ATE69723T1 - Verfahren zur herstellung multilamellarer vesikel mit grossem waessrigem volumen. - Google Patents

Verfahren zur herstellung multilamellarer vesikel mit grossem waessrigem volumen.

Info

Publication number
ATE69723T1
ATE69723T1 AT88904011T AT88904011T ATE69723T1 AT E69723 T1 ATE69723 T1 AT E69723T1 AT 88904011 T AT88904011 T AT 88904011T AT 88904011 T AT88904011 T AT 88904011T AT E69723 T1 ATE69723 T1 AT E69723T1
Authority
AT
Austria
Prior art keywords
aqueous volume
multilamellar vesicles
large aqueous
preparing multilamellar
vesicles
Prior art date
Application number
AT88904011T
Other languages
English (en)
Inventor
Donald F H Wallach
Original Assignee
Micro Pak Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Pak Inc filed Critical Micro Pak Inc
Application granted granted Critical
Publication of ATE69723T1 publication Critical patent/ATE69723T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0017—Multi-phase liquid compositions
    • C11D17/0021—Aqueous microemulsions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
    • C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT88904011T 1987-03-13 1988-03-08 Verfahren zur herstellung multilamellarer vesikel mit grossem waessrigem volumen. ATE69723T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2552587A 1987-03-13 1987-03-13
US07/078,658 US4855090A (en) 1987-03-13 1987-07-28 Method of producing high aqueous volume multilamellar vesicles
PCT/US1988/000721 WO1988006881A1 (en) 1987-03-13 1988-03-08 Method of producing high aqueous volume multilamellar vesicles
EP88904011A EP0349593B1 (de) 1987-03-13 1988-03-08 Verfahren zur herstellung multilamellarer vesikel mit grossem wässrigem volumen

Publications (1)

Publication Number Publication Date
ATE69723T1 true ATE69723T1 (de) 1991-12-15

Family

ID=26699865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88904011T ATE69723T1 (de) 1987-03-13 1988-03-08 Verfahren zur herstellung multilamellarer vesikel mit grossem waessrigem volumen.

Country Status (8)

