DE3885983D1 - Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C. - Google Patents

Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C.

Info

Publication number
DE3885983D1
DE3885983D1 DE88114769T DE3885983T DE3885983D1 DE 3885983 D1 DE3885983 D1 DE 3885983D1 DE 88114769 T DE88114769 T DE 88114769T DE 3885983 T DE3885983 T DE 3885983T DE 3885983 D1 DE3885983 D1 DE 3885983D1
Authority
DE
Germany
Prior art keywords
factor viii
human factor
recombinant human
transformant
arg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE88114769T
Other languages
English (en)
Other versions
DE3885983T2 (de
Inventor
Takashi Sugiyama
Kenichi Masuda
Yoshitaka Tajima
Hiroshi Yonemura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Publication of DE3885983D1 publication Critical patent/DE3885983D1/de
Application granted granted Critical
Publication of DE3885983T2 publication Critical patent/DE3885983T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE3885983T 1987-09-10 1988-09-09 Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C. Expired - Lifetime DE3885983T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22514787 1987-09-10
JP63085454A JPH0387173A (ja) 1987-09-10 1988-04-08 ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体

Publications (2)

Publication Number Publication Date
DE3885983D1 true DE3885983D1 (de) 1994-01-13
DE3885983T2 DE3885983T2 (de) 1994-06-23

Family

ID=26426457

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3885983T Expired - Lifetime DE3885983T2 (de) 1987-09-10 1988-09-09 Verfahren zur Herstellung des rekombinanten menschlichen Faktors VIII:C.

Country Status (9)

Country Link
EP (1) EP0306968B1 (de)
JP (1) JPH0387173A (de)
KR (1) KR950012804B1 (de)
AT (1) ATE97957T1 (de)
AU (1) AU627432B2 (de)
CA (1) CA1341236C (de)
DE (1) DE3885983T2 (de)
ES (1) ES2061582T3 (de)
NZ (1) NZ226082A (de)

Families Citing this family (45)

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Publication number Priority date Publication date Assignee Title
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
WO1990002175A1 (en) * 1988-08-16 1990-03-08 Novo Nordisk A/S A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors
ATE148165T1 (de) * 1989-07-24 1997-02-15 Bayer Ag Stabilisierung von hochgereinigten proteinen
ATE97958T1 (de) * 1989-08-11 1993-12-15 Zymogenetics Inc Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c.
FR2657884B1 (fr) * 1990-02-05 1994-09-02 Tm Innovation Procede pour la preparation du facteur viii humain et d'analogues du facteur viii.
US5378612A (en) * 1990-05-11 1995-01-03 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Culture medium for production of recombinant protein
US5859204A (en) * 1992-04-07 1999-01-12 Emory University Modified factor VIII
US6376463B1 (en) 1992-04-07 2002-04-23 Emory University Modified factor VIII
US6180371B1 (en) 1996-06-26 2001-01-30 Emory University Modified factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein
US7560107B2 (en) 1996-06-26 2009-07-14 Emory University Modified factor VIII
US6458563B1 (en) 1996-06-26 2002-10-01 Emory University Modified factor VIII
US5804420A (en) * 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
ES2394458T3 (es) * 1998-09-09 2013-01-31 Genzyme Corporation Metilación de vectores plasmídicos
DE60035260T2 (de) 1999-02-22 2007-10-18 The University Of Connecticut, Farmington Neue albuminfreie faktor viii formulierungen
SI1750733T1 (sl) 2004-05-03 2014-03-31 Emory University POSTOPEK DAJANJA PRAĹ IÄŚJEGA fVIII BREZ DOMENE B
JP4769034B2 (ja) * 2005-07-08 2011-09-07 大東榮紙工株式会社 食品収納容器
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
US7982010B2 (en) 2006-03-31 2011-07-19 Baxter International Inc. Factor VIII polymer conjugates
US7683158B2 (en) 2006-03-31 2010-03-23 Baxter International Inc. Pegylated factor VIII
US7985839B2 (en) 2006-03-31 2011-07-26 Baxter International Inc. Factor VIII polymer conjugates
EP2101821B1 (de) 2006-12-15 2014-08-13 Baxter International Inc. Faktor-viia-(poly)sialsäurekonjugat mit verlängerter in-vivo-halbwertszeit
KR101389376B1 (ko) 2007-02-23 2014-04-29 에스케이케미칼주식회사 제 ８ 인자 및 그의 유도체의 제조 및 정제 방법
WO2010045321A2 (en) 2008-10-15 2010-04-22 Baxter International Inc. Pegylation of recombinant blood coagulation factors in the presence of bound antibodies
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
EP2459224B1 (de) 2009-07-27 2016-06-01 Baxalta GmbH Koagulationsproteinkonjugate
US8642737B2 (en) 2010-07-26 2014-02-04 Baxter International Inc. Nucleophilic catalysts for oxime linkage
US8809501B2 (en) 2009-07-27 2014-08-19 Baxter International Inc. Nucleophilic catalysts for oxime linkage
NZ597600A (en) 2009-07-27 2014-05-30 Lipoxen Technologies Ltd Glycopolysialylation of non-blood coagulation proteins
SG10201401194VA (en) 2009-07-27 2014-07-30 Lipoxen Technologies Ltd Glycopolysialylation of non-blood coagulation proteins
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
KR102269494B1 (ko) 2010-07-30 2021-06-25 박스알타 인코퍼레이티드 옥심 결합용 친핵성 촉매
KR101948337B1 (ko) 2010-11-05 2019-02-14 박스알타 인코퍼레이티드 증가된 특이 활성도를 갖는 항혈우병 인자 ｖｉｉｉ의 신규 변이체
NZ612320A (en) 2010-12-22 2015-06-26 Baxter Healthcare Sa Materials and methods for conjugating a water soluble fatty acid derivative to a protein
AU2013204754C1 (en) 2012-05-16 2018-10-11 Takeda Pharmaceutical Company Limited Nucleophilic Catalysts for Oxime Linkage
PL3041513T3 (pl) 2013-09-08 2021-01-25 Kodiak Sciences Inc. Obojnaczojonowe polimerowe koniugaty czynnika viii
KR102670157B1 (ko) 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
KR102668200B1 (ko) 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
EP3167877A1 (de) 2015-11-12 2017-05-17 Bayer Pharma Aktiengesellschaft Verfahren zur herstellung von gefriergetrockneten pellets mit faktor viii
KR20180088727A (ko) 2015-12-03 2018-08-06 박스알타 인코퍼레이티드 연장된 반감기 및 감소된 리간드-결합 특성을 가진 인자 viii
CA3042512A1 (en) 2016-11-10 2018-05-17 Yuhan Corporation Pharmaceutical composition for preventing or treating hepatitis, hepatic fibrosis, and hepatic cirrhosis comprising fusion proteins
MX2019012331A (es) 2017-04-21 2020-01-23 Yuhan Corp Metodo para producir proteinas de doble funcion y sus derivados.
TW202039026A (zh) 2019-03-08 2020-11-01 美商美威高能離子醫療系統公司 藉由管柱之輻射遞送及自其產生治療計劃
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
EP0218712B1 (de) * 1985-04-12 1992-02-26 Genetics Institute, Inc. Neue prokoagulierungsproteine
KR910006424B1 (ko) * 1985-08-21 1991-08-24 인코텍스 비.브이 편성브리프(brief) 제조방법
EP0253870B1 (de) * 1986-01-03 1993-03-31 Genetics Institute, Inc. Verfahren zur herstellung von faktor-viii:c-typ-proteinen
FI98829C (fi) * 1986-01-27 1997-08-25 Chiron Corp Menetelmä rekombinoidun proteiinikompleksin valmistamiseksi, jolla on humaanitekijä VIII:C-aktiivisuutta
AU606925B2 (en) * 1987-01-30 1991-02-21 Biogen, Inc. A method for producing factor viii in high yield
IL86693A (en) * 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them

Also Published As

Publication number Publication date
CA1341236C (en) 2001-05-22
AU627432B2 (en) 1992-08-27
ATE97957T1 (de) 1993-12-15
ES2061582T3 (es) 1994-12-16
NZ226082A (en) 1990-09-26
AU2200388A (en) 1989-03-16
DE3885983T2 (de) 1994-06-23
KR890005268A (ko) 1989-05-13
EP0306968B1 (de) 1993-12-01
JPH0387173A (ja) 1991-04-11
KR950012804B1 (ko) 1995-10-21
EP0306968A2 (de) 1989-03-15
EP0306968A3 (en) 1989-04-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GENETICS INSTITUTE, INC., CAMBRIDGE, MASS., US

8327 Change in the person/name/address of the patent owner

Owner name: GENETICS INSTITUTE, LLC, CAMBRIDGE, MASS., US