AU2001271616A1 - 13-substituted methacycline compounds - Google Patents

13-substituted methacycline compounds

Info

Publication number
AU2001271616A1
AU2001271616A1 AU2001271616A AU7161601A AU2001271616A1 AU 2001271616 A1 AU2001271616 A1 AU 2001271616A1 AU 2001271616 A AU2001271616 A AU 2001271616A AU 7161601 A AU7161601 A AU 7161601A AU 2001271616 A1 AU2001271616 A1 AU 2001271616A1
Authority
AU
Australia
Prior art keywords
methacycline
compound
substituted
group
chlorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001271616A
Other languages
English (en)
Inventor
Beena Bhatia
Laura Mcintyre
Mark L Nelson
Glen Rennie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Tufts University
Original Assignee
Paratek Pharmaceuticals Inc
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc, Tufts University filed Critical Paratek Pharmaceuticals Inc
Publication of AU2001271616A1 publication Critical patent/AU2001271616A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2001271616A 2000-07-07 2001-06-29 13-substituted methacycline compounds Abandoned AU2001271616A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21658000P 2000-07-07 2000-07-07
US60216580 2000-07-07
PCT/US2001/020716 WO2002004405A2 (en) 2000-07-07 2001-06-29 13-substituted methacycline compounds

Publications (1)

Publication Number Publication Date
AU2001271616A1 true AU2001271616A1 (en) 2002-01-21

Family

ID=22807633

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001271616A Abandoned AU2001271616A1 (en) 2000-07-07 2001-06-29 13-substituted methacycline compounds

Country Status (16)

Country Link
EP (3) EP1661883B1 (hu)
JP (1) JP2004502751A (hu)
KR (1) KR20030017609A (hu)
CN (1) CN1452611A (hu)
AT (2) ATE465989T1 (hu)
AU (1) AU2001271616A1 (hu)
BR (1) BR0112268A (hu)
CA (1) CA2415172A1 (hu)
CZ (1) CZ2003332A3 (hu)
DE (1) DE60141994D1 (hu)
EA (1) EA200300136A1 (hu)
HR (1) HRP20030092A2 (hu)
HU (1) HUP0301429A2 (hu)
IL (1) IL153674A0 (hu)
MX (1) MXPA03000036A (hu)
WO (1) WO2002004405A2 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1716101A1 (en) 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3183267A (en) * 1962-09-06 1965-05-11 Pfizer & Co C 6-methylenetetracycline derivatives
GB1108310A (en) * 1964-04-30 1968-04-03 Pfizer & Co C Derivatives of 6-methylene-tetracycline and process for their preparation
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (hu) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
CA2672722C (en) 1999-09-14 2013-11-05 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries

Also Published As

Publication number Publication date
ATE465989T1 (de) 2010-05-15
EP1661883A1 (en) 2006-05-31
JP2004502751A (ja) 2004-01-29
MXPA03000036A (es) 2003-07-14
EA200300136A1 (ru) 2003-06-26
EP1301465A2 (en) 2003-04-16
EP2204361B1 (en) 2011-09-28
HUP0301429A2 (hu) 2003-09-29
KR20030017609A (ko) 2003-03-03
DE60141994D1 (de) 2010-06-10
CN1452611A (zh) 2003-10-29
IL153674A0 (en) 2003-07-06
EP2204361A1 (en) 2010-07-07
CZ2003332A3 (cs) 2003-05-14
WO2002004405A3 (en) 2002-03-14
HRP20030092A2 (en) 2004-06-30
WO2002004405A2 (en) 2002-01-17
BR0112268A (pt) 2003-05-27
ATE526308T1 (de) 2011-10-15
CA2415172A1 (en) 2002-01-17
EP1661883B1 (en) 2010-04-28

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