ATE97957T1 - Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c. - Google Patents

Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c.

Info

Publication number
ATE97957T1
ATE97957T1 AT88114769T AT88114769T ATE97957T1 AT E97957 T1 ATE97957 T1 AT E97957T1 AT 88114769 T AT88114769 T AT 88114769T AT 88114769 T AT88114769 T AT 88114769T AT E97957 T1 ATE97957 T1 AT E97957T1
Authority
AT
Austria
Prior art keywords
factor viii
human factor
recombinant human
transformant
arg
Prior art date
Application number
AT88114769T
Other languages
English (en)
Inventor
Takashi Sugiyama
Kenichi Masuda
Yoshitaka Tajima
Hiroshi Yonemura
Original Assignee
Chemo Sero Therapeut Res Inst
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst, Teijin Ltd filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE97957T1 publication Critical patent/ATE97957T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
AT88114769T 1987-09-10 1988-09-09 Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c. ATE97957T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22514787 1987-09-10
JP63085454A JPH0387173A (ja) 1987-09-10 1988-04-08 ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
EP88114769A EP0306968B1 (de) 1987-09-10 1988-09-09 Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C

Publications (1)

Publication Number Publication Date
ATE97957T1 true ATE97957T1 (de) 1993-12-15

Family

ID=26426457

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88114769T ATE97957T1 (de) 1987-09-10 1988-09-09 Verfahren zur herstellung des rekombinanten menschlichen faktors viii:c.

Country Status (9)

Country Link
EP (1) EP0306968B1 (de)
JP (1) JPH0387173A (de)
KR (1) KR950012804B1 (de)
AT (1) ATE97957T1 (de)
AU (1) AU627432B2 (de)
CA (1) CA1341236C (de)
DE (1) DE3885983T2 (de)
ES (1) ES2061582T3 (de)
NZ (1) NZ226082A (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
WO1990002175A1 (en) * 1988-08-16 1990-03-08 Novo Nordisk A/S A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
ATE148165T1 (de) * 1989-07-24 1997-02-15 Bayer Ag Stabilisierung von hochgereinigten proteinen
WO1991002065A1 (en) * 1989-08-11 1991-02-21 Zymogenetics, Inc. Cell culture methods for producing activated protein c
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
EP1832657B1 (de) * 1998-09-09 2012-10-24 Genzyme Corporation Methylierung von Plasmid-Vektoren
CN100553678C (zh) 1999-02-22 2009-10-28 巴克斯特国际有限公司 新的无白蛋白的因子ⅷ制剂
DK1750733T3 (da) 2004-05-03 2014-01-20 Univ Emory FREMGANGSMÅDE TIL INDGIVELSE AF SVINE-B-DOMÆNELØS fVIII
JP4769034B2 (ja) * 2005-07-08 2011-09-07 大東榮紙工株式会社 食品収納容器
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
US7985839B2 (en) 2006-03-31 2011-07-26 Baxter International Inc. Factor VIII polymer conjugates
US7982010B2 (en) 2006-03-31 2011-07-19 Baxter International Inc. Factor VIII polymer conjugates
KR20080108147A (ko) 2006-03-31 2008-12-11 백스터 인터내셔널 인코포레이티드 페질화된 인자 ｖｉｉｉ
BRPI0720282B8 (pt) 2006-12-15 2021-05-25 Baxalta GmbH construção proteica, composição farmacêutica, e, kit
WO2008102923A1 (en) 2007-02-23 2008-08-28 Sk Chemicals Co., Ltd. Process for producing and purifying factor viii and its derivatives
ES2441941T3 (es) 2008-10-15 2014-02-07 Baxter Healthcare Sa Pegilación de factores de coagulación sanguínea recombinantes en presencia de anticuerpos enlazados
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
EP2459226B1 (de) 2009-07-27 2016-06-29 Lipoxen Technologies Limited Glycopolysialylierung von proteinen anders als blutgerinnungsproteinen
RU2744370C2 (ru) 2009-07-27 2021-03-05 Баксалта Инкорпорейтед Конъюгаты белков свертывания крови
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
ES2597954T3 (es) 2009-07-27 2017-01-24 Baxalta GmbH Conjugados de proteína de la coagulación sanguínea
US8765432B2 (en) 2009-12-18 2014-07-01 Oligasis, Llc Targeted drug phosphorylcholine polymer conjugates
KR101969601B1 (ko) 2010-07-30 2019-04-17 박스알타 인코퍼레이티드 옥심 결합용 친핵성 촉매
JP5922141B2 (ja) 2010-11-05 2016-05-24 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 増加した比活性を有する抗血友病第ｖｉｉｉ因子の新規変異体
ES2800983T3 (es) 2010-12-22 2021-01-07 Baxalta GmbH Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína
AU2013204754C1 (en) 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
EP3760639A1 (de) 2013-09-08 2021-01-06 Kodiak Sciences Inc. Zwitterionische polymerkonjugate
KR20170049319A (ko) 2015-10-28 2017-05-10 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
KR20170049320A (ko) 2015-10-28 2017-05-10 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
EP3167877A1 (de) 2015-11-12 2017-05-17 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung von gefriergetrockneten pellets mit faktor viii
TW201731869A (zh) 2015-12-03 2017-09-16 百克莎塔股份有限公司 具有延長之半衰期及降低之配位體結合性質的因子ｖｉｉｉ
JP7328891B2 (ja) 2016-11-10 2023-08-17 ユーハン・コーポレイション 融合タンパク質を含む、肝炎、肝線維症、および肝硬変を予防または処置するための医薬組成物
EA201992516A1 (ru) 2017-04-21 2020-04-09 Юхан Корпорейшн Способ получения бифункциональных белков и их производных
WO2020185543A1 (en) 2019-03-08 2020-09-17 Mevion Medical Systems, Inc. Collimator and energy degrader for a particle therapy system
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL74909A (en) * 1984-04-20 1992-01-15 Genentech Inc Preparation of functional human factor viii and dna sequences,expression vectors,transformed microorganisms and cell lines used therein
DE3683980D1 (de) * 1985-04-12 1992-04-02 Genetics Inst Neue prokoagulierungsproteine.
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
EP0253870B1 (de) * 1986-01-03 1993-03-31 Genetics Institute, Inc. Verfahren zur herstellung von faktor-viii:c-typ-proteinen
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
JP2872255B2 (ja) * 1987-01-30 1999-03-17 バイオジエン，インコーポレイティド ファクター▲ｖｉｉｉ▼の高収量生産法
US5171844A (en) * 1987-06-12 1992-12-15 Gist-Brocades N.W. Proteins with factor viii activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
JPH0387173A (ja) 1991-04-11
EP0306968A3 (en) 1989-04-12
KR950012804B1 (ko) 1995-10-21
EP0306968B1 (de) 1993-12-01
EP0306968A2 (de) 1989-03-15
AU2200388A (en) 1989-03-16
CA1341236C (en) 2001-05-22
ES2061582T3 (es) 1994-12-16
DE3885983D1 (de) 1994-01-13
NZ226082A (en) 1990-09-26
AU627432B2 (en) 1992-08-27
KR890005268A (ko) 1989-05-13
DE3885983T2 (de) 1994-06-23

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEFA Change of the company name
EELA Cancelled due to lapse of time