09-21 2015-04-29 Abbott Lab Nutritional compositions including calcium beta-hydroxy-beta-methylbutyrate, protein and low levels of electrolytes
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
EP2945616B1 (en) 2013-01-15 2018-11-28 NuSirt Sciences, Inc. Treating pulmonary conditions
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9820504B2 (en) 2013-03-08 2017-11-21 Axiom Foods, Inc. Rice protein supplement and methods of use thereof
WO2014138304A1 (en) 2013-03-08 2014-09-12 Axiom Foods, Inc., Rice protein supplements
HK1220391A1 (zh) 2013-03-14 2017-05-05 Abbott Laboratories 与长期体力活动不足有关的胰岛素抗性的治疗
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150057350A1 (en) * 2013-08-23 2015-02-26 Abbott Laboratories Fibrosis biomarkers and methods of using same
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
JP6349575B2 (ja) * 2013-12-03 2018-07-04 小林香料株式会社 Hmbを含有する酸性飲料
WO2015094767A1 (en) * 2013-12-18 2015-06-25 Abbott Laboratories Methods for maintaining or increasing bodyweight using decaffeinated green tea extract
WO2015094925A1 (en) 2013-12-18 2015-06-25 Capsugel Belgium Nv Stable liquid filled hard capsule comprising beta-hydroxy-beta-methylbutyric acid
WO2015105981A2 (en) * 2014-01-09 2015-07-16 Abbott Laboratories Conditional essentiality of hmb
HK1223509A1 (zh) * 2014-03-14 2017-08-04 代谢科技有限公司 含有游离酸形式的β-羟基-β-甲基丁酸盐(HMB)的液体和食品
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
US10172818B2 (en) 2014-06-16 2019-01-08 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US20160184248A1 (en) * 2014-12-15 2016-06-30 University Of Central Florida Research Foundation Inc. Compositions and methods of use of -hydroxy-methylbutyrate (hmb) resulting in an acute endocrine response
WO2016196637A1 (en) * 2015-06-01 2016-12-08 Metabolic Technologies, Inc. Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (hmb) for decreasing fat mass
JP7114458B2 (ja) 2015-09-16 2022-08-08 メタボリック・テクノロジーズ,インコーポレーテッド 軟組織外傷からの回復を増強するためのβ-ヒドロキシ-β-メチルブチレート(HMB)の組成物および使用方法
US12208073B2 (en) 2015-09-16 2025-01-28 Metabolic Technologies, LLC Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma
WO2017123922A1 (en) * 2016-01-13 2017-07-20 Metabolic Technologies, Inc. COMPOSITIONS AND METHODS OF USE OF β-HYDROXY-β-METHYLBUTYRATE (HMB) FOR JOINT STABILITY
US11406609B2 (en) 2016-01-21 2022-08-09 Metabolic Technologies, Inc. Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for modulating autophagy and lipophagy
US10213399B2 (en) * 2016-01-21 2019-02-26 Metabolic Technologies, Inc. Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for modulating autophagy and lipophagy
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
MX2018014407A (es) 2016-05-25 2019-02-21 Tsi Group Ltd Estabilizacion de formulaciones de acido beta-hidroxiisovalerico en capsulas de gel blando.
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
EP3612570A4 (en) 2017-04-17 2021-01-13 The University of Chicago POLYMERIC MATERIALS FOR THE ADMINISTRATION OF SHORT-CHAIN FATTY ACIDS TO THE INTESTINE FOR HUMAN HEALTH AND DISEASE TREATMENT APPLICATIONS
CN110868870A (zh) 2017-05-12 2020-03-06 艾斯姆食品公司 大米产物及制备它们的系统和方法
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
CN111295187A (zh) 2017-08-14 2020-06-16 胺细拉健康公司 用于治疗肝脏疾病的氨基酸组合物
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
CN108558707A (zh) * 2018-04-13 2018-09-21 太仓运通新材料科技有限公司 一种三肌酸hmb盐的制备方法
CN110636847B (zh) * 2018-04-25 2023-06-09 昂科克罗斯株式会社 用于预防及治疗肌肉疾病的组合物
AR115585A1 (es) 2018-06-20 2021-02-03 Axcella Health Inc Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo
IL261670B (en) * 2018-09-06 2019-06-30 Tudu Holdings Ltd A preparation that includes magnesium and its uses
MA50490A (fr) 2018-09-24 2020-09-02 Amarin Pharmaceuticals Ie Ltd Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
US10888576B2 (en) 2018-10-08 2021-01-12 Metabolic Technologies, Inc. Composition of HMB and ATP and methods of use
JP7286964B2 (ja) * 2018-12-28 2023-06-06 日油株式会社 β-ヒドロキシ-β-メチル酪酸、タンパク質、及び液状油脂を含有する液状栄養組成物
CN111714616A (zh) * 2019-07-17 2020-09-29 江苏西宏生物医药有限公司 一种用于抗肿瘤的组合物
JP7594356B2 (ja) * 2019-10-30 2024-12-04 小林製薬株式会社 経口組成物
JP2022554020A (ja) 2019-11-12 2022-12-27 アマリン ファーマシューティカルズ アイルランド リミテッド 心房細動および/または心房粗動を患う対象における心血管イベントのリスクを低減する方法
EP4117646A1 (en) * 2020-03-12 2023-01-18 Abbott Laboratories Methods of treating diarrhea or inflammatory conditions of the gut
CA3183079A1 (en) * 2020-06-17 2021-12-23 John Rathmacher Compositions and methods of use of .beta.-hydroxy-.beta.-methylbutyrate (hmb) for improving muscle mass, strength and muscular function without exercise
WO2022090473A1 (en) * 2020-10-30 2022-05-05 Société des Produits Nestlé S.A. Compositions containing nicotinamide and vitamin b6 and methods of using such compositions for promoting muscle growth
AU2021372803A1 (en) * 2020-10-30 2023-04-06 Société des Produits Nestlé S.A. Compositions containing nicotinamide and vitamin B6 and methods of using such compositions for treating cachexia or precachexia
US20230398104A1 (en) * 2020-10-30 2023-12-14 Societe Des Produits Nestle S.A. Compositions containing nicotinamide and vitamin b6 and methods of using such compositions for rehabilitation
JP2023547038A (ja) * 2020-10-30 2023-11-09 ソシエテ・デ・プロデュイ・ネスレ・エス・アー ニコチンアミド及びビタミンb6を含有する組成物、並びにサルコペニア及び虚弱を治療するためにかかる組成物を使用する方法
AU2022263358A1 (en) 2021-04-21 2023-11-30 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure
EP4395756A1 (en) * 2021-08-31 2024-07-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of branched chain fatty acids (bcfas) for the treatment of intestinal inflammation
DE202023107635U1 (de) * 2023-12-22 2024-02-08 RenaCare NEPHROMED GmbH Zusammensetzung zur Eiweißsubstitution
CN120837469A (zh) * 2025-08-06 2025-10-28 中日友好医院(中日友好临床医学研究所) β-羟基-β-甲基丁酸作为GSDMD的抑制剂及其抗细胞焦亡的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014429A1 (en) * 1992-12-23 1994-07-07 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
WO1998004253A1 (en) * 1996-07-26 1998-02-05 Beale Paxton K Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal
WO1999066917A2 (en) * 1998-06-23 1999-12-29 Iowa State University Research Foundation, Inc. Composition comprising ss-hydroxy-ss-methylbutyric acid and at least one amino acid

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US597650A (en) 1898-01-18 morris
US3408210A (en) 1965-06-14 1968-10-29 Wilbert A. Heyman Dehydration of foods
US3542560A (en) 1967-12-06 1970-11-24 American Home Prod Infant formula with fat composition like human milk
GB1446965A (en) 1974-02-14 1976-08-18 Agricultural Vegetable Prod Preparation of food products
US4104290A (en) 1975-02-07 1978-08-01 H.L.S. Ltd., Industrial Engineering Company Process for separating oils and fats into liquid and solid fractions
US4311645A (en) 1980-03-24 1982-01-19 Hoffmann-La Roche Inc. Synthesis of SRS-active compounds
US4871768A (en) 1984-07-12 1989-10-03 New England Deaconess Hospital Corporation Dietary supplement utilizing ω-3/medium chain trigylceride mixtures
US4742081A (en) * 1986-01-06 1988-05-03 Alfred Stracher Carnitine coupled pharmaceutical agents
US4866040A (en) 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
DE3620433A1 (de) 1986-06-18 1987-12-23 Boehringer Ingelheim Kg Verwendung von 2-(n-2,6-dichlorphenyl-n-allyl-amino)-imidazolin-(2) als cytoprotektives mittel
DE68904874T2 (de) 1988-10-31 1993-07-15 Sandoz Nutrition Ltd Organische verbindungen.
US5000975A (en) 1988-12-29 1991-03-19 American Home Products Corporation Randomized palm oil fat composition for infant formulas
CA2010511A1 (en) 1989-03-01 1990-09-01 Roberto L. Ceriani Method of enhancing cancer therapy by administration of unsaturated fatty acids
US5457130A (en) * 1989-03-20 1995-10-10 Cancer Research Campaign Technology Limited Eicosapentaenoic acid used to treat cachexia
GB8906369D0 (en) * 1989-03-20 1989-05-04 Tisdale Michael J Eicosapentaenoic acid
US5157022A (en) 1989-11-22 1992-10-20 Adrian Barbul Method for reducing blood cholesterol using arginine
US5087472A (en) * 1990-01-30 1992-02-11 Iowa State University Research Foundation, Inc. Feed compositions for domestics animals containing hydroxymethylbutyrate
US5028440A (en) * 1990-01-30 1991-07-02 Iowa State University Research Foundation, Inc. Method of raising meat producing animals to increase lean tissue development
US4992470A (en) * 1990-02-08 1991-02-12 Iowa State University Research Foundation, Inc. Method of enhancing immune response of mammals
US5167957A (en) 1990-09-06 1992-12-01 Virginia Tech Intellectual Properties, Inc. Compositions and methods for the treatment of dietary deficiencies
US5601860A (en) 1990-11-30 1997-02-11 American Home Products Corporation Corandomized fat compositions for infant formulas
FR2674102B1 (fr) 1991-03-18 1994-05-20 Meiji Seika Kaisha Ltd Aliment pour porcs et methode d'elevage des porcs utilisant cet aliment.
US5085883A (en) 1991-06-27 1992-02-04 Abbott Laboratories Blend of dietary fiber for nutritional products
US5171442A (en) 1991-10-18 1992-12-15 Nakshbendi Ghassan F Water purification apparatus
US5223285A (en) 1992-03-31 1993-06-29 Abbott Laboratories Nutritional product for pulmonary patients
CA2142314C (en) * 1992-09-16 1999-06-01 Steven L. Nissen Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol
US5447732A (en) 1992-11-25 1995-09-05 Ajinomoto Co., Inc. High-absorption mineral-containing composition and foods
AU699683B2 (en) 1993-05-13 1998-12-10 Loders Croklaan B.V. Human milk fat replacers from interesterified blends of triglycerides
US6136858A (en) 1994-01-10 2000-10-24 Abbott Laboratories Infant formula and methods of improving infant stool patterns
US5952314A (en) 1994-04-01 1999-09-14 Demichele; Stephen Joseph Nutritional product for a person having ulcerative colitis
US5444054A (en) 1994-04-01 1995-08-22 Abbott Labatories Method of treating ulcerative colitis
US5780451A (en) 1994-04-01 1998-07-14 Abbott Laboratories Nutritional product for a person having ulcerative colitis
US5576287A (en) 1994-04-29 1996-11-19 Wake Forest University Method for treating acute renal disease and failure
US5726146A (en) * 1994-12-06 1998-03-10 Natural Supplement Association, Incorporated Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass
KR0140248B1 (ko) 1995-03-23 1998-06-15 한상기 신규한 카제인 포스포펩티드, 그것을 포함하는 카제인 및 그 제조방법
DE19528461A1 (de) 1995-08-03 1997-02-06 Braun Melsungen Ag Präparat zur Ernährung
US5641531A (en) 1995-09-28 1997-06-24 Abbott Laboratories Nutritional liquid supplement beverage and method of making same
CA2240260C (en) 1995-12-15 2002-11-12 The Procter & Gamble Company Beverages having stable flavor/cloud emulsions in the presence of polyphosphate-containing preservative systems and low levels of xanthan gum
CA2252051C (en) 1996-04-11 2005-05-24 Loders Croklaan Bv Free flowing fat compositions
