AU2002351816B8 - Pyridine Substituted Isoquinoline Derivatives - Google Patents

Pyridine Substituted Isoquinoline Derivatives Download PDF

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Publication number
AU2002351816B8
AU2002351816B8 AU2002351816A AU2002351816A AU2002351816B8 AU 2002351816 B8 AU2002351816 B8 AU 2002351816B8 AU 2002351816 A AU2002351816 A AU 2002351816A AU 2002351816 A AU2002351816 A AU 2002351816A AU 2002351816 B8 AU2002351816 B8 AU 2002351816B8
Authority
AU
Australia
Prior art keywords
lower alkyl
hydrogen
compound
pyridin
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002351816A
Other languages
English (en)
Other versions
AU2002351816A1 (en
AU2002351816B2 (en
Inventor
Alexander Alanine
Bernd Buettelmann
Marie-Paule Heitz Neidhart
Emmanuel Pinard
Rene Wyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2002351816A1 publication Critical patent/AU2002351816A1/en
Application granted granted Critical
Publication of AU2002351816B2 publication Critical patent/AU2002351816B2/en
Publication of AU2002351816B8 publication Critical patent/AU2002351816B8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2002351816A 2001-11-09 2002-11-02 Pyridine Substituted Isoquinoline Derivatives Ceased AU2002351816B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01126467.8 2001-11-09
EP01126467 2001-11-09
PCT/EP2002/012240 WO2003040128A1 (en) 2001-11-09 2002-11-02 Pyridine derivatives as nmda receptor ligands

Publications (3)

Publication Number Publication Date
AU2002351816A1 AU2002351816A1 (en) 2003-07-24
AU2002351816B2 AU2002351816B2 (en) 2008-03-06
AU2002351816B8 true AU2002351816B8 (en) 2008-04-03

Family

ID=8179179

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002351816A Ceased AU2002351816B8 (en) 2001-11-09 2002-11-02 Pyridine Substituted Isoquinoline Derivatives

Country Status (16)

Country Link
US (1) US6831087B2 (https=)
EP (1) EP1448547B1 (https=)
JP (1) JP4188837B2 (https=)
KR (1) KR100589995B1 (https=)
CN (1) CN100516061C (https=)
AR (1) AR037221A1 (https=)
AT (1) ATE293619T1 (https=)
AU (1) AU2002351816B8 (https=)
BR (1) BR0213977A (https=)
CA (1) CA2467973C (https=)
DE (1) DE60203820T2 (https=)
ES (1) ES2240829T3 (https=)
MX (1) MXPA04004308A (https=)
PL (1) PL369544A1 (https=)
RU (1) RU2303037C2 (https=)
WO (1) WO2003040128A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007008816A (ja) * 2003-10-15 2007-01-18 Ube Ind Ltd 新規イソキノリン誘導体
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
RU2320654C1 (ru) * 2006-05-24 2008-03-27 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) 2,2-ДИМЕТИЛ-4-(4,6-ДИМЕТИЛ-2-ПИРИДОН-3-ИЛ)-1,2-ДИГИДРО-БЕНЗО[f]ИЗОХИНОЛИНА ГИДРОХЛОРИД, ПРОЯВЛЯЮЩИЙ ПРЯМОЕ АНТИКОАГУЛЯНТНОЕ ДЕЙСТВИЕ
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) * 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US8450327B2 (en) 2007-10-18 2013-05-28 Boehringer Ingelheim International Gmbh CGRP antagonists
EP2065381A1 (de) 2007-10-18 2009-06-03 Boehringer Ingelheim Pharma GmbH & Co. KG CGRP Antagonisten
CA2705405A1 (en) 2007-11-22 2009-05-28 Boehringer Ingelheim International Gmbh New compounds
JP2011504481A (ja) * 2007-11-22 2011-02-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 有機化合物
EP2062889A1 (de) * 2007-11-22 2009-05-27 Boehringer Ingelheim Pharma GmbH & Co. KG Verbindungen
EA014100B1 (ru) * 2008-02-21 2010-08-30 Общество С Ограниченной Ответственностью "Валексфарм" Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения
RU2438672C1 (ru) 2010-04-30 2012-01-10 Общество с ограниченной ответственностью "Клевер Фарм" Агент, проявляющий свойства активатора когнитивных функций (варианты)
WO2025124571A1 (zh) * 2023-12-14 2025-06-19 斯莱普泰(上海)生物医药科技有限公司 Nmda受体拮抗剂及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023458A1 (en) * 1995-12-22 1997-07-03 Warner-Lambert Company Subtype-selective nmda receptor ligands and the use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1080074B1 (de) * 1998-05-25 2006-11-08 Abbott GmbH & Co. KG Heterocyclische substituierte Amide, deren Herstellung und Verwendung
US6440995B1 (en) * 1999-10-01 2002-08-27 Hoffman-La Roche Inc. Quinolin-4-yl derivatives
DK1088818T3 (da) 1999-10-01 2005-03-14 Hoffmann La Roche Quinolin-4-yl-derivater
US6339093B1 (en) 1999-10-08 2002-01-15 Hoffmann-La Roche Inc. Isoquinoline derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997023458A1 (en) * 1995-12-22 1997-07-03 Warner-Lambert Company Subtype-selective nmda receptor ligands and the use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Chatani et al J. Am. Chem. Soc. 2001 123(44), 10935-10941 *
Chatani et al. J. Am. Chem. Soc. 2000 122(51), 12882-12883 *
Saxena et al Indian Journal of Chemistry, section B: Organic Chemistry including Medicinal Chemistry 1980 19B(10), 873-8 *

Also Published As

Publication number Publication date
EP1448547A1 (en) 2004-08-25
BR0213977A (pt) 2004-08-31
CA2467973C (en) 2009-09-01
CN1585762A (zh) 2005-02-23
ES2240829T3 (es) 2005-10-16
MXPA04004308A (es) 2004-08-11
CA2467973A1 (en) 2003-05-15
JP2005513004A (ja) 2005-05-12
AR037221A1 (es) 2004-10-27
US6831087B2 (en) 2004-12-14
EP1448547B1 (en) 2005-04-20
WO2003040128A1 (en) 2003-05-15
US20030119870A1 (en) 2003-06-26
PL369544A1 (en) 2005-05-02
DE60203820D1 (de) 2005-05-25
RU2004117595A (ru) 2006-01-10
JP4188837B2 (ja) 2008-12-03
ATE293619T1 (de) 2005-05-15
AU2002351816B2 (en) 2008-03-06
DE60203820T2 (de) 2006-02-23
KR100589995B1 (ko) 2006-06-19
CN100516061C (zh) 2009-07-22
KR20050042252A (ko) 2005-05-06
RU2303037C2 (ru) 2007-07-20

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Legal Events

Date Code Title Description
TH Corrigenda

Free format text: IN VOL 22, NO 10, PAGE(S) 1150 UNDER THE HEADING APPLICATIONS ACCEPTED -NAME INDEX UNDER THE NAME F. HOFFMANN-LA ROCHE AG, APPLICATION NO. 2002351816, UNDER INID (54) CORRECT THE INVENTION TITLE TO READ PYRIDINE SUBSTITUTED ISOQUINOLINE DERIVATIVES AND UNDER INID (72) CORRECT THE CO-INVENTOR NAME TO READ HEITZ NEIDHART, MARIE-PAULE

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired