AU2004256404B2 - Modulation of C-reactive protein expression - Google Patents

Modulation of C-reactive protein expression Download PDF

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Publication number
AU2004256404B2
AU2004256404B2 AU2004256404A AU2004256404A AU2004256404B2 AU 2004256404 B2 AU2004256404 B2 AU 2004256404B2 AU 2004256404 A AU2004256404 A AU 2004256404A AU 2004256404 A AU2004256404 A AU 2004256404A AU 2004256404 B2 AU2004256404 B2 AU 2004256404B2
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Australia
Prior art keywords
compound
reactive protein
utr
oligonucleotide
seq
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Ceased
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AU2004256404A
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AU2004256404A1 (en
Inventor
Rosanne M. Crooke
Mark J. Graham
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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Priority to AU2010200325A priority Critical patent/AU2010200325B2/en
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    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • AHUMAN NECESSITIES
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/3212'-O-R Modification
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    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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AU2004256404A 2003-06-02 2004-06-02 Modulation of C-reactive protein expression Ceased AU2004256404B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2010200325A AU2010200325B2 (en) 2003-06-02 2010-01-28 Modulation of C-reactive protein expression

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US47527203P 2003-06-02 2003-06-02
US60/475,272 2003-06-02
US54004204P 2004-01-28 2004-01-28
US60/540,042 2004-01-28
US10/858,500 2004-06-01
US10/858,500 US7425545B2 (en) 2001-07-25 2004-06-01 Modulation of C-reactive protein expression
PCT/US2004/015576 WO2005005599A2 (en) 2003-06-02 2004-06-02 Modulation of c-reactive protein expression

Related Child Applications (1)

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AU2010200325A Division AU2010200325B2 (en) 2003-06-02 2010-01-28 Modulation of C-reactive protein expression

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AU2004256404A1 AU2004256404A1 (en) 2005-01-20
AU2004256404B2 true AU2004256404B2 (en) 2009-10-29

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AU2004256404A Ceased AU2004256404B2 (en) 2003-06-02 2004-06-02 Modulation of C-reactive protein expression
AU2010200325A Ceased AU2010200325B2 (en) 2003-06-02 2010-01-28 Modulation of C-reactive protein expression

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US (3) US7425545B2 (cg-RX-API-DMAC7.html)
EP (3) EP2218727B1 (cg-RX-API-DMAC7.html)
JP (2) JP4887140B2 (cg-RX-API-DMAC7.html)
AU (2) AU2004256404B2 (cg-RX-API-DMAC7.html)
CA (1) CA2527537A1 (cg-RX-API-DMAC7.html)
WO (1) WO2005005599A2 (cg-RX-API-DMAC7.html)

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