Country Link
US (1) US4855090A (de)
EP (1) EP0349593B1 (de)
JP (1) JPH06193B2 (de)
AT (1) ATE69723T1 (de)
AU (1) AU603447B2 (de)
CA (1) CA1289420C (de)
DE (1) DE3866544D1 (de)
WO (1) WO1988006881A1 (de)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234767A (en) * 1987-03-13 1993-08-10 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US5147723A (en) * 1987-07-28 1992-09-15 Micro-Pak, Inc. Paucilamellar lipid vesicles
US5023086A (en) * 1987-03-13 1991-06-11 Micro-Pak, Inc. Encapsulated ionophore growth factors
US5628936A (en) * 1987-03-13 1997-05-13 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
JP2617346B2 (ja) * 1987-03-13 1997-06-04 マイクロ ベシキュラー システムズ，インコーポレイテッド 表面活性剤とステロイドから形成される脂質小胞
US5474848A (en) * 1987-03-13 1995-12-12 Micro-Pak, Inc. Paucilamellar lipid vesicles
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
EP0324455A3 (de) * 1988-01-15 1991-03-27 Hans O. Ribi Neue polymerische Immuno-Adjuvans
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5013497A (en) * 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5019392A (en) * 1988-03-03 1991-05-28 Micro-Pak, Inc. Encapsulation of parasiticides
US5104736A (en) * 1988-03-03 1992-04-14 Micro-Pak, Inc. Reinforced paucilamellar lipid vesicles
US5230900A (en) * 1988-07-01 1993-07-27 The Biomembrane Institute Antibody-mediated and ligand-mediated targeting of differentiation-inducers to tumor cells
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
US5153000A (en) * 1988-11-22 1992-10-06 Kao Corporation Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome
US6177100B1 (en) 1988-12-02 2001-01-23 L'oreal Cosmetic or pharmaceutical composition for the treatment of the hair and scalp
LU87399A1 (fr) * 1988-12-02 1990-07-10 Oreal Composition cosmetique ou pharmaceutique pour le traitement des cheveux et du cuir chevelu
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US4971788A (en) * 1989-01-27 1990-11-20 Medicontrol Corporation Oral cavity and dental microemulsion products
GB8906234D0 (en) * 1989-03-17 1989-05-04 Albright & Wilson Agrochemical suspensions
EP0473645B1 (de) * 1989-05-25 1998-03-18 Technology Unlimited Incorporated Abstossmittel für insekten
US5173303A (en) * 1989-05-25 1992-12-22 Technology Unlimited, Inc. Cutaneous delivery of organic materials
AU701272B2 (en) * 1989-05-25 1999-01-21 Sdg, Inc. Insect repellant
US5221535A (en) * 1989-11-13 1993-06-22 Nova Pharmaceutical Corporation Sustained release formulations of insect repellent
FR2657607B1 (fr) * 1990-01-30 1992-04-30 Durand Muriel Procede de protection de la dihydroxyacetone, dihydroxyacetone protegee par ce procede et produit cosmetique contenant une telle dihydroxyacetone protegee.
FR2662605B1 (fr) * 1990-05-31 1994-12-02 Oreal Composition cosmetique ou pharmaceutique pour le traitement des cheveux et du cuir chevelu.
US5164191A (en) * 1991-02-12 1992-11-17 Micro Vesicular Systems, Inc. Lipid vesicles having an alkyd as a wall-forming material
US5213805A (en) * 1991-07-25 1993-05-25 Micro Vesicular Systems, Inc. Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid
US5958463A (en) * 1991-07-29 1999-09-28 Agri-Tek, Inc. Agricultural pesticide formulations
US5643600A (en) * 1991-09-17 1997-07-01 Micro-Pak, Inc. Lipid vesicles containing avocado oil unsaponifiables
US5439967A (en) * 1991-09-17 1995-08-08 Micro Vesicular Systems, Inc. Propylene glycol stearate vesicles
US5405615A (en) * 1991-09-17 1995-04-11 Micro Vesicular Systems, Inc. Sucrose distearate lipid vesicles
US5260065A (en) * 1991-09-17 1993-11-09 Micro Vesicular Systems, Inc. Blended lipid vesicles
GB9207731D0 (en) * 1992-04-07 1992-05-27 Proteus Molecular Design Improvements in or relating to vaccines
US5420253A (en) * 1993-09-09 1995-05-30 Willmar Poultry Company, Inc. Method for purifying egg yolk immunoglobulins
WO1995016437A1 (en) * 1993-12-17 1995-06-22 Micro-Pak, Inc. Method of transmitting a biologically active material to a cell
US5858398A (en) * 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US5827531A (en) * 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
CA2161388A1 (en) 1994-12-02 1996-06-03 Alexander Znaiden Cosmetic emulsions with a deposition triggering lipid.system
GB9426484D0 (en) * 1994-12-08 1995-03-08 Ciba Geigy Ag Compositions
US20020102236A1 (en) * 1994-12-08 2002-08-01 Taylor Peter William Liposomal interferon hybrid compositions
US5902604A (en) 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US5846551A (en) * 1996-06-10 1998-12-08 E-L Management Corp. Water-based makeup compositions and methods for their preparation
US6130186A (en) * 1996-10-25 2000-10-10 Monsanto Company Composition and method for treating plants with exogenous chemicals
CA2269726A1 (en) * 1996-10-25 1998-04-30 Monsanto Company Composition and method for treating plants with exogenous chemicals
EP0963198A4 (de) * 1997-02-11 2001-08-29 Bernard Salafsky ANTIPARASITISCHE WIRKUNG VON N,N-DIETHYL-m-TOLUAMID (DEET) UND FORMULIERUNGEN DIE SEINE WIRKUNG IN DER HAUT VERLÄNGERN
FR2761886B1 (fr) * 1997-04-14 2000-05-05 Virbac Sa Compositions contenant au moins un polymere cationique et au moins une molecule active contenue dans au moins un vecteur micro ou nanoparticulaire, et leur utilisation pour le traitement de surfaces vivantes ou inertes
FR2761912B1 (fr) † 1997-04-14 1999-07-02 Capsulis Procede destine a faire adherer un produit sur une surface
US6039960A (en) * 1997-05-28 2000-03-21 E-L Management Corp. Water containing wax-based product
DE19748796A1 (de) * 1997-11-05 1999-05-06 Beiersdorf Ag Verfahren zur Herstellung von Liposomen
TW476788B (en) 1998-04-08 2002-02-21 Kimberly Clark Co A cleanser and the making process thereof
EP1146959B1 (de) 1998-11-13 2008-06-04 William A. Heriot Vorrichtung zur herstellung von liposomen
US6855296B1 (en) 1998-11-13 2005-02-15 Optime Therapeutics, Inc. Method and apparatus for liposome production
EP1140021B1 (de) 1998-12-23 2004-08-04 Idea Ag Verbesserte formulierung zur topischen, nichtinvasiven anwendung in vivo
ATE216223T1 (de) 1999-01-27 2002-05-15 Idea Ag Transnasaler transport bzw. impfung mit hochadaptierbaren trägern
EP1031346B1 (de) 1999-01-27 2002-05-02 Idea Ag Nichtinvasive Impfung durch die Haut
MXPA02000053A (es) 1999-07-05 2003-07-21 Idea Ag Un metodo para mejorar el tratamiento a traves de barreras adaptables semipermeables.
GB0219611D0 (en) * 2002-08-22 2002-10-02 Syngenta Ltd Composition
US7473432B2 (en) 2002-10-11 2009-01-06 Idea Ag NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery
US20040087564A1 (en) * 2002-10-31 2004-05-06 Wright D. Craig Delivery composition and method
US8034796B2 (en) * 2004-04-07 2011-10-11 The University Of Georgia Research Foundation, Inc. Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods
WO2005116086A2 (en) 2004-04-07 2005-12-08 The University Of Georgia Research Foundation, Inc. Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods
JP4616602B2 (ja) * 2004-09-16 2011-01-19 大日本塗料株式会社 単分散粒子の製造方法
ES2747978T3 (es) * 2005-10-03 2020-03-12 Mark A Pinsky Liposomas no fosfolipídicos que comprenden ácido hialurónico
CA2675745A1 (en) * 2007-01-18 2008-07-24 Mark A. Pinsky Materials and methods for delivering antioxidants into the skin
EP2222270B1 (de) 2007-12-26 2018-11-14 Mark A. Pinsky Collagenformulierungen für verbesserte hautpflege
US10251839B2 (en) * 2008-01-22 2019-04-09 Igi Laboratories, Inc. Lipid vesicles derived from olive oil fatty acids
GR1008481B (el) 2013-12-05 2015-05-12 Συμβουλοι Αναπτυξης Πωλησεων Επε, Μεθοδος εγκλωβισμου φυτικων ελαιων και ιδιαιτερα ελαιολαδου με τη χρηση εξειδικευμενων βρωσιμων λιποσωματων, χωρις φωσφολιπιδια, για εφαρμογες στον τομεα τροφιμων και ειδικοτερα προϊοντων αλλαντοποιιας, γαλακτοκομικων και ιχθυοσκευασματων
WO2022204305A2 (en) 2021-03-24 2022-09-29 Glo Pharma, Inc. Peptides and methods for reducing skin pigmentation

