AU2004246904B2 - Sphingolipids polyalkylamine conjugates for use in transfection - Google Patents

Sphingolipids polyalkylamine conjugates for use in transfection Download PDF

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Publication number
AU2004246904B2
AU2004246904B2 AU2004246904A AU2004246904A AU2004246904B2 AU 2004246904 B2 AU2004246904 B2 AU 2004246904B2 AU 2004246904 A AU2004246904 A AU 2004246904A AU 2004246904 A AU2004246904 A AU 2004246904A AU 2004246904 B2 AU2004246904 B2 AU 2004246904B2
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AU
Australia
Prior art keywords
sphingoid
polyalkylamine
nucleic acid
conjugate
acid molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004246904A
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English (en)
Other versions
AU2004246904A1 (en
Inventor
Yechezkel Barenholz
Dmitri Simberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biolab Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Biolab Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biolab Ltd, Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Biolab Ltd
Publication of AU2004246904A1 publication Critical patent/AU2004246904A1/en
Application granted granted Critical
Publication of AU2004246904B2 publication Critical patent/AU2004246904B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2004246904A 2003-06-18 2004-06-17 Sphingolipids polyalkylamine conjugates for use in transfection Ceased AU2004246904B2 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US47918503P 2003-06-18 2003-06-18
US60/479,185 2003-06-18
US50563803P 2003-09-25 2003-09-25
US60/505,638 2003-09-25
US53755304P 2004-01-21 2004-01-21
US60/537,553 2004-01-21
US54550504P 2004-02-19 2004-02-19
US60/545,505 2004-02-19
PCT/IL2004/000533 WO2004110499A1 (en) 2003-06-18 2004-06-17 Sphingolipids polyalkylamine conjugates for use in transfection

Publications (2)

Publication Number Publication Date
AU2004246904A1 AU2004246904A1 (en) 2004-12-23
AU2004246904B2 true AU2004246904B2 (en) 2010-02-04

Family

ID=33556649

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2004246904A Ceased AU2004246904B2 (en) 2003-06-18 2004-06-17 Sphingolipids polyalkylamine conjugates for use in transfection
AU2004247505A Ceased AU2004247505B2 (en) 2003-06-18 2004-06-17 Sphingolipids' polyalkylamines conjugates
AU2004246905A Ceased AU2004246905B2 (en) 2003-06-18 2004-06-17 Sphingoid polyalkylamine conjugates for vaccination

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2004247505A Ceased AU2004247505B2 (en) 2003-06-18 2004-06-17 Sphingolipids' polyalkylamines conjugates
AU2004246905A Ceased AU2004246905B2 (en) 2003-06-18 2004-06-17 Sphingoid polyalkylamine conjugates for vaccination

Country Status (8)

Country Link
US (4) US8242089B2 (https=)
EP (3) EP1638919B1 (https=)
JP (3) JP4695075B2 (https=)
AU (3) AU2004246904B2 (https=)
BR (1) BRPI0411505A (https=)
CA (1) CA2528402A1 (https=)
MX (1) MXPA05013746A (https=)
WO (3) WO2004110980A1 (https=)

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Also Published As

Publication number Publication date
JP2006527762A (ja) 2006-12-07
AU2004246905A1 (en) 2004-12-23
US20060252718A1 (en) 2006-11-09
AU2004246904A1 (en) 2004-12-23
US8673285B2 (en) 2014-03-18
US8242089B2 (en) 2012-08-14
EP1638610A1 (en) 2006-03-29
AU2004246905B2 (en) 2010-01-21
WO2004110980A1 (en) 2004-12-23
EP1638611A1 (en) 2006-03-29
US20070264273A1 (en) 2007-11-15
EP1638610B1 (en) 2015-03-18
AU2004247505B2 (en) 2010-01-21
EP1638919B1 (en) 2012-09-26
US7771711B2 (en) 2010-08-10
WO2004110496A1 (en) 2004-12-23
BRPI0411505A (pt) 2006-07-25
US20080112917A1 (en) 2008-05-15
US20060252717A1 (en) 2006-11-09
JP2006527761A (ja) 2006-12-07
CA2528402A1 (en) 2004-12-23
JP4782675B2 (ja) 2011-09-28
JP2006527763A (ja) 2006-12-07
MXPA05013746A (es) 2006-06-27
WO2004110499A1 (en) 2004-12-23
AU2004247505A1 (en) 2004-12-23
EP1638919A1 (en) 2006-03-29
EP1638611B1 (en) 2012-10-03
JP4695075B2 (ja) 2011-06-08

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