CA2521313A1 - Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists - Google Patents
Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists Download PDFInfo
- Publication number
- CA2521313A1 CA2521313A1 CA002521313A CA2521313A CA2521313A1 CA 2521313 A1 CA2521313 A1 CA 2521313A1 CA 002521313 A CA002521313 A CA 002521313A CA 2521313 A CA2521313 A CA 2521313A CA 2521313 A1 CA2521313 A1 CA 2521313A1
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- Prior art keywords
- group
- ethyl
- dioxo
- compound
- disorder
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- Abandoned
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46149003P | 2003-04-09 | 2003-04-09 | |
| US60/461,490 | 2003-04-09 | ||
| PCT/US2004/010596 WO2004092189A1 (en) | 2003-04-09 | 2004-04-07 | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521313A1 true CA2521313A1 (en) | 2004-10-28 |
Family
ID=33299828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002521313A Abandoned CA2521313A1 (en) | 2003-04-09 | 2004-04-07 | Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.o)non-1(7)-3n-2-yl)-al kyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7253153B2 (enExample) |
| EP (1) | EP1611144B1 (enExample) |
| JP (1) | JP4621659B2 (enExample) |
| CN (1) | CN1863810B (enExample) |
| AR (1) | AR044013A1 (enExample) |
| AT (1) | ATE481103T1 (enExample) |
| AU (1) | AU2004230895B2 (enExample) |
| BR (1) | BRPI0409255A (enExample) |
| CA (1) | CA2521313A1 (enExample) |
| CL (1) | CL2004000769A1 (enExample) |
| CY (1) | CY1110863T1 (enExample) |
| DE (1) | DE602004029146D1 (enExample) |
| DK (1) | DK1611144T3 (enExample) |
| ES (1) | ES2350449T3 (enExample) |
| MX (1) | MXPA05010760A (enExample) |
| PL (1) | PL1611144T3 (enExample) |
| PT (1) | PT1611144E (enExample) |
| TW (1) | TWI349674B (enExample) |
| WO (1) | WO2004092189A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7687080B2 (en) | 2002-11-25 | 2010-03-30 | Taraxos Inc. | Treatment of neuropathy |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| GT200400213A (es) * | 2003-10-22 | 2007-09-05 | Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo | |
| BRPI0516549A (pt) * | 2004-10-08 | 2008-09-09 | Wyeth Corp | derivados de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)alquil ]fosfÈnico e métodos para sua fabricação |
| EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
| US9126987B2 (en) | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| CN101896205A (zh) * | 2007-08-27 | 2010-11-24 | 惠氏有限责任公司 | 使用nmda拮抗剂用于获得麻醉剂节约效果的组合物和方法 |
| CN101868469B (zh) | 2007-11-29 | 2014-04-02 | 埃科特莱茵药品有限公司 | 膦酸衍生物及其作为p2y12受体拮抗剂 |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AR071653A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AU2009296457A1 (en) | 2008-09-27 | 2010-04-01 | Taraxos Inc. | Topical formulations for treatment of neuropathy |
| MA33260B1 (fr) | 2009-04-08 | 2012-05-02 | Actelion Pharmaceuticals Ltd | 6-(3-azabicyclo[3.1.0.]hex-3-yl)-2-phenylpyrimidines |
| CA2772488C (en) | 2009-09-11 | 2018-04-17 | Probiodrug Ag | Heterocyclic derivatives as inhibitors of glutaminyl cyclase |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| JP5945532B2 (ja) | 2010-04-21 | 2016-07-05 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
| ES2779225T3 (es) * | 2011-04-08 | 2020-08-14 | Sphaera Pharma Pte Ltd | Reactivos de merilformilo sustituido y procedimiento de uso de los mismos para modificar propiedades fisicoquímicas y/o farmacocinéticas de compuestos |
| PT3515924T (pt) | 2016-09-22 | 2022-03-11 | Idorsia Pharmaceuticals Ltd | Formas cristalinas |
| US11179390B2 (en) | 2017-03-15 | 2021-11-23 | Idorsia Pharmaceuticals Ltd | Subcutaneous administration of a P2Y12 receptor antagonist |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
| US10902020B2 (en) * | 2018-06-08 | 2021-01-26 | International Business Machines Corporation | Multiple cache processing of streaming data |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5624898A (en) * | 1989-12-05 | 1997-04-29 | Ramsey Foundation | Method for administering neurologic agents to the brain |
| US5168103A (en) * | 1991-01-22 | 1992-12-01 | American Home Products Corporation | [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl) amino]alkyl]-acid derivatives |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
| DK124393D0 (da) | 1993-11-03 | 1993-11-03 | Lundbeck & Co As H | Compounds |
| TW427904B (en) | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
| UA52698C2 (uk) | 1996-10-04 | 2003-01-15 | Х. Луннбек А/С | Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі |
| NZ502509A (en) | 1997-08-01 | 2002-08-28 | Wyeth Corp | Process for the preparation of [2-((8,9)- dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)-ethyl] phosphonic acid |
| US5990307A (en) * | 1997-08-01 | 1999-11-23 | American Home Products Corporation | Process for the preparation of [2-((8.9)-Dioxo-2,6-Diazabicyclo [5.2.0]-Non-1(7)-en-2yl) Ethyl]Phosphonic acid |
| US6541669B1 (en) | 1998-06-08 | 2003-04-01 | Theravance, Inc. | β2-adrenergic receptor agonists |
| US6225343B1 (en) * | 1999-06-16 | 2001-05-01 | Nastech Pharmaceutical Company, Inc. | Compositions and methods comprising morphine gluconate |
| UA78529C2 (en) * | 2001-10-10 | 2007-04-10 | Wyeth Corp | Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain |
| US20040082543A1 (en) | 2002-10-29 | 2004-04-29 | Pharmacia Corporation | Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain |
| CA2521394A1 (en) * | 2003-04-09 | 2004-10-28 | Wyeth | Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof |
| US6933289B2 (en) | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
| US20050142192A1 (en) * | 2003-10-15 | 2005-06-30 | Wyeth | Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives |
-
2004
- 2004-04-07 CA CA002521313A patent/CA2521313A1/en not_active Abandoned
- 2004-04-07 JP JP2006509747A patent/JP4621659B2/ja not_active Expired - Fee Related
- 2004-04-07 PT PT04759168T patent/PT1611144E/pt unknown
- 2004-04-07 DK DK04759168.0T patent/DK1611144T3/da active
- 2004-04-07 PL PL04759168T patent/PL1611144T3/pl unknown
- 2004-04-07 AR ARP040101199A patent/AR044013A1/es not_active Application Discontinuation
- 2004-04-07 US US10/820,216 patent/US7253153B2/en not_active Expired - Fee Related
- 2004-04-07 DE DE602004029146T patent/DE602004029146D1/de not_active Expired - Lifetime
- 2004-04-07 AT AT04759168T patent/ATE481103T1/de active
- 2004-04-07 CN CN200480009542XA patent/CN1863810B/zh not_active Expired - Fee Related
- 2004-04-07 WO PCT/US2004/010596 patent/WO2004092189A1/en not_active Ceased
- 2004-04-07 ES ES04759168T patent/ES2350449T3/es not_active Expired - Lifetime
- 2004-04-07 AU AU2004230895A patent/AU2004230895B2/en not_active Ceased
- 2004-04-07 EP EP04759168A patent/EP1611144B1/en not_active Expired - Lifetime
- 2004-04-07 MX MXPA05010760A patent/MXPA05010760A/es active IP Right Grant
- 2004-04-07 BR BRPI0409255-4A patent/BRPI0409255A/pt not_active IP Right Cessation
- 2004-04-08 TW TW093109670A patent/TWI349674B/zh not_active IP Right Cessation
- 2004-04-08 CL CL200400769A patent/CL2004000769A1/es unknown
-
2007
- 2007-06-01 US US11/757,006 patent/US7879825B2/en not_active Expired - Fee Related
-
2010
- 2010-10-25 CY CY20101100967T patent/CY1110863T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070225257A1 (en) | 2007-09-27 |
| CY1110863T1 (el) | 2015-06-10 |
| CN1863810B (zh) | 2010-12-01 |
| US7879825B2 (en) | 2011-02-01 |
| DE602004029146D1 (de) | 2010-10-28 |
| EP1611144A1 (en) | 2006-01-04 |
| ES2350449T3 (es) | 2011-01-24 |
| ATE481103T1 (de) | 2010-10-15 |
| MXPA05010760A (es) | 2005-12-12 |
| PT1611144E (pt) | 2010-11-12 |
| PL1611144T3 (pl) | 2011-03-31 |
| AR044013A1 (es) | 2005-08-24 |
| DK1611144T3 (da) | 2010-11-22 |
| AU2004230895A1 (en) | 2004-10-28 |
| TW200504085A (en) | 2005-02-01 |
| JP2006523694A (ja) | 2006-10-19 |
| BRPI0409255A (pt) | 2006-03-28 |
| WO2004092189A1 (en) | 2004-10-28 |
| CL2004000769A1 (es) | 2005-02-04 |
| TWI349674B (en) | 2011-10-01 |
| AU2004230895B2 (en) | 2010-09-09 |
| US20050004080A1 (en) | 2005-01-06 |
| US7253153B2 (en) | 2007-08-07 |
| CN1863810A (zh) | 2006-11-15 |
| EP1611144B1 (en) | 2010-09-15 |
| JP4621659B2 (ja) | 2011-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20140408 |