AU2004245198B2 - Indole derivatives with apoptosis-inducing effect - Google Patents

Indole derivatives with apoptosis-inducing effect Download PDF

Info

Publication number
AU2004245198B2
AU2004245198B2 AU2004245198A AU2004245198A AU2004245198B2 AU 2004245198 B2 AU2004245198 B2 AU 2004245198B2 AU 2004245198 A AU2004245198 A AU 2004245198A AU 2004245198 A AU2004245198 A AU 2004245198A AU 2004245198 B2 AU2004245198 B2 AU 2004245198B2
Authority
AU
Australia
Prior art keywords
substituted
unsubstituted
alkyl
indol
chlorobenzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004245198A
Other languages
English (en)
Other versions
AU2004245198A1 (en
Inventor
Silke Bassner
Peter Emig
Matthias Gerlach
Eckhard Gunther
Peter Schmidt
Tilmann Schuster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aeterna Zentaris GmbH
Original Assignee
Zentaris AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/de
Priority claimed from EP04011598A external-priority patent/EP1595878A1/de
Application filed by Zentaris AG filed Critical Zentaris AG
Publication of AU2004245198A1 publication Critical patent/AU2004245198A1/en
Application granted granted Critical
Publication of AU2004245198B2 publication Critical patent/AU2004245198B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2004245198A 2003-06-05 2004-05-25 Indole derivatives with apoptosis-inducing effect Ceased AU2004245198B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
US60/476,277 2003-06-05
EP03012868A EP1484329A1 (de) 2003-06-06 2003-06-06 Indolderivate mit Apoptose induzierender Wirkung
EP03012868.0 2003-06-06
EP04011598A EP1595878A1 (de) 2004-05-15 2004-05-15 Indolderivate mit Apoptose induzierender Wirkung
EP04011598.2 2004-05-15
PCT/EP2004/005593 WO2004108702A1 (de) 2003-06-05 2004-05-25 Indolderivate mit apoptose induzierender wirkung

Publications (2)

Publication Number Publication Date
AU2004245198A1 AU2004245198A1 (en) 2004-12-16
AU2004245198B2 true AU2004245198B2 (en) 2009-04-23

Family

ID=43661564

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004245198A Ceased AU2004245198B2 (en) 2003-06-05 2004-05-25 Indole derivatives with apoptosis-inducing effect

Country Status (12)

Country Link
EP (1) EP1641777A1 (ru)
JP (1) JP4878285B2 (ru)
KR (1) KR101132599B1 (ru)
CN (1) CN1816543B (ru)
AU (1) AU2004245198B2 (ru)
BR (1) BRPI0410998A (ru)
CA (1) CA2526663C (ru)
MX (1) MXPA05013121A (ru)
NZ (1) NZ543853A (ru)
RS (1) RS20050901A (ru)
RU (1) RU2327696C2 (ru)
WO (1) WO2004108702A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5527972B2 (ja) * 2005-11-11 2014-06-25 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のピリドピラジン及び前記ピリドピラジンをキナーゼのモジュレーターとして用いる使用
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
US8883841B2 (en) 2005-11-23 2014-11-11 The Board Of Regents Of The University Of Texas System Oncogenic ras-specific cytotoxic compound and methods of use thereof
EA018724B1 (ru) * 2006-08-07 2013-10-30 Айронвуд Фармасьютикалз, Инк. Соединения индола
WO2008066807A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
AU2009305588B2 (en) * 2008-10-16 2015-08-13 Array Biopharma Inc. Inhibitors of mitosis for increasing apoptosis in therapy
WO2012017325A2 (en) * 2010-07-19 2012-02-09 Procaps Sa Apparatus and process for encapsulating microparticles with liquid in soft gel capsules

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232327B1 (en) * 1998-04-02 2001-05-15 Asta Medica Aktiengesellschaft Indolyl-3-glyoxylic acid derivatives having antitumor action
WO2002008225A1 (en) * 2000-07-25 2002-01-31 Novuspharma S.P.A. 2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer
US20030100597A1 (en) * 2000-07-28 2003-05-29 Peter Emig Novel indole derivatives and their use as medicaments

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI269654B (en) * 1999-09-28 2007-01-01 Baxter Healthcare Sa N-substituted indole-3-glyoxylamide compounds having anti-tumor action
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232327B1 (en) * 1998-04-02 2001-05-15 Asta Medica Aktiengesellschaft Indolyl-3-glyoxylic acid derivatives having antitumor action
WO2002008225A1 (en) * 2000-07-25 2002-01-31 Novuspharma S.P.A. 2-(1h-indol-3-yl)-2-oxo-acetic acid amides with antitumor activity
US20030100597A1 (en) * 2000-07-28 2003-05-29 Peter Emig Novel indole derivatives and their use as medicaments
WO2003022280A2 (en) * 2001-09-13 2003-03-20 Synta Pharmaceuticals Corp. 3-glyoxlylamideindoles for treating cancer

Also Published As

Publication number Publication date
CN1816543A (zh) 2006-08-09
CN1816543B (zh) 2011-01-19
JP4878285B2 (ja) 2012-02-15
CA2526663C (en) 2011-07-19
RS20050901A (en) 2007-12-31
JP2007523850A (ja) 2007-08-23
KR20060034230A (ko) 2006-04-21
NZ543853A (en) 2009-09-25
RU2327696C2 (ru) 2008-06-27
WO2004108702A1 (de) 2004-12-16
CA2526663A1 (en) 2004-12-16
RU2006100022A (ru) 2006-05-27
MXPA05013121A (es) 2006-03-17
AU2004245198A1 (en) 2004-12-16
KR101132599B1 (ko) 2012-06-21
EP1641777A1 (de) 2006-04-05
BRPI0410998A (pt) 2006-07-04

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired