ATE555774T1 - Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats - Google Patents

Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats

Info

Publication number
ATE555774T1
ATE555774T1 AT06776126T AT06776126T ATE555774T1 AT E555774 T1 ATE555774 T1 AT E555774T1 AT 06776126 T AT06776126 T AT 06776126T AT 06776126 T AT06776126 T AT 06776126T AT E555774 T1 ATE555774 T1 AT E555774T1
Authority
AT
Austria
Prior art keywords
granule
producing
drying process
spray drying
carnitine powder
Prior art date
Application number
AT06776126T
Other languages
English (en)
Inventor
Max Baumgartner
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of ATE555774T1 publication Critical patent/ATE555774T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Detergent Compositions (AREA)
AT06776126T 2005-07-05 2006-07-05 Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats ATE555774T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05014529 2005-07-05
PCT/EP2006/006551 WO2007003425A2 (en) 2005-07-05 2006-07-05 Spray-drying process for producing a dry carnitine powder or granulate

Publications (1)

Publication Number Publication Date
ATE555774T1 true ATE555774T1 (de) 2012-05-15

Family

ID=37562145

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06776126T ATE555774T1 (de) 2005-07-05 2006-07-05 Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats

Country Status (11)

Country Link
US (1) US9084431B2 (de)
EP (1) EP1901715B1 (de)
JP (1) JP5149172B2 (de)
KR (1) KR101327700B1 (de)
CN (2) CN101912045B (de)
AT (1) ATE555774T1 (de)
AU (1) AU2006265280B2 (de)
BR (1) BRPI0612611A2 (de)
CA (1) CA2611901C (de)
ES (1) ES2385046T3 (de)
WO (1) WO2007003425A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5463526B2 (ja) * 2008-03-21 2014-04-09 国立大学法人東京海洋大学 健康機能成分を吸着・濃縮した乾燥脱脂穀類糠、該糠から調製した健康機能成分の濃縮物、及びそれらの製造方法
EP2335495A1 (de) * 2009-12-11 2011-06-22 Lonza Ltd. Carnitin-Granulat und Verfahren zu dessen Herstellung
JP6460791B2 (ja) * 2011-07-08 2019-01-30 ピュラック バイオケム ビー． ブイ． 飼料製品における使用の為の活性組成物
EP2920143B1 (de) 2012-11-16 2020-04-29 Lonza Ltd Verfahren zum entfärben von zusammensetzungen mit betainen
KR101721145B1 (ko) * 2015-07-29 2017-03-29 제너럴바이오(주) Ｌ-카르니틴 구연산 마그네슘을 포함하는 배변촉진 겸용 다이어트용 식품 조성물
CN106957238A (zh) * 2017-04-19 2017-07-18 黄冈华阳药业有限公司 一种肉碱的制备工艺
JP7240098B2 (ja) * 2018-01-17 2023-03-15 昭和産業株式会社 飼料原料及び飼料
BR112021017623A2 (pt) 2019-03-06 2021-11-09 Xianfeng Peng Uso do composto de butirato de amônio ?-quaternário na preparação de aditivo para a alimentação animal
CN111838421B (zh) * 2020-07-27 2023-04-21 中国科学院天津工业生物技术研究所 一种从发酵液中制备5-氨基乙酰丙酸的方法及其应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
US4751182A (en) * 1984-04-20 1988-06-14 Wisconsin Alumni Research Foundation Process for preparing L-carnitine from DL-carnitine
CA2018137C (en) 1989-06-14 2000-01-11 Thomas Scholl L-carnitine magnesium citrate
DE69019524T2 (de) 1989-07-31 1996-01-04 Univ Georgia Res Found Karnitindiät für ausgewachsene schweine.
JPH03120211A (ja) * 1989-10-04 1991-05-22 Earth Chem Corp Ltd 粒状カルニチン製剤
US5073376A (en) 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
CN1058523C (zh) 1993-10-08 2000-11-15 瑞士隆萨股份公司 丁内铵盐/巴豆甜菜碱－l－肉毒碱代谢基因及其在微生物法生成l－肉毒碱中的用途
JPH0812569A (ja) * 1994-06-24 1996-01-16 Takeda Chem Ind Ltd 塩化カルニチン吸着固形物
PT914315E (pt) * 1996-05-31 2001-07-31 Sigma Tau Ind Farmaceuti Sais nao higroscopicos estaveis de l(-)carnitina e alcanoil l(-)carnitinas processo para a sua preparacao e composicoes solidas administraveis oralmente contendo tais sais
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
JP4452341B2 (ja) * 1999-01-13 2010-04-21 雪印乳業株式会社 Ｌ−カルニチン剤
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
CA2383814C (en) * 1999-09-03 2010-08-17 Sigma-Tau Healthscience S.P.A. Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
DE50106272D1 (de) 2000-08-29 2005-06-23 Lonza Ag Verfahren zur herstellung einer granulierbaren mischung und carnitin-magnesium-hydroxycitrat
CN1203776C (zh) * 2000-12-07 2005-06-01 东北制药总厂 左旋肉碱饲料添加剂及其制备方法
CN1233832C (zh) 2001-01-31 2005-12-28 隆萨股份公司 制造l－肉毒碱的微生物学方法
US7169770B2 (en) * 2001-04-24 2007-01-30 Lonza Ltd. Method of enhancing reproductive performance in sows
WO2003009854A1 (en) * 2001-07-20 2003-02-06 Lonza Ag Lipid lowering composition comprising carnitine and phytosterol
US20030235646A1 (en) 2002-03-15 2003-12-25 Lonza Inc. Method for improving quality of meat by supplementing pig diets and concentrates used therefor

Also Published As

Publication number Publication date
JP2009500026A (ja) 2009-01-08
CA2611901A1 (en) 2007-01-11
US9084431B2 (en) 2015-07-21
WO2007003425A3 (en) 2007-03-08
BRPI0612611A2 (pt) 2010-12-07
US20090082449A1 (en) 2009-03-26
WO2007003425A2 (en) 2007-01-11
CN101912045B (zh) 2013-07-31
ES2385046T3 (es) 2012-07-17
JP5149172B2 (ja) 2013-02-20
EP1901715A2 (de) 2008-03-26
AU2006265280B2 (en) 2011-07-14
EP1901715B1 (de) 2012-05-02
KR101327700B1 (ko) 2013-11-11
AU2006265280A1 (en) 2007-01-11
CA2611901C (en) 2012-12-11
KR20080030650A (ko) 2008-04-04
CN101912045A (zh) 2010-12-15
CN101212956A (zh) 2008-07-02

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