AU2001259785A1 - Microfluidics devices and methods for performing cell based assays - Google Patents

Microfluidics devices and methods for performing cell based assays

Info

Publication number
AU2001259785A1
AU2001259785A1 AU2001259785A AU5978501A AU2001259785A1 AU 2001259785 A1 AU2001259785 A1 AU 2001259785A1 AU 2001259785 A AU2001259785 A AU 2001259785A AU 5978501 A AU5978501 A AU 5978501A AU 2001259785 A1 AU2001259785 A1 AU 2001259785A1
Authority
AU
Australia
Prior art keywords
based assays
methods
cell based
performing cell
microfluidics devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001259785A
Other languages
English (en)
Inventor
Bruce Carvalho
Christina Feakes
Greg Kellogg
Norman F. Sheppard Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tecan Trading AG
Original Assignee
Tecan Trading AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tecan Trading AG filed Critical Tecan Trading AG
Publication of AU2001259785A1 publication Critical patent/AU2001259785A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/712Feed mechanisms for feeding fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71Feed mechanisms
    • B01F35/717Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/07Centrifugal type cuvettes
    • AHUMAN NECESSITIES
    • A63SPORTS; GAMES; AMUSEMENTS
    • A63BAPPARATUS FOR PHYSICAL TRAINING, GYMNASTICS, SWIMMING, CLIMBING, OR FENCING; BALL GAMES; TRAINING EQUIPMENT
    • A63B63/00Targets or goals for ball games
    • A63B63/08Targets or goals for ball games with substantially horizontal opening for ball, e.g. for basketball
    • A63B63/083Targets or goals for ball games with substantially horizontal opening for ball, e.g. for basketball for basketball
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0803Disc shape
    • B01L2300/0806Standardised forms, e.g. compact disc [CD] format
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867Multiple inlets and one sample wells, e.g. mixing, dilution
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0861Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874Three dimensional network
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/10Means to control humidity and/or other gases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1805Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0677Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0688Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/08Regulating or influencing the flow resistance
    • B01L2400/084Passive control of flow resistance
    • B01L2400/088Passive control of flow resistance by specific surface properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00495Centrifuges
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00495Centrifuges
    • G01N2035/00504Centrifuges combined with carousels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00514Stationary mixing elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465Separating and mixing arrangements
    • G01N2035/00524Mixing by agitating sample carrier
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N35/00069Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/11Automated chemical analysis
    • Y10T436/111666Utilizing a centrifuge or compartmented rotor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Inspection Of Paper Currency And Valuable Securities (AREA)
AU2001259785A 2000-05-15 2001-05-15 Microfluidics devices and methods for performing cell based assays Abandoned AU2001259785A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20426400P 2000-05-15 2000-05-15
US60/204,265 2000-05-15
PCT/US2001/015823 WO2001087486A2 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for performing cell based assays

Publications (1)

Publication Number Publication Date
AU2001259785A1 true AU2001259785A1 (en) 2001-11-26

Family

ID=22757246

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001259786A Abandoned AU2001259786A1 (en) 2000-05-15 2001-05-15 Bidirectional flow centrifugal microfluidic devices
AU2001259785A Abandoned AU2001259785A1 (en) 2000-05-15 2001-05-15 Microfluidics devices and methods for performing cell based assays

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2001259786A Abandoned AU2001259786A1 (en) 2000-05-15 2001-05-15 Bidirectional flow centrifugal microfluidic devices

Country Status (7)

Country Link
US (3) US6818435B2 (ja)
EP (2) EP1284818B1 (ja)
JP (2) JP2003533681A (ja)
AT (1) ATE345868T1 (ja)
AU (2) AU2001259786A1 (ja)
DE (1) DE60124699T2 (ja)
WO (2) WO2001087487A2 (ja)

Families Citing this family (317)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050069923A1 (en) * 1996-07-08 2005-03-31 Mullis Kary Banks Dual bead assays using cleavable spacers and/or ligation to improve specificity and sensitivity including related methods and apparatus
US6248542B1 (en) * 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
DE60012562D1 (de) * 1999-06-18 2004-09-02 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
ATE215673T1 (de) * 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US20020151078A1 (en) * 2000-05-15 2002-10-17 Kellogg Gregory J. Microfluidics devices and methods for high throughput screening
US6734401B2 (en) * 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6720187B2 (en) * 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US20030118486A1 (en) * 2000-07-03 2003-06-26 Xeotron Corporation Fluidic methods and devices for parallel chemical reactions
EP1410044A2 (en) * 2000-11-08 2004-04-21 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
EP1343973B2 (en) * 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7026131B2 (en) * 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
US7087203B2 (en) 2000-11-17 2006-08-08 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-disc
AU2002239289A1 (en) * 2000-11-22 2002-06-03 Burstein Technologies, Inc. Apparatus and methods for separating agglutinants and disperse particles
WO2002043866A2 (en) * 2000-12-01 2002-06-06 Burstein Technologies, Inc. Apparatus and methods for separating components of particulate suspension
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US7054258B2 (en) 2000-12-08 2006-05-30 Nagaoka & Co., Ltd. Optical disc assemblies for performing assays
EP1410026A2 (en) * 2000-12-08 2004-04-21 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
WO2002046721A2 (en) 2000-12-08 2002-06-13 Burstein Technologies, Inc. Optical discs for measuring analytes
US7091034B2 (en) * 2000-12-15 2006-08-15 Burstein Technologies, Inc. Detection system for disk-based laboratory and improved optical bio-disc including same
AU2002256992B2 (en) * 2001-02-07 2007-06-07 Massachusetts Institute Of Technology Optoelectronic detection system
US7422860B2 (en) * 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
EP1384076B1 (en) 2001-03-19 2012-07-25 Gyros Patent Ab Characterization of reaction variables
US7033747B2 (en) * 2001-04-11 2006-04-25 Nagaoka & Co., Ltd Multi-parameter assays including analysis discs and methods relating thereto
WO2004058405A1 (en) * 2001-05-02 2004-07-15 3M Innovative Properties Company Sample processing device with resealable process chamber
WO2004010099A2 (en) * 2001-05-16 2004-01-29 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US6811609B2 (en) * 2001-06-08 2004-11-02 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force in different directions
US6761766B2 (en) * 2001-06-08 2004-07-13 Syrrx, Inc. Method for parallel delivery and mixing of fluids by rotating a microfluidic device
US6837927B2 (en) * 2001-06-08 2005-01-04 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6780240B2 (en) * 2001-06-08 2004-08-24 Syrrx, Inc. Method for causing fluid movement by centrifugal force
US7014705B2 (en) * 2001-06-08 2006-03-21 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
US6719840B2 (en) * 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6837926B2 (en) * 2001-06-08 2005-01-04 Syrrx, Inc. Device for detecting precipitate formation in microvolumes
US6916372B2 (en) * 2001-06-08 2005-07-12 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6797056B2 (en) * 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US20030230383A1 (en) * 2001-07-24 2003-12-18 Glenn Sasaki Method and apparatus for bonded fluidic circuit for optical bio-disc
WO2003010563A2 (en) * 2001-07-24 2003-02-06 Burstein Technologies, Inc. Magnetic assisted detection of magnetic beads using optical disc drives
EP1483052B1 (en) 2001-08-28 2010-12-22 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6791677B2 (en) * 2001-08-28 2004-09-14 Tosoh Corporation Information measuring apparatus using a fine channel device
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
WO2003021222A2 (en) * 2001-08-31 2003-03-13 Burstein Technologies, Inc. Capture layer assemblies for cellular assays including related optical analysis discs and methods
EP1423699A4 (en) * 2001-09-07 2006-01-18 Burstein Technologies Inc CELLULAR MORPHOLOGY BASED IDENTIFICATION AND QUANTIFICATION OF WHITE BLOOD CELL TYPES USING OPTICAL BIO-DISC SYSTEMS
ATE477054T1 (de) 2001-09-17 2010-08-15 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
US20030082632A1 (en) * 2001-10-25 2003-05-01 Cytoprint, Inc. Assay method and apparatus
US20030138969A1 (en) * 2002-01-24 2003-07-24 Jakobsen Mogens Havsteen Closed substrate platforms suitable for analysis of biomolecules
EP1448992A4 (en) * 2001-11-20 2005-11-02 Burstein Technologies Inc OPTICAL BIODISTICS AND FLUIDIC CIRCUITS FOR CELL ANALYSIS AND CORRESPONDING METHODS
AU2002365278A1 (en) * 2001-12-20 2003-07-09 Radius Biosciences Centrifugal array processing device
US6889468B2 (en) * 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
CN100382870C (zh) * 2001-12-28 2008-04-23 株式会社日立高新技术 提取装置与化学分析装置及化学分析方法
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
US20050221048A1 (en) * 2002-01-31 2005-10-06 James Rodney Norton Manufacturing processes for making optical analysis discs including successive patterning operations and optical discs thereby manufactured
US20040241381A1 (en) * 2002-01-31 2004-12-02 Chen Yihfar Microfluidic structures with circumferential grooves for bonding adhesives and related optical analysis discs
WO2003065355A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safety features for optical analysis disc and disc system including same
WO2003064996A2 (en) * 2002-01-31 2003-08-07 Burstein Technologies, Inc. Bio-safe dispenser and optical analysis disc assembly
JP2003225083A (ja) * 2002-02-05 2003-08-12 Sony Corp 円盤状培養媒体
CA2480728A1 (en) * 2002-04-01 2003-10-16 Fluidigm Corporation Microfluidic particle-analysis systems
CN1650173B (zh) 2002-04-30 2012-06-06 爱科来株式会社 分析用具、使用分析用具的试样分析方法及分析装置、和分析用具的开口形成方法
EP1525451B1 (en) * 2002-04-30 2009-07-15 Gyros Patent Ab Method of analysing a catalytic system using an integrated microfluidic device
US8361783B2 (en) * 2002-05-09 2013-01-29 Nanologix, Inc. Micromethod and device for the rapid detection, enumeration and identification of microorganisms
US8663909B2 (en) * 2002-05-09 2014-03-04 Nanologix, Inc. Device for rapid detection and identification of single microorganisms without preliminary growth
