ES2174132T3 - N-acil-a,omp-alquil-hidrazino-carboximidamidas. - Google Patents
N-acil-a,omp-alquil-hidrazino-carboximidamidas.Info
- Publication number
- ES2174132T3 ES2174132T3 ES96945113T ES96945113T ES2174132T3 ES 2174132 T3 ES2174132 T3 ES 2174132T3 ES 96945113 T ES96945113 T ES 96945113T ES 96945113 T ES96945113 T ES 96945113T ES 2174132 T3 ES2174132 T3 ES 2174132T3
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- composition
- group containing
- inhibiting
- hidrazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
- Fats And Perfumes (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Steroid Compounds (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A COMPOSICIONES Y METODOS QUE INHIBEN LA RETICULACION NO ENZIMATICA (ENVEJECIMIENTO DE PROTEINAS) UTILIZANDO COMPUESTOS DE FORMULA (I), DONDE ALK ES UN GRUPO ALQUILENO DE CADENA LINEAL O RAMIFICADA QUE CONTIENE ENTRE 2 Y 8 ATOMOS DE CARBONO, Y R ES UN GRUPO ALQUILO INFERIOR QUE CONTIENE ENTRE 1 Y 6 ATOMOS DE CARBONO; ASI COMO SUS SALES DE ADICION BIOLOGICA O FARMACEUTICAMENTE ACEPTABLES. CONSECUENTEMENTE, SE DESCRIBE UNA COMPOSICION QUE COMPRENDE DICHAS N ACILAMINOALQUILHIDRAZINCARBOXIMIDAMIDAS, QUE SON CAPACES DE INHIBIR LA FORMACION DE PRODUCTOS FINALES DE GLICOSILACION AVANZADA DE PROTEINAS DIANA. DICHO METODO CONSISTE EN PONER EN CONTACTO LA PROTEINA DIANA CON DICHA COMPOSICION. SE PREVEN APLICACIONES TANTO INDUSTRIALES COMO TERAPEUTICAS PARA LA INVENCION, COMO EL TRATAMIENTO DE LA DEGRADACION DE ALIMENTOS Y EL ENVEJECIMIENTO DE PROTEINAS ANIMALES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US922095P | 1995-12-26 | 1995-12-26 | |
US61840796A | 1996-03-19 | 1996-03-19 | |
US08/771,959 US5877217A (en) | 1995-12-26 | 1996-12-23 | N-acylaminoalkyl-hydrazinecarboximidamides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2174132T3 true ES2174132T3 (es) | 2002-11-01 |
Family
ID=27358809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96945113T Expired - Lifetime ES2174132T3 (es) | 1995-12-26 | 1996-12-26 | N-acil-a,omp-alquil-hidrazino-carboximidamidas. |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0888293B1 (es) |
JP (1) | JP2000502684A (es) |
CN (1) | CN1209117A (es) |
AT (1) | ATE215068T1 (es) |
AU (1) | AU720796B2 (es) |
BR (1) | BR9612304A (es) |
CA (1) | CA2241746A1 (es) |
DE (1) | DE69620253T2 (es) |
DK (1) | DK0888293T3 (es) |
ES (1) | ES2174132T3 (es) |
NO (1) | NO982976L (es) |
NZ (1) | NZ326238A (es) |
PT (1) | PT888293E (es) |
TW (1) | TW502012B (es) |
WO (1) | WO1997023447A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
JP5323684B2 (ja) | 2006-05-04 | 2013-10-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 多形体 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
CN107011345A (zh) | 2008-12-23 | 2017-08-04 | 勃林格殷格翰国际有限公司 | 有机化合物的盐形式 |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
EP2504002B1 (en) | 2009-11-27 | 2019-10-09 | Boehringer Ingelheim International GmbH | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
MX341025B (es) | 2010-05-05 | 2016-08-04 | Boehringer Ingelheim Int Gmbh * | Terapia de combinacion. |
NZ603319A (en) | 2010-06-24 | 2015-04-24 | Boehringer Ingelheim Int | Diabetes therapy |
AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
PL2731947T3 (pl) | 2011-07-15 | 2019-07-31 | Boehringer Ingelheim International Gmbh | Podstawiona dimeryczna pochodna chinazoliny, sposób jej wytwarzania i jej zastosowanie w kompozycjach farmaceutycznych do leczenia cukrzycy typu I i II |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
ES2950384T3 (es) | 2014-02-28 | 2023-10-09 | Boehringer Ingelheim Int | Uso médico de un inhibidor de DPP-4 |
EP4233840A3 (en) | 2016-06-10 | 2023-10-18 | Boehringer Ingelheim International GmbH | Combinations of linagliptin and metformin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758583A (en) * | 1984-03-19 | 1988-07-19 | The Rockefeller University | Method and agents for inhibiting protein aging |
-
1996
- 1996-12-26 WO PCT/US1996/020810 patent/WO1997023447A1/en active IP Right Grant
- 1996-12-26 EP EP96945113A patent/EP0888293B1/en not_active Expired - Lifetime
- 1996-12-26 DE DE69620253T patent/DE69620253T2/de not_active Expired - Fee Related
- 1996-12-26 CN CN96199999A patent/CN1209117A/zh active Pending
- 1996-12-26 DK DK96945113T patent/DK0888293T3/da active
- 1996-12-26 CA CA002241746A patent/CA2241746A1/en not_active Abandoned
- 1996-12-26 ES ES96945113T patent/ES2174132T3/es not_active Expired - Lifetime
- 1996-12-26 NZ NZ326238A patent/NZ326238A/xx unknown
- 1996-12-26 AU AU13560/97A patent/AU720796B2/en not_active Ceased
- 1996-12-26 JP JP09523883A patent/JP2000502684A/ja active Pending
- 1996-12-26 AT AT96945113T patent/ATE215068T1/de not_active IP Right Cessation
- 1996-12-26 PT PT96945113T patent/PT888293E/pt unknown
- 1996-12-26 BR BR9612304A patent/BR9612304A/pt unknown
-
1997
- 1997-01-09 TW TW086100168A patent/TW502012B/zh active
-
1998
- 1998-06-26 NO NO982976A patent/NO982976L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0888293A1 (en) | 1999-01-07 |
TW502012B (en) | 2002-09-11 |
NO982976L (no) | 1998-08-26 |
DE69620253D1 (en) | 2002-05-02 |
AU1356097A (en) | 1997-07-17 |
DK0888293T3 (da) | 2002-04-22 |
PT888293E (pt) | 2002-07-31 |
BR9612304A (pt) | 1999-07-13 |
NZ326238A (en) | 1999-11-29 |
CA2241746A1 (en) | 1997-07-03 |
EP0888293B1 (en) | 2002-03-27 |
NO982976D0 (no) | 1998-06-26 |
DE69620253T2 (de) | 2002-09-19 |
WO1997023447A1 (en) | 1997-07-03 |
JP2000502684A (ja) | 2000-03-07 |
ATE215068T1 (de) | 2002-04-15 |
AU720796B2 (en) | 2000-06-15 |
CN1209117A (zh) | 1999-02-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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