ATE68349T1 - Medizinische verwendung von nukleosiden. - Google Patents

Medizinische verwendung von nukleosiden.

Info

Publication number
ATE68349T1
ATE68349T1 AT87904641T AT87904641T ATE68349T1 AT E68349 T1 ATE68349 T1 AT E68349T1 AT 87904641 T AT87904641 T AT 87904641T AT 87904641 T AT87904641 T AT 87904641T AT E68349 T1 ATE68349 T1 AT E68349T1
Authority
AT
Austria
Prior art keywords
nucleosides
medical use
treatment
infections
formulawherein
Prior art date
Application number
AT87904641T
Other languages
English (en)
Inventor
Bertil Frank Harald Eriksson
Karl Nils Gunnar Johansson
Goeran Bertil Stening
Bo Fredrik Oeberg
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Application granted granted Critical
Publication of ATE68349T1 publication Critical patent/ATE68349T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT87904641T 1986-07-04 1987-07-02 Medizinische verwendung von nukleosiden. ATE68349T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE8602981A SE8602981D0 (sv) 1986-07-04 1986-07-04 Novel medicinal use
PCT/SE1987/000316 WO1988000050A1 (en) 1986-07-04 1987-07-02 Novel medicinal use of nucleosides
EP87904641A EP0277151B1 (de) 1986-07-04 1987-07-02 Medizinische verwendung von nukleosiden

Publications (1)

Publication Number Publication Date
ATE68349T1 true ATE68349T1 (de) 1991-11-15

Family

ID=20365027

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87904641T ATE68349T1 (de) 1986-07-04 1987-07-02 Medizinische verwendung von nukleosiden.

Country Status (10)

Country Link
US (1) US6358934B1 (de)
EP (1) EP0277151B1 (de)
JP (1) JP2540576B2 (de)
AT (1) ATE68349T1 (de)
AU (1) AU598575B2 (de)
CA (1) CA1286991C (de)
DE (1) DE3773892D1 (de)
DK (1) DK172617B1 (de)
SE (1) SE8602981D0 (de)
WO (1) WO1988000050A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9800452D0 (sv) * 1998-02-13 1998-02-13 Medivir Ab Antivirals
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
US5506215A (en) * 1987-11-03 1996-04-09 Medivir Ab 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
GB8904855D0 (en) * 1989-03-03 1989-04-12 Beecham Group Plc Pharmaceutical treatment
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB9003543D0 (en) * 1990-02-16 1990-04-11 Wellcome Found Therapeutic nucleosides
DK0625158T3 (da) * 1992-01-06 1999-10-11 Wellcome Found Terapeutiske nucleosider af 2',3'-dideoxy-3'-fluorpurinrækken
GB9200150D0 (en) * 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
US5360714A (en) * 1992-08-28 1994-11-01 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
US5334525A (en) * 1992-08-28 1994-08-02 Fox Chase Cancer Center Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof
TW374087B (en) * 1993-05-25 1999-11-11 Univ Yale L-2',3'-dideoxy nucleotide analogs as anti-hepatitis B(HBV) and anti-HIV agents
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
DE69533856T2 (de) * 1994-10-24 2005-12-08 Genencor International, Inc., Palo Alto L-pyranosyl-nukleoside
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
SG96604A1 (en) * 1997-08-15 2003-06-16 Medivir Ab Nucleosides analogues, such as antivirals including inhibitors of retroviral reverse transcriptase and the dna polymerase of hepatitis b virus (hbv)
WO2004002433A1 (en) * 2002-06-27 2004-01-08 Medivir Ab Synergistic interaction of abacavir and alovudine
WO2004087169A1 (en) * 2003-03-27 2004-10-14 Boehringer Ingelheim International Gmbh Antiviral combination of nevirapine and a further antiretroviral compound
EP1610782A1 (de) * 2003-03-27 2006-01-04 Boehringer Ingelheim International GmbH Antivirale kombination eines dipyridodiazepinons und einer weiteren antiretroviralen verbindung
WO2004087139A1 (en) 2003-03-27 2004-10-14 Boehringer Ingelheim International Gmbh Antiviral combination of tipranavir and a further antiretroviral compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
DD139793A1 (de) * 1978-11-06 1980-01-23 Waltraud Braun Mittel gegen psoriasis
DD158903A1 (de) * 1981-05-18 1983-02-09 Gotthard Kowollik Verfahren zur herstellung von 3'-fluor-2',3'-didesoxyadenosin
DD209197A1 (de) * 1981-07-21 1984-04-25 Akad Wissenschaften Ddr Verfahren zur herstellung von 3'-fluor-2',3'-didesoxyguanosin
US4724232A (en) 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
DE3689976T2 (de) * 1985-05-15 1995-03-16 Wellcome Found Therapeutische Nucleoside und deren Herstellung.
EP0258412A1 (de) 1986-02-20 1988-03-09 GREER, Sheldon B. Zubereitung und verfahren zur behandlung von aids und verwandten krankheiten

Also Published As

Publication number Publication date
DK172617B1 (da) 1999-03-01
JP2540576B2 (ja) 1996-10-02
DK92788D0 (da) 1988-02-23
DK92788A (da) 1988-02-23
US6358934B1 (en) 2002-03-19
DE3773892D1 (de) 1991-11-21
EP0277151B1 (de) 1991-10-16
JPH01500193A (ja) 1989-01-26
CA1286991C (en) 1991-07-30
AU598575B2 (en) 1990-06-28
SE8602981D0 (sv) 1986-07-04
EP0277151A1 (de) 1988-08-10
WO1988000050A1 (en) 1988-01-14
AU7700587A (en) 1988-01-29

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties