ES2301697T3 - Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. - Google Patents
Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. Download PDFInfo
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- ES2301697T3 ES2301697T3 ES02792510T ES02792510T ES2301697T3 ES 2301697 T3 ES2301697 T3 ES 2301697T3 ES 02792510 T ES02792510 T ES 02792510T ES 02792510 T ES02792510 T ES 02792510T ES 2301697 T3 ES2301697 T3 ES 2301697T3
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000007944 thiolates Chemical class 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24918 | 2001-12-18 | ||
| US10/024,918 US20020168718A1 (en) | 1997-04-03 | 2001-12-18 | Enzyme-mediated modification of fibrin for tissue engineering |
| PCT/EP2002/012458 WO2003040235A1 (en) | 2001-11-07 | 2002-11-07 | Synthetic matrix for controlled cell ingrowth and tissue regeneration |
| WOPCT/EP02/12458 | 2002-11-07 | ||
| US323046 | 2002-12-17 | ||
| US10/323,046 US7601685B2 (en) | 1998-08-27 | 2002-12-17 | Growth factor modified protein matrices for tissue engineering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2301697T3 true ES2301697T3 (es) | 2008-07-01 |
Family
ID=27807134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02792510T Expired - Lifetime ES2301697T3 (es) | 2001-12-18 | 2002-12-18 | Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JP4560291B2 (de) |
| AT (1) | ATE386545T1 (de) |
| AU (2) | AU2002358272B2 (de) |
| BR (1) | BRPI0215192B8 (de) |
| CA (1) | CA2470419A1 (de) |
| DE (1) | DE60225185T2 (de) |
| ES (1) | ES2301697T3 (de) |
| MX (1) | MXPA04006021A (de) |
| WO (1) | WO2003052091A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351423B2 (en) | 2004-09-01 | 2008-04-01 | Depuy Spine, Inc. | Musculo-skeletal implant having a bioactive gradient |
| KR101206345B1 (ko) * | 2004-12-10 | 2012-12-06 | 스트라우만 홀딩 에이쥐 | 신규한 단백질 배합물 |
| EP1862170B1 (de) | 2004-12-10 | 2012-03-14 | Straumann Holding AG | Emailleformulierung mit Amelogenin |
| SE0403014D0 (sv) | 2004-12-10 | 2004-12-10 | Straumann Holding Ag | New protein formulation |
| EP1828244A2 (de) * | 2004-12-22 | 2007-09-05 | Kuros Biosurgery AG | Synthetische biologische materialien mit darin über enzymatisch abbaubare bindungen eingearbeiteten biologisch aktiven faktoren |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| ES2593051T3 (es) * | 2005-01-06 | 2016-12-05 | Kuros Biosurgery Ag | Matrices suplementadas para la reparación de fracturas óseas |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| WO2008124166A2 (en) | 2007-04-09 | 2008-10-16 | The Board Of Trustees Of The University Of Arkansas | Fusion proteins of collagen-binding domain and parathyroid hormone |
| JP2010523243A (ja) | 2007-04-13 | 2010-07-15 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | 高分子組織シーラント |
| WO2009047361A2 (en) * | 2007-10-12 | 2009-04-16 | Kuros Biosurgery Ag | Injectable fibrin compositions for tissue augmentation comprising strontium salt |
| MX2010011440A (es) | 2008-04-18 | 2010-12-21 | Kuros Biosurgery Ag | Un dispositivo de suministro, un kit que contiene el dispositivo, y metodo para operar el dispositivo. |
| WO2011025957A2 (en) * | 2009-08-28 | 2011-03-03 | Ecole Polytechnique Federal De Lausanne | Tg-aprotinin fusion proteins and matrices thereof |
| US9927334B2 (en) * | 2011-02-03 | 2018-03-27 | Northeastern University | Methods, compositions and devices employing alginic acid hydrogels for highly specific capture and release of biological materials |
| WO2012123028A1 (en) | 2011-03-16 | 2012-09-20 | Kuros Biosurgery Ag | Pharmaceutical formulation for use in spinal fusion |
| JP6366507B2 (ja) | 2011-12-14 | 2018-08-01 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | コラーゲン結合タンパク質による治療剤の送達 |
| WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
| US9421245B2 (en) | 2012-06-25 | 2016-08-23 | The Brigham And Women's Hospital, Inc. | Targeted therapeutics |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
| PT3347061T (pt) * | 2015-09-09 | 2021-08-25 | Eth Zuerich | Hidrogéis macroporosos injetáveis |
| JP7397440B2 (ja) | 2017-02-10 | 2023-12-13 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | コラーゲン結合薬剤組成物およびその使用方法 |
| EP3536353A1 (de) | 2018-03-09 | 2019-09-11 | Kuros Biosurgery AG | Verfahren und kits zur herstellung einer fibrinmatrix |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171670A (en) * | 1989-05-12 | 1992-12-15 | The General Hospital Corporation | Recombinant dna method for production of parathyroid hormone |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU7566396A (en) * | 1995-11-16 | 1997-06-05 | Boehringer Mannheim Gmbh | Process for the preparation of peptides by way of streptavidin fusion proteins |
| PL341209A1 (en) * | 1997-12-18 | 2001-03-26 | Lilly Co Eli | Crystalline teriparatide |
| DK1181323T3 (da) * | 1999-02-01 | 2011-10-17 | Eidgenoess Tech Hochschule | Biomaterialer dannet med nukleofil additionsreaktion med konjugerede uimættede grupper |
| JP2001190280A (ja) * | 1999-02-19 | 2001-07-17 | Terumo Corp | コラーゲン結合性生理活性ポリペプチド |
-
2002
- 2002-12-18 CA CA002470419A patent/CA2470419A1/en not_active Abandoned
- 2002-12-18 AT AT02792510T patent/ATE386545T1/de not_active IP Right Cessation
- 2002-12-18 JP JP2003552958A patent/JP4560291B2/ja not_active Expired - Lifetime
- 2002-12-18 BR BRPI0215192A patent/BRPI0215192B8/pt not_active IP Right Cessation
- 2002-12-18 DE DE60225185T patent/DE60225185T2/de not_active Expired - Lifetime
- 2002-12-18 MX MXPA04006021A patent/MXPA04006021A/es active IP Right Grant
- 2002-12-18 ES ES02792510T patent/ES2301697T3/es not_active Expired - Lifetime
- 2002-12-18 WO PCT/US2002/041114 patent/WO2003052091A1/en active IP Right Grant
- 2002-12-18 AU AU2002358272A patent/AU2002358272B2/en not_active Expired
-
2009
- 2009-01-13 JP JP2009005240A patent/JP2009102383A/ja active Pending
- 2009-04-21 AU AU2009201588A patent/AU2009201588B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JP4560291B2 (ja) | 2010-10-13 |
| WO2003052091A8 (en) | 2003-08-07 |
| AU2002358272A1 (en) | 2003-06-30 |
| MXPA04006021A (es) | 2005-08-19 |
| AU2002358272B2 (en) | 2009-01-22 |
| DE60225185T2 (de) | 2009-02-19 |
| BRPI0215192B8 (pt) | 2021-07-27 |
| DE60225185D1 (de) | 2008-04-03 |
| JP2009102383A (ja) | 2009-05-14 |
| BR0215192A (pt) | 2005-04-26 |
| BRPI0215192B1 (pt) | 2016-03-22 |
| WO2003052091A1 (en) | 2003-06-26 |
| JP2005517658A (ja) | 2005-06-16 |
| ATE386545T1 (de) | 2008-03-15 |
| CA2470419A1 (en) | 2003-06-26 |
| AU2009201588B2 (en) | 2011-02-24 |
| AU2009201588A1 (en) | 2009-05-14 |
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