US7781159B2 (en) * 2002-05-09 2010-08-24 Nanologix, Inc. Micromethod and device for rapid detection, enumeration and identification of entities
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
US7083974B2 (en) * 2002-07-12 2006-08-01 Applera Corporation Rotatable sample disk and method of loading a sample disk
US7041258B2 (en) * 2002-07-26 2006-05-09 Applera Corporation Micro-channel design features that facilitate centripetal fluid transfer
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
AU2003268201A1 (en) * 2002-08-27 2004-03-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
US7790443B2 (en) * 2002-08-27 2010-09-07 Vanderbilt University Bioreactors with substance injection capacity
US7534601B2 (en) * 2002-08-27 2009-05-19 Vanderbilt University Capillary perfused bioreactors with multiple chambers
US7094345B2 (en) * 2002-09-09 2006-08-22 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
AU2003293399A1 (en) 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
EP1578533A2 (en) * 2002-12-24 2005-09-28 Tecan Trading AG Microfluidics devices and methods for diluting samples and reagents
US7332129B2 (en) * 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
SE0300822D0 (sv) 2003-03-23 2003-03-23 Gyros Ab A collection of Micro Scale Devices
JP3888632B2 (ja) * 2003-03-26 2007-03-07 靖浩 堀池 マイクロミキサ、試料分析キット及びその製造方法
WO2004087281A2 (en) * 2003-03-31 2004-10-14 Cytonome, Inc. Implementation of microfluidic components, including molecular fractionation devices, in a microfluidic system
EP1620205A2 (en) * 2003-04-04 2006-02-01 Tecan Trading AG Elastomeric tools for fabricating of polymeric devices and uses thereof
US20050037484A1 (en) * 2003-04-23 2005-02-17 Norbert Staimer Optical bio-discs including spiral fluidic circuits for performing assays
WO2004098741A2 (en) * 2003-04-30 2004-11-18 Biovitesse Apparatus and method for detecting live cells with an integrated filter and growth detection device
JP2007501633A (ja) * 2003-05-06 2007-02-01 ベル ブルック ラブズ リミテッド ライアビリティ カンパニー 微小規模の流体ハンドリングシステムにおける三次元細胞培養
US7225937B2 (en) * 2003-05-13 2007-06-05 Schroeder Michael D Package system
US7435381B2 (en) * 2003-05-29 2008-10-14 Siemens Healthcare Diagnostics Inc. Packaging of microfluidic devices
US7160025B2 (en) * 2003-06-11 2007-01-09 Agency For Science, Technology And Research Micromixer apparatus and methods of using same
WO2004113871A2 (en) * 2003-06-19 2004-12-29 Nagaoka & Co., Ltd. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US7390464B2 (en) 2003-06-19 2008-06-24 Burstein Technologies, Inc. Fluidic circuits for sample preparation including bio-discs and methods relating thereto
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
WO2005001429A2 (en) * 2003-06-27 2005-01-06 Nagaoka & Co., Ltd. Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
US20080257754A1 (en) * 2003-06-27 2008-10-23 Pugia Michael J Method and apparatus for entry of specimens into a microfluidic device
US7238269B2 (en) * 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
JP2007500351A (ja) * 2003-07-25 2007-01-11 長岡実業株式会社 バイオディスクを有するサンプル調製用流体回路及びそれに関連した方法
US7524623B2 (en) * 2003-07-28 2009-04-28 Nanologix, Inc. Method and device for rapid detection of microorganisms by changing the shape of micro-colonies
US20060210426A1 (en) * 2003-08-05 2006-09-21 Taiyo Yuden Co., Ltd. Sample analyzer and disk-like sample analyzing medium
US7347617B2 (en) * 2003-08-19 2008-03-25 Siemens Healthcare Diagnostics Inc. Mixing in microfluidic devices
US7582472B2 (en) * 2003-08-26 2009-09-01 Smith Kenneth E Apparatus and method for liquid sample testing
JP3959436B2 (ja) * 2003-08-29 2007-08-15 独立行政法人物質・材料研究機構 流れ変動構造及びマイクロミキサ
JP4336834B2 (ja) * 2003-10-03 2009-09-30 独立行政法人物質・材料研究機構 チップの使用方法及び検査チップ
US7776272B2 (en) * 2003-10-03 2010-08-17 Gyros Patent Ab Liquid router
US7147362B2 (en) * 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US7837947B2 (en) * 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
US20050130177A1 (en) * 2003-12-12 2005-06-16 3M Innovative Properties Company Variable valve apparatus and methods
US7322254B2 (en) * 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods
JP4632400B2 (ja) * 2003-12-16 2011-02-16 キヤノン株式会社 細胞培養用基板、その製造方法、それを用いた細胞スクリーニング法
US20050142571A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using solid phase material
US20050142570A1 (en) * 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US7407799B2 (en) * 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
GB0401045D0 (en) * 2004-01-17 2004-02-18 Univ Sheffield Fluid-contactor
SE0400181D0 (sv) 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
JP2005257337A (ja) * 2004-03-09 2005-09-22 Brother Ind Ltd 検査対象受体、検査装置、及び検査方法
US7432106B2 (en) * 2004-03-24 2008-10-07 Applied Biosystems Inc. Liquid processing device including gas trap, and system and method
JP2005295877A (ja) * 2004-04-09 2005-10-27 Taiyo Yuden Co Ltd 核酸分析方法、分析装置及び分析用ディスク
US7491363B2 (en) * 2004-07-15 2009-02-17 Applied Biosystems, Llc. Fluid processing device
CA2583406A1 (en) * 2004-09-20 2007-01-04 Boston Microfluidics Microfluidic device for detecting soluble molecules
DE102004046396A1 (de) * 2004-09-24 2006-04-13 Land Baden-Württemberg, vertreten durch das Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg, vertreten durch den Minister Partikelsedimentationsvorrichtung und Verfahren zum Durchführen einer Partikelsedimentation
JP4742184B2 (ja) * 2004-09-30 2011-08-10 アークレイ株式会社 分析装置
JP4368383B2 (ja) * 2004-10-01 2009-11-18 株式会社アドバンス 固液分離構造体
JP2006110523A (ja) * 2004-10-18 2006-04-27 Hitachi Software Eng Co Ltd 化学反応装置
JP4458253B2 (ja) * 2004-10-28 2010-04-28 有限会社バイオデバイステクノロジー 検体試料用マイクロチップ
WO2006062149A1 (ja) * 2004-12-08 2006-06-15 Matsushita Electric Industrial Co., Ltd. 生体サンプル分析用プレート
JP2006177837A (ja) * 2004-12-24 2006-07-06 Hitachi Ltd 発光検出装置
US20080233594A1 (en) 2005-01-17 2008-09-25 Gyros Patent Ab Method For Detecting An At Least Bivalent Analyte Using Two Affinity Reactants
JP4422623B2 (ja) * 2005-01-17 2010-02-24 株式会社日立ハイテクノロジーズ 化学分析装置および化学分析カートリッジ
KR100668323B1 (ko) * 2005-01-19 2007-01-12 삼성전자주식회사 표면 플라즈몬 공명을 이용한 휴대용 바이오칩 스캐너
WO2006106608A1 (ja) * 2005-04-04 2006-10-12 Matsushita Electric Industrial Co., Ltd. 液体均一化装置およびそれを用いた分析装置
US8206650B2 (en) * 2005-04-12 2012-06-26 Chromedx Inc. Joint-diagnostic spectroscopic and biosensor meter
US7740804B2 (en) * 2005-04-12 2010-06-22 Chromedx Inc. Spectroscopic sample holder
CA2507323A1 (en) * 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
CA2517299A1 (en) * 2005-08-26 2007-02-26 Chromedx Inc. Hollow needle assembly
US20100245803A1 (en) * 2005-04-12 2010-09-30 Chromedx Inc. Blood sample holder for spectroscopic analysis
WO2006110095A1 (en) 2005-04-14 2006-10-19 Gyros Patent Ab A microfluidic device with finger valves
WO2006110093A1 (en) * 2005-04-14 2006-10-19 Gyros Patent Ab Liquid plugs
EP1874677B1 (en) * 2005-04-14 2013-03-20 Gyros Patent Ab Microfluidic device with meander
WO2006110097A1 (en) * 2005-04-14 2006-10-19 Gyros Patent Ab Separation structure
JP4927818B2 (ja) * 2005-04-14 2012-05-09 ギロス・パテント・エービー 蛇行体(meander)
EP1874675A4 (en) * 2005-04-14 2010-08-04 Gyros Patent Ab UP MICRO LINES
NZ590930A (en) 2005-05-09 2012-11-30 Theranos Inc Improving the calibration accuracy of a fluidic system by comparing test readings with a calibration curve and then adjusting the signal output
US20060263265A1 (en) * 2005-05-23 2006-11-23 Der-Ren Kang Blood micro-separator
JP3805352B1 (ja) * 2005-05-25 2006-08-02 株式会社エンプラス 流体取扱装置およびそれに用いる流体取扱ユニット
US20060281192A1 (en) * 2005-06-13 2006-12-14 Harding Philip H Method for mixing fluids in microfluidic systems
US7935318B2 (en) * 2005-06-13 2011-05-03 Hewlett-Packard Development Company, L.P. Microfluidic centrifugation systems
US7437914B2 (en) * 2005-06-28 2008-10-21 Hewlett-Packard Development Company, L.P. Microfluidic test systems with gas bubble reduction
US7754474B2 (en) * 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7323660B2 (en) * 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
US7763210B2 (en) * 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
WO2007021919A1 (en) * 2005-08-12 2007-02-22 Clemson University Co-culture bioreactor system
US20090104643A1 (en) * 2005-09-15 2009-04-23 Bartholomeusz Daniel A Bioluminescence-based sensor with centrifugal separation and enhanced light collection
KR100733914B1 (ko) 2005-09-22 2007-07-02 한국과학기술원 미세유체 기술을 이용한 3차원 세포배양 시스템
US8449837B2 (en) * 2005-10-11 2013-05-28 The Johns Hopkins University Microfluidic device for high-throughput cellular gradient and dose response studies
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
JP4687413B2 (ja) * 2005-11-16 2011-05-25 コニカミノルタエムジー株式会社 マイクロチップにおける2種類以上の液体の混合方法およびマイクロ総合分析システム
US10296720B2 (en) 2005-11-30 2019-05-21 Gearbox Llc Computational systems and methods related to nutraceuticals
US7974856B2 (en) 2005-11-30 2011-07-05 The Invention Science Fund I, Llc Computational systems and methods related to nutraceuticals
US20080103746A1 (en) 2005-11-30 2008-05-01 Searete Llc, A Limited Liability Corporation Systems and methods for pathogen detection and response
US8297028B2 (en) 2006-06-14 2012-10-30 The Invention Science Fund I, Llc Individualized pharmaceutical selection and packaging
US7827042B2 (en) 2005-11-30 2010-11-02 The Invention Science Fund I, Inc Methods and systems related to transmission of nutraceutical associated information
US8340944B2 (en) 2005-11-30 2012-12-25 The Invention Science Fund I, Llc Computational and/or control systems and methods related to nutraceutical agent selection and dosing
US8000981B2 (en) 2005-11-30 2011-08-16 The Invention Science Fund I, Llc Methods and systems related to receiving nutraceutical associated information
US20080241935A1 (en) 2007-03-27 2008-10-02 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US7927787B2 (en) 2006-06-28 2011-04-19 The Invention Science Fund I, Llc Methods and systems for analysis of nutraceutical associated components
DE102005057685A1 (de) * 2005-12-01 2007-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalator und Speicher für eine trockene Arzneimittelformulierung sowie diesbezügliche Verfahren und Verwendung
EP2032984A1 (en) 2005-12-12 2009-03-11 Gyros Patent Ab Microfluidic assays and microfluidic devices
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US7651869B2 (en) * 2006-03-14 2010-01-26 Research International, Inc. Optical assay apparatus and methods
JP4754394B2 (ja) * 2006-04-14 2011-08-24 ローム株式会社 マイクロチップ
JP4593517B2 (ja) * 2006-05-15 2010-12-08 株式会社日立ハイテクノロジーズ 化学分析装置
JP4597091B2 (ja) * 2006-05-24 2010-12-15 株式会社日立ハイテクノロジーズ 生化学分析装置及びそれに用いる検査カートリッジ
GB0614297D0 (en) * 2006-07-19 2006-08-30 Shaw Water Engineering Ltd Apparatus, system and method for detecting particles
KR101335920B1 (ko) * 2006-08-02 2013-12-03 삼성전자주식회사 박막화학분석장치 및 이를 이용한 분석방법
WO2008039207A1 (en) * 2006-09-27 2008-04-03 The Scripps Research Institute Biochemical applications of a microfluidic serial dilution circuit
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8008034B2 (en) * 2006-10-13 2011-08-30 Theranos, Inc. Reducing optical interference in a fluidic device
JP5166430B2 (ja) * 2006-11-09 2013-03-21 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ 統合された流体含有構造を有するフォトニック結晶センサ
US20080131955A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
EP2117713B1 (en) 2006-12-22 2019-08-07 DiaSorin S.p.A. Thermal transfer methods for microfluidic systems
TW200844420A (en) * 2006-12-22 2008-11-16 3M Innovative Properties Co Enhanced sample processing devices, systems and methods
WO2008078475A1 (ja) 2006-12-26 2008-07-03 Nsk Ltd. 可視下遠心装置及び観察装置
US10001496B2 (en) 2007-01-29 2018-06-19 Gearbox, Llc Systems for allergen detection
US8617903B2 (en) 2007-01-29 2013-12-31 The Invention Science Fund I, Llc Methods for allergen detection
KR101305976B1 (ko) * 2007-02-12 2013-09-12 삼성전자주식회사 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
CN101715553A (zh) * 2007-03-02 2010-05-26 拉瓦尔大学 用于流体装置或微流体装置的连续虹吸阀
US20100227338A1 (en) * 2007-03-22 2010-09-09 Nanologix, Inc. Method and Apparatus for Rapid Detection and Identification of Live Microorganisms Immobilized On Permeable Membrane by Antibodies
US9068216B2 (en) 2007-03-22 2015-06-30 Bret T. Barnhizer Methods and devices for rapid detection and identification of live microorganisms by aptamers and/or antibodies immobilized on permeable membranes
US20090215157A1 (en) * 2007-03-27 2009-08-27 Searete Llc Methods for pathogen detection
KR100858091B1 (ko) * 2007-04-24 2008-09-10 삼성전자주식회사 시료 분배 구조를 갖는 원심력 기반의 미세유동장치 및이를 포함하는 미세유동시스템
EP2140001A2 (en) * 2007-04-25 2010-01-06 3M Innovative Properties Company Methods for nucleic acid amplification
US20080277356A1 (en) * 2007-05-07 2008-11-13 Caliper Life Sciences, Inc. Microfluidic Device with a Filter
JP4911514B2 (ja) * 2007-05-14 2012-04-04 独立行政法人産業技術総合研究所 マイクロチップ、液体分注方法
JP4836272B2 (ja) * 2007-05-15 2011-12-14 独立行政法人産業技術総合研究所 液体導入用デバイス
KR101228308B1 (ko) 2007-05-23 2013-01-31 삼성전자주식회사 미세유동 칩을 이용한 디스크형 미세유동장치 및 생체물질마이크로어레이 칩을 이용한 디스크형 미세유동장치
KR101335726B1 (ko) 2007-06-04 2013-12-04 삼성전자주식회사 면역혈청 검사 및 생화학 검사를 동시에 수행하는 디스크형미세유동장치
KR20080107212A (ko) * 2007-06-05 2008-12-10 삼성전자주식회사 유체 컨테이너를 구비한 미세유동 장치
IL184183A0 (en) * 2007-06-25 2007-10-31 Benjamin Alspector Bi directional transfer of an aliquot of fluid between compartments
KR101335727B1 (ko) * 2007-08-22 2013-12-04 삼성전자주식회사 원심력 기반의 혈액 검사용 디스크형 미세유동장치
NZ584963A (en) 2007-10-02 2012-11-30 Theranos Inc Modular Point-of-care devices as addressible assay units with tips of assay units having interior to immobilize reagents by capillary action
EP2209008B1 (en) * 2007-10-04 2016-12-21 Panasonic Healthcare Holdings Co., Ltd. Analysis device, and analysis apparatus and method using the same
TWI362491B (en) * 2007-11-02 2012-04-21 Ind Tech Res Inst Fluid analytical device and fluid analytical method thereof
US20090122637A1 (en) * 2007-11-14 2009-05-14 Jan Kruyer Sinusoidal mixing and shearing apparatus and associated methods
US20110097814A1 (en) * 2007-11-20 2011-04-28 Bommarito G Marco Detection devices and methods
WO2009066897A2 (en) * 2007-11-22 2009-05-28 Jae Chern Yoo Thin film valve device and its controlling apparatus
JP5174627B2 (ja) * 2008-01-21 2013-04-03 パナソニック株式会社 分析装置
US8486333B2 (en) * 2008-02-04 2013-07-16 Micropoint Biosciences, Inc. Centrifugal fluid analyzer rotor
WO2009108654A2 (en) * 2008-02-25 2009-09-03 Clemson University Differential pressure pump system
WO2009111461A2 (en) * 2008-03-04 2009-09-11 University Of Utah Research Foundation Microfluidic flow cell
US8632243B2 (en) * 2008-03-10 2014-01-21 The Hong Kong Polytechnic University Microfluidic mixing using continuous acceleration/deceleration methodology
US8735846B1 (en) 2008-03-14 2014-05-27 Advanced Technology Applications, Llc Electromagnetic biosensor
US7812318B1 (en) 2008-03-14 2010-10-12 Advanced Technology Applications, Llc Electromagnetic biosensor
KR20100128340A (ko) * 2008-03-27 2010-12-07 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 종이 기반 마이크로유체 시스템
KR20100009482A (ko) * 2008-07-18 2010-01-27 삼성전자주식회사 공기 출구 및 밸브가 구비된 구조물을 포함하는 미세 유동 장치, 및 이를 이용한 액체 이송 방법
US8430558B1 (en) * 2008-09-05 2013-04-30 University Of Central Florida Research Foundation, Inc. Microfluidic mixer having channel width variation for enhanced fluid mixing
US9289765B2 (en) * 2008-09-23 2016-03-22 Samsung Electronics Co., Ltd. Micro-fluidic device and sample testing apparatus using the same
KR100997144B1 (ko) * 2008-09-23 2010-11-30 삼성전자주식회사 미세유동장치
US20100075863A1 (en) * 2008-09-25 2010-03-25 Northrop Grumman Systems Corporation Rotary array module for multiplexing spot-based optical readouts
GB2464300A (en) * 2008-10-10 2010-04-14 Univ Dublin City Microfluidic multiplexed cellular and molecular analysis device and method
KR101099495B1 (ko) * 2008-10-14 2011-12-28 삼성전자주식회사 원심력 기반의 미세유동장치, 이의 제조 방법 및 이를 이용한 시료분석방법
US7993583B2 (en) * 2008-10-29 2011-08-09 Lawrence Livermore National Security, Llc Passive microfluidic array card and reader
WO2010080236A1 (en) 2008-12-19 2010-07-15 3M Innovative Properties Company System and method for processing samples
CN102301220B (zh) 2008-12-19 2014-06-25 3M创新有限公司 用于浓缩样品的系统和方法
US20120135446A1 (en) * 2009-03-04 2012-05-31 Maine Institute For Human Genetics & Health, Inc Microfluidic Device and Related Methods
KR20100101526A (ko) * 2009-03-09 2010-09-17 삼성전자주식회사 스트로보 박막 화학 분석 장치 및 이를 이용한 분석 방법
EP2405983A4 (en) * 2009-03-13 2014-04-09 Terrasep Llc Method and apparatus for central liquid chromatography
EP2408900B1 (en) * 2009-03-20 2018-01-10 International Business Machines Corporation Microorganism culture device and method of operation thereof
CN102387864B (zh) * 2009-04-09 2014-06-25 皇家飞利浦电子股份有限公司 用于分析的含细胞流体薄层的制备
US8383025B2 (en) * 2009-05-19 2013-02-26 Nanyang Technological University Method of manufacturing micro patterned device and device obtained by the method
US20100323434A1 (en) * 2009-06-19 2010-12-23 In Hong Yang Compartmentalized Nerve Culture System
US9120067B2 (en) * 2009-09-25 2015-09-01 Konica Minolta, Inc. Micro mixer and microfluidic chip
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
USD667561S1 (en) 2009-11-13 2012-09-18 3M Innovative Properties Company Sample processing disk cover
USD638951S1 (en) 2009-11-13 2011-05-31 3M Innovative Properties Company Sample processing disk cover
USD638550S1 (en) 2009-11-13 2011-05-24 3M Innovative Properties Company Sample processing disk cover
KR101422573B1 (ko) * 2009-11-26 2014-07-25 삼성전자 주식회사 원심력기반의 미세유동장치 및 이를 이용한 면역혈청검사방법
KR101722548B1 (ko) * 2010-01-29 2017-04-03 삼성전자주식회사 원심력기반의 미세유동장치 및 이를 이용한 유체시료 내 분석대상물질 검출방법
US8428398B2 (en) * 2010-02-01 2013-04-23 Lawrence Livermore National Security, Llc Hand-held portable microarray reader for biodetection
JP2011155921A (ja) * 2010-02-02 2011-08-18 Seiko Epson Corp バイオチップ、検体反応装置及び検体反応方法
CN102262051B (zh) 2010-05-25 2015-04-08 香港城市大学 光学传感装置和使用该光学传感装置检测样本的方法
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US20130115606A1 (en) * 2010-07-07 2013-05-09 The University Of British Columbia System and method for microfluidic cell culture
US9795961B1 (en) 2010-07-08 2017-10-24 National Technology & Engineering Solutions Of Sandia, Llc Devices, systems, and methods for detecting nucleic acids using sedimentation
TW202208825A (zh) 2011-01-21 2022-03-01 美商拉布拉多診斷有限責任公司 樣本使用最大化之系統及方法
CN103403521B (zh) * 2011-03-08 2016-08-10 拉瓦勒大学 流体向心装置
WO2012158988A1 (en) 2011-05-18 2012-11-22 3M Innovative Properties Company Systems and methods for valving on a sample processing device
AU2012255151B2 (en) 2011-05-18 2015-09-03 Diasorin Italia S.P.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
US8931331B2 (en) 2011-05-18 2015-01-13 3M Innovative Properties Company Systems and methods for volumetric metering on a sample processing device
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
JP2014526041A (ja) 2011-06-30 2014-10-02 スリーエム イノベイティブ プロパティズ カンパニー フィルター及び微細構造化表面を使用して、サンプル中の目的の検体を検出するためのシステム及び方法
WO2013003308A1 (en) 2011-06-30 2013-01-03 3M Innovative Properties Company Systems and methods for detecting an analyte of interest in a sample using microstructured surfaces
WO2013029153A1 (en) 2011-08-30 2013-03-07 National Research Council Of Canada Centrifugally-enhanced capture method and device
WO2013037284A1 (en) 2011-09-15 2013-03-21 The Chinese University Of Hong Kong Microfluidic platform and method for controlling the same
CA2858160C (en) 2011-12-07 2019-10-15 Royal Melbourne Institute Of Technology Centrifugal microfluidic device
US20130211289A1 (en) 2012-01-25 2013-08-15 Tasso, Inc. Handheld Device for Drawing, Collecting, and Analyzing Bodily Fluid
US9244065B1 (en) 2012-03-16 2016-01-26 Sandia Corporation Systems, devices, and methods for agglutination assays using sedimentation
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
JP6196661B2 (ja) 2012-04-20 2017-09-13 スリップチップ, エルエルシー サンプル調製または自律分析のための流体デバイスおよびシステム
EP2856110B1 (en) * 2012-06-05 2018-04-18 Siemens Healthcare Diagnostics Inc. System for serum sample quality determination
US8953168B2 (en) 2012-06-08 2015-02-10 City University Of Hong Kong Optical sensing devices and methods for detecting samples using the same
US9903001B1 (en) 2012-07-19 2018-02-27 National Technology & Engineering Solutions Of Sandia, Llc Quantitative detection of pathogens in centrifugal microfluidic disks
AU2013293078B2 (en) 2012-07-23 2017-09-07 Tasso, Inc. Methods, systems, and devices relating to open microfluidic channels
TWI475226B (zh) * 2012-08-01 2015-03-01 Univ Feng Chia 利用分流結構進行生化檢測之裝置及其運作方法
BR112015002561A2 (pt) 2012-08-08 2018-05-22 Koninklijke Philips Nv sistema para separação de um analito heterogêneo, e método para separação de um analito heterogêneo.
WO2014058757A2 (en) 2012-10-08 2014-04-17 General Electric Company Centripetal microfluidic platform for lal-reactive substances testing
DE102012220250A1 (de) 2012-11-07 2014-05-08 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikmodul für eine zentrifugale filtration und verfahren zum filtern einer probe
WO2014078785A1 (en) * 2012-11-19 2014-05-22 The General Hospital Corporation System and method for integrated multiplexed photometry module
US10215687B2 (en) 2012-11-19 2019-02-26 The General Hospital Corporation Method and system for integrated mutliplexed photometry module
US11366061B2 (en) 2013-01-24 2022-06-21 Grace Bio-Labs, Inc. Protein microarray assay imager
US9308508B2 (en) 2013-07-22 2016-04-12 Kianoosh Peyvan Sequential delivery device and method
US9803238B1 (en) 2013-11-26 2017-10-31 National Technology & Engineering Solutions Of Sandia, Llc Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid
WO2015185763A1 (en) 2014-06-06 2015-12-10 Roche Diagnostics Gmbh Rotatable cartridge with a metering chamber for analyzing a biological sample
EP2952258A1 (en) * 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for analyzing a biological sample
EP2952257A1 (en) 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for processing and analyzing a biological sample
EP2957890A1 (en) * 2014-06-16 2015-12-23 Roche Diagnostics GmbH Cartridge with a rotatable lid
CN113440134A (zh) 2014-08-01 2021-09-28 塔索公司 用于重力增强的微流体采集、液体的处理和输送的装置、系统和方法
GB201415804D0 (en) * 2014-09-08 2014-10-22 Univ Singapore Assay Device
US9702871B1 (en) * 2014-11-18 2017-07-11 National Technology & Engineering Solutions Of Sandia, Llc System and method for detecting components of a mixture including a valving scheme for competition assays
KR101776245B1 (ko) 2014-11-20 2017-09-11 울산과학기술원 입자 여과 장치 및 입자 여과 방법
US10166541B2 (en) * 2014-12-10 2019-01-01 The Regents Of The University Of California Centrifugal microfluidic platform for automated media exchange
JP6264595B2 (ja) * 2015-03-09 2018-01-24 パナソニックIpマネジメント株式会社 マイクロ流体デバイス
US10254298B1 (en) 2015-03-25 2019-04-09 National Technology & Engineering Solutions Of Sandia, Llc Detection of metabolites for controlled substances
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US11154860B2 (en) 2015-10-23 2021-10-26 Unist (Ulsan National Institute Of Science & Technology) Centrifugal force-based nanoparticle separation apparatus and method for separating nanoparticles using the same
WO2017069573A1 (ko) * 2015-10-23 2017-04-27 울산과학기술원 원심력 기반 나노 입자 분리장치 및 이를 이용한 나노 입자 분리방법
CN107427829A (zh) 2015-12-16 2017-12-01 拜奥塞菲特公司 用于处理液体的方法和装置
WO2017112793A1 (en) 2015-12-21 2017-06-29 Tasso, Inc. Devices, systems and methods for actuation and retraction in fluid collection
US11331665B2 (en) 2016-01-18 2022-05-17 The Board Of Trustees Of The Leland Stanford Junior University Paperfuge: An integrated paper-based centrifugation and microfluidics platform for low-cost diagnostics
FR3048778A1 (fr) * 2016-03-10 2017-09-15 Archimej Tech Dispositif d'analyse, de preference pour chimiometrie d'un echantillon sanguin.
KR20230136674A (ko) 2016-06-08 2023-09-26 더 리전트 오브 더 유니버시티 오브 캘리포니아 조직 및 세포를 프로세싱하기 위한 방법 및 장치
CN107949437A (zh) 2016-06-09 2018-04-20 拜奥塞菲特公司 用于旋转地驱动液流的液体处理装置及使用该装置的方法
KR101868961B1 (ko) * 2016-06-21 2018-06-19 울산과학기술원 미세 유체 장치
CA3030138A1 (en) * 2016-07-07 2018-01-11 Vanderbilt University Fluidic device for the detection, capture, or removal of a disease material
CN106076445B (zh) * 2016-07-18 2018-06-15 天津德祥生物技术有限公司 微流控试剂卡及其检测方法和应用
US10981174B1 (en) 2016-08-04 2021-04-20 National Technology & Engineering Solutions Of Sandia, Llc Protein and nucleic acid detection for microfluidic devices
US10406528B1 (en) 2016-08-04 2019-09-10 National Technology & Engineering Solutions Of Sandia, Llc Non-contact temperature control system for microfluidic devices
US10786811B1 (en) 2016-10-24 2020-09-29 National Technology & Engineering Solutions Of Sandia, Llc Detection of active and latent infections with microfluidic devices and systems thereof
WO2018088856A2 (ko) * 2016-11-10 2018-05-17 재단법인 아산사회복지재단 마이크로유체칩, 삼차원 채널 구조물, 이를 이용한 세포 배양 방법 및 이를 이용한 생리활성 물질의 활성평가 방법
GB201700340D0 (en) * 2017-01-09 2017-02-22 Gsg Tech Ltd fluid manipulation cartridge and controller mechanism
TWI671397B (zh) * 2017-07-14 2019-09-11 國立中興大學 粒線體萃取裝置
EP3668649B1 (en) * 2017-08-15 2022-03-02 The General Hospital Corporation Microfluidic device
JP7121244B2 (ja) * 2017-10-23 2022-08-18 国立大学法人山梨大学 分注デバイス、それを用いた分注装置及び方法、並びに検査装置及び方法
IT201800006089A1 (it) * 2018-06-06 2019-12-06 Dispositivo microfluidico per la concentrazione di particelle
DE102018212930B3 (de) * 2018-08-02 2019-11-07 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zum Leiten einer Flüssigkeit durch ein poröses Medium
EP3840883A1 (en) * 2018-08-24 2021-06-30 Zoetis Services LLC Microfluidic rotor device
JP7460607B2 (ja) 2018-09-14 2024-04-02 タッソ インコーポレイテッド 体液収集装置および関連方法
CN109211860B (zh) * 2018-09-29 2023-11-17 厦门大学 一种多项式检测光盘和检测方法
CN110180465A (zh) * 2019-06-18 2019-08-30 金华职业技术学院 一种微量液体混合反应装置
CN110237775A (zh) * 2019-06-18 2019-09-17 金华职业技术学院 一种微量液体混合反应方法
CN112807656B (zh) * 2020-12-31 2022-02-25 吉林师范大学 一种用于篮球投篮的新人训练装置
GB202201074D0 (en) * 2021-07-29 2022-03-16 Osler Diagnostics Ltd Liquid handling device for allowing the presence or absence of a volume of liquid to be determined
CN114471765B (zh) * 2022-01-18 2023-04-21 北京保利微芯科技有限公司 离心式液滴生成芯片
US20230381393A1 (en) * 2022-05-27 2023-11-30 Actorius Innovations Research Co Devices and methods for recovering disease-causing toxic constituents in the blood

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3679367A (en) * 1970-09-14 1972-07-25 Technicon Instr Apparatus for determining the pack volume of particulates in liquid mixtures
BE792465A (fr) 1971-12-09 1973-03-30 Atomic Energy Commission Rotor perfectionne pour analyseur photometrique rotatif convenant en particulier dans des conditions d'apesanteur
US4030834A (en) * 1976-04-08 1977-06-21 The United States Of America As Represented By The United States Energy Research And Development Administration Dynamic multistation photometer
FR2400700A1 (fr) * 1977-08-18 1979-03-16 Guigan Jean Dispositif de conditionnement d'un echantillon de liquide en vue de son analyse
US4760067A (en) 1979-08-15 1988-07-26 Merck & Co., Inc. Allylsulfoxide enzyme inhibitors
US5496520A (en) * 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
US4675285A (en) 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
FR2575293B1 (fr) * 1984-12-21 1987-03-20 Inovelf Sa Rotor a pipetage dynamique pour dispositif d'analyse a centrifugation
US5164598A (en) 1985-08-05 1992-11-17 Biotrack Capillary flow device
US5242803A (en) * 1987-07-17 1993-09-07 Martin Marietta Energy Systems, Inc. Rotor assembly and assay method
US5173262A (en) * 1987-07-17 1992-12-22 Martin Marietta Energy Systems, Inc. Rotor assembly and method for automatically processing liquids
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5061381A (en) * 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
US5242606A (en) * 1990-06-04 1993-09-07 Abaxis, Incorporated Sample metering port for analytical rotor having overflow chamber
US5122284A (en) * 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
US5186844A (en) * 1991-04-01 1993-02-16 Abaxis, Inc. Apparatus and method for continuous centrifugal blood cell separation
US5173193A (en) * 1991-04-01 1992-12-22 Schembri Carol T Centrifugal rotor having flow partition
DE69118295T2 (de) * 1990-10-01 1996-09-19 Canon Kk Vorrichtung und Verfahren zur Messung einer Probe
US5569779A (en) 1991-12-23 1996-10-29 Albemarle Corporation Polyfunctional michael addition products
US5304348A (en) * 1992-02-11 1994-04-19 Abaxis, Inc. Reagent container for analytical rotor
AU4047493A (en) * 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5478750A (en) * 1993-03-31 1995-12-26 Abaxis, Inc. Methods for photometric analysis
US5591643A (en) * 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
US5409665A (en) * 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5976896A (en) * 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
US5639428A (en) * 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
JP2002503331A (ja) 1995-12-05 2002-01-29 ガメラ バイオサイエンス コーポレイション 機内に搭載された情報科学を備えた超微量液体素子工学システムにおいて液体移動を推進するために求心性加速を使用するための装置及び方法
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
WO1998028623A1 (en) * 1996-12-20 1998-07-02 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
WO1998053311A2 (en) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
DE60028819T2 (de) * 1999-12-23 2007-01-11 Gyros Patent Ab Verfahren zur behandlung einer matrixnukleinsäure unter verwendung einer integrierten mikrofluidischen platte

Also Published As

Publication number Publication date
US20020106786A1 (en) 2002-08-08
EP1284817A2 (en) 2003-02-26
US6818435B2 (en) 2004-11-16
DE60124699D1 (de) 2007-01-04
AU2001259786A1 (en) 2001-11-26
JP2003533681A (ja) 2003-11-11
WO2001087487A3 (en) 2002-04-18
DE60124699T2 (de) 2007-09-13
WO2001087486A2 (en) 2001-11-22
US20030152491A1 (en) 2003-08-14
ATE345868T1 (de) 2006-12-15
US20020097632A1 (en) 2002-07-25
WO2001087487A2 (en) 2001-11-22
EP1284818B1 (en) 2006-11-22
US6527432B2 (en) 2003-03-04
EP1284818A2 (en) 2003-02-26
WO2001087486A3 (en) 2002-10-24
JP2003533682A (ja) 2003-11-11

Similar Documents

Publication Publication Date Title
AU2001259785A1 (en) Microfluidics devices and methods for performing cell based assays
WO2005028096A3 (en) Microfluidics devices and methods for performing cell based assays
WO2002101357A3 (en) Molecular signatures of commonly fatal carcinomas
AU5494900A (en) Devices and methods for the performance of miniaturized homogeneous assays
WO2004051218A8 (en) Multiplex amplification of polynucleotides
WO2005068628A3 (en) Methods for nucleic acid isolation and kits using solid phase material
EP2305809A3 (en) Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
SG157224A1 (en) A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby
DE60211651D1 (de) Proteom-analyseverfahren
EP1371980A3 (en) Assay chamber
AU2002311773A1 (en) Labeled cells for use as an internal functional control in rare cell detection assays
EP1293574A3 (en) Reagents, methods and devices for detecting analytes
WO2005017646A3 (en) System, software and methods for biomarker identification
WO2002043758A3 (en) Uses of mammalian genes and related reagents
WO2005002416A3 (en) Predictors of renal disease
AU2003224674A8 (en) Compounds and methods for analyzing the proteome
AU2001241433A1 (en) Methods for predicting the biological, chemical, and physical properties of molecules from their spectral properties
AU9066998A (en) Use of check surfaces for identifying disturbing samples in a detection procedure
DK0921857T3 (da) Flerbröndsplader med lav baggrund til fluorescensmålinger af biologiske og biokemiske pröver
EP1710562A3 (en) Microfluidic system and method of utilization
WO2002059379A3 (en) Methods for detecting, grading or monitoring an $i(h. pylori) infection
CA2500407A1 (en) Diagnostic devices
WO2003050291A3 (en) Sensor for the use in testing biological chemical or environmental samples
AU2003257133A1 (en) Methods, devices and kits for multiplex blotting of biological samples from multi-well plates
WO2004010143A3 (en) Electrochemical lateral flow and flow-through devices