AU2002358272B2 - Growth factor modified protein matrices for tissue engineering - Google Patents

Growth factor modified protein matrices for tissue engineering Download PDF

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Publication number
AU2002358272B2
AU2002358272B2 AU2002358272A AU2002358272A AU2002358272B2 AU 2002358272 B2 AU2002358272 B2 AU 2002358272B2 AU 2002358272 A AU2002358272 A AU 2002358272A AU 2002358272 A AU2002358272 A AU 2002358272A AU 2002358272 B2 AU2002358272 B2 AU 2002358272B2
Authority
AU
Australia
Prior art keywords
matrix
pth
fusion peptide
domain
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2002358272A
Other languages
English (en)
Other versions
AU2002358272A1 (en
Inventor
Jeffrey A. Hubbell
Anna Jen
Matthias Lutolf
Jason Schense
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Zuerich
Original Assignee
Eidgenoessische Technische Hochschule Zurich ETHZ
Universitaet Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/024,918 external-priority patent/US20020168718A1/en
Priority claimed from PCT/EP2002/012458 external-priority patent/WO2003040235A1/en
Priority claimed from US10/323,046 external-priority patent/US7601685B2/en
Application filed by Eidgenoessische Technische Hochschule Zurich ETHZ, Universitaet Zuerich filed Critical Eidgenoessische Technische Hochschule Zurich ETHZ
Publication of AU2002358272A1 publication Critical patent/AU2002358272A1/en
Assigned to EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH, UNIVERSITAT ZURICH reassignment EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH Request for Assignment Assignors: EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH, HUBBELL, JEFFREY, UNIVERSITAT ZURICH
Application granted granted Critical
Publication of AU2002358272B2 publication Critical patent/AU2002358272B2/en
Priority to AU2009201588A priority Critical patent/AU2009201588B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225Fibrin; Fibrinogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/635Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2002358272A 2001-12-18 2002-12-18 Growth factor modified protein matrices for tissue engineering Expired AU2002358272B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2009201588A AU2009201588B2 (en) 2001-12-18 2009-04-21 Growth factor modified protein matrices for tissue engineering

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10/024,918 US20020168718A1 (en) 1997-04-03 2001-12-18 Enzyme-mediated modification of fibrin for tissue engineering
US10/024,918 2001-12-18
AUPCT/EP2002/012458 2002-11-07
PCT/EP2002/012458 WO2003040235A1 (en) 2001-11-07 2002-11-07 Synthetic matrix for controlled cell ingrowth and tissue regeneration
US10/323,046 US7601685B2 (en) 1998-08-27 2002-12-17 Growth factor modified protein matrices for tissue engineering
US10/325,021 2002-12-18
PCT/US2002/041114 WO2003052091A1 (en) 2001-12-18 2002-12-18 Growth factor modified protein matrices for tissue engineering

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2009201588A Division AU2009201588B2 (en) 2001-12-18 2009-04-21 Growth factor modified protein matrices for tissue engineering

Publications (2)

Publication Number Publication Date
AU2002358272A1 AU2002358272A1 (en) 2003-06-30
AU2002358272B2 true AU2002358272B2 (en) 2009-01-22

Family

ID=27807134

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002358272A Expired AU2002358272B2 (en) 2001-12-18 2002-12-18 Growth factor modified protein matrices for tissue engineering
AU2009201588A Expired AU2009201588B2 (en) 2001-12-18 2009-04-21 Growth factor modified protein matrices for tissue engineering

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2009201588A Expired AU2009201588B2 (en) 2001-12-18 2009-04-21 Growth factor modified protein matrices for tissue engineering

Country Status (9)

Country Link
JP (2) JP4560291B2 (de)
AT (1) ATE386545T1 (de)
AU (2) AU2002358272B2 (de)
BR (1) BRPI0215192B8 (de)
CA (1) CA2470419A1 (de)
DE (1) DE60225185T2 (de)
ES (1) ES2301697T3 (de)
MX (1) MXPA04006021A (de)
WO (1) WO2003052091A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
SE0403014D0 (sv) 2004-12-10 2004-12-10 Straumann Holding Ag New protein formulation
EP1862170B1 (de) 2004-12-10 2012-03-14 Straumann Holding AG Emailleformulierung mit Amelogenin
AU2005315253B2 (en) * 2004-12-10 2011-07-21 Straumann Holding Ag Protein formulation
US20060147443A1 (en) * 2004-12-22 2006-07-06 Kuros Biosurgery Ag Synthetic biomaterials having incorporated therein bioactive factors through enzymatically degradable linkages
ES2902872T3 (es) * 2005-01-06 2022-03-30 Kuros Biosurgery Ag Matrices suplementadas para la reparación de fracturas óseas
WO2006073711A2 (en) * 2005-01-06 2006-07-13 Kuros Biosurgery Ag Use of a matrix comprising a contrast agent in soft tissues
US8575101B2 (en) 2005-01-06 2013-11-05 Kuros Biosurgery Ag Supplemented matrices for the repair of bone fractures
CA2930681C (en) 2007-04-09 2019-10-15 The Board Of Trustees Of The University Of Arkansas Fusion protein of collagen-binding domain and parathyroid hormone
JP2010523243A (ja) 2007-04-13 2010-07-15 クロス・バイオサージェリー・アクチェンゲゼルシャフト 高分子組織シーラント
CA2702190A1 (en) * 2007-10-12 2009-04-16 Kuros Biosurgery Ag Injectable radio-opaque compositions for tissue augmentation
CA2721477A1 (en) 2008-04-18 2009-12-03 Kuros Biosurgery Ag Dispensing device, kit containing the device, and method of operating the device
WO2011025957A2 (en) * 2009-08-28 2011-03-03 Ecole Polytechnique Federal De Lausanne Tg-aprotinin fusion proteins and matrices thereof
ES2687144T3 (es) * 2011-02-03 2018-10-23 Northeastern University Métodos y composiciones para la captura y liberación altamente específicas de materiales biológicos
ES2882852T3 (es) 2011-03-16 2021-12-02 Kuros Biosurgery Ag Formulación farmacéutica para la utilización en la fusión espinal
WO2013120060A1 (en) 2012-02-09 2013-08-15 The Board Of Trustees Of The University Of Arkansas Delivery of therapeutic agents by a collagen binding protein
CA2859412C (en) 2011-12-14 2021-05-25 The Board Of Trustees Of The University Of Arkansas Delivery of therapeutic agents using bacterial collagen-binding polypeptide segments
JP5918909B2 (ja) 2012-06-25 2016-05-18 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. 標的化治療薬
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
PT3347061T (pt) * 2015-09-09 2021-08-25 Eth Zuerich Hidrogéis macroporosos injetáveis
WO2018148573A1 (en) 2017-02-10 2018-08-16 The Board Of Trustees Of The University Of Arkansas Collagen-binding agent compositions and methods of using the same
EP3536353A1 (de) 2018-03-09 2019-09-11 Kuros Biosurgery AG Verfahren und kits zur herstellung einer fibrinmatrix

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
US5840837A (en) * 1992-07-14 1998-11-24 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone relate peptide synthesis and use for the treatment of osteoporosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7566396A (en) * 1995-11-16 1997-06-05 Boehringer Mannheim Gmbh Process for the preparation of peptides by way of streptavidin fusion proteins
KR20010033268A (ko) * 1997-12-18 2001-04-25 피터 지. 스트링거 결정형 테리파라타이드
US7744912B1 (en) * 1999-02-01 2010-06-29 Eidgenossische Technische Hochschule Zurich Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups
JP2001190280A (ja) * 1999-02-19 2001-07-17 Terumo Corp コラーゲン結合性生理活性ポリペプチド

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
US5840837A (en) * 1992-07-14 1998-11-24 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone relate peptide synthesis and use for the treatment of osteoporosis

Also Published As

Publication number Publication date
AU2002358272A1 (en) 2003-06-30
MXPA04006021A (es) 2005-08-19
JP2005517658A (ja) 2005-06-16
WO2003052091A8 (en) 2003-08-07
JP4560291B2 (ja) 2010-10-13
DE60225185D1 (de) 2008-04-03
WO2003052091A1 (en) 2003-06-26
BRPI0215192B1 (pt) 2016-03-22
CA2470419A1 (en) 2003-06-26
BRPI0215192B8 (pt) 2021-07-27
ATE386545T1 (de) 2008-03-15
JP2009102383A (ja) 2009-05-14
AU2009201588B2 (en) 2011-02-24
ES2301697T3 (es) 2008-07-01
DE60225185T2 (de) 2009-02-19
AU2009201588A1 (en) 2009-05-14
BR0215192A (pt) 2005-04-26

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH; UNIVE

Free format text: FORMER APPLICANT(S): HUBBELL, JEFFREY; UNIVERSITAT ZURICH; EIDGENOSSISCHE TECHNISCHE HOCHSCHULE ZURICH

MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted
NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO GAIN ACCEPTANCE HAS BEEN EXTENDED TO 22 DEC 2008.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired