ATE70310T1 - Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag. - Google Patents

Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag.

Info

Publication number
ATE70310T1
ATE70310T1 AT85113585T AT85113585T ATE70310T1 AT E70310 T1 ATE70310 T1 AT E70310T1 AT 85113585 T AT85113585 T AT 85113585T AT 85113585 T AT85113585 T AT 85113585T AT E70310 T1 ATE70310 T1 AT E70310T1
Authority
AT
Austria
Prior art keywords
hbsag
monoclonal antibodies
production
hybridomas
antibodies
Prior art date
Application number
AT85113585T
Other languages
English (en)
Inventor
Yasuyuki Eda
Toshihiro Maeda
Kiyoto Nishiyama
Akira Tashiro
Original Assignee
Chemo Sero Therapeut Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeut Res Inst filed Critical Chemo Sero Therapeut Res Inst
Application granted granted Critical
Publication of ATE70310T1 publication Critical patent/ATE70310T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT85113585T 1984-10-26 1985-10-25 Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag. ATE70310T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59226394A JPS61104796A (ja) 1984-10-26 1984-10-26 モノクロ−ナル抗体の製造方法
EP85113585A EP0179483B1 (de) 1984-10-26 1985-10-25 Verfahren zur Herstellung von monoklonalen Antikörpern gegen HBsAg

Publications (1)

Publication Number Publication Date
ATE70310T1 true ATE70310T1 (de) 1991-12-15

Family

ID=16844430

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85113585T ATE70310T1 (de) 1984-10-26 1985-10-25 Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag.

Country Status (7)

Country Link
US (1) US4883752A (de)
EP (1) EP0179483B1 (de)
JP (1) JPS61104796A (de)
KR (1) KR930001278B1 (de)
AT (1) ATE70310T1 (de)
CA (1) CA1339202C (de)
DE (1) DE3584872D1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565354A (en) * 1986-09-05 1996-10-15 Sandoz Ltd. Production of human monoclonal antibodies specific for hepatitis B surface antigen
FR2637184A1 (fr) * 1988-10-05 1990-04-06 Inst Nat Sante Rech Med Anticorps monoclonal reconnaissant une region pre-s1 de la grande proteine d'enveloppe du virus de l'hepatite b et ses applications, notamment pour le diagnostic in vitro et le traitement de l'hepatite b
EP0591548A4 (en) * 1992-03-30 1999-04-28 Suntory Ltd Anti-hbs antibody gene and expression plasmid thereof
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
SE501668C2 (sv) * 1993-08-06 1995-04-10 Biolin Medical Ab Kvantifiering av CD-transferrin vid hög alkoholkonsumtion med HPLC
US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
IL118626A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
IL118625A0 (en) 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibodies
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
WO1999024066A2 (en) * 1997-11-10 1999-05-20 Cytimmune Sciences, Inc. Methods and compositions for enhancing immune response and for the production of in vitro mabs
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
KR100419555B1 (ko) * 2000-05-29 2004-02-19 주식회사유한양행 비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자
EP1694301A4 (de) 2003-12-02 2009-11-18 Cytimmune Sciences Inc Verfahren und zusammensetzungen zur herstellung von monoklonalen antikörpern
WO2009062151A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies
WO2019229699A1 (en) * 2018-05-31 2019-12-05 Novartis Ag Hepatitis b antibodies
CN116731978B (zh) * 2023-08-14 2023-11-28 山东硕景生物科技有限公司 抗人乙肝表面抗原单克隆抗体杂交瘤细胞株、抗人乙肝表面抗原单克隆抗体的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI64952C (fi) * 1977-06-15 1984-02-10 Wistar Inst Foerfarande foer framstaellning av genetiskt stabila cellinjer
US4271145A (en) * 1979-10-22 1981-06-02 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
EP0038642B1 (de) * 1980-04-09 1989-02-08 National Research Development Corporation Monoklonaler Antikörper gegen Hepatitis B und seine Herstellung, ein den monoklonalen Antikörper produzierendes Hybridom und diesen enthaltende Zusammensetzung, die Vermehrung des Hybridoms und der monoklonale Antikörper für den Gebrauch als antivirales Agenz gegen Hepatitus B und für die Isolierung von Hepatitus B Oberflächenantigen aus einer Probe
NZ198851A (en) * 1980-11-07 1984-07-31 Wistar Inst Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line
US4594325A (en) * 1981-03-26 1986-06-10 The Regents Of The University Of Calif. High fusion frequency fusible lymphoblastoid cell line
JPS5872526A (ja) * 1981-10-23 1983-04-30 Green Cross Corp:The モノクロ−ルｈｂｓ抗体の製造方法
US4689299A (en) * 1982-09-30 1987-08-25 University Of Rochester Human monoclonal antibodies against bacterial toxins
US4693966A (en) * 1983-03-11 1987-09-15 Sloan-Kettering Institute For Cancer Research Human monoclonal antibodies from lymphocytes of patients with malignant melanoma

Also Published As

Publication number Publication date
JPS61104796A (ja) 1986-05-23
EP0179483A3 (en) 1989-03-01
US4883752A (en) 1989-11-28
EP0179483A2 (de) 1986-04-30
DE3584872D1 (de) 1992-01-23
EP0179483B1 (de) 1991-12-11
KR860003021A (ko) 1986-05-19
CA1339202C (en) 1997-08-05
KR930001278B1 (ko) 1993-02-25

Similar Documents

Publication Publication Date Title
ATE70310T1 (de) Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag.
DK153385A (da) Monoklonale antistoffer, hybridoma-cellelinier samt fremgangsmaade til fremstilling af monoklonale antistoffer
DE69726734D1 (de) Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen
DE69721713T2 (de) Humaner monoklonaler antikörper gegen hepatitis b virus oberflächen antigen (hbvsag)
ATE14454T1 (de) Monoklonaler antikoerper gegen menschliche helfer- t-zellen, verfahren zu seiner herstellung, ihn produzierende hybridzellinie, seine diagnostischen und therapeutischen verwendungen und diesen antikoerper enthaltende diagnostische und therapeutische zusammensetzungen.
DE69131686D1 (de) EIN MIT HIV-1-GLYKOPROTEIN REAGIERENDER MENSCHLICHER MONOKLONALER IgG-1-ANTIKÖRPER UND VERWENDUNGSMETHODE
ATE14899T1 (de) Hybridzellinie zur herstellung monoklonaler antikoerper gegen ein menschliches monozytantigen, antikoerper und verfahren.
ATE14233T1 (de) Monoklonaler antikoerper gegen menschliche tzellen, verfahren zu seiner herstellung, ihn produzierende hybridzellinie, ihn enthaltende therapeutische zusammensetzung und ihn verwendendes diagnostisches verfahren.
DE3582358D1 (de) Monoklonaler antikoerper und verfahren zur quantitativen bestimmung von immunoglobulinen mittels dieses antikoerpers.
FR2560212B1 (fr) Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
ATE148348T1 (de) Behandlung von einer autoimmun-krankheit
DE60141832D1 (de) Humaner monoklonaler antikörper gegen das hepatitis c virus e2 glykoprotein
RU2008144703A (ru) Слитые клетки-партнеры
KR890016165A (ko) 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도
FR2571146B1 (fr) Antigenes carcino-foetaux du pancreas humain et un procede de purification, antiserum contre ces antigenes et son procede de preparation et compositions diagnostiques les contenant
CA2254931A1 (en) Human monoclonal antibodies to the hepatitis b surface antigen
SE8200403L (sv) Hybridceller, antikroppar, sett for framstellning av hybridceller, som producerar en antikropp samt sett for framstellning av antikroppar
DE69232140D1 (de) Die herstellung von menschlichen, monoklonalen antikörpern, die gegen das oberflächenantigen von hepatitis b aktiv sind
EP0127173A3 (de) Verfahren zur Gewinnung von gegen Tumorantigene gerichteten monoklonalen Antikörpern und diese enthaltende Arzneimittel
KR880001806A (ko) γ-인터페론의 제조방법과 그 용도
ATE59860T1 (de) Antileishmania monoklonale antikoerper, diese antikoerper ausscheidende hybridomas, von diesen antikoerpern erkannte leishmaniaantigene, verfahren zur herstellung und verwendung von diesen monoklonalen antikoerpern und antigenen.
ATE126704T1 (de) Bcrf1-antagonisten zur behandlung von epstein- barr-virus-infektionen.
Pistillo et al. Human Anti-HLA Monoclonal Antibodies
RO87004B1 (ro) Procedeu de obtinere a gamaglobulinei pentru administrare intravenoasa
RU93019968A (ru) Штамм гибридных культивируемых клеток животного mus musculus - продуцент моноклональных антител к с-концевой части белка р24 вируса иммунодефицита человека i типа

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties