BRPI0410998A - derivados de indol com efeito de indução de apoptose - Google Patents
derivados de indol com efeito de indução de apoptoseInfo
- Publication number
- BRPI0410998A BRPI0410998A BRPI0410998-8A BRPI0410998A BRPI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A BR PI0410998 A BRPI0410998 A BR PI0410998A
- Authority
- BR
- Brazil
- Prior art keywords
- indole derivatives
- apoptosis inducing
- inducing effect
- medicaments
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47627703P | 2003-06-05 | 2003-06-05 | |
| EP03012868A EP1484329A1 (de) | 2003-06-06 | 2003-06-06 | Indolderivate mit Apoptose induzierender Wirkung |
| EP04011598A EP1595878A1 (de) | 2004-05-15 | 2004-05-15 | Indolderivate mit Apoptose induzierender Wirkung |
| PCT/EP2004/005593 WO2004108702A1 (de) | 2003-06-05 | 2004-05-25 | Indolderivate mit apoptose induzierender wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0410998A true BRPI0410998A (pt) | 2006-07-04 |
Family
ID=43661564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0410998-8A BRPI0410998A (pt) | 2003-06-05 | 2004-05-25 | derivados de indol com efeito de indução de apoptose |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1641777A1 (ru) |
| JP (1) | JP4878285B2 (ru) |
| KR (1) | KR101132599B1 (ru) |
| CN (1) | CN1816543B (ru) |
| AU (1) | AU2004245198B2 (ru) |
| BR (1) | BRPI0410998A (ru) |
| CA (1) | CA2526663C (ru) |
| MX (1) | MXPA05013121A (ru) |
| NZ (1) | NZ543853A (ru) |
| RS (1) | RS20050901A (ru) |
| RU (1) | RU2327696C2 (ru) |
| WO (1) | WO2004108702A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5527972B2 (ja) * | 2005-11-11 | 2014-06-25 | エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規のピリドピラジン及び前記ピリドピラジンをキナーゼのモジュレーターとして用いる使用 |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| US8883841B2 (en) | 2005-11-23 | 2014-11-11 | The Board Of Regents Of The University Of Texas System | Oncogenic ras-specific cytotoxic compound and methods of use thereof |
| EA018724B1 (ru) * | 2006-08-07 | 2013-10-30 | Айронвуд Фармасьютикалз, Инк. | Соединения индола |
| WO2008066807A1 (en) * | 2006-11-28 | 2008-06-05 | Ziopharm Oncology, Inc. | Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer |
| AU2009305588B2 (en) * | 2008-10-16 | 2015-08-13 | Array Biopharma Inc. | Inhibitors of mitosis for increasing apoptosis in therapy |
| WO2012017325A2 (en) * | 2010-07-19 | 2012-02-09 | Procaps Sa | Apparatus and process for encapsulating microparticles with liquid in soft gel capsules |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19814838C2 (de) * | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
| TWI269654B (en) * | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
| DE19962300A1 (de) * | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
| IT1318641B1 (it) * | 2000-07-25 | 2003-08-27 | Novuspharma Spa | Ammidi di acidi 2-(1h-indol-3-il)-2-oxo-acetici ad attivita'antitumorale. |
| DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| CA2460347A1 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 3-glyoxlylamideindoles for treating cancer |
-
2004
- 2004-05-25 RS YUP-2005/0901A patent/RS20050901A/sr unknown
- 2004-05-25 AU AU2004245198A patent/AU2004245198B2/en not_active Ceased
- 2004-05-25 BR BRPI0410998-8A patent/BRPI0410998A/pt not_active IP Right Cessation
- 2004-05-25 EP EP04734662A patent/EP1641777A1/de not_active Withdrawn
- 2004-05-25 CN CN2004800192716A patent/CN1816543B/zh not_active Expired - Fee Related
- 2004-05-25 MX MXPA05013121A patent/MXPA05013121A/es active IP Right Grant
- 2004-05-25 WO PCT/EP2004/005593 patent/WO2004108702A1/de active Application Filing
- 2004-05-25 RU RU2006100022/04A patent/RU2327696C2/ru not_active IP Right Cessation
- 2004-05-25 NZ NZ543853A patent/NZ543853A/en not_active IP Right Cessation
- 2004-05-25 KR KR1020057023347A patent/KR101132599B1/ko not_active IP Right Cessation
- 2004-05-25 CA CA2526663A patent/CA2526663C/en not_active Expired - Fee Related
- 2004-05-25 JP JP2006508197A patent/JP4878285B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1816543A (zh) | 2006-08-09 |
| CN1816543B (zh) | 2011-01-19 |
| JP4878285B2 (ja) | 2012-02-15 |
| CA2526663C (en) | 2011-07-19 |
| RS20050901A (en) | 2007-12-31 |
| JP2007523850A (ja) | 2007-08-23 |
| KR20060034230A (ko) | 2006-04-21 |
| NZ543853A (en) | 2009-09-25 |
| RU2327696C2 (ru) | 2008-06-27 |
| AU2004245198B2 (en) | 2009-04-23 |
| WO2004108702A1 (de) | 2004-12-16 |
| CA2526663A1 (en) | 2004-12-16 |
| RU2006100022A (ru) | 2006-05-27 |
| MXPA05013121A (es) | 2006-03-17 |
| AU2004245198A1 (en) | 2004-12-16 |
| KR101132599B1 (ko) | 2012-06-21 |
| EP1641777A1 (de) | 2006-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: ZENTARIS GMBH (DE) Free format text: SEDE ALTERADA CONFORME PETICAO NO 020060058923-RJ DE 27.04.2006. |
|
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014. |