DK0912611T3 - Humane monoklonale antistoffer til hepatitis B overfladeantigenet - Google Patents

Humane monoklonale antistoffer til hepatitis B overfladeantigenet

Info

Publication number
DK0912611T3
DK0912611T3 DK97924227T DK97924227T DK0912611T3 DK 0912611 T3 DK0912611 T3 DK 0912611T3 DK 97924227 T DK97924227 T DK 97924227T DK 97924227 T DK97924227 T DK 97924227T DK 0912611 T3 DK0912611 T3 DK 0912611T3
Authority
DK
Denmark
Prior art keywords
hbvsag
antibodies
cell lines
hepatitis
mice
Prior art date
Application number
DK97924227T
Other languages
Danish (da)
English (en)
Inventor
Yair Reisner
Shlomo Dagan
Original Assignee
Yeda Res & Dev
Xtl Biopharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Xtl Biopharmaceuticals Ltd filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK0912611T3 publication Critical patent/DK0912611T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK97924227T 1996-06-11 1997-06-10 Humane monoklonale antistoffer til hepatitis B overfladeantigenet DK0912611T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11862596A IL118625A0 (en) 1996-06-11 1996-06-11 Anti HBV antibodies
PCT/IL1997/000184 WO1997047654A1 (en) 1996-06-11 1997-06-10 Human monoclonal antibodies to the hepatitis b surface antigen

Publications (1)

Publication Number Publication Date
DK0912611T3 true DK0912611T3 (da) 2004-03-29

Family

ID=11068955

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97924227T DK0912611T3 (da) 1996-06-11 1997-06-10 Humane monoklonale antistoffer til hepatitis B overfladeantigenet

Country Status (11)

Country Link
US (2) US6254867B1 (de)
EP (1) EP0912611B9 (de)
JP (1) JP3672933B2 (de)
AT (1) ATE256148T1 (de)
AU (1) AU2975697A (de)
DE (1) DE69726734T2 (de)
DK (1) DK0912611T3 (de)
ES (1) ES2210527T3 (de)
IL (1) IL118625A0 (de)
PT (1) PT912611E (de)
WO (1) WO1997047654A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118626A0 (en) * 1996-06-11 1996-10-16 Xtl Biopharmaceuticals Limited Anti HBV antibody
DE19726597C1 (de) * 1997-06-23 1998-11-19 Wengler Georg S Verfahren zur Herstellung von monoklonalen Antikörper
JP2004517636A (ja) * 2000-10-02 2004-06-17 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー Ｂ型肝炎ウイルスの表面抗原ｓに対するヒト化抗体及びその製造方法
SG153666A1 (en) * 2001-10-04 2009-07-29 Yeda Res & Dev Treatment of hepatitis b virus infection with human monoclonal antibodies
WO2003028722A1 (en) * 2001-10-04 2003-04-10 Xtl Biopharmaceuticals Ltd Treatment of hepatitis b virus infection with human monoclonal antibodies
KR100467706B1 (ko) * 2002-01-15 2005-01-24 주식회사 녹십자홀딩스 Ｂ형 간염 바이러스의 표면 항원에 대한 인간항체
WO2003068915A2 (en) * 2002-02-11 2003-08-21 Alexion Pharmaceuticals, Inc. Production of human antibodies in immunodeficient, non-human, mammalian hosts
WO2003080672A1 (en) 2002-03-22 2003-10-02 Aprogen, Inc. Humanized antibody and process for preparing same
US7977098B2 (en) 2002-05-31 2011-07-12 Children's Hospital Medical Center Antigenic binding patterns of norovirus to human histo-blood group antigens
AU2003273206B2 (en) * 2002-05-31 2009-08-20 Children's Hospital Medical Center Method, composition and kit for antigenic binding of Norwalk-Like viruses
EP1848740A1 (de) * 2005-01-14 2007-10-31 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, An hepatitis-b-virus bindende oder dieses neutralisierende monoklonale antikörper
ES2407468T3 (es) 2005-04-18 2013-06-12 Yeda Research And Development Company Limited Formulaciones de anticuerpos anti-hepatitis B (HBV) estabilizadas
US20110152263A1 (en) * 2006-11-16 2011-06-23 Xi Jiang Composition and method for inhibiting norovirus infection
US20100150942A1 (en) * 2008-12-03 2010-06-17 Cantor Thomas L Affinity purified human polyclonal antibodies and methods of making and using them
CN107043408B (zh) 2009-06-09 2021-02-09 儿童医院医疗中心 抗原-诺罗病毒p-结构域单体和二聚体，抗原-诺罗病毒p-粒子分子，及其制备和应用方法
WO2014032176A1 (en) * 2012-08-30 2014-03-06 Replicor Inc. Methods for the treatment of hepatitis b and hepatitis d infections
US9512201B2 (en) 2012-09-27 2016-12-06 Janssen Vaccines & Prevention B.V. Human binding molecules capable of binding to and neutralizing hepatitis B viruses and uses thereof
AR093447A1 (es) * 2012-11-13 2015-06-10 Genentech Inc Enriquecimiento de plasmablastos especificos de antigeno
US9321803B2 (en) 2013-07-12 2016-04-26 Children's Hospital Medical Center Compositions and methods for inhibiting norovirus infection
EP3519436A4 (de) * 2016-09-30 2020-09-09 Baylor College of Medicine Antikörperbasierte gentherapie mit gewebegerichteter expression
CA3053522A1 (en) 2017-03-28 2018-10-04 Children's Hospital Medical Center Norovirus s particle based vaccines and methods of making and using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61104796A (ja) 1984-10-26 1986-05-23 Chemo Sero Therapeut Res Inst モノクロ−ナル抗体の製造方法
EP0438053B1 (de) 1990-01-15 1999-06-16 Yeda Research And Development Company Limited Dauerhafte Verpflanzung und Entwicklung menschlicher hämatopoietischer Zellinien bei normalen Säugetieren
US5849288A (en) 1990-01-15 1998-12-15 Yeda Research And Development Co. Ltd. Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5652373A (en) 1990-01-15 1997-07-29 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
US5858328A (en) 1991-06-04 1999-01-12 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5849987A (en) 1992-06-02 1998-12-15 Yeda Research And Development Co. Ltd. Animal model for hepatitis virus infection
US5804160A (en) 1991-06-04 1998-09-08 Yeda Research And Development Co. Ltd Animal model for hepatitis virus infection
US5866757A (en) 1992-06-02 1999-02-02 Yeda Research And Development Co. Ltd. Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
CA2147600A1 (en) * 1992-11-06 1994-05-26 Lars G. Ostberg Production of human monoclonal antibodies active against hepatitis b surface antigen
WO1994026784A1 (en) * 1993-05-10 1994-11-24 Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis Composition of antibodies against hepatitis b surface antigen

Also Published As

Publication number Publication date
ATE256148T1 (de) 2003-12-15
EP0912611B1 (de) 2003-12-10
AU2975697A (en) 1998-01-07
IL118625A0 (en) 1996-10-16
ES2210527T3 (es) 2004-07-01
EP0912611A1 (de) 1999-05-06
DE69726734T2 (de) 2004-09-30
US6254867B1 (en) 2001-07-03
JP2000513215A (ja) 2000-10-10
USRE40831E1 (en) 2009-07-07
PT912611E (pt) 2004-04-30
DE69726734D1 (de) 2004-01-22
JP3672933B2 (ja) 2005-07-20
WO1997047654A1 (en) 1997-12-18
EP0912611B9 (de) 2004-12-01

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