US6077828A (en) * 1996-04-25 2000-06-20 Abbott Laboratories Method for the prevention and treatment of cachexia and anorexia
US7504376B2 (en) 1996-08-12 2009-03-17 Natural Alternatives International Methods and compositions for increasing the anaerobic working capacity in tissues
US6080788A (en) 1997-03-27 2000-06-27 Sole; Michael J. Composition for improvement of cellular nutrition and mitochondrial energetics
DE29707308U1 (de) 1997-04-23 1997-06-26 Kunz, Armin, 66450 Bexbach Präparat zur Muskelerhaltung bzw. zur Förderung des Muskelaufbaus
US6660258B1 (en) 1997-05-09 2003-12-09 Pharma Pacific Pty Ltd Oromucosal cytokine compositions and uses thereof
US6103764A (en) * 1997-11-07 2000-08-15 Iowa State University Research Foundation, Inc. Method for increasing the aerobic capacity of muscle
US6013665A (en) 1997-12-16 2000-01-11 Abbott Laboratories Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides
US6194379B1 (en) 1998-05-01 2001-02-27 Abbott Laboratories Elemental enteral formula
US6475539B1 (en) 1998-05-07 2002-11-05 Abbott Laboratories Nutritionally complete low pH enteral formula
JP4175698B2 (ja) 1998-06-19 2008-11-05 サントリー株式会社 新規なトリグリセリド及びそれを含む組成物
CA2338638C (en) 1998-07-30 2009-03-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US5976550A (en) * 1998-11-20 1999-11-02 Engel; Peter H. Dietary food supplement
US20010008641A1 (en) * 1998-11-25 2001-07-19 R. Douglas Krotzer Nutritionally active composition for bodybuilding
JP3973786B2 (ja) 1998-12-28 2007-09-12 松下電器産業株式会社 スパッタリング方法及び装置
US6294206B1 (en) 1999-04-09 2001-09-25 Abbott Laboratories Powdered human milk fortifier
US6291525B1 (en) 1999-09-08 2001-09-18 Iowa State University Research Foundation, Inc. Method for improving a human's perception of his emotional state
JP2003511094A (ja) 1999-10-18 2003-03-25 マッスルテク リサーチ アンド ディヴェロプメント インコーポレーション 無脂肪体重及び体力を増強するための食物補充物質
GB9929919D0 (en) 1999-12-17 2000-02-09 Hannah Research Inst The Calcium phosphate nanoclusters and their applications
US6521591B1 (en) 2000-02-10 2003-02-18 N.V. Nutricia Pharmaceutical composition for muscular anabolism
US7250397B2 (en) 2000-02-23 2007-07-31 Zealand Pharma A/S Antiarrhythmic peptides
WO2001077271A2 (en) 2000-04-06 2001-10-18 Conlinco, Inc. Conjugated linoleic acid compositions
JP4625156B2 (ja) * 2000-04-10 2011-02-02 イーエヌ大塚製薬株式会社 癌化学療法に伴う副作用軽減剤
US6420342B1 (en) 2000-05-08 2002-07-16 N.V. Nutricia Nutritional preparation comprising ribose and medical use thereof
US20050106219A1 (en) 2000-05-30 2005-05-19 Karlheinz Bortlik Primary composition comprising a lipophilic bioactive compound
EP1307230B1 (en) 2000-08-03 2013-10-23 North Carolina State University Enhancement of development of oviparous species by in ovo feeding
AU2001289849A1 (en) * 2000-08-29 2002-03-13 Lonza A.G. Method for preparing a mixture that can be granulated and carnitine-magnesium hydroxycitrate
US20030203070A1 (en) 2000-09-26 2003-10-30 The Procter & Gamble Company Compositions containing sorbitan monoesters
EP1198991B1 (en) 2000-10-20 2012-12-19 Nutriz N.V: Non-dairy products derived from rice
AU2002233639B2 (en) 2001-02-15 2007-03-01 Adeka Corporation Products containing $G(b)-glucan
JP3735070B2 (ja) 2001-03-26 2006-01-11 花王株式会社 容器詰乳化飲料
US6620427B2 (en) 2001-04-24 2003-09-16 Abbott Laboratories Method for improving bone mineralization
US20030021877A1 (en) 2001-06-13 2003-01-30 Cain Frederick William Micronised fat particles
DE10145818C1 (de) 2001-09-17 2002-10-10 Alfill Engineering Gmbh & Co K Sterilisiervorrichtung mit H202-Verdampfer
