AU2003267098B2 - Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors - Google Patents

Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors Download PDF

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Publication number
AU2003267098B2
AU2003267098B2 AU2003267098A AU2003267098A AU2003267098B2 AU 2003267098 B2 AU2003267098 B2 AU 2003267098B2 AU 2003267098 A AU2003267098 A AU 2003267098A AU 2003267098 A AU2003267098 A AU 2003267098A AU 2003267098 B2 AU2003267098 B2 AU 2003267098B2
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AU
Australia
Prior art keywords
alkyl
rarb
haloalkyl
dihydroxy
dione
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003267098A
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English (en)
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AU2003267098A1 (en
Inventor
Thorsten E. Fisher
Boyoung Kim
H. Marie Langford
Terry A. Lyle
Kyle A. Robinson
John S. Wai
Peter D. Williams
Linghang Zhuang
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Merck and Co Inc
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Merck and Co Inc
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Publication date
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Publication of AU2003267098A1 publication Critical patent/AU2003267098A1/en
Application granted granted Critical
Publication of AU2003267098B2 publication Critical patent/AU2003267098B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2003267098A 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors Ceased AU2003267098B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40974102P 2002-09-11 2002-09-11
US60/409,741 2002-09-11
PCT/US2003/028366 WO2004024078A2 (en) 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
AU2003267098A1 AU2003267098A1 (en) 2004-04-30
AU2003267098B2 true AU2003267098B2 (en) 2008-11-20

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ID=31993997

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AU2003267098A Ceased AU2003267098B2 (en) 2002-09-11 2003-09-10 Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors

Country Status (6)

Country Link
US (1) US7517532B2 (cg-RX-API-DMAC7.html)
EP (1) EP1549315A4 (cg-RX-API-DMAC7.html)
JP (1) JP2006506352A (cg-RX-API-DMAC7.html)
AU (1) AU2003267098B2 (cg-RX-API-DMAC7.html)
CA (1) CA2498111A1 (cg-RX-API-DMAC7.html)
WO (1) WO2004024078A2 (cg-RX-API-DMAC7.html)

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AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
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US9493479B2 (en) 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
RS61724B1 (sr) 2013-06-07 2021-05-31 Aclaris Therapeutics Inc Metil/fluoro-piridinil-metoksi supstituisana piridinon-piridinil jedinjenja i fluoro-pirimidinil-metoksi supstituisana piridinon-piridinil jedinjenja
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TWI695003B (zh) 2014-12-23 2020-06-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
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PT3466490T (pt) 2015-04-02 2020-12-24 Gilead Sciences Inc Compostos de carbamoilpiridona policíclicos e sua utilização farmacêutica
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Also Published As

Publication number Publication date
AU2003267098A1 (en) 2004-04-30
WO2004024078A2 (en) 2004-03-25
WO2004024078A3 (en) 2004-05-13
CA2498111A1 (en) 2004-03-25
EP1549315A4 (en) 2007-05-23
US7517532B2 (en) 2009-04-14
JP2006506352A (ja) 2006-02-23
EP1549315A2 (en) 2005-07-06
US20060024330A1 (en) 2006-02-02

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired