AU2003215869B2 - Hybrid and single chain meganucleases and use thereof - Google Patents

Hybrid and single chain meganucleases and use thereof Download PDF

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Publication number
AU2003215869B2
AU2003215869B2 AU2003215869A AU2003215869A AU2003215869B2 AU 2003215869 B2 AU2003215869 B2 AU 2003215869B2 AU 2003215869 A AU2003215869 A AU 2003215869A AU 2003215869 A AU2003215869 A AU 2003215869A AU 2003215869 B2 AU2003215869 B2 AU 2003215869B2
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Prior art keywords
meganuclease
domain
hybrid
dodecapeptide
derived
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AU2003215869A1 (en
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Sylvain Arnould
Patrick Chames
Andre Choulika
Jean-Charles Epinat
Emmanuel Lacroix
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Cellectis SA
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Cellectis SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2003215869A 2002-03-15 2003-03-14 Hybrid and single chain meganucleases and use thereof Expired AU2003215869B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36411302P 2002-03-15 2002-03-15
US60/364,113 2002-03-15
PCT/IB2003/001352 WO2003078619A1 (en) 2002-03-15 2003-03-14 Hybrid and single chain meganucleases and use thereof

Publications (2)

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AU2003215869A1 AU2003215869A1 (en) 2003-09-29
AU2003215869B2 true AU2003215869B2 (en) 2008-04-24

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AU2003215869A Expired AU2003215869B2 (en) 2002-03-15 2003-03-14 Hybrid and single chain meganucleases and use thereof

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US (2) US8206965B2 (OSRAM)
EP (1) EP1485475B2 (OSRAM)
JP (3) JP2005520519A (OSRAM)
AT (1) ATE372379T1 (OSRAM)
AU (1) AU2003215869B2 (OSRAM)
CA (1) CA2479153C (OSRAM)
DE (1) DE60316124T3 (OSRAM)
DK (1) DK1485475T3 (OSRAM)
ES (1) ES2292994T3 (OSRAM)
WO (1) WO2003078619A1 (OSRAM)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
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EP1485475B1 (en) 2007-09-05
CA2479153A1 (en) 2003-09-25
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US8206965B2 (en) 2012-06-26
ATE372379T1 (de) 2007-09-15
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