ATE554777T1 - Zubereitung eines nukleierten zell- und/oder thrombozyten-konzentrats aus einer physiologischen lösung - Google Patents

Zubereitung eines nukleierten zell- und/oder thrombozyten-konzentrats aus einer physiologischen lösung

Info

Publication number
ATE554777T1
ATE554777T1 AT05745438T AT05745438T ATE554777T1 AT E554777 T1 ATE554777 T1 AT E554777T1 AT 05745438 T AT05745438 T AT 05745438T AT 05745438 T AT05745438 T AT 05745438T AT E554777 T1 ATE554777 T1 AT E554777T1
Authority
AT
Austria
Prior art keywords
physiological solution
preparation
nuclated
cell
thrombocyte concentrate
Prior art date
Application number
AT05745438T
Other languages
English (en)
Inventor
Samuel Sowemimo-Coker
Marcus Scott
Marc Long
Ed Margerrison
Michael Cooper
Original Assignee
Smith & Nephew Inc
Pall Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith & Nephew Inc, Pall Corp filed Critical Smith & Nephew Inc
Application granted granted Critical
Publication of ATE554777T1 publication Critical patent/ATE554777T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/02—Separating microorganisms from the culture medium; Concentration of biomass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0087—Purging against subsets of blood cells, e.g. purging alloreactive T cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Sustainable Development (AREA)
AT05745438T 2004-03-29 2005-03-23 Zubereitung eines nukleierten zell- und/oder thrombozyten-konzentrats aus einer physiologischen lösung ATE554777T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/811,549 US7291450B2 (en) 2003-03-28 2004-03-29 Preparation of a cell concentrate from a physiological solution
PCT/US2005/010004 WO2005094914A1 (en) 2004-03-29 2005-03-23 Preparation of a nucleated cell and/or platelet concentrate from a physiological solution

Publications (1)

Publication Number Publication Date
ATE554777T1 true ATE554777T1 (de) 2012-05-15

Family

ID=34968667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05745438T ATE554777T1 (de) 2004-03-29 2005-03-23 Zubereitung eines nukleierten zell- und/oder thrombozyten-konzentrats aus einer physiologischen lösung

Country Status (8)

Country Link
US (5) US7291450B2 (de)
EP (1) EP1729831B1 (de)
JP (1) JP4987694B2 (de)
KR (1) KR101299789B1 (de)
AT (1) ATE554777T1 (de)
AU (1) AU2005229049B9 (de)
CA (1) CA2559865C (de)
WO (1) WO2005094914A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
US7608258B2 (en) * 2002-04-13 2009-10-27 Allan Mishra Method for treatment of tendinosis using platelet rich plasma
US7291450B2 (en) * 2003-03-28 2007-11-06 Smith & Nephew, Inc. Preparation of a cell concentrate from a physiological solution
US7744869B2 (en) * 2003-08-20 2010-06-29 Ebi, Llc Methods of treatment using electromagnetic field stimulated mesenchymal stem cells
TWI242460B (en) * 2003-12-23 2005-11-01 Ind Tech Res Inst Method and device for separating fibrin glue from blood plasma
US7767221B2 (en) 2004-03-05 2010-08-03 The Trustees Of Columbia University In The City Of New York Multi-phased, biodegradable and osteointegrative composite scaffold for biological fixation of musculoskeletal soft tissue to bone
US7993578B2 (en) * 2004-10-29 2011-08-09 Depuy Spine, Inc. Methods and kits for aseptic filling of products
AU2005309599A1 (en) 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer
US7364657B2 (en) * 2005-03-31 2008-04-29 Abbott Cardiovascular Systems Inc. Integrated system for on-site cell acquisition, processing, and delivery
US20060251628A1 (en) * 2005-05-06 2006-11-09 Mohamed Attawia Defatted, dewatered bone marrow
US20070105769A1 (en) * 2005-11-07 2007-05-10 Ebi, L.P. Methods of treating tissue defects
JP2008189594A (ja) * 2007-02-05 2008-08-21 Olympus Corp 生体組織補填体の製造装置および製造方法
WO2008097230A1 (en) * 2007-02-09 2008-08-14 Harvest Technologies Corporation Tissue graft composition comprising autologous bone marrow and purified autologous thrombin
US8753391B2 (en) 2007-02-12 2014-06-17 The Trustees Of Columbia University In The City Of New York Fully synthetic implantable multi-phased scaffold
AU2008200733A1 (en) * 2007-02-16 2008-09-04 Harvest Technologies Corporation Method for adjusting sedimentation rates
CN101678250B (zh) * 2007-03-02 2013-04-24 史密夫及内修公开有限公司 用于在生物样品过滤中通过超声、回洗和过滤器运动进行过滤器清洁的装置和方法
US8034014B2 (en) * 2007-03-06 2011-10-11 Biomet Biologics, Llc Angiogenesis initation and growth
JP2010531142A (ja) * 2007-06-22 2010-09-24 サークル バイオロジクス、 エルエルシー． 液体濃縮装置、オートロガスな濃縮体液、およびそれらの使用方法
US9095562B2 (en) 2007-07-05 2015-08-04 Regenerative Sciences, Inc. Methods and compositions for optimized expansion and implantation of mesenchymal stem cells
CN101945994A (zh) 2007-12-19 2011-01-12 再生科学有限责任公司 促进干细胞移植和植入的组合物和方法
EP2257176B1 (de) 2008-03-14 2013-09-18 Regenerative Sciences, LLC Zusammensetzungen und verfahren zur knorpelreparatur
KR20100007180A (ko) * 2008-07-11 2010-01-22 세원셀론텍(주) 뼈 재생용 콜라겐 젤 조성물의 제조방법
JP5629683B2 (ja) 2008-07-25 2014-11-26 スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ 分離装置用コントローラ
US20100112081A1 (en) * 2008-10-07 2010-05-06 Bioparadox, Llc Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities
US8440459B2 (en) * 2008-10-09 2013-05-14 Allan Kumar Mishra Platelet rich plasma formulations for cardiac treatments
JP2010099052A (ja) * 2008-10-27 2010-05-06 Olympus Corp 細胞分離方法
US9192695B2 (en) * 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US8177072B2 (en) 2008-12-04 2012-05-15 Thermogenesis Corp. Apparatus and method for separating and isolating components of a biological fluid
KR20120006481A (ko) 2008-12-05 2012-01-18 리제너러티브 사이언시즈, 엘엘씨 무혈관 조직의 복구를 촉진하기 위한 방법 및 조성물
US9320761B2 (en) 2008-12-18 2016-04-26 Vivex Biomedical, Inc. Bone induction system and methods
KR101218101B1 (ko) * 2009-03-20 2013-01-03 주식회사 스템메디언스 양수 내 태아 유래 중간엽줄기세포를 이용한 발모촉진용 조성물
KR101078419B1 (ko) 2009-03-20 2011-10-31 주식회사 스템메디언스 양수 내 태아 유래 중간엽줄기세포를 이용한 피부 상태개선용 조성물
EP2264150A1 (de) * 2009-06-09 2010-12-22 Astley E. Smith Dreifachspin-, Doppelpool- und Wiedervoluminisierungsverfahren zum Konzentrieren von Blutplättchen und abgeleitetes Blutplättchenkonzentrat
WO2011037658A1 (en) * 2009-09-25 2011-03-31 Tornier, Inc. Implantable patch and surgical kit for preparation thereof
US20110123497A1 (en) * 2009-11-20 2011-05-26 Fina Biotech, S.L.U. Graft composition for neural tissue regeneration, method of production and uses thereof
AU2013204820B2 (en) * 2009-12-23 2014-01-30 Cytovera, Inc. A System and Method for Particle Filtration
MX344460B (es) * 2009-12-23 2016-12-14 Cytovera Inc * Sistema y método para la filtración de partículas.
WO2011127071A1 (en) * 2010-04-05 2011-10-13 Allan Mishra Platelet rich plasma formulations
US8790321B2 (en) * 2010-04-21 2014-07-29 Genesis Medical Devices, LLC Apparatus, system, and method for harvesting improved bone graft material with reamer-irrigator-aspirator (RIA) device
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9090863B2 (en) * 2010-05-17 2015-07-28 Pall Corporation System for seeding cells onto three dimensional scaffolds
KR101435402B1 (ko) * 2010-05-17 2014-08-28 예일 유니버시티 3 차원 스캐폴드 상에 세포 접종을 위한 시스템
WO2011163328A2 (en) * 2010-06-22 2011-12-29 The Trustees Of Columbia University In The City Of New York Methods for producing tissue scaffold directing differentiation of seeded cells and tissue scaffolds produced thereby
JP5821847B2 (ja) * 2010-07-01 2015-11-24 株式会社カネカ 細胞培養用ディスポセット、細胞培養装置及び細胞調製方法
JP5562754B2 (ja) * 2010-07-30 2014-07-30 オリンパス株式会社 細胞処理システム
US9555171B2 (en) 2010-09-30 2017-01-31 Depuy Mitek, Llc Methods and devices for collecting separate components of whole blood
US20120213754A1 (en) * 2011-02-23 2012-08-23 Stem Cell Partners Llc Method of Preconditioning of Cell Suspensions
US9011684B2 (en) 2011-03-07 2015-04-21 Spinesmith Holdings, Llc Fluid concentrator with removable cartridge
ES2803499T3 (es) 2011-06-29 2021-01-27 Biorestorative Therapies Inc Composiciones y métodos de células grasas marrones
US20130143195A1 (en) 2011-12-05 2013-06-06 Pall Corporation Leukocyte purification
EP2806914B1 (de) 2012-01-23 2021-09-22 Estar Technologies Ltd System und verfahren zur entnahme einer mit definierten zellen wie erythrozytenreichem plasma angereicherten zellulären probe
CA2865170C (en) 2012-02-21 2020-12-22 Cytonics Corporation Systems, compositions, and methods for transplantation
EP2644259A1 (de) 2012-03-29 2013-10-02 Roche Diagniostics GmbH Mikroflussfiltrationssystem und Flussfiltrationsverfahren
EP2644258A1 (de) * 2012-03-29 2013-10-02 Roche Diagniostics GmbH Mikroflussfiltrationssystem und Flussfiltrationsverfahren für eine Flüssigkeitsprobe
US9427512B2 (en) 2012-06-08 2016-08-30 Pall Corporation Filter device
US9421317B2 (en) 2012-06-08 2016-08-23 Pall Corporation Cell harvesting device and system
US9333447B2 (en) 2012-10-19 2016-05-10 Warsaw Orthopedic, Inc. Filtration device
US10016527B2 (en) 2012-10-23 2018-07-10 Orthovita, Inc. Materials and methods for repair of cartilage defects
US10493194B2 (en) * 2012-10-23 2019-12-03 Spinesmith Partners, L.P. Automated device for point-of-care cell processing
CA2870368A1 (en) * 2012-12-09 2014-06-12 Chromedx Inc. Automated ultra-filtration apparatus
US9114190B2 (en) 2013-02-08 2015-08-25 Laser Spine Institute, Llc Regeneration of spinal discs
CA2899713C (en) 2013-03-15 2022-07-19 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
EP2983643A4 (de) 2013-04-12 2016-12-28 Univ Columbia Verfahren für wirtszellen-homing und zahnmarkregeneration
KR101658364B1 (ko) * 2013-06-04 2016-09-22 김홍 전혈로부터 고농축혈장을 추출하는 장치 및 방법
US20140356893A1 (en) 2013-06-04 2014-12-04 Allan Mishra Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation
DE102013012676A1 (de) * 2013-07-31 2015-02-05 Mann + Hummel Gmbh Vorrichtung zur Querstromfiltration
AU2014312249A1 (en) 2013-08-28 2016-03-24 Cytonics Corporation Systems, compositions, and methods for transplantation and treating conditions
EP3045520A4 (de) * 2013-09-13 2017-04-26 Medinet Co., Ltd. Filtrationsinstrument für eine zellsuspension und verfahren zur herstellung einer tropfinfusionslösung mit der zellsuspension
JP5896571B2 (ja) * 2013-10-15 2016-03-30 キム ホンＫｉｍ Ｈｏｎｇ 全血から高濃縮血漿を抽出する装置及び方法
DE102013017035A1 (de) * 2013-10-15 2015-04-16 Mann + Hummel Gmbh Blutfiltervorrichtung
EP3057600B1 (de) 2013-10-18 2019-03-13 Fortus Medical, Inc. Herstellungsmethode eines durch ein knochenmarkabsaugungsprodukt verbessertes knochenimplantat
ITTO20130925A1 (it) * 2013-11-14 2015-05-15 Eltek Spa Dispositivo medicale, in particolare per la separazione di un fluido
US10213526B2 (en) 2014-03-21 2019-02-26 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods for preparation of a terminally sterilized hydrogel derived from extracellular matrix
US10905819B2 (en) 2014-08-19 2021-02-02 Fenwal, Inc. Systems and methods for automated recovery of white blood cells after producing a leuko-reduced blood product
GB201421013D0 (en) * 2014-11-26 2015-01-07 Turzi Antoine New standardizations & medical devices for the preparation of platelet rich plasma (PRP) or bone marrow centrate (BMC)
EP3227003A1 (de) * 2014-12-03 2017-10-11 Bend Research, Inc. Einwegzellenentfernungssystem
US10376620B2 (en) * 2015-04-02 2019-08-13 Fenwal, Inc. Systems and methods for leukoreducing a red blood cell-containing fluid and concentrated red blood cells
US10610242B2 (en) 2015-05-08 2020-04-07 Fortus Medical, Inc. Bone fragment and tissue harvesting system
US20180291325A1 (en) * 2015-05-14 2018-10-11 Merck Sharp & Dohme Corp. In vitro pharmacokinetic-pharmacodynamic device
US10927347B2 (en) * 2015-05-15 2021-02-23 Black Tie Medical Inc. Device and method for breaking down and sizing harvested fat
CA3177726A1 (en) 2015-05-21 2016-11-24 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
WO2017023542A1 (en) 2015-07-31 2017-02-09 DePuy Synthes Products, Inc. Method of preparing an osteogenic bone graft
ITUB20154668A1 (it) * 2015-10-14 2017-04-14 Mario Goisis Dispositivo per la filtrazione del grasso estratto con procedure chirurgiche di liposuzione
JP6957468B2 (ja) 2015-12-11 2021-11-02 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル 最適化された患者特異的組織操作血管移植片のためのシステムおよび方法
CA3011294A1 (en) 2016-01-13 2017-07-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vascular extracellular matrix hydrogel
AU2017204355B2 (en) 2016-07-08 2021-09-09 Mako Surgical Corp. Scaffold for alloprosthetic composite implant
US10456502B2 (en) 2016-09-07 2019-10-29 Fortus Medical, Inc. Bone void filler preparation system
EP3295972B1 (de) 2016-09-14 2020-11-25 Fenwal, Inc. Zellverarbeitungssytem und -verfahren mit fülloptionen
EP3858395A1 (de) 2016-12-01 2021-08-04 Fenwal, Inc. Füll- und endbearbeitungssysteme und -verfahren
EP3634245A4 (de) 2017-06-07 2021-03-17 Fortus Medical, Inc. Bindegewebevorläuferzellenaspirations- und -verarbeitungssystem
WO2019059235A1 (ja) * 2017-09-19 2019-03-28 株式会社メガカリオン 精製血小板の製造方法、血小板製剤の製造方法、血液製剤の製造方法、血小板保存液、血小板保存剤および血小板の保存方法
US11027239B2 (en) 2017-10-05 2021-06-08 Global Life Sciences Solutions Usa Llc Systems and methods for utilizing crossflow filtration for cell enrichment
EP3700630A4 (de) * 2017-10-27 2021-11-17 Arteriocyte Medical Systems, Inc. Erhöhung der fruchtbarkeit durch thrombozytenreiches plasma
US11278336B2 (en) * 2018-03-22 2022-03-22 Fortus Medical, Inc. Osteomedullary tissue processing system
US11191880B2 (en) 2018-05-16 2021-12-07 Fenwal, Inc. Fill and finish systems and methods for small volume processing
CN109354214B (zh) * 2018-10-31 2021-05-28 浙江工业大学上虞研究院有限公司 一种基于多形态碳材料的生物膜反应器及其制备方法
CA3127191A1 (en) 2019-01-21 2020-07-30 Eclipse Medcorp, Llc Methods, systems and apparatus for separating components of a biological sample
US11478755B2 (en) 2019-08-15 2022-10-25 Fenwal, Inc. Small volume processing systems and methods
WO2021038313A1 (en) * 2019-08-28 2021-03-04 Foss Analytical A/S Liquid analyser using reciprocated tangential flow filtration
US20210123937A1 (en) 2019-10-24 2021-04-29 Fenwal, Inc. Small volume processing systems and methods with capacitive sensing
CA3159372A1 (en) 2019-10-31 2021-05-06 Eclipse Medcorp, Llc Systems, methods and apparatus for separating components of a sample
WO2023147120A1 (en) * 2022-01-28 2023-08-03 University Of Massachusetts Expansion of human hematopoietic stem cells from human yellow bone marrow
CN116948783B (zh) * 2023-07-26 2024-02-23 重庆富沃思医疗器械有限公司 一种骨髓血活性成分富集装置及富集方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422504D0 (en) * 1994-11-08 1995-01-04 Robertson Patricia M B Blood testing
US5733545A (en) 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5674394A (en) * 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
JPH11508813A (ja) 1995-06-06 1999-08-03 クウォンティック バイオメディカル パートナーズ 血漿を濃縮するための装置及び方法
US5824157A (en) * 1995-09-06 1998-10-20 International Business Machines Corporation Fluid jet impregnation
JPH09121849A (ja) * 1995-11-06 1997-05-13 Asahi Medical Co Ltd 細胞採取システムおよび細胞採取方法
JP2000503542A (ja) * 1996-01-16 2000-03-28 デピュイ オーソピーディック，インコーポレイテッド 造血及び非造血組織からの前駆細胞の分離及び ｉｎ ｖｉｖｏ 骨及び軟骨再生におけるそれらの使用
US6117394A (en) * 1996-04-10 2000-09-12 Smith; James C. Membrane filtered pipette tip
US5824084A (en) 1996-07-03 1998-10-20 The Cleveland Clinic Foundation Method of preparing a composite bone graft
CA2278208C (en) * 1997-01-24 2011-09-20 Asahi Medical Co., Ltd. Cell separation method
WO1998045413A1 (en) 1997-04-08 1998-10-15 Pall Corporation Method of harvesting rare cells from blood products
US6979307B2 (en) * 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US6120474A (en) 1997-12-15 2000-09-19 Nissho Corporation Blood component-recovering apparatus and a method for recovering blood components using the same
JP3758012B2 (ja) * 1997-12-15 2006-03-22 ニプロ株式会社 血液成分採取方法およびその採取器具
JP3635654B2 (ja) * 1997-12-26 2005-04-06 ニプロ株式会社 血液成分採取器具
CN1238083C (zh) 1999-04-12 2006-01-25 丰收技术股份有限公司 制造富含血小板的血浆和/或血小板浓缩液的方法和设备
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
DE50012484D1 (de) 1999-04-20 2006-05-18 Heim Medizintechnik Gmbh Vorrichtung zum auftrennen von blut in einzelne und/oder gruppen seiner bestandteile
KR20010055742A (ko) * 1999-12-13 2001-07-04 김정근 포유동물의 골격결손 치유시 골이식을 위한 농축혈소판혈장겔 및 그 제조방법
WO2001072369A1 (en) * 2000-03-29 2001-10-04 Bioaccess, Inc. System and method for processing bone marrow
CN1253233C (zh) * 2001-01-29 2006-04-26 旭医学株式会社 血液处理用过滤器及其制备方法
WO2002067867A2 (en) 2001-02-23 2002-09-06 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US7056738B2 (en) * 2001-03-23 2006-06-06 Tulane University Early stage multipotential stem cells in colonies of bone marrow stromal cells
US7011852B2 (en) 2001-05-07 2006-03-14 Hemogenesis, Llc Separation of platelets from whole blood for use as a healant
DE10392686T5 (de) 2002-05-24 2005-07-07 Biomet Mfg. Corp., Warsaw Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten
AU2003257684A1 (en) * 2002-08-23 2004-03-11 Asahi Medical Co., Ltd. Fibrin-containing composition
US7776594B2 (en) * 2002-10-10 2010-08-17 Wright Medical Technology, Inc. Bone marrow infusion chamber and method
EP1580551B1 (de) * 2002-11-19 2013-02-20 Sekisui Medical Co., Ltd. Membran zur trennung von plasma oder serum und filter vorrichtung mit der membran zur trennung von plasma oder serum
US7141054B2 (en) 2003-02-03 2006-11-28 Biomet, Inc. Method and apparatus for intramedullary delivery of a material
US7291450B2 (en) 2003-03-28 2007-11-06 Smith & Nephew, Inc. Preparation of a cell concentrate from a physiological solution
US20060064070A1 (en) 2004-09-07 2006-03-23 Jeffrey Martin Methods and devices for sterile field transfer
US7207240B2 (en) 2004-09-14 2007-04-24 Arvinmeritor Technology, Llc Control circuit for reducing splitter cycles in an auxiliary drive box
AU2005309599A1 (en) 2004-11-23 2006-06-01 Smith & Nephew, Inc. Composite mixer

Also Published As

Publication number Publication date
CA2559865C (en) 2013-10-22
EP1729831A1 (de) 2006-12-13
CA2559865A1 (en) 2005-10-13
AU2005229049A1 (en) 2005-10-13
WO2005094914A1 (en) 2005-10-13
US20110159053A1 (en) 2011-06-30
KR20070000505A (ko) 2007-01-02
US7291450B2 (en) 2007-11-06
AU2005229049B9 (en) 2011-09-01
US20050205498A1 (en) 2005-09-22
JP2007530691A (ja) 2007-11-01
JP4987694B2 (ja) 2012-07-25
US20080081033A1 (en) 2008-04-03
US7923203B2 (en) 2011-04-12
US20150164949A1 (en) 2015-06-18
US20080081367A1 (en) 2008-04-03
US7858296B2 (en) 2010-12-28
KR101299789B1 (ko) 2013-08-23
AU2005229049B2 (en) 2011-02-03
US10206950B2 (en) 2019-02-19
EP1729831B1 (de) 2012-04-25

Similar Documents

Publication Publication Date Title
ATE554777T1 (de) Zubereitung eines nukleierten zell- und/oder thrombozyten-konzentrats aus einer physiologischen lösung
BRPI0416898A (pt) dispositivos de filtragem de fluxo tangencial e métodos para o enriquecimento de células-tronco
Indumathi et al. Exploring the stem cell and non-stem cell constituents of human breast milk
EP1855719A4 (de) Neutralisierende monoklonale antikörper gegen coronaviren in zusammenhang mit schwerem akutem atemwegssyndrom
HN2012002664A (es) Compuestos, composiciones de tioacetato y metodos de uso
BRPI0516105A (pt) composições de fator de crescimento derivado de plaqueta e métodos de uso destas
NO20043259L (no) Bindingsproteiner som biosensorer
DK1755634T3 (da) Oligopeptider til formindskelse af forhöjet blodurinstofkoncentration
DK1766400T3 (da) Fremgangsmåde til at udföre fuldblodsanalyser
BR112015021757A2 (pt) moléculas tendo certas utilidades pesticidas, e intermediários, composições, e processos relacionados com elas
BR112014010823A2 (pt) anticorpos gp41 neutralizantes e seus usos
DK1356052T3 (da) Produktion af hele antistoffer i prokaryotiske celler
EA200800514A1 (ru) Замещённые 7-азаиндазолы, содержащие их композиции, способ получения и применения
CL2004002050A1 (es) Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros.
BR112013006797A2 (pt) método para causar a coagulação de sangue ou derivado por meio de um implante
AR065314A1 (es) Nuevas composiciones cosmeticas y/o farmaceuticas y sus aplicaciones
DE602006018721D1 (de) Cyanidfreie lösungsmittelzusammensetzung und verwendungsverfahren dafür zur messung von hämoglobin und weissen blutkörperchen
MX2022000613A (es) Moleculas que tienen ciertas utilidades plaguicidas e intermedios, composiciones y procesos relacionados con ellas.
BR9910573A (pt) Compostos antipicornavirais, preparação e uso dos mesmos
EA201490995A1 (ru) Использование фо-ти для усиления мобилизации и пролиферации стволовых клеток
MX2018008843A (es) Moléculas que tienen utilidad plaguicida, e intermediarios, composiciones y procesos, relacionados con ellas.
DK1960789T3 (da) Detektion af føtale celler maternelt blod
WO2005042060A3 (en) Method and composition comprising pyruvate, inosine, adenine, phosphate and an aziridino compound for treating a biological sample
MX2018002331A (es) Moleculas que tienen utilidad plaguicida, e intermediarios, composiciones y procesos, relacionados con ellas.
EA200401111A1 (ru) Биполярные соли транс-каротиноидов и их применение