AU2001287635A1 - Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by meansof asymmetric, catalytic hydrogenation - Google Patents

Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by meansof asymmetric, catalytic hydrogenation

Info

Publication number
AU2001287635A1
AU2001287635A1 AU2001287635A AU8763501A AU2001287635A1 AU 2001287635 A1 AU2001287635 A1 AU 2001287635A1 AU 2001287635 A AU2001287635 A AU 2001287635A AU 8763501 A AU8763501 A AU 8763501A AU 2001287635 A1 AU2001287635 A1 AU 2001287635A1
Authority
AU
Australia
Prior art keywords
sub
asymmetric
meansof
dihydroxy
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001287635A
Other languages
English (en)
Inventor
Rainer Gewald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Asta Medica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica GmbH filed Critical Asta Medica GmbH
Publication of AU2001287635A1 publication Critical patent/AU2001287635A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Epoxy Compounds (AREA)
AU2001287635A 2000-07-27 2001-07-17 Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by meansof asymmetric, catalytic hydrogenation Abandoned AU2001287635A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10036516 2000-07-27
DE10036516A DE10036516A1 (de) 2000-07-27 2000-07-27 Verfahren zur Herstellung von enantiomerenreinen 6,8-Dihydroxyoctansäureestern durch assymetrische katalytische Hydrierung
PCT/EP2001/008244 WO2002010113A1 (de) 2000-07-27 2001-07-17 Verfahren zur herstellung von enantiomerenreinen 6,8-dihydroxyoctansäureestern durch asymmetrische katalytische hydrierung

Publications (1)

Publication Number Publication Date
AU2001287635A1 true AU2001287635A1 (en) 2002-02-13

Family

ID=7650351

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001287635A Abandoned AU2001287635A1 (en) 2000-07-27 2001-07-17 Method for producing enantiomer-free 6,8 dihydroxy octanoic acid esters by meansof asymmetric, catalytic hydrogenation

Country Status (15)

Country Link
US (1) US6965029B2 (de)
EP (1) EP1303475B1 (de)
JP (1) JP2004505104A (de)
AT (1) ATE297370T1 (de)
AU (1) AU2001287635A1 (de)
BR (1) BR0112773A (de)
CA (1) CA2417269A1 (de)
CZ (1) CZ2003191A3 (de)
DE (2) DE10036516A1 (de)
EE (1) EE200300038A (de)
ES (1) ES2241866T3 (de)
HU (1) HUP0301503A2 (de)
PL (1) PL358717A1 (de)
PT (1) PT1303475E (de)
WO (1) WO2002010113A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1510517A1 (de) * 2003-09-01 2005-03-02 Lonza AG Verfahren zur asymmetrischen Hydrierung von Beta-Aminoketonen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6163690A (ja) 1984-09-04 1986-04-01 Takasago Corp ルテニウム−ホスフイン錯体
JPS62265293A (ja) 1986-05-13 1987-11-18 Takasago Corp ルテニウム−ホスフイン錯体
JPS6341487A (ja) 1986-08-06 1988-02-22 Takasago Corp ルテニウム−ホスフイン錯体
DE3629116A1 (de) * 1986-08-27 1988-03-10 Asta Pharma Ag Verfahren zur herstellung enantiomerenreiner r-(+)-(alpha)-liponsaeure und s-(-)-(alpha)-liponsaeure (thioctsaeure) sowie nonen- beziehungsweise mesylderivate als zwischenprodukte hierfuer
EP0272787B1 (de) 1986-11-14 1992-05-06 Takasago International Corporation Katalytische Produktion von optisch aktiven Carbonsäuren
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
PT95826B (pt) 1989-11-09 1997-11-28 Asta Medica Ag Processo para a preparacao de composicoes farmaceuticas contendo como ingrediente activo acido r-alfa-liponico ou acido s-alfa-liponico
JP2775335B2 (ja) * 1990-08-01 1998-07-16 高砂香料工業株式会社 ルテニウム―ホスフィン錯体及びその製造中間体
DE4037440A1 (de) 1990-11-24 1992-05-27 Basf Ag Verfahren zur herstellung von (6s)-6,8-dihydroxyoctansaeureestern
DE4330730A1 (de) 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
IT1270082B (it) 1994-07-12 1997-04-28 Univ Degli Studi Milano Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
DE19709069C2 (de) 1997-03-06 2000-04-06 Asta Medica Ag Enantiomerenreine 3-Hydroxyoctandisäurediester, Verfahren zur Herstellung derselben durch asymmetrische katalytische Hydrierung sowie Verfahren zur Herstellung von R-(+)- und S-(-)-alpha-Liponsäure

Also Published As

Publication number Publication date
DE10036516A1 (de) 2002-02-07
WO2002010113A1 (de) 2002-02-07
CA2417269A1 (en) 2003-01-24
DE50106461D1 (de) 2005-07-14
US6965029B2 (en) 2005-11-15
ATE297370T1 (de) 2005-06-15
BR0112773A (pt) 2003-06-24
HUP0301503A2 (en) 2003-08-28
EP1303475B1 (de) 2005-06-08
CZ2003191A3 (cs) 2003-04-16
EP1303475A1 (de) 2003-04-23
EE200300038A (et) 2004-10-15
PT1303475E (pt) 2005-09-30
PL358717A1 (en) 2004-08-09
ES2241866T3 (es) 2005-11-01
US20040030178A1 (en) 2004-02-12
JP2004505104A (ja) 2004-02-19

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