AU1430892A - Anticoagulants and processes for preparing such - Google Patents

Anticoagulants and processes for preparing such

Info

Publication number
AU1430892A
AU1430892A AU14308/92A AU1430892A AU1430892A AU 1430892 A AU1430892 A AU 1430892A AU 14308/92 A AU14308/92 A AU 14308/92A AU 1430892 A AU1430892 A AU 1430892A AU 1430892 A AU1430892 A AU 1430892A
Authority
AU
Australia
Prior art keywords
groups
sulphated
saccharide
residues
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU14308/92A
Other languages
English (en)
Inventor
Benito Casu
Giordana Grazioli
Helgi Hermann Hannesson
Barbara Jann
Klaus Jann
Marion Kusche
Ulf Lindahl
Annamaria Naggi
Pasqua Oreste
Nahid Razi
Giangiacomo Torri
Giorgio Zoppetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Italfarmaco SpA
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Italfarmaco SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Italfarmaco SpA filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of AU1430892A publication Critical patent/AU1430892A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU14308/92A 1991-03-28 1992-03-30 Anticoagulants and processes for preparing such Abandoned AU1430892A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9106757 1991-03-28
GB9106757A GB2254083A (en) 1991-03-28 1991-03-28 Anticoagulants from e.coli saccharide

Publications (1)

Publication Number Publication Date
AU1430892A true AU1430892A (en) 1992-11-02

Family

ID=10692438

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14308/92A Abandoned AU1430892A (en) 1991-03-28 1992-03-30 Anticoagulants and processes for preparing such

Country Status (12)

Country Link
JP (1) JPH07501684A (ja)
AU (1) AU1430892A (ja)
CA (1) CA2107124A1 (ja)
FI (1) FI934141A (ja)
GB (2) GB2254083A (ja)
HU (1) HUT67208A (ja)
IE (1) IE920982A1 (ja)
IT (1) IT1254564B (ja)
PT (1) PT100316A (ja)
TW (1) TW209225B (ja)
WO (1) WO1992017507A1 (ja)
ZA (1) ZA922313B (ja)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684385B1 (fr) * 1991-11-28 1997-08-01 Sanofi Elf Heparosanes-n,o-sulfates de haute masse moleculaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IT1270823B (it) * 1993-06-04 1997-05-13 Italfarmaco Spa Polisaccaridi ad elevata attivita' antitrombotica e anticoagulante
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
IT1271057B (it) * 1994-11-04 1997-05-26 Inalco Spa Polisaccaridi aventi un elevato contenuto di acido iduronico
IT1282994B1 (it) * 1996-05-10 1998-04-03 Inalco Spa Derivati del polisaccaride k5 aventi elevata attivita' anticoagulante
AUPO556297A0 (en) * 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
ITMI991465A1 (it) * 1999-07-02 2001-01-02 Inalco Spa Processo per la preparazione dei polisaccaridi k4 e k5 da escherichiacoli
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
ITMI20010397A1 (it) 2001-02-27 2002-08-27 Giorgio Zoppetti Derivati altamente n,o-solfatati del polisaccaride k5 e loro preparazione
ITMI20010779A1 (it) * 2001-04-12 2002-10-12 Giorgio Zoppetti Uso di polisaccaridi batterici solfati atti all'inibizione dell'angiogenesi
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
CA2489870A1 (en) 2002-06-18 2003-12-24 Glycores 2000 S.R.L. Low molecular weight oversulfated polysaccharide
EP1638581A2 (en) 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
JP2011503104A (ja) 2007-11-09 2011-01-27 カリフォルニア インスティテュート オブ テクノロジー 免疫調節化合物ならびに関連組成物および方法
ITMI20091445A1 (it) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico Derivati semi-sintetici del polisaccaride k5 per la prevenzione ed il trattamento del danno tissutale associato a ischemia e/o riperfusione
EP2555753B1 (en) 2010-04-07 2018-08-01 California Institute of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
WO2011146910A1 (en) 2010-05-20 2011-11-24 Round June L Antigen specific tregs and related compositions, methods and systems
CN102199175A (zh) * 2011-04-07 2011-09-28 福州大学 硫酸类肝素二糖的制备纯化方法及其纯化产品
EP2731617A4 (en) 2011-07-12 2015-07-01 Brigham & Womens Hospital LIPID-CONTAINING PSA COMPOSITIONS, METHODS OF ISOLATION AND METHODS OF USING SAME
EP2994161B1 (en) 2013-05-10 2020-10-28 California Institute of Technology Probiotic prevention and treatment of colon cancer
US11331335B2 (en) 2015-06-10 2022-05-17 California Institute Of Technology Sepsis treatment and related compositions methods and systems
JP6918365B2 (ja) 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化ｐｓａ組成物および方法
CA3030974A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
FR2548189B1 (fr) * 1983-07-01 1986-04-11 Choay Sa Nouveaux produits contenant des oligosaccharides, leur preparation et leurs applications biologiques et biochimiques
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
FR2669932B1 (fr) * 1990-12-03 1994-07-01 Sanofi Sa Nouvel heparosane-n,o-sulfate, son procede de preparation et les compositions pharmaceutiques qui le contiennent.

Also Published As

Publication number Publication date
ITMI920722A0 (it) 1992-03-26
ITMI920722A1 (it) 1993-09-26
WO1992017507A1 (en) 1992-10-15
GB2286193A (en) 1995-08-09
ZA922313B (en) 1993-08-02
FI934141A0 (fi) 1993-09-22
HU9302732D0 (en) 1994-01-28
TW209225B (ja) 1993-07-11
PT100316A (pt) 1993-07-30
CA2107124A1 (en) 1992-09-29
IE920982A1 (en) 1992-10-07
JPH07501684A (ja) 1995-02-23
GB9106757D0 (en) 1991-05-15
GB9508157D0 (en) 1995-06-07
GB2254083A (en) 1992-09-30
FI934141A (fi) 1993-09-22
HUT67208A (en) 1995-02-28
IT1254564B (it) 1995-09-25

Similar Documents

Publication Publication Date Title
AU1430892A (en) Anticoagulants and processes for preparing such
Kaplan et al. Structural studies of the capsular polysaccharide of Acinetobacter calcoaceticus BD4
US5384398A (en) High molecular mass N,O-sulphated heparosans, process for their preparation and the pharmaceutical compositions which contain them
Cote et al. Characterization of the exocellular polysaccharides from Azotobacter chroococcum
RU2099353C1 (ru) N,о-сульфатированные гепарозаны, способ их получения и фармацевтическая композиция, обладающая антитромботической активностью
US4826827A (en) Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
JP3605414B2 (ja) 糖化合物
CN110331178B (zh) 一种酶切法制备小分子透明质酸的方法及所得小分子透明质酸与其应用
EP0355831B1 (en) Purification of glycosaminoglycan degrading enzymes
US20060166335A1 (en) Glucuronofucan sulfate
CN111154819B (zh) 一种非动物源低分子量肝素及其制备方法与应用
JP2007501305A (ja) 血漿中で高度の抗血栓活性を有する多糖類誘導体
JP3110064B2 (ja) 新規ヘパリチナーゼ、その製造法及びその生産菌
CA1180292A (en) Short chain oligosaccharides possessing biological properties, their preparation and their use as medicaments
EP0608636B1 (en) Cycloisomaltooligosaccharides, an enzyme and process for producing said oligosaccharides, and a process for producing said enzyme
EP0231585B1 (en) Biosynthesis of heteropolysaccharides
Manzoni et al. Production of K5 polysaccharides of different molecular weight by Escherichia coli
EP0577665A1 (en) Anticoagulants and processes for preparing such
EP0614972B1 (en) N-Acetyl-D-glucosamine deacetylase and a process for preparing the same
Matsuyama et al. Production of a novel exopolysaccharide by Rahnella aquatilis
WO1994029352A1 (en) Polysaccharides having high antithrombotic and anticoagulant activity
Misaki et al. Degradation of elsinan by alpha amylases, and elucidation of its fine structure
Lifely et al. The teichuronic acid from the walls of Bacillus licheniformis ATCC 9945
KR890001287B1 (ko) 발효방법 및 이에 따라 생산된 탈아세틸화된 헤테로폴리사카라이드
Manzoni et al. Influence of the culture conditions on extracellular lyase activity related to K5 polysaccharide