ATE96175T1 - Verfahren zur enzymatischen herstellung von dipeptiden. - Google Patents
Verfahren zur enzymatischen herstellung von dipeptiden.Info
- Publication number
- ATE96175T1 ATE96175T1 AT88301230T AT88301230T ATE96175T1 AT E96175 T1 ATE96175 T1 AT E96175T1 AT 88301230 T AT88301230 T AT 88301230T AT 88301230 T AT88301230 T AT 88301230T AT E96175 T1 ATE96175 T1 AT E96175T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- amino
- formula
- acid
- optionally
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 150000008575 L-amino acids Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 1
- 102000005367 Carboxypeptidases Human genes 0.000 abstract 1
- 108010006303 Carboxypeptidases Proteins 0.000 abstract 1
- 150000007650 D alpha amino acids Chemical class 0.000 abstract 1
- 150000007649 L alpha amino acids Chemical class 0.000 abstract 1
- -1 L-amino acid esters Chemical class 0.000 abstract 1
- 101000978265 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Carboxypeptidase Y Proteins 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical class NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003573 thiols Chemical class 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK072587A DK72587D0 (da) | 1987-02-13 | 1987-02-13 | Fremgangsmaade til enzymatisk fremstilling af dipeptider |
| EP88301230A EP0278787B1 (de) | 1987-02-13 | 1988-02-15 | Verfahren zur enzymatischen Herstellung von Dipeptiden |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE96175T1 true ATE96175T1 (de) | 1993-11-15 |
Family
ID=8096821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88301230T ATE96175T1 (de) | 1987-02-13 | 1988-02-15 | Verfahren zur enzymatischen herstellung von dipeptiden. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0278787B1 (de) |
| JP (1) | JPH01502158A (de) |
| AT (1) | ATE96175T1 (de) |
| AU (1) | AU613348B2 (de) |
| DE (1) | DE3884976T2 (de) |
| DK (1) | DK72587D0 (de) |
| FI (1) | FI884653A7 (de) |
| HU (1) | HU203790B (de) |
| WO (1) | WO1988006187A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3733198A1 (de) * | 1987-10-01 | 1989-04-13 | Kernforschungsanlage Juelich | Enzymatisches verfahren zur herstellung von dipeptiden |
| DK163435C (da) * | 1988-08-12 | 1992-07-20 | Carlsberg Biotechnology Ltd | Fremgangsmaade til enzymatisk fremstilling af dipeptider og derivater deraf |
| DK53291D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Smaa peptider og peptidrelaterede stoffer samt farmaceutiske praeparater indeholdende saadanne forbindelser |
| DK53191D0 (da) * | 1991-03-25 | 1991-03-25 | Carlbiotech Ltd As | Organosvovlforbindelse og farmaceutisk praeparat indeholdende en saadan forbindelse |
| EP0566824A1 (de) * | 1992-01-28 | 1993-10-27 | F. Hoffmann-La Roche Ag | Enzymatische Peptidsynthese |
| DE4423724A1 (de) * | 1994-07-08 | 1996-01-11 | Degussa | Kinetisch kontrolliertes Verfahren zur enzymatischen Herstellung von Peptiden |
| CN100422207C (zh) * | 2001-07-26 | 2008-10-01 | 味之素株式会社 | 二肽生产方法,所用的l-氨基酸酰胺水解酶,以及l-氨基酸酰胺水解酶生产方法 |
| DE10156274A1 (de) * | 2001-11-16 | 2003-06-12 | Noxxon Pharma Ag | Verfahren zur Synthese von all-D-Polypeptiden |
| CA2634269C (en) | 2002-07-26 | 2012-06-12 | Ajinomoto Co., Inc. | Novel peptide-forming enzyme gene |
| ATE458056T1 (de) | 2002-07-26 | 2010-03-15 | Ajinomoto Kk | Verfahren zur herstellung eines tripeptids oder höheren peptids |
| WO2004022733A1 (ja) * | 2002-07-26 | 2004-03-18 | Ajinomoto Co., Inc. | ペプチドを生成する新規酵素およびこれを生産する微生物およびこれらを用いるジペプチドの製造方法 |
| JP2005040037A (ja) | 2003-07-25 | 2005-02-17 | Ajinomoto Co Inc | ジペプチドの製造方法、それに用いるペプチド生成酵素、およびペプチド生成酵素の製造方法 |
| JP2005168405A (ja) * | 2003-12-11 | 2005-06-30 | Ajinomoto Co Inc | ジペプチドの製造方法 |
| US8420605B2 (en) | 2005-09-07 | 2013-04-16 | The University Of Strathclyde | Hydrogel compositions |
| JP5754682B2 (ja) * | 2010-01-27 | 2015-07-29 | 国立大学法人鳥取大学 | Ｄ−，ｌ−ペプチドの立体選択的合成法 |
| JP2013532124A (ja) * | 2010-05-03 | 2013-08-15 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 芳香族系陽イオンペプチド及びその使用 |
| CN107496899A (zh) | 2011-09-29 | 2017-12-22 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| JP6146304B2 (ja) | 2011-10-07 | 2017-06-14 | 味の素株式会社 | 変異型γ−グルタミルトランスフェラーゼ、及び、γ−グルタミルバリルグリシン又はその塩の製造法 |
| CN107936089B (zh) * | 2017-11-07 | 2021-01-29 | 重庆大学 | 一种合成苯丙氨酰-赖氨酸二肽的方法 |
| EP3810569A1 (de) | 2018-06-22 | 2021-04-28 | Basf Se | Aminosäurebasierte tenside als beistoffe für biozide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972773A (en) * | 1975-04-29 | 1976-08-03 | Sagami Chemical Research Center | Process for producing peptide |
| US4086136A (en) * | 1975-10-23 | 1978-04-25 | (Zaidanhojin) Sagami Chemical Research Center | Process for producing a peptide using a serine or thiol proteinase |
| WO1980002157A1 (en) * | 1979-04-06 | 1980-10-16 | Forenede Bryggerier As | A process for enzymatic production of peptides |
| US4506011A (en) * | 1981-09-05 | 1985-03-19 | Toyo Soda Manufacturing Co., Ltd. | Process for preparation of aspartylphenylalanine alkyl esters |
| DK28283A (da) * | 1982-01-26 | 1983-07-27 | Kazutomo Imahori | Fremgangsmaade til syntetisering af peptider eller peptidderivater |
| JPS5917997A (ja) * | 1982-07-23 | 1984-01-30 | Toyo Soda Mfg Co Ltd | ジペプチドエステルとアミノ酸エステルとの付加化合物の製造方法 |
| JPH01501995A (ja) * | 1986-04-10 | 1989-07-13 | コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガニゼイション | 酵素合成方法 |
-
1987
- 1987-02-13 DK DK072587A patent/DK72587D0/da not_active Application Discontinuation
-
1988
- 1988-02-15 EP EP88301230A patent/EP0278787B1/de not_active Expired - Lifetime
- 1988-02-15 HU HU881675A patent/HU203790B/hu not_active IP Right Cessation
- 1988-02-15 AU AU13484/88A patent/AU613348B2/en not_active Ceased
- 1988-02-15 DE DE88301230T patent/DE3884976T2/de not_active Expired - Fee Related
- 1988-02-15 AT AT88301230T patent/ATE96175T1/de active
- 1988-02-15 WO PCT/DK1988/000022 patent/WO1988006187A1/en not_active Ceased
- 1988-02-15 JP JP63501981A patent/JPH01502158A/ja active Pending
- 1988-10-11 FI FI884653A patent/FI884653A7/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU613348B2 (en) | 1991-08-01 |
| JPH01502158A (ja) | 1989-08-03 |
| FI884653A0 (fi) | 1988-10-11 |
| DE3884976D1 (de) | 1993-11-25 |
| EP0278787B1 (de) | 1993-10-20 |
| DK72587D0 (da) | 1987-02-13 |
| HU203790B (en) | 1991-09-30 |
| AU1348488A (en) | 1988-09-14 |
| WO1988006187A1 (en) | 1988-08-25 |
| HUT50879A (en) | 1990-03-28 |
| DE3884976T2 (de) | 1994-02-17 |
| FI884653A7 (fi) | 1988-10-11 |
| EP0278787A1 (de) | 1988-08-17 |
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