CN1863810B - [2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用 - Google Patents

[2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用 Download PDF

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CN1863810B
CN1863810B CN200480009542XA CN200480009542A CN1863810B CN 1863810 B CN1863810 B CN 1863810B CN 200480009542X A CN200480009542X A CN 200480009542XA CN 200480009542 A CN200480009542 A CN 200480009542A CN 1863810 B CN1863810 B CN 1863810B
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disorder
ethyl
dioxo
pain
ester
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CN1863810A (zh
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R·B·鲍蒂
J·A·布特拉
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Wyeth LLC
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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CN200480009542XA 2003-04-09 2004-04-07 [2-(8，9-二氧代-2，6-二氮杂二环[5.2.0]壬-1(7)-烯-2-基)烷基]膦酸衍生物及其作为n-甲基-d-天冬氨酸(nmda)受体拮抗剂的应用 Expired - Fee Related CN1863810B (zh)

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US46149003P 2003-04-09 2003-04-09
US60/461,490 2003-04-09
PCT/US2004/010596 WO2004092189A1 (en) 2003-04-09 2004-04-07 Derivatives of 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl phosphonic acid and their use as n-methyl-d-aspartate (nmda) recetor antagonists

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CN1863810A CN1863810A (zh) 2006-11-15
CN1863810B true CN1863810B (zh) 2010-12-01

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EP1611144A1 (en) 2006-01-04
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ATE481103T1 (de) 2010-10-15
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US20050004080A1 (en) 2005-01-06
US7253153B2 (en) 2007-08-07
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EP1611144B1 (en) 2010-09-15
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