ATE70310T1 - Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag. - Google Patents
Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag.Info
- Publication number
- ATE70310T1 ATE70310T1 AT85113585T AT85113585T ATE70310T1 AT E70310 T1 ATE70310 T1 AT E70310T1 AT 85113585 T AT85113585 T AT 85113585T AT 85113585 T AT85113585 T AT 85113585T AT E70310 T1 ATE70310 T1 AT E70310T1
- Authority
- AT
- Austria
- Prior art keywords
- hbsag
- monoclonal antibodies
- production
- hybridomas
- antibodies
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004408 hybridoma Anatomy 0.000 abstract 2
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000005104 human peripheral blood lymphocyte Anatomy 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59226394A JPS61104796A (ja) | 1984-10-26 | 1984-10-26 | モノクロ−ナル抗体の製造方法 |
EP85113585A EP0179483B1 (de) | 1984-10-26 | 1985-10-25 | Verfahren zur Herstellung von monoklonalen Antikörpern gegen HBsAg |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE70310T1 true ATE70310T1 (de) | 1991-12-15 |
Family
ID=16844430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85113585T ATE70310T1 (de) | 1984-10-26 | 1985-10-25 | Verfahren zur herstellung von monoklonalen antikoerpern gegen hbsag. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4883752A (de) |
EP (1) | EP0179483B1 (de) |
JP (1) | JPS61104796A (de) |
KR (1) | KR930001278B1 (de) |
AT (1) | ATE70310T1 (de) |
CA (1) | CA1339202C (de) |
DE (1) | DE3584872D1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565354A (en) * | 1986-09-05 | 1996-10-15 | Sandoz Ltd. | Production of human monoclonal antibodies specific for hepatitis B surface antigen |
FR2637184A1 (fr) * | 1988-10-05 | 1990-04-06 | Inst Nat Sante Rech Med | Anticorps monoclonal reconnaissant une region pre-s1 de la grande proteine d'enveloppe du virus de l'hepatite b et ses applications, notamment pour le diagnostic in vitro et le traitement de l'hepatite b |
EP0591548A4 (en) * | 1992-03-30 | 1999-04-28 | Suntory Ltd | Anti-hbs antibody gene and expression plasmid thereof |
US6274552B1 (en) | 1993-03-18 | 2001-08-14 | Cytimmune Sciences, Inc. | Composition and method for delivery of biologically-active factors |
SE501668C2 (sv) * | 1993-08-06 | 1995-04-10 | Biolin Medical Ab | Kvantifiering av CD-transferrin vid hög alkoholkonsumtion med HPLC |
US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
IL118626A0 (en) * | 1996-06-11 | 1996-10-16 | Xtl Biopharmaceuticals Limited | Anti HBV antibody |
IL118625A0 (en) | 1996-06-11 | 1996-10-16 | Xtl Biopharmaceuticals Limited | Anti HBV antibodies |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
WO1999024066A2 (en) * | 1997-11-10 | 1999-05-20 | Cytimmune Sciences, Inc. | Methods and compositions for enhancing immune response and for the production of in vitro mabs |
US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
KR100419555B1 (ko) * | 2000-05-29 | 2004-02-19 | 주식회사유한양행 | 비형간염바이러스의 에스-표면항원을 인식하는단일클론항체의 가변영역 및 이를 코딩하는 유전자 |
EP1694301A4 (de) | 2003-12-02 | 2009-11-18 | Cytimmune Sciences Inc | Verfahren und zusammensetzungen zur herstellung von monoklonalen antikörpern |
WO2009062151A1 (en) | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
WO2019229699A1 (en) * | 2018-05-31 | 2019-12-05 | Novartis Ag | Hepatitis b antibodies |
CN116731978B (zh) * | 2023-08-14 | 2023-11-28 | 山东硕景生物科技有限公司 | 抗人乙肝表面抗原单克隆抗体杂交瘤细胞株、抗人乙肝表面抗原单克隆抗体的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI64952C (fi) * | 1977-06-15 | 1984-02-10 | Wistar Inst | Foerfarande foer framstaellning av genetiskt stabila cellinjer |
US4271145A (en) * | 1979-10-22 | 1981-06-02 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
EP0038642B1 (de) * | 1980-04-09 | 1989-02-08 | National Research Development Corporation | Monoklonaler Antikörper gegen Hepatitis B und seine Herstellung, ein den monoklonalen Antikörper produzierendes Hybridom und diesen enthaltende Zusammensetzung, die Vermehrung des Hybridoms und der monoklonale Antikörper für den Gebrauch als antivirales Agenz gegen Hepatitus B und für die Isolierung von Hepatitus B Oberflächenantigen aus einer Probe |
NZ198851A (en) * | 1980-11-07 | 1984-07-31 | Wistar Inst | Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line |
US4594325A (en) * | 1981-03-26 | 1986-06-10 | The Regents Of The University Of Calif. | High fusion frequency fusible lymphoblastoid cell line |
JPS5872526A (ja) * | 1981-10-23 | 1983-04-30 | Green Cross Corp:The | モノクロ−ルhbs抗体の製造方法 |
US4689299A (en) * | 1982-09-30 | 1987-08-25 | University Of Rochester | Human monoclonal antibodies against bacterial toxins |
US4693966A (en) * | 1983-03-11 | 1987-09-15 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies from lymphocytes of patients with malignant melanoma |
-
1984
- 1984-10-26 JP JP59226394A patent/JPS61104796A/ja active Pending
-
1985
- 1985-10-24 US US06/791,163 patent/US4883752A/en not_active Expired - Lifetime
- 1985-10-24 KR KR1019850007864A patent/KR930001278B1/ko not_active IP Right Cessation
- 1985-10-25 CA CA000493835A patent/CA1339202C/en not_active Expired - Fee Related
- 1985-10-25 DE DE8585113585T patent/DE3584872D1/de not_active Expired - Lifetime
- 1985-10-25 EP EP85113585A patent/EP0179483B1/de not_active Expired - Lifetime
- 1985-10-25 AT AT85113585T patent/ATE70310T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPS61104796A (ja) | 1986-05-23 |
EP0179483A3 (en) | 1989-03-01 |
US4883752A (en) | 1989-11-28 |
EP0179483A2 (de) | 1986-04-30 |
DE3584872D1 (de) | 1992-01-23 |
EP0179483B1 (de) | 1991-12-11 |
KR860003021A (ko) | 1986-05-19 |
CA1339202C (en) | 1997-08-05 |
KR930001278B1 (ko) | 1993-02-25 |
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