DE69726734D1 - Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen - Google Patents

Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen

Info

Publication number
DE69726734D1
DE69726734D1 DE69726734T DE69726734T DE69726734D1 DE 69726734 D1 DE69726734 D1 DE 69726734D1 DE 69726734 T DE69726734 T DE 69726734T DE 69726734 T DE69726734 T DE 69726734T DE 69726734 D1 DE69726734 D1 DE 69726734D1
Authority
DE
Germany
Prior art keywords
hbvsag
antibodies
cell lines
mice
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69726734T
Other languages
English (en)
Other versions
DE69726734T2 (de
Inventor
Yair Reisner
Shlomo Dagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
XTL Biopharmaceuticals Ltd
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by XTL Biopharmaceuticals Ltd, Yeda Research and Development Co Ltd filed Critical XTL Biopharmaceuticals Ltd
Application granted granted Critical
Publication of DE69726734D1 publication Critical patent/DE69726734D1/de
Publication of DE69726734T2 publication Critical patent/DE69726734T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Husbandry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69726734T 1996-06-11 1997-06-10 Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen Expired - Lifetime DE69726734T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11862596A IL118625A0 (en) 1996-06-11 1996-06-11 Anti HBV antibodies
IL11862596 1996-06-11
PCT/IL1997/000184 WO1997047654A1 (en) 1996-06-11 1997-06-10 Human monoclonal antibodies to the hepatitis b surface antigen

Publications (2)

Publication Number Publication Date
DE69726734D1 true DE69726734D1 (de) 2004-01-22
DE69726734T2 DE69726734T2 (de) 2004-09-30

Family

ID=11068955

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69726734T Expired - Lifetime DE69726734T2 (de) 1996-06-11 1997-06-10 Menschliche monoklonale antikörper gegen das hepatitis b oberflächenantigen

Country Status (11)

Country Link
US (2) USRE40831E1 (de)
EP (1) EP0912611B9 (de)
JP (1) JP3672933B2 (de)
AT (1) ATE256148T1 (de)
AU (1) AU2975697A (de)
DE (1) DE69726734T2 (de)
DK (1) DK0912611T3 (de)
ES (1) ES2210527T3 (de)
IL (1) IL118625A0 (de)
PT (1) PT912611E (de)
WO (1) WO1997047654A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118626A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
DE19726597C1 (de) * 1997-06-23 1998-11-19 Wengler Georg S Verfahren zur Herstellung von monoklonalen Antikörper
JP2004517636A (ja) * 2000-10-02 2004-06-17 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー Ｂ型肝炎ウイルスの表面抗原ｓに対するヒト化抗体及びその製造方法
SG153666A1 (en) * 2001-10-04 2009-07-29 Yeda Res & Dev Treatment of hepatitis b virus infection with human monoclonal antibodies
IL161138A0 (en) * 2001-10-04 2004-08-31 Xtl Biopharmaceuticals Ltd Treatment of hepatitis b virus infection with human monoclonal antibodies
KR100467706B1 (ko) * 2002-01-15 2005-01-24 주식회사 녹십자홀딩스 Ｂ형 간염 바이러스의 표면 항원에 대한 인간항체
EP1474682A4 (de) * 2002-02-11 2005-10-12 Alexion Pharma Inc Produktion von menschlichen antikörpern in immundefizienten, nicht-menschlichen säugerwirten
AU2003210060B2 (en) 2002-03-22 2010-02-25 Aprogen, Inc. Humanized antibody and process for preparing same
IL165486A0 (en) * 2002-05-31 2006-01-15 Pendu Le Jacques Method composition and kit for antigenic binding of norwalk-like viruses
US7977098B2 (en) 2002-05-31 2011-07-12 Children's Hospital Medical Center Antigenic binding patterns of norovirus to human histo-blood group antigens
CA2594922A1 (en) * 2005-01-14 2006-07-20 The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services Monoclonal antibodies that bind or neutralize hepatitis b virus
EP1871803B1 (de) 2005-04-18 2013-02-20 Yeda Research And Development Company Limited Stabilisierte anti-hepatitis-b-(hbv-)antikörperformulierungen
US20110152263A1 (en) * 2006-11-16 2011-06-23 Xi Jiang Composition and method for inhibiting norovirus infection
US20100150942A1 (en) * 2008-12-03 2010-06-17 Cantor Thomas L Affinity purified human polyclonal antibodies and methods of making and using them
EP2440582B1 (de) 2009-06-09 2018-11-07 Children's Hospital Medical Center Monomere und dimere der antigen-norovirus-p-domäne, moleküle aus antigen-norovirus-partikeln sowie verfahren zu ihrer herstellung und verwendung
JP6270846B2 (ja) * 2012-08-30 2018-01-31 レプリコール インコーポレーティッド Ｂ型肝炎感染及びｄ型肝炎感染の治療方法
WO2014048910A1 (en) 2012-09-27 2014-04-03 Crucell Holland B.V. Human binding molecules capable of binding to and neutralizing hepatitis b viruses and uses thereof
WO2014078280A1 (en) * 2012-11-13 2014-05-22 Genentech, Inc. Enrichment of antigen-specific plasmablasts
US9321803B2 (en) 2013-07-12 2016-04-26 Children's Hospital Medical Center Compositions and methods for inhibiting norovirus infection
JP2019529499A (ja) * 2016-09-30 2019-10-17 ベイラー カレッジ オブ メディスンＢａｙｌｏｒ Ｃｏｌｌｅｇｅ Ｏｆ Ｍｅｄｉｃｉｎｅ 組織指向性発現を用いた抗体ベースの遺伝子治療
JP2020515531A (ja) 2017-03-28 2020-05-28 チルドレンズ ホスピタル メディカル センター ノロウイルスｓ粒子ベースのワクチンならびにその作製および使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61104796A (ja) 1984-10-26 1986-05-23 Chemo Sero Therapeut Res Inst モノクロ−ナル抗体の製造方法
US5652373A (en) 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
DE69131331T2 (de) 1990-01-15 2000-03-02 Yeda Research And Development Co., Ltd. Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
US5804160A (en) 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5858328A (en) 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5849987A (en) 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
CA2147600A1 (en) * 1992-11-06 1994-05-26 Lars G. Ostberg Production of human monoclonal antibodies active against hepatitis b surface antigen
EP0698042A1 (de) * 1993-05-10 1996-02-28 Stichting Centraal Laboratorium van de Bloedtransfusiedienst van het Nederlandse Rode Kruis Antikoerperzusammensetzung gegen hepatitis-b-virus oberflaechenantigen

Also Published As

Publication number Publication date
WO1997047654A1 (en) 1997-12-18
AU2975697A (en) 1998-01-07
DK0912611T3 (da) 2004-03-29
JP3672933B2 (ja) 2005-07-20
USRE40831E1 (en) 2009-07-07
DE69726734T2 (de) 2004-09-30
ES2210527T3 (es) 2004-07-01
US6254867B1 (en) 2001-07-03
IL118625A0 (en) 1996-10-16
EP0912611B9 (de) 2004-12-01
JP2000513215A (ja) 2000-10-10
PT912611E (pt) 2004-04-30
ATE256148T1 (de) 2003-12-15
EP0912611A1 (de) 1999-05-06
EP0912611B1 (de) 2003-12-10

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Legal Events

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8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: YEDA RESEARCH AND DEVELOPMENT CO., LTD., REHOV, IL