WO2003052091A8 - Growth factor modified protein matrices for tissue engineering - Google Patents
Growth factor modified protein matrices for tissue engineeringInfo
- Publication number
- WO2003052091A8 WO2003052091A8 PCT/US2002/041114 US0241114W WO03052091A8 WO 2003052091 A8 WO2003052091 A8 WO 2003052091A8 US 0241114 W US0241114 W US 0241114W WO 03052091 A8 WO03052091 A8 WO 03052091A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- matrix
- heparin
- drug
- protein
- regeneration
- Prior art date
Links
- 239000003102 growth factor Substances 0.000 title abstract 2
- 102000035118 modified proteins Human genes 0.000 title 1
- 108091005573 modified proteins Proteins 0.000 title 1
- 239000011159 matrix material Substances 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- 229920000669 heparin Polymers 0.000 abstract 3
- 229960002897 heparin Drugs 0.000 abstract 3
- 238000011069 regeneration method Methods 0.000 abstract 3
- 238000012377 drug delivery Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000008929 regeneration Effects 0.000 abstract 2
- 230000017423 tissue regeneration Effects 0.000 abstract 2
- 108010000196 Factor XIIIa Proteins 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 238000007634 remodeling Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000007838 tissue remodeling Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020047009700A KR100925070B1 (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering |
| MXPA04006021A MXPA04006021A (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering. |
| BRPI0215192A BRPI0215192B8 (en) | 2001-12-18 | 2002-12-18 | fusion peptide, kit and matrix comprising the same, and method for creating a matrix |
| DE60225185T DE60225185T2 (en) | 2001-12-18 | 2002-12-18 | GROWTH FACTOR-MODIFIED PROTEIN MATRICES FOR TISSUE ENGINEERING |
| EP02792510A EP1465989B1 (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering |
| CA002470419A CA2470419A1 (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering |
| JP2003552958A JP4560291B2 (en) | 2001-12-18 | 2002-12-18 | Growth factor-modified protein matrix for tissue manipulation |
| AU2002358272A AU2002358272B2 (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering |
| NO20043031A NO331726B1 (en) | 2001-12-18 | 2004-07-15 | Fusion peptide comprising a first domain comprising parathyroid hormone (PTH) and a second domain comprising a substrate domain, set and matrix comprising the fusion peptide, and methods for producing a matrix |
| HK04110140A HK1067147A1 (en) | 2001-12-18 | 2004-12-22 | Growth factor modified protein matrices for tissueengineering |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/024,918 | 2001-12-18 | ||
| US10/024,918 US20020168718A1 (en) | 1997-04-03 | 2001-12-18 | Enzyme-mediated modification of fibrin for tissue engineering |
| PCT/EP2002/012458 WO2003040235A1 (en) | 2001-11-07 | 2002-11-07 | Synthetic matrix for controlled cell ingrowth and tissue regeneration |
| EPPCT/EP02/12458 | 2002-11-07 | ||
| US10/323,046 US7601685B2 (en) | 1998-08-27 | 2002-12-17 | Growth factor modified protein matrices for tissue engineering |
| US10/325,021 | 2002-12-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003052091A1 WO2003052091A1 (en) | 2003-06-26 |
| WO2003052091A8 true WO2003052091A8 (en) | 2003-08-07 |
Family
ID=27807134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2002/041114 WO2003052091A1 (en) | 2001-12-18 | 2002-12-18 | Growth factor modified protein matrices for tissue engineering |
Country Status (9)
| Country | Link |
|---|---|
| JP (2) | JP4560291B2 (en) |
| AT (1) | ATE386545T1 (en) |
| AU (2) | AU2002358272B2 (en) |
| BR (1) | BRPI0215192B8 (en) |
| CA (1) | CA2470419A1 (en) |
| DE (1) | DE60225185T2 (en) |
| ES (1) | ES2301697T3 (en) |
| MX (1) | MXPA04006021A (en) |
| WO (1) | WO2003052091A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8961947B2 (en) | 2007-04-13 | 2015-02-24 | Kuros Biosurgery Ag | Polymeric tissue sealant |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7351423B2 (en) | 2004-09-01 | 2008-04-01 | Depuy Spine, Inc. | Musculo-skeletal implant having a bioactive gradient |
| EP2329832A1 (en) | 2004-12-10 | 2011-06-08 | Straumann Holding AG | Protein formulation |
| SE0403014D0 (en) | 2004-12-10 | 2004-12-10 | Straumann Holding Ag | New protein formulation |
| EP1862170B1 (en) | 2004-12-10 | 2012-03-14 | Straumann Holding AG | Enamel formulation with amelogenin |
| AU2005318097A1 (en) * | 2004-12-22 | 2006-06-29 | Kuros Biosurgery Ag | Michael-type addition reaction functionalised peg hydrogels with factor XIIIA incorporated biofactors |
| US8575101B2 (en) | 2005-01-06 | 2013-11-05 | Kuros Biosurgery Ag | Supplemented matrices for the repair of bone fractures |
| ES2902872T3 (en) * | 2005-01-06 | 2022-03-30 | Kuros Biosurgery Ag | Supplemented matrices for bone fracture repair |
| WO2006073711A2 (en) * | 2005-01-06 | 2006-07-13 | Kuros Biosurgery Ag | Use of a matrix comprising a contrast agent in soft tissues |
| DK2155874T3 (en) | 2007-04-09 | 2016-08-01 | Univ Arkansas | FUSION PROTEIN OF COLLAGE BINDING DOMAIN AND parathyroid hormone |
| MX2010003969A (en) * | 2007-10-12 | 2010-06-30 | Kuros Biosurgery Ag | Injectable radio-opaque compositions for tissue augmentation. |
| JP2011516228A (en) | 2008-04-18 | 2011-05-26 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | Dispensing device, kit including dispensing device, and method of operating dispensing device |
| WO2011025957A2 (en) * | 2009-08-28 | 2011-03-03 | Ecole Polytechnique Federal De Lausanne | Tg-aprotinin fusion proteins and matrices thereof |
| KR101922741B1 (en) * | 2011-02-03 | 2019-02-20 | 노스이스턴 유니버시티 | Methods and compositions for highly specific capture and release of biological materials |
| EP2686027B1 (en) | 2011-03-16 | 2021-05-05 | Kuros Biosurgery AG | Pharmaceutical formulation for use in spinal fusion |
| WO2013120060A1 (en) | 2012-02-09 | 2013-08-15 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents by a collagen binding protein |
| CA3113972C (en) | 2011-12-14 | 2023-08-01 | The Board Of Trustees Of The University Of Arkansas | Delivery of therapeutic agents using bacterial collagen-binding polypeptide segments |
| US9790264B2 (en) | 2012-06-25 | 2017-10-17 | The Brigham And Women's Hospital, Inc. | Compounds and methods for modulating pharmacokinetics |
| JP5918909B2 (en) * | 2012-06-25 | 2016-05-18 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． | Targeted therapeutics |
| EP3347061B1 (en) * | 2015-09-09 | 2021-05-19 | ETH Zürich | Injectable macroporous hydrogels |
| US11624060B2 (en) | 2017-02-10 | 2023-04-11 | The Board Of Trustees Of The University Of Arkansas | Collagen-binding agent compositions and methods of using the same |
| EP3536353A1 (en) | 2018-03-09 | 2019-09-11 | Kuros Biosurgery AG | Method and kits for producing a fibrin matrix |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5171670A (en) * | 1989-05-12 | 1992-12-15 | The General Hospital Corporation | Recombinant dna method for production of parathyroid hormone |
| US5589452A (en) * | 1992-07-14 | 1996-12-31 | Syntex (U.S.A.) Inc. | Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis |
| AU7566396A (en) * | 1995-11-16 | 1997-06-05 | Boehringer Mannheim Gmbh | Process for the preparation of peptides by way of streptavidin fusion proteins |
| WO1999031137A1 (en) * | 1997-12-18 | 1999-06-24 | Eli Lilly And Company | Crystalline teriparatide |
| ATE514729T1 (en) * | 1999-02-01 | 2011-07-15 | Eidgenoess Tech Hochschule | BIOMATERIALS ADDED BY NUCLEOPHILIC REACTION ON CONJUGATE UNSATURATED GROUPS |
| JP2001190280A (en) * | 1999-02-19 | 2001-07-17 | Terumo Corp | Collagen-binding physiologically active polypeptide |
-
2002
- 2002-12-18 WO PCT/US2002/041114 patent/WO2003052091A1/en active IP Right Grant
- 2002-12-18 ES ES02792510T patent/ES2301697T3/en not_active Expired - Lifetime
- 2002-12-18 AU AU2002358272A patent/AU2002358272B2/en not_active Expired
- 2002-12-18 CA CA002470419A patent/CA2470419A1/en not_active Abandoned
- 2002-12-18 BR BRPI0215192A patent/BRPI0215192B8/en not_active IP Right Cessation
- 2002-12-18 DE DE60225185T patent/DE60225185T2/en not_active Expired - Lifetime
- 2002-12-18 AT AT02792510T patent/ATE386545T1/en not_active IP Right Cessation
- 2002-12-18 JP JP2003552958A patent/JP4560291B2/en not_active Expired - Lifetime
- 2002-12-18 MX MXPA04006021A patent/MXPA04006021A/en active IP Right Grant
-
2009
- 2009-01-13 JP JP2009005240A patent/JP2009102383A/en active Pending
- 2009-04-21 AU AU2009201588A patent/AU2009201588B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8961947B2 (en) | 2007-04-13 | 2015-02-24 | Kuros Biosurgery Ag | Polymeric tissue sealant |
| US9180222B2 (en) | 2007-04-13 | 2015-11-10 | Kuros Biosurgery Ag | Polymeric tissue sealant |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002358272B2 (en) | 2009-01-22 |
| BR0215192A (en) | 2005-04-26 |
| MXPA04006021A (en) | 2005-08-19 |
| AU2002358272A1 (en) | 2003-06-30 |
| BRPI0215192B1 (en) | 2016-03-22 |
| JP2009102383A (en) | 2009-05-14 |
| ATE386545T1 (en) | 2008-03-15 |
| WO2003052091A1 (en) | 2003-06-26 |
| JP2005517658A (en) | 2005-06-16 |
| JP4560291B2 (en) | 2010-10-13 |
| DE60225185D1 (en) | 2008-04-03 |
| AU2009201588B2 (en) | 2011-02-24 |
| ES2301697T3 (en) | 2008-07-01 |
| BRPI0215192B8 (en) | 2021-07-27 |
| AU2009201588A1 (en) | 2009-05-14 |
| DE60225185T2 (en) | 2009-02-19 |
| CA2470419A1 (en) | 2003-06-26 |
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