AR029558A1 - Proceso para la preparacion de (r) -2-alquilo-3-fenilo-1 propanoles y compuestos intermediarios - Google Patents
Proceso para la preparacion de (r) -2-alquilo-3-fenilo-1 propanoles y compuestos intermediariosInfo
- Publication number
- AR029558A1 AR029558A1 ARP010103176A ARP010103176A AR029558A1 AR 029558 A1 AR029558 A1 AR 029558A1 AR P010103176 A ARP010103176 A AR P010103176A AR P010103176 A ARP010103176 A AR P010103176A AR 029558 A1 AR029558 A1 AR 029558A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- acid esters
- propanols
- rent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/17—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Compuestos de la formula 1 donde R1 y R2 son, independientemente uno de otro, H, C1-6 alquilo, C1-6 halogenoalquilo, C1-6 alcoxi, C1-6 alcoxi-C1-6 alquilo, o C1-6 alcoxi-C1-6 alquiloxi, y R3 es C1-6 alquilo son obtenibles en altos rendimientos por medio de la adicion estereoselectiva de ésteres de ácido propionico R3-sustituídos a R1 y R2 benzaldehidos sustituídos de la formula R-CHO para formar los ésteres de ácido propionico 3-R-3-hidroxi-2-R3 correspondientes, la conversion del grupo OH en un grupo saliente, la eliminacion regioselectiva subsiguiente para formar ésteres de ácido propénico 3-R-2-R3 y la reduccion a los alcoholes 3-R-2-R3-allil y su hidrogenacion enantioselectiva, donde R es (a).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH13182000 | 2000-07-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029558A1 true AR029558A1 (es) | 2003-07-02 |
Family
ID=4565375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010103176A AR029558A1 (es) | 2000-07-03 | 2001-07-03 | Proceso para la preparacion de (r) -2-alquilo-3-fenilo-1 propanoles y compuestos intermediarios |
Country Status (12)
Country | Link |
---|---|
US (1) | US6881868B2 (es) |
EP (1) | EP1296912B1 (es) |
JP (1) | JP4841799B2 (es) |
CN (1) | CN1293026C (es) |
AR (1) | AR029558A1 (es) |
AT (1) | ATE316518T1 (es) |
AU (1) | AU2001273762A1 (es) |
BR (1) | BR0112128A (es) |
CA (1) | CA2414844C (es) |
DE (1) | DE60116874T2 (es) |
TW (1) | TW575537B (es) |
WO (1) | WO2002002487A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003304125A1 (en) * | 2002-12-18 | 2004-12-03 | Cardinal Cg Company | Plasma-enhanced film deposition |
DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
EP1979323A1 (en) * | 2006-01-30 | 2008-10-15 | Speedel Experimenta AG | Process for the stereoselective preparation of alcohols from alpha, beta-insaturated compounds |
EP1921069A1 (de) * | 2006-11-08 | 2008-05-14 | Speedel Experimenta AG | Verfahren zur Herstellung von 2-Alkyl-3-heterocyclyl-prop-2-en-1-olen |
TW200837046A (en) * | 2006-11-08 | 2008-09-16 | Speedel Experimenta Ag | Process for preparing organic compounds |
EP1939182A1 (de) * | 2006-12-22 | 2008-07-02 | Speedel Experimenta AG | Verfahren zur Herstellung von (R oder S)-2-Alkyl-3-heterocyclyl-1-propanolen |
EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
AR065792A1 (es) * | 2007-03-21 | 2009-07-01 | Speedel Experimenta Ag | Proceso para preparar (r o s) -5- (1 -azido-3-(6-metoxi-5-(3-metoxi-propoxi) -piridin-3-ilmetil) -4-metil- pentil) -3-alquil-dihidro-furan-2-ona |
EP2178816A1 (en) * | 2007-07-11 | 2010-04-28 | DSM Fine Chemicals Austria Nfg GmbH & Co KG | Alpha-substituted , -unsaturated e- or z-aldehydes, use thereof, and processes for their preparation , |
CN101801903A (zh) * | 2007-07-11 | 2010-08-11 | 帝斯曼知识产权资产管理有限公司 | 饱和醛的制备 |
DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
US8203005B2 (en) | 2009-10-29 | 2012-06-19 | Carbo Design Llc | Manufacturing process for enantiomerically pure 8-aryloctanoic acids as Aliskiren |
TW201202178A (en) | 2010-06-04 | 2012-01-16 | Chemo Iberica Sa | Process for producing Aliskiren |
US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2709268A1 (de) * | 1977-03-03 | 1978-09-07 | Merck Patent Gmbh | Diphenylaetherderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen enthaltend diese verbindungen |
ZA838831B (en) * | 1982-12-31 | 1984-07-25 | Fujisawa Pharmaceutical Co | New nitro aliphatic compounds,process for preparation thereof and use thereof |
JPH0694441B2 (ja) * | 1992-11-18 | 1994-11-24 | 和光純薬工業株式会社 | DL−スレオ−2−(3,4−ジ低級アルキルオキシ−α−ヒドロキシベンジル)イソ吉草酸アルキル及びその製造法 |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
DE19516968A1 (de) * | 1995-05-12 | 1996-11-14 | Basf Ag | Optisch aktive Phosphine, deren Herstellung, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese |
BR0112146A (pt) * | 2000-07-03 | 2003-05-06 | Speedel Pharma Ag | Preparação de ácidos (r)-2-alquil-3-fenilpropiÈnicos |
-
2001
- 2001-06-26 CA CA2414844A patent/CA2414844C/en not_active Expired - Fee Related
- 2001-06-26 CN CNB018122337A patent/CN1293026C/zh not_active Expired - Fee Related
- 2001-06-26 DE DE60116874T patent/DE60116874T2/de not_active Expired - Lifetime
- 2001-06-26 WO PCT/CH2001/000398 patent/WO2002002487A1/en active IP Right Grant
- 2001-06-26 AU AU2001273762A patent/AU2001273762A1/en not_active Abandoned
- 2001-06-26 AT AT01940046T patent/ATE316518T1/de active
- 2001-06-26 US US10/312,992 patent/US6881868B2/en not_active Expired - Fee Related
- 2001-06-26 JP JP2002507746A patent/JP4841799B2/ja not_active Expired - Fee Related
- 2001-06-26 EP EP01940046A patent/EP1296912B1/en not_active Expired - Lifetime
- 2001-06-26 BR BR0112128-6A patent/BR0112128A/pt not_active IP Right Cessation
- 2001-06-29 TW TW90115928A patent/TW575537B/zh not_active IP Right Cessation
- 2001-07-03 AR ARP010103176A patent/AR029558A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1296912A1 (en) | 2003-04-02 |
EP1296912B1 (en) | 2006-01-25 |
CA2414844C (en) | 2010-05-11 |
US6881868B2 (en) | 2005-04-19 |
DE60116874T2 (de) | 2006-11-02 |
WO2002002487A1 (en) | 2002-01-10 |
JP4841799B2 (ja) | 2011-12-21 |
US20040092766A1 (en) | 2004-05-13 |
BR0112128A (pt) | 2003-05-13 |
CN1440374A (zh) | 2003-09-03 |
DE60116874D1 (de) | 2006-04-13 |
AU2001273762A1 (en) | 2002-01-14 |
JP2004502656A (ja) | 2004-01-29 |
CA2414844A1 (en) | 2002-01-10 |
ATE316518T1 (de) | 2006-02-15 |
TW575537B (en) | 2004-02-11 |
CN1293026C (zh) | 2007-01-03 |
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