JP2003137790A (ja) * 2001-11-01 2003-05-14 Mie Kariyou Kk β−2,1(β2→β1)結合連鎖フラクトースオリゴマーを含有するフラクトオリゴ糖を有効成分とする医薬
GB2381451A (en) 2001-11-01 2003-05-07 New Technology Res Ltd Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect
CN1267174C (zh) 2001-12-12 2006-08-02 马泰克生物科学博尔德公司 从含油种子和微生物来源提取和冬化脂类的方法
US7168581B2 (en) 2001-12-21 2007-01-30 Rexam Medical Packaging Inc. Closure for a retort processed container having a peelable seal
DE10163676A1 (de) 2001-12-21 2003-07-10 Phenion Gmbh & Co Kg Verwendung von Hyperforin oder Extrakten aus Johanniskraut gegen anaphylaktische Schockzustände oder Osteoporose
US20030165579A1 (en) 2002-02-27 2003-09-04 Chih-Hui Lin Euphorbia antiquorum extract, a pharmaceutical composition containing the same and methods for treatment of cancers
CA2483162C (en) 2002-04-23 2011-08-23 Aventis Pharmaceuticals Inc. Use of 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino benzo[b]thiophene-2-carboxylic acid derivatives as il-4 inhibitors
SE0201581D0 (sv) 2002-05-29 2002-05-29 Scandinavian Biotechnology Res New improved acyltransferase
US20040013787A1 (en) 2002-06-28 2004-01-22 Theuer Richard C. Fat compositions for infant formula and methods therefor
US20040048925A1 (en) 2002-09-09 2004-03-11 Wiley David B. Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20040106678A1 (en) 2002-09-17 2004-06-03 Dobbins Thomas A Compositions for the parenteral administration of calcium and magnesium
US7411039B2 (en) 2002-10-14 2008-08-12 Novo Nordisk A/S GLP-2 compounds, formulations, and uses thereof
US7445807B2 (en) * 2002-10-15 2008-11-04 Western Holdings, Llc Agglomerated granular protein-rich nutritional supplement
GB0301554D0 (en) 2003-01-23 2003-02-26 Molecularnature Ltd Immunostimulatory compositions
US7332178B2 (en) 2003-04-25 2008-02-19 Abbott Laboratories Stable nutritional powder containing ascorbyl palmitate
FR2856596B1 (fr) 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
CA2542612A1 (en) 2003-10-14 2005-04-21 Kingston Henry Gordon Mills Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease
IL158555A0 (en) 2003-10-22 2004-05-12 Enzymotec Ltd Human breast milk lipid mimetic as dietary supplement
WO2005060952A1 (en) 2003-12-24 2005-07-07 N.V. Nutricia Compositions comprising pantothenic acid or derivatives thereof and their use for stimulating appetite
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
US20050249650A1 (en) 2004-05-07 2005-11-10 Fmc Technologies, Inc. Immersion retort
EP1799052B2 (en) 2004-09-09 2020-01-08 Société des Produits Nestlé S.A. Methods for the manufacture of nutritional products having improved quality
WO2006031699A2 (en) 2004-09-10 2006-03-23 Diversa Corporation Compositions and methods for making and modifying oils
PL371081A1 (pl) 2004-11-08 2006-05-15 Sgp & Sons Ab Preparat farmaceutyczny wpływający na procesy wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt oraz zastosowanie preparatu farmaceutycznego w procesie wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt
US8067052B2 (en) 2005-02-25 2011-11-29 Siddharth Shastri Nutritional composition and a container for the convenient transport and storage of the nutritional composition
CA2537452C (en) 2005-03-09 2013-12-24 Abbott Laboratories Concentrated human milk fortifier liquid
US9332771B2 (en) 2005-04-27 2016-05-10 Enzymotec Ltd. Human milk fat substitutes
CA2606300A1 (en) 2005-06-06 2006-12-14 Bristol-Myers Squibb Company Low-phytate infant formulas
RU2385647C2 (ru) 2005-08-26 2010-04-10 Нестек С.А. Питание для пациентов, страдающих ожирением
MY147363A (en) 2005-09-20 2012-11-30 Nestec Sa Water dispersible composition and method for preparing same
EP1968402A2 (en) 2005-10-07 2008-09-17 Ocean Nutrition Canada Limited Salts of fatty acids and methods of making and using thereof
EP1973426A2 (en) 2005-11-03 2008-10-01 Southwest Immunology Inc. Compositions for preventing and reducing delayed onset muscle soreness
CA2632262C (en) 2005-12-19 2015-04-07 Abbott Laboratories Method of using .beta.-hydroxy-.beta.-methylbutyrate
DE602007008062D1 (de) 2006-01-31 2010-09-09 Nestec Sa Nährstoffzusammensetzung für säuglinge mit niedrigem geburtsgewicht
US20080119552A1 (en) 2006-11-17 2008-05-22 Novus International Inc. Matrix-embedded compositions having organic acids and fatty acids
US20080194407A1 (en) 2007-02-14 2008-08-14 Ashmead H Dewayne High nitrogen containing chelate compositions suitable for plant delivery
US20090110674A1 (en) 2007-10-24 2009-04-30 Loizou Nicos C Health supplement
US8029830B2 (en) 2008-04-18 2011-10-04 Nuvocare Health Services Inc. Composition and method for promoting internal health and external appearance
MX2010012171A (es) 2008-05-21 2010-11-30 Stokely Van Camp Inc Bebida de recupercion a base de leche.
PL2381784T3 (pl) 2008-12-09 2019-01-31 Metabolic Technologies, Inc. Interwencyjny produkt odżywczy w celu poprawy funkcji i siły mięśni
JP2009155336A (ja) 2009-03-31 2009-07-16 Tsujido Chemical Corp 治療剤
US20090312419A1 (en) 2009-08-12 2009-12-17 Kneller Bruce W CREATINE -ßALANINATE: A NOVEL SALT FOR INCREASING ATHLETIC PERFORMANCE
PL217815B1 (pl) 2009-12-14 2014-08-29 Olimp Lab Spółka Z Ograniczoną Odpowiedzialnością Napój izotoniczny z chelatami
CN101785566A (zh) 2010-01-22 2010-07-28 北京康比特体育科技股份有限公司 一种含有hmb的运动饮料
CN102711524B (zh) 2010-01-29 2014-09-10 雅培制药有限公司 包含hmb钙的营养乳剂
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣hmb及可溶性蛋白質之實質上透明營養液
US10869843B2 (en) 2010-11-23 2020-12-22 Chemi Nutra Method for increasing muscle mass and strength
SG191369A1 (en) 2010-12-27 2013-08-30 Abbott Lab Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate
WO2012097061A1 (en) 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism
TW201320908A (zh) 2011-10-13 2013-06-01 Abbott Lab 包含β-丙胺酸之營養產品
WO2013170189A1 (en) 2012-05-11 2013-11-14 Abbott Laboratories Combination of beta - hydroxy - beta - methylbutyrate and beta - alanine for increasing muscle blood flow
US20150119339A1 (en) 2012-06-11 2015-04-30 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014429A1 (en) * 1992-12-23 1994-07-07 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
WO1998004253A1 (en) * 1996-07-26 1998-02-05 Beale Paxton K Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal
WO1999066917A2 (en) * 1998-06-23 1999-12-29 Iowa State University Research Foundation, Inc. Composition comprising ss-hydroxy-ss-methylbutyric acid and at least one amino acid

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AIDS Alert, April 1999, Vol. 14, No. 4, pp 41-43 (Newspaper Article) *
CLARK R H et al., Journal of Parenteral and Enteral Nutrition, 2000, Vol. 24, No. 3, pp 133-139 *
May P E et al., The American Journal of Surgery, 2002, vol. 183, no. 4, pp 471-479 *
SMITH H J et al., Cancer Research, December 2004, Vol. 64, No. 23, pp 8731-8735 *
SMITH H J et al., Cancer Research, January 2005, Vol. 65, No. 1, pp 277-283 *

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