ATE92522T1 - Alpha-amidierungsenzym. - Google Patents

Alpha-amidierungsenzym.

Info

Publication number
ATE92522T1
ATE92522T1 AT85904514T AT85904514T ATE92522T1 AT E92522 T1 ATE92522 T1 AT E92522T1 AT 85904514 T AT85904514 T AT 85904514T AT 85904514 T AT85904514 T AT 85904514T AT E92522 T1 ATE92522 T1 AT E92522T1
Authority
AT
Austria
Prior art keywords
enzyme
alpha
glycine
purified
peptidyl
Prior art date
Application number
AT85904514T
Other languages
English (en)
Inventor
James P Gilligan
Barry N Jones
Original Assignee
Unigene Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24628603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE92522(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unigene Lab Inc filed Critical Unigene Lab Inc
Application granted granted Critical
Publication of ATE92522T1 publication Critical patent/ATE92522T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/17—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced ascorbate as one donor, and incorporation of one atom of oxygen (1.14.17)
    • C12Y114/17003—Peptidylglycine monooxygenase (1.14.17.3)
AT85904514T 1984-09-27 1985-08-26 Alpha-amidierungsenzym. ATE92522T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/655,366 US4708934A (en) 1984-09-27 1984-09-27 α-amidation enzyme
EP85904514A EP0201511B1 (de) 1984-09-27 1985-08-26 Alpha-amidierungsenzym
PCT/US1985/001616 WO1986002099A1 (en) 1984-09-27 1985-08-26 Alpha-amidation enzyme

Publications (1)

Publication Number Publication Date
ATE92522T1 true ATE92522T1 (de) 1993-08-15

Family

ID=24628603

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85904514T ATE92522T1 (de) 1984-09-27 1985-08-26 Alpha-amidierungsenzym.

Country Status (13)

