AU2001276331A1 - Diagnosis of diseases associated with metastasis - Google Patents

Diagnosis of diseases associated with metastasis

Info

Publication number
AU2001276331A1
AU2001276331A1 AU2001276331A AU7633101A AU2001276331A1 AU 2001276331 A1 AU2001276331 A1 AU 2001276331A1 AU 2001276331 A AU2001276331 A AU 2001276331A AU 7633101 A AU7633101 A AU 7633101A AU 2001276331 A1 AU2001276331 A1 AU 2001276331A1
Authority
AU
Australia
Prior art keywords
dna
recited
sequences
genes
oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001276331A
Other languages
English (en)
Inventor
Kurt Berlin
Alexander Olek
Christian Piepenbrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epigenomics AG
Original Assignee
Epigenomics AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10019058A external-priority patent/DE10019058A1/de
Priority claimed from DE10032529A external-priority patent/DE10032529A1/de
Application filed by Epigenomics AG filed Critical Epigenomics AG
Publication of AU2001276331A1 publication Critical patent/AU2001276331A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
AU2001276331A 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis Abandoned AU2001276331A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DE10019058A DE10019058A1 (de) 2000-04-06 2000-04-06 Detektion von Variationen des DNA-Methylierungsprofils
DE10019058.8 2000-04-06
DE10019173 2000-04-07
DE10019173.8 2000-04-07
DE10032529.7 2000-06-30
DE10032529A DE10032529A1 (de) 2000-06-30 2000-06-30 Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC)
DE10043826.1 2000-09-01
DE10043826 2000-09-01
PCT/EP2001/003970 WO2001077376A2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis

Publications (1)

Publication Number Publication Date
AU2001276331A1 true AU2001276331A1 (en) 2001-10-23

Family

ID=27437807

Family Applications (9)

Application Number Title Priority Date Filing Date
AU2001254794A Abandoned AU2001254794A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts
AU2001276331A Abandoned AU2001276331A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metastasis
AU2001277487A Abandoned AU2001277487A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
AU2001289600A Abandoned AU2001289600A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
AU2001278420A Abandoned AU2001278420A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
AU2001254788A Abandoned AU2001254788A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
AU2001275663A Abandoned AU2001275663A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with DNA replication by assessing DNA methylation
AU2001276330A Ceased AU2001276330B2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU7633001A Pending AU7633001A (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001254794A Abandoned AU2001254794A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna adducts

Family Applications After (7)

Application Number Title Priority Date Filing Date
AU2001277487A Abandoned AU2001277487A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with metabolism
AU2001289600A Abandoned AU2001289600A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
AU2001278420A Abandoned AU2001278420A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with dna repair
AU2001254788A Abandoned AU2001254788A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with gene regulation
AU2001275663A Abandoned AU2001275663A1 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with DNA replication by assessing DNA methylation
AU2001276330A Ceased AU2001276330B2 (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis
AU7633001A Pending AU7633001A (en) 2000-04-06 2001-04-06 Diagnosis of diseases associated with apoptosis

Country Status (7)

Country Link
US (7) US20030162194A1 (de)
EP (9) EP2014776A3 (de)
JP (3) JP2004508807A (de)
AT (1) ATE353975T1 (de)
AU (9) AU2001254794A1 (de)
DE (1) DE60126593T2 (de)
WO (8) WO2001092565A2 (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
US8076063B2 (en) 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
WO2001092565A2 (en) * 2000-04-06 2001-12-06 Epigenomics Ag Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
CA2412026A1 (en) * 2000-06-07 2001-12-13 Biosynexus Incorporated Immunostimulatory rna/dna hybrid molecules
EP1297185A2 (de) * 2000-06-30 2003-04-02 Epigenomics AG Diagnose von krankheiten, welche mit signaltransduktion assoziiert sind
AUPR142500A0 (en) * 2000-11-13 2000-12-07 Human Genetic Signatures Pty Ltd A peptide nucleic acid-based assay for the detection of specific nucleic acid sequences
DE10128508A1 (de) 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
JP2003144172A (ja) * 2001-11-16 2003-05-20 Nisshinbo Ind Inc メチル化検出用オリゴヌクレオチド固定化基板
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
DE10161625A1 (de) * 2001-12-14 2003-07-10 Epigenomics Ag Verfahren und Nukleinsäuren für die Analyse einer Lungenzell-Zellteilungsstörung
WO2003076593A2 (en) 2002-03-07 2003-09-18 The Johns Hopkins University School Of Medicine Genomic screen for epigenetically silenced genes associated with cancer
EP1344832A1 (de) * 2002-03-15 2003-09-17 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse der Methylierung im Melastatin-Gen
WO2003083107A1 (en) * 2002-03-25 2003-10-09 The Board Of Trustees Of The University Of Arkansas Cpg retrieval of dna from formalin-fixed pathology specimen for promoter methylation analysis
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
US7807803B2 (en) 2002-07-03 2010-10-05 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
JP2005532067A (ja) * 2002-07-03 2005-10-27 コーリー ファーマシューティカル グループ，インコーポレイテッド 刺激性免疫応答用の核酸組成物
EP1554407B1 (de) * 2002-10-01 2009-07-29 Epigenomics AG Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
US20060094016A1 (en) * 2002-12-02 2006-05-04 Niall Gormley Determination of methylation of nucleic acid sequences
DE10304219B3 (de) * 2003-01-30 2004-08-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
WO2004070062A2 (en) * 2003-02-04 2004-08-19 Wyeth Compositions and methods for diagnosing and treating cancers
US20050009059A1 (en) * 2003-05-07 2005-01-13 Affymetrix, Inc. Analysis of methylation status using oligonucleotide arrays
WO2004111266A1 (en) 2003-06-17 2004-12-23 Human Genetic Signatures Pty Ltd Methods for genome amplification
US8415100B2 (en) 2003-08-14 2013-04-09 Case Western Reserve University Methods and compositions for detecting gastrointestinal and other cancers
JP4781267B2 (ja) * 2003-08-14 2011-09-28 ケース ウエスタン リザーブ ユニバーシティ 大腸癌を検出する方法及び組成物
DE10338308B4 (de) 2003-08-15 2006-10-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in DNA
WO2005024053A1 (en) 2003-09-04 2005-03-17 Human Genetic Signatures Pty Ltd Nucleic acid detection assay
AU2004281299B2 (en) * 2003-10-20 2010-11-18 St Vincent's Hospital Sydney Limited Assessment of disease risk by quantitative determination of epimutation in normal tissues
WO2005054517A2 (en) * 2003-12-01 2005-06-16 Epigenomics Ag Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
EP1561821B1 (de) 2003-12-11 2011-02-16 Epigenomics AG Marker zur Prognose der Reaktion auf Therapie bzw. der Überlebensrate von Brustkrebspatienten
EP1568786A3 (de) * 2004-02-13 2007-08-29 Affymetrix, Inc. (A US Entity) Analyse der Methylierung mittels Nukleinsäurearrays
US8168777B2 (en) 2004-04-29 2012-05-01 Human Genetic Signatures Pty. Ltd. Bisulphite reagent treatment of nucleic acid
EP1794173B1 (de) 2004-09-10 2010-08-04 Human Genetic Signatures PTY Ltd Amplifikationsblocker umfassend interkalierende nukleinsäuren (ina) enthaltend interkalierende pseudonukleotide (ipn)
KR20060026595A (ko) 2004-09-21 2006-03-24 (주)지노믹트리 제한효소와 ｄｎａ 칩을 이용한 프로모터의 메틸화 검출방법
KR100617649B1 (ko) * 2004-09-24 2006-09-04 (주)지노믹트리 대장암 특이적 발현감소 유전자의 메틸화된 프로모터를 함유하는 암 진단용 조성물 및 그 용도
US7833942B2 (en) 2004-12-03 2010-11-16 Human Genetic Signatures Pty. Ltd. Methods for simplifying microbial nucleic acids by chemical modification of cytosines
US20060134650A1 (en) * 2004-12-21 2006-06-22 Illumina, Inc. Methylation-sensitive restriction enzyme endonuclease method of whole genome methylation analysis
WO2006088978A1 (en) 2005-02-16 2006-08-24 Epigenomics, Inc. Method for determining the methylation pattern of a polynucleic acid
JP5133238B2 (ja) 2005-04-15 2013-01-30 エピゲノミックス アクチェンゲゼルシャフト 遠隔サンプル由来のｄｎａ断片を提供する方法
WO2006111586A2 (es) * 2005-04-20 2006-10-26 Proyecto De Biomedicina Cima, S.L. Procedimiento para la determinación in vitro del grado de metilación del promotor de line-1
JP2008541705A (ja) 2005-05-26 2008-11-27 ヒューマン ジェネティック シグネチャーズ ピーティーワイ リミテッド 非標準塩基を含むプライマーを使用する等温鎖置換増幅
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US8343738B2 (en) 2005-09-14 2013-01-01 Human Genetic Signatures Pty. Ltd. Assay for screening for potential cervical cancer
US7465544B2 (en) * 2006-01-11 2008-12-16 Wisconsin Alumni Research Foundation Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use
AU2007204826B2 (en) 2006-01-11 2013-01-10 Genomic Health, Inc. Gene expression markers for colorectal cancer prognosis
ES2367012T3 (es) * 2006-02-28 2011-10-27 Charite-Universitätsmedizin Berlin Detección y control de calidad de linfocitos t reguladores a través del análisis de metilación del adn del gen foxp3.
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
EP2194143B1 (de) * 2006-05-02 2016-06-29 University of Southampton Phänotyp-Vorhersage
US8084734B2 (en) * 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
WO2008096146A1 (en) 2007-02-07 2008-08-14 Solexa Limited Preparation of templates for methylation analysis
CN102099485A (zh) * 2007-10-23 2011-06-15 临床基因组学有限公司 诊断新生物的方法-ⅱ
WO2009067743A1 (en) 2007-11-27 2009-06-04 Human Genetic Signatures Pty Ltd Enzymes for amplification and copying bisulphite modified nucleic acids
ES2606703T3 (es) * 2008-07-15 2017-03-27 Epigenomics Ag Método para predecir el pronóstico de una terapia de cáncer de mama con base en el análisis de metilación del gen
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
US8110796B2 (en) 2009-01-17 2012-02-07 The George Washington University Nanophotonic production, modulation and switching of ions by silicon microcolumn arrays
US9490113B2 (en) * 2009-04-07 2016-11-08 The George Washington University Tailored nanopost arrays (NAPA) for laser desorption ionization in mass spectrometry
WO2010127322A1 (en) 2009-05-01 2010-11-04 Genomic Health Inc. Gene expression profile algorithm and test for likelihood of recurrence of colorectal cancer and response to chemotherapy
WO2011025852A1 (en) 2009-08-28 2011-03-03 Cellular Dynamics International, Inc. Identifying genetic variation in affected tissues
WO2011080314A2 (en) * 2009-12-31 2011-07-07 Deutsches Krebsforschungszentrum Novel modulators of trail signalling
WO2012149245A2 (en) * 2011-04-28 2012-11-01 Ostrer Harry Genomic signatures of metastasis in prostate cancer
US10435743B2 (en) 2011-05-20 2019-10-08 The Regents Of The University Of California Method to estimate age of individual based on epigenetic markers in biological sample
MX350658B (es) 2011-09-07 2017-09-13 Human Genetic Signatures Pty Ltd Ensayo de detección molecular.
WO2013129397A1 (ja) * 2012-02-29 2013-09-06 シスメックス株式会社 肝細胞癌由来の癌細胞の存否の判定方法、判定用マーカーおよびキット
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
KR101302173B1 (ko) 2012-12-07 2013-08-30 이화여자대학교 산학협력단 Ｈｍｏｘ１ 유전자의 메틸화 변화를 이용한 알츠하이머 질환의 진단용 조성물 및 이를 이용한 알츠하이머 질환의 진단방법
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer
CN106460050A (zh) * 2014-04-28 2017-02-22 西格马-奥尔德里奇有限责任公司 使用靶向核酸内切酶进行哺乳动物基因组的表观遗传修饰
US20220049305A1 (en) * 2018-09-14 2022-02-17 Gen Shinozaki Systems and methods for detection of delirium risk using epigenetic markers
CN111217900A (zh) * 2018-11-27 2020-06-02 上海交通大学 一种血管新生的转录调控因子及其用途
JP7320067B2 (ja) 2019-01-18 2023-08-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 保存された遺伝子座に基づく、哺乳動物に関するｄｎａメチル化測定
WO2021075797A2 (ko) 2019-10-14 2021-04-22 주식회사 젠큐릭스 특정 유전자의 cpg 메틸화 변화를 이용한 간암 진단용 조성물 및 이의 용도
KR102637032B1 (ko) 2020-01-28 2024-02-15 주식회사 젠큐릭스 특정 유전자의 CpG 메틸화 변화를 이용한 방광암 진단용 조성물 및 이의 용도
KR20210125442A (ko) 2020-04-08 2021-10-18 주식회사 젠큐릭스 GLRB 유전자의 CpG 메틸화 변화를 이용한 대장암, 직장암 또는 대장 선종 진단용 조성물 및 이의 용도
CN111500702B (zh) * 2020-04-26 2021-04-20 江苏大学附属医院 RPN1基因cg00843506位点甲基化在诊断哮喘中的用途
WO2023175019A1 (en) 2022-03-15 2023-09-21 Genknowme S.A. Method determining the difference between the biological age and the chronological age of a subject

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
SE501439C2 (sv) 1993-06-22 1995-02-13 Pharmacia Lkb Biotech Sätt och anordning för analys av polynukleotidsekvenser
US5837832A (en) 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
EP0730663B1 (de) * 1993-10-26 2003-09-24 Affymetrix, Inc. Felder von nukleinsaeuresonden auf biologischen chips
JPH09506253A (ja) 1993-11-30 1997-06-24 マクギル・ユニヴァーシティ Ｄｎａメチルトランスフェラーゼの阻害
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US6017704A (en) 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19750172C1 (de) * 1997-11-12 1998-10-01 Deutsches Krebsforsch DNA mit Promotor-Aktivität für Zellzyklus-Gen
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
ATE217028T1 (de) * 1997-12-05 2002-05-15 Max Planck Gesellschaft Verfahren zur identifikation von nucleinsäuren durch matrix-assistierte laser desorptions/ionisations massenspektrometrie
AU5128999A (en) * 1998-07-24 2000-02-14 Yeda Research And Development Co. Ltd. Prevention of metastasis with 5-aza-2'-deoxycytidine
DE19905082C1 (de) * 1999-01-29 2000-05-18 Epigenomics Gmbh Verfahren zur Identifikation von Cytosin-Methylierungsmustern in genomischen DNA-Proben
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
US7332275B2 (en) * 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
EP1283905A2 (de) * 2000-03-15 2003-02-19 Epigenomics AG Diagnose von krankheiten, welche mit dem zellzyklus assoziiert sind
WO2001092565A2 (en) 2000-04-06 2001-12-06 Epigenomics Ag Diagnosis of diseases associated dna transcription by means of assessing the methylation status of genes associated with dna transcription
EP1297185A2 (de) 2000-06-30 2003-04-02 Epigenomics AG Diagnose von krankheiten, welche mit signaltransduktion assoziiert sind
DE10037769A1 (de) 2000-08-03 2002-02-21 Epigenomics Gmbh Diagnose von mit CD24 assoziierten Krankheiten
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
DE10054972A1 (de) 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit humos assoziierten Krankheiten
DE10054974A1 (de) 2000-11-06 2002-06-06 Epigenomics Ag Diagnose von mit Cdk4 assoziierten Krankheiten
DE10128508A1 (de) * 2001-06-14 2003-02-06 Epigenomics Ag Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren
EP1502222A2 (de) * 2001-07-02 2005-02-02 Epigenomics AG Verteiltes system zur epigenetisch-basierten vorhersagung von komplexen phänotypen

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US20050282157A1 (en) 2005-12-22
ATE353975T1 (de) 2007-03-15
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