MX2019003176A - Receptores de linfocitos t (tcr) especificos del antigeno menor de histocompatibilidad (h) ah-1 y sus usos. - Google Patents

Receptores de linfocitos t (tcr) especificos del antigeno menor de histocompatibilidad (h) ah-1 y sus usos.

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Publication number
MX2019003176A
MX2019003176A MX2019003176A MX2019003176A MX2019003176A MX 2019003176 A MX2019003176 A MX 2019003176A MX 2019003176 A MX2019003176 A MX 2019003176A MX 2019003176 A MX2019003176 A MX 2019003176A MX 2019003176 A MX2019003176 A MX 2019003176A
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Mexico
Prior art keywords
antigen
hematological malignancy
receptor
cell
minor histocompatibility
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MX2019003176A
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English (en)
Inventor
Bleakley Marie
DOSSA Robson
Sommermeyer Daniel
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Hutchinson Fred Cancer Res
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Publication of MX2019003176A publication Critical patent/MX2019003176A/es

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    • A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
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Abstract

La presente descripción proporciona composiciones y métodos para dirigirse a un antígeno menor de histocompatibilidad (H) (AH-1H?), por ejemplo, para prevenir o controlar la recidiva de una neoplasia maligna hematológica tras un trasplante de células madre hematopoyéticas (HCT) alogénico. También se proporcionan construcciones transgénicas que codifican proteínas de unión modificadas, como un receptor de linfocitos T o un receptor de antígenos quiméricos, que codifican opcionalmente componentes adicionales, como un correceptor y/o un intercambiador de seguridad. Estas construcciones transgénicas pueden someterse a transducción en una célula inmunitaria, como un linfocito T, y usarse como inmunoterapia en un sujeto que padezca una neoplasia maligna hematológica o se encuentre en riesgo de recidiva de la neoplasia maligna hematológica (p. ej., leucemia, linfoma, mieloma).
MX2019003176A 2016-09-23 2017-09-22 Receptores de linfocitos t (tcr) especificos del antigeno menor de histocompatibilidad (h) ah-1 y sus usos. MX2019003176A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662399291P 2016-09-23 2016-09-23
PCT/US2017/053112 WO2018058002A1 (en) 2016-09-23 2017-09-22 Tcrs specific for minor histocompatibility (h) antigen ha-1 and uses thereof

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MX2019003176A true MX2019003176A (es) 2019-07-04

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US (3) US10538574B2 (es)
EP (1) EP3516044A4 (es)
JP (2) JP6866475B2 (es)
KR (1) KR102397771B1 (es)
CN (1) CN109996868A (es)
AU (1) AU2017331362A1 (es)
BR (1) BR112019005633A8 (es)
CA (1) CA3035075A1 (es)
EA (1) EA201990591A1 (es)
IL (2) IL265449B (es)
MX (1) MX2019003176A (es)
WO (1) WO2018058002A1 (es)

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