Country Link
US (1) US4708934A (de)
EP (1) EP0201511B1 (de)
JP (1) JP2594037B2 (de)
AT (1) ATE92522T1 (de)
CA (1) CA1341037C (de)
DE (1) DE3587506T2 (de)
DK (1) DK241486D0 (de)
FI (1) FI100993B1 (de)
HU (1) HU195857B (de)
LT (1) LT2661B (de)
NO (1) NO862100L (de)
RU (1) RU1802814C (de)
WO (1) WO1986002099A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) * 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
DE3612302A1 (de) * 1986-04-11 1987-10-15 Hoechst Ag Chromophore peptide, verfahren zu ihrer herstellung und ihre verwendung zum nachweis der peptidylglycin-(alpha)-amidierenden monooxygenase
JPH0775541B2 (ja) * 1986-06-07 1995-08-16 壽之 松尾 Ｃ末端アミド化酵素及びその製造方法
US5821083A (en) * 1987-07-17 1998-10-13 Suntory Limited Recombinant C-terminal α-amidating enzyme
JP2598050B2 (ja) 1987-07-17 1997-04-09 サントリー株式会社 Ｃ−末端α−アミド化酵素
US5789234A (en) * 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US6255067B1 (en) * 1987-09-15 2001-07-03 The Johns Hopkins University cDNA encoding peptidyl-glycine alpha-amidating monooxygenase (PAM)
JP2653820B2 (ja) * 1988-03-14 1997-09-17 壽之 松尾 アミド化酵素及びその製造方法
JP2512575B2 (ja) * 1988-05-30 1996-07-03 株式会社資生堂 Ｃ末端アミド化酵素組成物、調製方法および使用
DE68917154T2 (de) * 1988-05-30 1994-12-22 Shiseido Co Ltd C-terminus-amidierungsenzym-zusammensetzung, verfahren zur herstellung und verwendung.
JP2845468B2 (ja) * 1989-01-17 1999-01-13 サントリー株式会社 ヒト甲状腺由来Ｃ―末端α―アミド化酵素
US5871995A (en) * 1989-08-15 1999-02-16 Shiseido Company, Ltd. Purified enzymes participating in C-terminal amidation
EP0448513A3 (en) * 1990-03-21 1991-12-27 Japat Ltd Process for production of peptidylglycine alpha-hydroxylating monooxygenase and use thereof
US5580751A (en) * 1990-09-14 1996-12-03 Carlsberg A/S Process for the preparation of C-terminally amidated peptides
DK220890D0 (da) * 1990-09-14 1990-09-14 Ole Buchardt Fremgangsmaade til fremstilling af c-terminalt amiderede peptider
JP2774769B2 (ja) * 1993-04-26 1998-07-09 賢治 寒川 アドレノメデュリン
WO1997013410A1 (en) * 1995-10-13 1997-04-17 Boston Medical Center Corporation Hybrid molecules containing amidated polypeptide binding ligands
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
ATE522598T1 (de) 1997-04-16 2011-09-15 Unigene Lab Inc Direkte expression von peptiden in nährmedien
US6507788B1 (en) 1999-02-25 2003-01-14 Société de Conseils de Recherches et D'Applications Scientifiques (S.C.R.A.S.) Rational selection of putative peptides from identified nucleotide, or peptide sequences, of unknown function
US8088734B2 (en) 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US7445911B2 (en) * 2004-11-24 2008-11-04 Unigene Laboratories Inc. Enzymatic reactions in the presence of keto acids
DE102004058306A1 (de) * 2004-12-01 2006-07-27 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP4856177B2 (ja) * 2005-06-24 2012-01-18 ユニジーン・ラボラトリーズ・インコーポレーテッド アミド化生成物の調製に有用な酵素を発現させるための細胞株
US8377863B2 (en) 2007-05-29 2013-02-19 Unigene Laboratories Inc. Peptide pharmaceutical for oral delivery
WO2009005140A1 (ja) * 2007-06-29 2009-01-08 Asubio Pharma Co., Ltd. 組換えＣ－末端α－アミド化酵素誘導体
CA2750035C (en) 2009-01-22 2018-02-27 Unigene Laboratories Inc. Treatment for obesity
WO2011067283A1 (en) 2009-12-01 2011-06-09 Novo Nordisk A/S Novel peptidyl alpha-hydroxyglycine alpha-amidating lyases
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
EP2720707B1 (de) 2011-06-15 2018-12-19 ResoTher Pharma ApS Entzündungshemmende pharmazeutische produkte
US9533022B2 (en) 2011-11-02 2017-01-03 KeyBioscience A/S Peptide analogs for treating diseases and disorders
PT3095484T (pt) 2011-11-02 2018-06-20 Keybioscience Ag Miméticas de calcitonina para tratar doenças e distúrbios
CA2854175A1 (en) 2011-11-02 2013-05-10 Keybioscience Ag Peptide analogs for treating diseases and disorders
PL3321278T3 (pl) 2013-11-14 2019-06-28 Keybioscience Ag Mimetyki kalcytoniny do leczenia chorób i zaburzeń
WO2015084875A1 (en) 2013-12-02 2015-06-11 Stealth Peptides International, Inc. Compositions and methods for treating vitiligo
WO2015183995A2 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
WO2015183988A1 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including therapeutic small molecules and uses thereof
US10627392B2 (en) 2014-06-17 2020-04-21 Stealth Biotherapeutics Corp Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening
GB201500263D0 (en) 2015-01-08 2015-02-25 Keybioscience Ag Calcitonin analogues for treating diseases and disorders
KR102294577B1 (ko) 2015-01-12 2021-08-26 엔터리스 바이오파마, 인크. 고체 경구 제형
EP3256144B1 (de) 2015-02-13 2021-03-24 The Board of Trustees of the University of Illionis Peptidhemmung von ccr3-vermittelten krankheiten oder zuständen
GB201704429D0 (en) 2017-03-21 2017-05-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201707955D0 (en) 2017-05-18 2017-07-05 Keybioscience Ag Dual amylin and calcitonin receptor agonists for treating diseases and disorders
GB201813677D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Calcitonin mimetics for treating diseases and disorders
GB201813678D0 (en) 2018-08-22 2018-10-03 Keybioscience Ag Acylated calcitonin mimetics
WO2021021774A1 (en) 2019-07-29 2021-02-04 The Board Of Trustees Of The University Of Illinois Composition and method for promoting wound healing
GB202001024D0 (en) 2020-01-24 2020-03-11 Key Bioscience Ag Oxyntomodulin mimetics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6319685B1 (en) * 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use

Also Published As

Publication number Publication date
US4708934A (en) 1987-11-24
JPS62500560A (ja) 1987-03-12
DE3587506T2 (de) 1994-01-13
DK241486A (da) 1986-05-23
WO1986002099A1 (en) 1986-04-10
HU195857B (en) 1988-07-28
EP0201511A1 (de) 1986-11-20
NO862100L (no) 1986-05-27
DE3587506D1 (en) 1993-09-09
CA1341037C (en) 2000-06-27
NO175214B (de) 1994-06-06
FI94361B (fi) 1995-05-15
FI100993B1 (fi) 1998-03-31
FI862216A (fi) 1986-05-26
RU1802814C (ru) 1993-03-15
JP2594037B2 (ja) 1997-03-26
NO175214C (de) 1994-09-14
AU594026B2 (en) 1990-03-01
DK241486D0 (da) 1986-05-23
HUT41444A (en) 1987-04-28
EP0201511A4 (de) 1988-05-31
EP0201511B1 (de) 1993-08-04
FI94361C (fi) 1995-08-25
FI862216A0 (fi) 1986-05-26
LT2661B (lt) 1994-04-25
AU4802785A (en) 1986-04-17

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