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
FR2315991A1 (fr) * 1975-06-30 1977-01-28 Oreal Procede de fabrication de dispersions aqueuses de spherules lipidiques et nouvelles compositions correspondantes
FR2408387A2 (fr) * 1975-06-30 1979-06-08 Oreal Compositions a base de dispersions aqueuses de spherules lipidiques
GB1578776A (en) * 1976-06-10 1980-11-12 Univ Illinois Hemoglobin liposome and method of making the same
US4217344A (en) * 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
EP0032622B1 (de) * 1979-12-20 1985-08-14 Dennis Chapman Polymerisationsfähige Phospholipide und deren Polymere, Verfahren zu deren Herstellung, Verfahren zu deren Verwendung für die Bildung von Überzugschichten auf Substraten und zum Bilden von Liposomen und die daraus entstehenden Liposomzusammensetzungen und Substrate mit Überzugschichten
DE3068743D1 (en) * 1980-01-16 1984-08-30 Weder Hans G Process and dialysis-installation for the preparation of bilayer-vesicles and their use
DE3161962D1 (en) * 1980-07-01 1984-02-23 Oreal Process for obtaining stable dispersions in an aqueous phase of at least a water immiscible liquid phase, and corresponding dispersions
FR2485921A1 (fr) * 1980-07-01 1982-01-08 Oreal Composition cosmetique a base d'une dispersion aqueuse de spherules lipidiques
US4564599A (en) * 1982-08-23 1986-01-14 The Liposome Company, Inc. Liposome composition for lupus assay
JPS5916534A (ja) * 1982-07-19 1984-01-27 Lion Corp 非イオン性界面活性剤系ベシクル分散液
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
US4485054A (en) * 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
JPS59106423A (ja) * 1982-12-08 1984-06-20 Hiroshi Kiwada リポソ−ム
FR2543018B1 (fr) * 1983-03-22 1985-07-26 Oreal Procede de preparation de vesicules lipidiques par vaporisation de solvants
JPS6072831A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
FR2553002B1 (fr) * 1983-10-06 1992-03-27 Centre Nat Rech Scient Procede perfectionne d'obtention de liposomes unilamellaires de diametres eleves, leur application pharmacologique pour l'encapsulage d'un principe actif en vue de son administration extemporanee et dispositif correspondant
US4692433A (en) * 1983-10-12 1987-09-08 The Regents Of The University Of California Method and composition for regulating serum calcium levels of mammals
US4695554A (en) * 1984-02-14 1987-09-22 Becton Dickinson And Company Sac or liposome containing dye (sulforhodamine) for immunoassay
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4619913A (en) * 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
JPS61207324A (ja) * 1985-03-11 1986-09-13 Agency Of Ind Science & Technol リポソ−ム

Also Published As

Publication number Publication date
EP0349593B1 (de) 1991-11-27
JPH02503646A (ja) 1990-11-01
WO1988006881A1 (en) 1988-09-22
US4855090A (en) 1989-08-08
AU1683688A (en) 1988-10-10
AU603447B2 (en) 1990-11-15
JPH06193B2 (ja) 1994-01-05
EP0349593A1 (de) 1990-01-10
DE3866544D1 (de) 1992-01-09
CA1289420C (en) 1991-09-24

Similar Documents

Publication Publication Date Title
ATE69723T1 (de) Verfahren zur herstellung multilamellarer vesikel mit grossem waessrigem volumen.
NL7711610A (nl) Heparine bevattende liposomen en werkwijze ter bereiding ervan.
DE3678308D1 (de) Verfahren zur herstellung von mikrokapseln.
ATA154680A (de) Verfahren zur herstellung von neuen glycinamidderivaten
ATA108879A (de) Verfahren zur herstellung von neuen aminozucker-derivaten
DE3762604D1 (de) Verfahren zur herstellung von waessrigen loesungen von freiem hydroxylamin.
AT375378B (de) Verfahren zur herstellung von 4'-deoxydaunorubicin
ATE87486T1 (de) Verfahren zur herstellung von toxoid.
AT363206B (de) Verfahren zur herstellung von neuen dipeptidderivaten
DE2965476D1 (en) Process for producing a cellulose acetate-type permselective membrane, permselective membrane thus produced, and use of such membrane in artificial kidney
AT386197B (de) Verfahren zur herstellung von neuen indolderivaten
AT355741B (de) Verfahren zur herstellung von neuen dipeptid- derivaten
ATE116636T1 (de) Verfahren zur herstellung von 2,6- dichlordiphenylaminessigsäurederivaten.
DE3872875D1 (de) Verfahren zur herstellung von liposomen.
JPS5527297A (en) Duplication set and method of producing same
AT371443B (de) Verfahren zur herstellung von neuen 1-benzyl -1,2,3,6-tetrahydropyridinderivaten
JPS553946A (en) Method of producing tortoiseeshell ornaments
ATE116646T1 (de) Verfahren zur herstellung von hochreinem propylencarbonat und zur gleichzeitigen herstellung von passivierten elektroden.
DE3761372D1 (de) Verfahren zur herstellung von zirkoniumcarboxylat.
ATA113977A (de) Verfahren zur herstellung von neuen dipeptid- derivaten
ATE56966T1 (de) Verfahren zur herstellung von optisch aktiven alpha-halogenketalen.
ATA815178A (de) Verfahren zur herstellung von neuen derivaten des trans-2,3-dhydro-2-(4-hydroxy-3-methoxyphenyll) -7-methoxy-3-methyl-5-(e)-propenylbenzofurans
SU600170A1 (ru) Способ культивировани плесневых грибов
JPS5294451A (en) Method of producing heattresistan and shape keepable process cheese
JPS5534931A (en) Method of producing fancy venier

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties