AU2003237347B2 - Treatment of cell proliferative disorders with chlorotoxin - Google Patents

Treatment of cell proliferative disorders with chlorotoxin Download PDF

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Publication number
AU2003237347B2
AU2003237347B2 AU2003237347A AU2003237347A AU2003237347B2 AU 2003237347 B2 AU2003237347 B2 AU 2003237347B2 AU 2003237347 A AU2003237347 A AU 2003237347A AU 2003237347 A AU2003237347 A AU 2003237347A AU 2003237347 B2 AU2003237347 B2 AU 2003237347B2
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AU
Australia
Prior art keywords
cancer
chlorotoxin
seq
peptide
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003237347A
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English (en)
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AU2003237347A1 (en
Inventor
Vernon L. Alvarez
Matthew A. Gonda
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Transmolecular Inc
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Transmolecular Inc
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Filing date
Publication date
Application filed by Transmolecular Inc filed Critical Transmolecular Inc
Publication of AU2003237347A1 publication Critical patent/AU2003237347A1/en
Application granted granted Critical
Publication of AU2003237347B2 publication Critical patent/AU2003237347B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Insects & Arthropods (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AU2003237347A 2002-05-31 2003-06-02 Treatment of cell proliferative disorders with chlorotoxin Ceased AU2003237347B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38417102P 2002-05-31 2002-05-31
US60/384,171 2002-05-31
US40603302P 2002-08-27 2002-08-27
US60/406,033 2002-08-27
PCT/US2003/017411 WO2003101475A1 (en) 2002-05-31 2003-06-02 Treatment of cell proliferative disorders with chlorotoxin

Publications (2)

Publication Number Publication Date
AU2003237347A1 AU2003237347A1 (en) 2003-12-19
AU2003237347B2 true AU2003237347B2 (en) 2009-07-23

Family

ID=29715313

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2003240496A Expired AU2003240496B2 (en) 2002-05-31 2003-06-02 Combination chemotherapy with chlorotoxin
AU2003237347A Ceased AU2003237347B2 (en) 2002-05-31 2003-06-02 Treatment of cell proliferative disorders with chlorotoxin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2003240496A Expired AU2003240496B2 (en) 2002-05-31 2003-06-02 Combination chemotherapy with chlorotoxin

Country Status (10)

Country Link
US (1) US20060166892A1 (enExample)
EP (4) EP2431385A3 (enExample)
JP (3) JP2005537234A (enExample)
AT (1) ATE458751T1 (enExample)
AU (2) AU2003240496B2 (enExample)
CA (2) CA2487425A1 (enExample)
DE (1) DE60331458D1 (enExample)
ES (1) ES2341767T3 (enExample)
MX (1) MXPA04011871A (enExample)
WO (2) WO2003101474A1 (enExample)

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US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
WO2005053611A2 (en) * 2003-11-26 2005-06-16 Transmolecular, Inc. Treatment of phosphatidylinositol phospholipid disorders
ES2339683T3 (es) * 2004-04-06 2010-05-24 Transmolecular, Inc. Diagnostico y tratamiento de canceres de celulas mieloides y linfoides.
EP1877428B1 (en) * 2005-04-22 2011-03-16 University of Washington Cyanine- chlorotoxin conjugate and method for intra-operative visualization of cancer
WO2007117467A2 (en) * 2006-03-31 2007-10-18 Transmolecular, Inc. Use of tm-601 for the diagnosis and treatment of tumors
US8106013B2 (en) 2006-05-19 2012-01-31 Georgia Tech Research Corporation ABC transporter ligand GATX1
CN100590130C (zh) * 2007-07-31 2010-02-17 厦门北大之路生物工程有限公司 抗癌活性肽
US20110091380A1 (en) * 2007-08-07 2011-04-21 Transmolecular, Inc. Chlorotoxins as drug carriers
WO2009049184A2 (en) * 2007-10-12 2009-04-16 Transmolecular, Inc. Systemic administration of chlorotoxin agents for the diagnosis and treatment of tumors
BRPI0912683A2 (pt) * 2008-05-15 2016-01-26 Transmolecular Inc tratamento de tumores metastáticos
CN102438646A (zh) * 2008-05-15 2012-05-02 特兰斯莫莱库拉公司 转移性肿瘤的治疗
WO2010086964A1 (ja) * 2009-01-28 2010-08-05 株式会社 静岡カフェイン工業所 がん治療のための併用療法
CN106995493B (zh) 2010-02-04 2021-09-24 卫材公司 氯毒素多肽和结合物及其应用
ES2601182T3 (es) * 2010-05-11 2017-02-14 Fred Hutchinson Cancer Research Center Variantes de clorotoxina, conjugados y métodos para su utilización
CU24055B1 (es) * 2010-09-27 2014-12-26 Grupo Empresarial De Producciones Biofarmacéuticas Y Químicas Labiofam Composiciones farmacéuticas de veneno de escorpión rhopalurus junceus
GB201106004D0 (en) 2011-04-08 2011-05-25 Univ Edinburgh Optical imaging probes
WO2013003507A1 (en) 2011-06-27 2013-01-03 Morphotek, Inc. Multifunctional agents
JP6245481B2 (ja) 2012-04-17 2017-12-13 メリマック ファーマシューティカルズ インコーポレーティッド 非侵襲的イメージングのための組成物および方法
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
US10156559B2 (en) 2012-12-10 2018-12-18 Fred Hutchinson Cancer Research Center Lipocalin fusion partners
CA2909434A1 (en) * 2013-04-18 2014-10-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US20160303264A1 (en) * 2013-10-23 2016-10-20 Merrimack Pharmaceuticals, Inc. Liposomes useful for non-invasive imaging and drug delivery
US9522114B1 (en) * 2014-03-27 2016-12-20 University Of South Florida Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
SG10201913073YA (en) 2015-08-20 2020-03-30 Ipsen Biopharm Ltd Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment
SG10201913077QA (en) 2015-08-21 2020-02-27 Ipsen Biopharm Ltd Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin
CA3053242A1 (en) * 2016-02-19 2017-08-24 Dignity Health Antibody fusion protein and related compositions for targeting cancer
US12048732B2 (en) 2016-04-15 2024-07-30 Blaze Bioscience, Inc. Methods of treating breast cancer
KR101678393B1 (ko) * 2016-08-25 2016-12-06 (주)넥스젠바이오텍 피부 세포 증식 효과가 증가한 전갈독 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선, 피부 탄력 증대 및 항노화 화장료 조성물
BR112019007844A2 (pt) 2016-11-02 2019-07-16 Ipsen Biopharm Ltd tratamento de câncer gástrico usando terapias de combinação compreendendo irinotecano lipossômico, oxaliplatina, 5-fluoroacila (e leucovorina)
US11826399B2 (en) 2017-09-15 2023-11-28 Eisai Inc. Chlorotoxin agents and uses thereof
US11866466B2 (en) 2017-12-19 2024-01-09 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof

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UA29466C2 (uk) * 1993-01-14 2000-11-15 Канзер Рісерч Кампейн Технолоджі, Лтд Фармацевтична композиція з антипухлинною активністю
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Also Published As

Publication number Publication date
MXPA04011871A (es) 2005-07-26
JP2005537234A (ja) 2005-12-08
EP2182004A1 (en) 2010-05-05
JP2011153149A (ja) 2011-08-11
EP2431385A3 (en) 2012-07-04
EP2431385A2 (en) 2012-03-21
US20060166892A1 (en) 2006-07-27
CA2487425A1 (en) 2003-12-11
EP1553962A1 (en) 2005-07-20
AU2003240496B2 (en) 2008-01-10
EP1539207A4 (en) 2008-01-02
ES2341767T3 (es) 2010-06-28
WO2003101475A1 (en) 2003-12-11
ATE458751T1 (de) 2010-03-15
EP1539207A1 (en) 2005-06-15
EP1553962B1 (en) 2010-02-24
JP2015214562A (ja) 2015-12-03
AU2003240496A1 (en) 2003-12-19
DE60331458D1 (de) 2010-04-08
AU2003237347A1 (en) 2003-12-19
JP5856744B2 (ja) 2016-02-10
EP1553962A4 (en) 2008-01-02
WO2003101474A1 (en) 2003-12-11
CA2494451A1 (en) 2003-12-11

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MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase
NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO ENTER THE NATIONAL PHASE HAS BEEN EXTENDED TO 31 JAN 2005.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired