AU2004230895B2 - Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as N-methyl-D-aspartate (NMDA) receptor antagonists - Google Patents
Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as N-methyl-D-aspartate (NMDA) receptor antagonists Download PDFInfo
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- AU2004230895B2 AU2004230895B2 AU2004230895A AU2004230895A AU2004230895B2 AU 2004230895 B2 AU2004230895 B2 AU 2004230895B2 AU 2004230895 A AU2004230895 A AU 2004230895A AU 2004230895 A AU2004230895 A AU 2004230895A AU 2004230895 B2 AU2004230895 B2 AU 2004230895B2
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46149003P | 2003-04-09 | 2003-04-09 | |
| US60/461,490 | 2003-04-09 | ||
| PCT/US2004/010596 WO2004092189A1 (en) | 2003-04-09 | 2004-04-07 | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004230895A1 AU2004230895A1 (en) | 2004-10-28 |
| AU2004230895B2 true AU2004230895B2 (en) | 2010-09-09 |
Family
ID=33299828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004230895A Ceased AU2004230895B2 (en) | 2003-04-09 | 2004-04-07 | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as N-methyl-D-aspartate (NMDA) receptor antagonists |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7253153B2 (enExample) |
| EP (1) | EP1611144B1 (enExample) |
| JP (1) | JP4621659B2 (enExample) |
| CN (1) | CN1863810B (enExample) |
| AR (1) | AR044013A1 (enExample) |
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| US7687080B2 (en) | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| GT200400213A (es) * | 2003-10-22 | 2007-09-05 | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo | |
| BRPI0516549A (pt) * | 2004-10-08 | 2008-09-09 | Wyeth Corp | derivados de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)alquil ]fosfÈnico e métodos para sua fabricação |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| CN101896205A (zh) * | 2007-08-27 | 2010-11-24 | 惠氏有限责任公司 | 使用nmda拮抗剂用于获得麻醉剂节约效果的组合物和方法 |
| CN101868469B (zh) | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AU2009296457A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| CA2772488C (en) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Heterocyclic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US10902020B2 (en) * | 2018-06-08 | 2021-01-26 | International Business Machines Corporation | Multiple cache processing of streaming data |
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- 2004-04-07 CA CA002521313A patent/CA2521313A1/en not_active Abandoned
- 2004-04-07 JP JP2006509747A patent/JP4621659B2/ja not_active Expired - Fee Related
- 2004-04-07 PT PT04759168T patent/PT1611144E/pt unknown
- 2004-04-07 DK DK04759168.0T patent/DK1611144T3/da active
- 2004-04-07 PL PL04759168T patent/PL1611144T3/pl unknown
- 2004-04-07 AR ARP040101199A patent/AR044013A1/es not_active Application Discontinuation
- 2004-04-07 US US10/820,216 patent/US7253153B2/en not_active Expired - Fee Related
- 2004-04-07 DE DE602004029146T patent/DE602004029146D1/de not_active Expired - Lifetime
- 2004-04-07 AT AT04759168T patent/ATE481103T1/de active
- 2004-04-07 CN CN200480009542XA patent/CN1863810B/zh not_active Expired - Fee Related
- 2004-04-07 WO PCT/US2004/010596 patent/WO2004092189A1/en not_active Ceased
- 2004-04-07 ES ES04759168T patent/ES2350449T3/es not_active Expired - Lifetime
- 2004-04-07 AU AU2004230895A patent/AU2004230895B2/en not_active Ceased
- 2004-04-07 EP EP04759168A patent/EP1611144B1/en not_active Expired - Lifetime
- 2004-04-07 MX MXPA05010760A patent/MXPA05010760A/es active IP Right Grant
- 2004-04-07 BR BRPI0409255-4A patent/BRPI0409255A/pt not_active IP Right Cessation
- 2004-04-08 TW TW093109670A patent/TWI349674B/zh not_active IP Right Cessation
- 2004-04-08 CL CL200400769A patent/CL2004000769A1/es unknown
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| US20070225257A1 (en) | 2007-09-27 |
| CY1110863T1 (el) | 2015-06-10 |
| CN1863810B (zh) | 2010-12-01 |
| US7879825B2 (en) | 2011-02-01 |
| DE602004029146D1 (de) | 2010-10-28 |
| EP1611144A1 (en) | 2006-01-04 |
| ES2350449T3 (es) | 2011-01-24 |
| ATE481103T1 (de) | 2010-10-15 |
| CA2521313A1 (en) | 2004-10-28 |
| MXPA05010760A (es) | 2005-12-12 |
| PT1611144E (pt) | 2010-11-12 |
| PL1611144T3 (pl) | 2011-03-31 |
| AR044013A1 (es) | 2005-08-24 |
| DK1611144T3 (da) | 2010-11-22 |
| AU2004230895A1 (en) | 2004-10-28 |
| TW200504085A (en) | 2005-02-01 |
| JP2006523694A (ja) | 2006-10-19 |
| BRPI0409255A (pt) | 2006-03-28 |
| WO2004092189A1 (en) | 2004-10-28 |
| CL2004000769A1 (es) | 2005-02-04 |
| TWI349674B (en) | 2011-10-01 |
| US20050004080A1 (en) | 2005-01-06 |
| US7253153B2 (en) | 2007-08-07 |
| CN1863810A (zh) | 2006-11-15 |
| EP1611144B1 (en) | 2010-09-15 |
| JP4621659B2 (ja) | 2011-01-26 |
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| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ DERIVATIVES OF 2-(8,9-DIOXO-2,6-DIAZABICYCLO(5.2.0)NON-1(7)-EN-2-YL)ALKYL PHOSPHONIC ACID AND THEIR USE AS N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONISTS. |
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| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ DERIVATIVES OF 2-(8,9-DIOXO-2,6-DIAZABICYCLO(5.2.0)NON-1(7)-EN-2-YL)ALKYL PHOSPHONIC ACID AND THEIR USE AS N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONISTS |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |