ES2301697T3 - Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. - Google Patents
Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. Download PDFInfo
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- ES2301697T3 ES2301697T3 ES02792510T ES02792510T ES2301697T3 ES 2301697 T3 ES2301697 T3 ES 2301697T3 ES 02792510 T ES02792510 T ES 02792510T ES 02792510 T ES02792510 T ES 02792510T ES 2301697 T3 ES2301697 T3 ES 2301697T3
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 210000003460 periosteum Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001444 polymaleic acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000009822 protein phosphorylation Effects 0.000 description 1
- 230000004850 protein–protein interaction Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 108091006024 signal transducing proteins Proteins 0.000 description 1
- 102000034285 signal transducing proteins Human genes 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 150000007944 thiolates Chemical class 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24918 | 2001-12-18 | ||
| US10/024,918 US20020168718A1 (en) | 1997-04-03 | 2001-12-18 | Enzyme-mediated modification of fibrin for tissue engineering |
| WOPCT/EP02/12458 | 2002-11-07 | ||
| PCT/EP2002/012458 WO2003040235A1 (en) | 2001-11-07 | 2002-11-07 | Synthetic matrix for controlled cell ingrowth and tissue regeneration |
| US323046 | 2002-12-17 | ||
| US10/323,046 US7601685B2 (en) | 1998-08-27 | 2002-12-17 | Growth factor modified protein matrices for tissue engineering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2301697T3 true ES2301697T3 (es) | 2008-07-01 |
Family
ID=27807134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02792510T Expired - Lifetime ES2301697T3 (es) | 2001-12-18 | 2002-12-18 | Matrices de proteina modificada con factor de crecimiento para ingenieria de tejidos. |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JP4560291B2 (de) |
| AT (1) | ATE386545T1 (de) |
| AU (2) | AU2002358272B2 (de) |
| BR (1) | BRPI0215192B8 (de) |
| CA (1) | CA2470419A1 (de) |
| DE (1) | DE60225185T2 (de) |
| ES (1) | ES2301697T3 (de) |
| MX (1) | MXPA04006021A (de) |
| WO (1) | WO2003052091A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351423B2 (en) | 2004-09-01 | 2008-04-01 | Depuy Spine, Inc. | Musculo-skeletal implant having a bioactive gradient |
| SE0403014D0 (sv) | 2004-12-10 | 2004-12-10 | Straumann Holding Ag | New protein formulation |
| EP1862170B1 (de) | 2004-12-10 | 2012-03-14 | Straumann Holding AG | Emailleformulierung mit Amelogenin |
| JP5069125B2 (ja) * | 2004-12-10 | 2012-11-07 | シュトラウマン・ホールディング・アクチェンゲゼルシャフト | 新規なタンパク質配合物 |
| AU2005318097A1 (en) * | 2004-12-22 | 2006-06-29 | Kuros Biosurgery Ag | Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors |
| CA2592973A1 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| EP3091075B1 (de) | 2007-04-09 | 2018-06-13 | The Board of Trustees of The University of Arkansas | Fusionsproteine von kollagenbindender domäne und parathyroidhormon |
| ATE543520T1 (de) | 2007-04-13 | 2012-02-15 | Kuros Biosurgery Ag | Polymergewebeversiegelung |
| EP2203195A2 (de) * | 2007-10-12 | 2010-07-07 | Kuros Biosurgery AG | Injizierbare fibrinzusammensetzungen für gewebevermehrung mit strontiumsalz |
| EP2279021B1 (de) | 2008-04-18 | 2013-02-13 | Kuros Biosurgery AG | Ausgabevorrichtung, kit mit dieser vorrichtung und verfahren zum betrieb der vorrichtung |
| WO2011025957A2 (en) * | 2009-08-28 | 2011-03-03 | Ecole Polytechnique Federal De Lausanne | Tg-aprotinin fusion proteins and matrices thereof |
| JP6120778B2 (ja) * | 2011-02-03 | 2017-04-26 | ノースイースタン ユニヴァーシティ | 生物学的材料の極めて特異的な捕獲および遊離のための方法および組成物 |
| EP2686027B1 (de) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmazeutische formulierung zur verwendung für die wirbelsäulenfusion |
| ES2816009T3 (es) | 2011-12-14 | 2021-03-31 | Univ Arkansas | Administración de agentes terapéuticos mediante una proteína de unión a colágeno |
| US9526765B2 (en) | 2012-02-09 | 2016-12-27 | The Kitasato Institute | Delivery of therapeutic agents by a collagen binding protein |
| CN104619727B (zh) * | 2012-06-25 | 2019-04-05 | 布里格姆及妇女医院股份有限公司 | 靶向治疗 |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
| CA2992692C (en) * | 2015-09-09 | 2021-12-21 | Eth Zurich | Injectable macroporous hydrogels |
| WO2018148573A1 (en) | 2017-02-10 | 2018-08-16 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| EP3536353A1 (de) | 2018-03-09 | 2019-09-11 | Kuros Biosurgery AG | Verfahren und kits zur herstellung einer fibrinmatrix |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171670A (en) * | 1989-05-12 | 1992-12-15 | The General Hospital Corporation | Recombinant dna method for production of parathyroid hormone |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| JP2000500019A (ja) * | 1995-11-16 | 2000-01-11 | ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング | ストレプトアビジン融合タンパク質経由でのペプチドの生産方法 |
| CN1281467A (zh) * | 1997-12-18 | 2001-01-24 | 伊莱利利公司 | 结晶特立帕肽 |
| ATE514729T1 (de) * | 1999-02-01 | 2011-07-15 | Eidgenoess Tech Hochschule | Biomaterialien die durch nukleophile reaktion auf konjugierten ungesättigten gruppen addiert sind |
| JP2001190280A (ja) * | 1999-02-19 | 2001-07-17 | Terumo Corp | コラーゲン結合性生理活性ポリペプチド |
-
2002
- 2002-12-18 ES ES02792510T patent/ES2301697T3/es not_active Expired - Lifetime
- 2002-12-18 WO PCT/US2002/041114 patent/WO2003052091A1/en active IP Right Grant
- 2002-12-18 AT AT02792510T patent/ATE386545T1/de not_active IP Right Cessation
- 2002-12-18 MX MXPA04006021A patent/MXPA04006021A/es active IP Right Grant
- 2002-12-18 DE DE60225185T patent/DE60225185T2/de not_active Expired - Lifetime
- 2002-12-18 JP JP2003552958A patent/JP4560291B2/ja not_active Expired - Lifetime
- 2002-12-18 CA CA002470419A patent/CA2470419A1/en not_active Abandoned
- 2002-12-18 BR BRPI0215192A patent/BRPI0215192B8/pt not_active IP Right Cessation
- 2002-12-18 AU AU2002358272A patent/AU2002358272B2/en not_active Expired
-
2009
- 2009-01-13 JP JP2009005240A patent/JP2009102383A/ja active Pending
- 2009-04-21 AU AU2009201588A patent/AU2009201588B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04006021A (es) | 2005-08-19 |
| JP2009102383A (ja) | 2009-05-14 |
| JP4560291B2 (ja) | 2010-10-13 |
| CA2470419A1 (en) | 2003-06-26 |
| BR0215192A (pt) | 2005-04-26 |
| WO2003052091A1 (en) | 2003-06-26 |
| ATE386545T1 (de) | 2008-03-15 |
| AU2009201588B2 (en) | 2011-02-24 |
| DE60225185T2 (de) | 2009-02-19 |
| AU2009201588A1 (en) | 2009-05-14 |
| BRPI0215192B1 (pt) | 2016-03-22 |
| WO2003052091A8 (en) | 2003-08-07 |
| AU2002358272B2 (en) | 2009-01-22 |
| BRPI0215192B8 (pt) | 2021-07-27 |
| AU2002358272A1 (en) | 2003-06-30 |
| JP2005517658A (ja) | 2005-06-16 |
| DE60225185D1 (de) | 2008-04-03 |
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