AU2003267098B2 - Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors - Google Patents

Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors Download PDF

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Publication number
AU2003267098B2
AU2003267098B2 AU2003267098A AU2003267098A AU2003267098B2 AU 2003267098 B2 AU2003267098 B2 AU 2003267098B2 AU 2003267098 A AU2003267098 A AU 2003267098A AU 2003267098 A AU2003267098 A AU 2003267098A AU 2003267098 B2 AU2003267098 B2 AU 2003267098B2
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AU
Australia
Prior art keywords
alkyl
rarb
haloalkyl
dihydroxy
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003267098A
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English (en)
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AU2003267098A1 (en
Inventor
Thorsten E. Fisher
Boyoung Kim
H. Marie Langford
Terry A. Lyle
Kyle A. Robinson
John S. Wai
Peter D. Williams
Linghang Zhuang
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Merck and Co Inc
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Merck and Co Inc
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Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU2003267098A1 publication Critical patent/AU2003267098A1/en
Application granted granted Critical
Publication of AU2003267098B2 publication Critical patent/AU2003267098B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003267098A 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors Ceased AU2003267098B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40974102P 2002-09-11 2002-09-11
US60/409,741 2002-09-11
PCT/US2003/028366 WO2004024078A2 (en) 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
AU2003267098A1 AU2003267098A1 (en) 2004-04-30
AU2003267098B2 true AU2003267098B2 (en) 2008-11-20

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AU2003267098A Ceased AU2003267098B2 (en) 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors

Country Status (6)

Country Link
US (1) US7517532B2 (enExample)
EP (1) EP1549315A4 (enExample)
JP (1) JP2006506352A (enExample)
AU (1) AU2003267098B2 (enExample)
CA (1) CA2498111A1 (enExample)
WO (1) WO2004024078A2 (enExample)

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AR080314A1 (es) * 2010-02-26 2012-03-28 Japan Tobacco Inc Derivado de 1,3,4,8-tetrahidro-2h-pirido (1,2-a) pirazina y su uso como inhibidor de la hiv integrasa
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WO2012131539A1 (en) * 2011-03-31 2012-10-04 Pfizer Inc. Novel bicyclic pyridinones
ES2585009T3 (es) * 2012-05-16 2016-10-03 Janssen Pharmaceuticals, Inc. Derivados de 3,4-dihidro-2H-pirido[1,2-a]pirazina-1,6-diona sustituidos útiles para el tratamiento de (inter alia) enfermedad de Alzheimer
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
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CA2889249C (en) 2012-12-20 2021-02-16 Francois Paul Bischoff Tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators
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EP2986291B1 (en) 2013-04-16 2020-05-27 Merck Sharp & Dohme Corp. 4-pyridone derivative compounds and uses thereof as hiv integrase inhibitors
PT3003039T (pt) 2013-06-07 2021-03-04 Aclaris Therapeutics Inc Compostos piridinona-piridinilo substituídos com metil/fluoro-piridinil-metoxilo e compostos piridinona-pirimidinilo substituídos com fluoro-pirimidinil-metoxilo
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JP6081662B2 (ja) * 2013-09-27 2017-02-15 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖインテグラーゼ阻害薬として有用な置換されたキノリジン誘導体
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TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
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Also Published As

Publication number Publication date
EP1549315A2 (en) 2005-07-06
EP1549315A4 (en) 2007-05-23
US7517532B2 (en) 2009-04-14
WO2004024078A2 (en) 2004-03-25
WO2004024078A3 (en) 2004-05-13
AU2003267098A1 (en) 2004-04-30
JP2006506352A (ja) 2006-02-23
US20060024330A1 (en) 2006-02-02
CA2498111A1 (en) 2004-03-25

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired