BR0213977A - Derivados de piridina como ligantes de receptores de nmda - Google Patents
Derivados de piridina como ligantes de receptores de nmdaInfo
- Publication number
- BR0213977A BR0213977A BR0213977-4A BR0213977A BR0213977A BR 0213977 A BR0213977 A BR 0213977A BR 0213977 A BR0213977 A BR 0213977A BR 0213977 A BR0213977 A BR 0213977A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- lower alkyl
- nmda receptor
- pyridine derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE PIRIDINA COMO LIGANTES DE RECEPTORES DE NMDA". A presente invenção refere-se a compostos de fórmulas (IA) ou (IB) onde R^ 1^' e R^ 2^ são independentemente um do outro hidrogênio, alquila inferior, -(CH~ 2~)~ n~-OH, -(CH~ 2~)~ n~-N(R^ 6^)~ 2~, -NR^ 6^C(O)C(O)O-alquila inferior, -NR^ 6^- (CH~ 2)~ n~-OH, -NR^ 6^C(O)-alquila inferior, -NH-benzila ou NR^ 6^C(O)-(CH~ 2~)~ n~-OH; R^ 6^ é independentemente um do outro hidrogênio ou alquila inferior; R<39> é hidrogênio ou alquila inferior; R^ 3^ é hidrogênio ou amino; R^ 4^ é hidrogênio ou alquila inferior; R^ 5^ é hidrogênio ou halogênio; ou R^ 1^ e R<39>^ poderão ser juntamente com os átomos de carbono aos quais se ligam o grupo -(CH~ 2~)~ 4~-; ou R^ 2^ e R^ 3^ poderão ser juntamente com os átomos de carbono aos quais se ligam o grupo -N(R^ 6^)-CH~ 2~-O-CH~ 2~-; n é 0, 1, 2 ou 3; e a sais de adição de ácidos farmaceuticamente aceitáveis desses compostos. Mostrou-se que esses compostos apresentam uma boa afinidade ao receptor de NMDA e poderão portanto ser usados para o tratamento de doenças relacionadas com esse receptor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01126467 | 2001-11-09 | ||
PCT/EP2002/012240 WO2003040128A1 (en) | 2001-11-09 | 2002-11-02 | Pyridine derivatives as nmda receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0213977A true BR0213977A (pt) | 2004-08-31 |
Family
ID=8179179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0213977-4A BR0213977A (pt) | 2001-11-09 | 2002-11-02 | Derivados de piridina como ligantes de receptores de nmda |
Country Status (16)
Country | Link |
---|---|
US (1) | US6831087B2 (pt) |
EP (1) | EP1448547B1 (pt) |
JP (1) | JP4188837B2 (pt) |
KR (1) | KR100589995B1 (pt) |
CN (1) | CN100516061C (pt) |
AR (1) | AR037221A1 (pt) |
AT (1) | ATE293619T1 (pt) |
AU (1) | AU2002351816B8 (pt) |
BR (1) | BR0213977A (pt) |
CA (1) | CA2467973C (pt) |
DE (1) | DE60203820T2 (pt) |
ES (1) | ES2240829T3 (pt) |
MX (1) | MXPA04004308A (pt) |
PL (1) | PL369544A1 (pt) |
RU (1) | RU2303037C2 (pt) |
WO (1) | WO2003040128A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007008816A (ja) * | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
US20050089559A1 (en) * | 2003-10-23 | 2005-04-28 | Istvan Szelenyi | Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains |
US8722929B2 (en) * | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
US8367684B2 (en) * | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
US8563566B2 (en) * | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
US7786146B2 (en) * | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
EP2205599B1 (de) | 2007-10-18 | 2012-06-06 | Boehringer Ingelheim International GmbH | Cgrp-antagonisten |
EP2065381A1 (de) | 2007-10-18 | 2009-06-03 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP Antagonisten |
CA2705599A1 (en) * | 2007-11-22 | 2009-05-28 | Boehringer Ingelheim International Gmbh | New compounds |
EP2062889A1 (de) | 2007-11-22 | 2009-05-27 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verbindungen |
US8829006B2 (en) | 2007-11-22 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Compounds |
EA014100B1 (ru) * | 2008-02-21 | 2010-08-30 | Общество С Ограниченной Ответственностью "Валексфарм" | Производные 2,4-диаминопиридина, фармацевтическая композиция, лекарственное средство на их основе для лечения или предупреждения заболеваний и нарушений, вызванных гиперактивацией nmda-рецепторов и/или в качестве стимуляторов когнитивных функций и способ лечения |
RU2438672C1 (ru) * | 2010-04-30 | 2012-01-10 | Общество с ограниченной ответственностью "Клевер Фарм" | Агент, проявляющий свойства активатора когнитивных функций (варианты) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
EP1080074B1 (de) * | 1998-05-25 | 2006-11-08 | Abbott GmbH & Co. KG | Heterocyclische substituierte Amide, deren Herstellung und Verwendung |
US6440995B1 (en) * | 1999-10-01 | 2002-08-27 | Hoffman-La Roche Inc. | Quinolin-4-yl derivatives |
EP1088818B1 (en) | 1999-10-01 | 2004-11-03 | F. Hoffmann-La Roche Ag | Quinolin-4-yl derivatives |
US6339093B1 (en) | 1999-10-08 | 2002-01-15 | Hoffmann-La Roche Inc. | Isoquinoline derivatives |
-
2002
- 2002-10-29 US US10/282,365 patent/US6831087B2/en not_active Expired - Fee Related
- 2002-11-02 DE DE60203820T patent/DE60203820T2/de not_active Expired - Lifetime
- 2002-11-02 EP EP02787541A patent/EP1448547B1/en not_active Expired - Lifetime
- 2002-11-02 ES ES02787541T patent/ES2240829T3/es not_active Expired - Lifetime
- 2002-11-02 CA CA002467973A patent/CA2467973C/en not_active Expired - Fee Related
- 2002-11-02 AU AU2002351816A patent/AU2002351816B8/en not_active Ceased
- 2002-11-02 WO PCT/EP2002/012240 patent/WO2003040128A1/en active IP Right Grant
- 2002-11-02 RU RU2004117595/04A patent/RU2303037C2/ru not_active IP Right Cessation
- 2002-11-02 AT AT02787541T patent/ATE293619T1/de not_active IP Right Cessation
- 2002-11-02 BR BR0213977-4A patent/BR0213977A/pt not_active IP Right Cessation
- 2002-11-02 JP JP2003542174A patent/JP4188837B2/ja not_active Expired - Fee Related
- 2002-11-02 MX MXPA04004308A patent/MXPA04004308A/es active IP Right Grant
- 2002-11-02 PL PL02369544A patent/PL369544A1/xx unknown
- 2002-11-02 CN CNB028222512A patent/CN100516061C/zh not_active Expired - Fee Related
- 2002-11-02 KR KR1020047007031A patent/KR100589995B1/ko not_active IP Right Cessation
- 2002-11-06 AR ARP020104227A patent/AR037221A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
ATE293619T1 (de) | 2005-05-15 |
PL369544A1 (en) | 2005-05-02 |
AU2002351816B8 (en) | 2008-04-03 |
DE60203820T2 (de) | 2006-02-23 |
ES2240829T3 (es) | 2005-10-16 |
CN1585762A (zh) | 2005-02-23 |
JP2005513004A (ja) | 2005-05-12 |
EP1448547B1 (en) | 2005-04-20 |
DE60203820D1 (de) | 2005-05-25 |
EP1448547A1 (en) | 2004-08-25 |
KR20050042252A (ko) | 2005-05-06 |
CA2467973C (en) | 2009-09-01 |
JP4188837B2 (ja) | 2008-12-03 |
CN100516061C (zh) | 2009-07-22 |
AR037221A1 (es) | 2004-10-27 |
MXPA04004308A (es) | 2004-08-11 |
KR100589995B1 (ko) | 2006-06-19 |
WO2003040128A1 (en) | 2003-05-15 |
US6831087B2 (en) | 2004-12-14 |
RU2303037C2 (ru) | 2007-07-20 |
CA2467973A1 (en) | 2003-05-15 |
AU2002351816B2 (en) | 2008-03-06 |
RU2004117595A (ru) | 2006-01-10 |
US20030119870A1 (en) | 2003-06-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUI DADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 9A ANUIDADE. |