ATE548450T1 - Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung - Google Patents

Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Info

Publication number
ATE548450T1
ATE548450T1 AT07758102T AT07758102T ATE548450T1 AT E548450 T1 ATE548450 T1 AT E548450T1 AT 07758102 T AT07758102 T AT 07758102T AT 07758102 T AT07758102 T AT 07758102T AT E548450 T1 ATE548450 T1 AT E548450T1
Authority
AT
Austria
Prior art keywords
polypeptides
activity
production
monatin
methods
Prior art date
Application number
AT07758102T
Other languages
English (en)
Inventor
Ellen Burke
Paula Hicks
Peter Luginbuhl
Toby Richardson
David Weiner
Lishan Zhao
Original Assignee
Verenium Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verenium Corp filed Critical Verenium Corp
Application granted granted Critical
Publication of ATE548450T1 publication Critical patent/ATE548450T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C12Y401/03016—4-Hydroxy-2-oxoglutarate aldolase (4.1.3.16)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/03—Oxo-acid-lyases (4.1.3)
    • C12Y401/03017—4-Hydroxy-4-methyl-2-oxoglutarate aldolase (4.1.3.17)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Fodder In General (AREA)
AT07758102T 2006-03-07 2007-03-07 Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung ATE548450T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78051506P 2006-03-07 2006-03-07
PCT/US2007/063515 WO2007103989A2 (en) 2006-03-07 2007-03-07 Aldolases, nucleic acids encoding them and methods for making and using them

Publications (1)

Publication Number Publication Date
ATE548450T1 true ATE548450T1 (de) 2012-03-15

Family

ID=38475839

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07758102T ATE548450T1 (de) 2006-03-07 2007-03-07 Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung

Country Status (13)

Country Link
US (3) US8546118B2 (de)
EP (4) EP2385108B1 (de)
JP (3) JP5733777B2 (de)
KR (4) KR101622894B1 (de)
CN (3) CN102690833B (de)
AT (1) ATE548450T1 (de)
AU (1) AU2007223086B2 (de)
BR (2) BRPI0708614A2 (de)
CA (1) CA2645225A1 (de)
EA (2) EA029538B1 (de)
ES (1) ES2383767T3 (de)
MX (1) MX2008011442A (de)
WO (1) WO2007103989A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006113897A2 (en) * 2005-04-20 2006-10-26 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
JP5441417B2 (ja) 2006-03-07 2014-03-12 カーギル・インコーポレイテッド アルドース、それをコードする核酸、ならびにそれを生成および使用する方法
RU2505606C2 (ru) 2010-10-14 2014-01-27 Адзиномото Ко., Инк. Способ получения монатина
CN102181471B (zh) * 2011-03-23 2014-07-02 深圳大学 莱茵衣藻分泌型表达载体及分泌型表达系统的构建方法
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
MY170910A (en) 2011-12-22 2019-09-14 Xyleco Inc Processing biomass
CN102559722B (zh) * 2012-03-12 2017-05-17 杭州师范大学 一种高酶活、耐热醛缩酶基因、酶、载体、工程菌及应用
WO2013148325A1 (en) 2012-03-26 2013-10-03 Pronutria, Inc. Nutritive fragments, proteins and methods
SG11201405841RA (en) 2012-03-26 2014-10-30 Pronutria Inc Nutritive fragments, proteins and methods
JP2015518470A (ja) 2012-03-26 2015-07-02 プロニュートリア・インコーポレイテッドＰｒｏｎｕｔｒｉａ， Ｉｎｃ． 栄養タンパク質および方法
CN104470946A (zh) 2012-03-26 2015-03-25 普罗努塔利亚公司 带电荷营养性蛋白质和方法
US9850512B2 (en) 2013-03-15 2017-12-26 The Research Foundation For The State University Of New York Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield
EP3048904A2 (de) 2013-09-25 2016-08-03 Pronutria Biosciences, Inc. Zusammensetzungen und formulierungen zur behandlung von absorptionsstörungen und entzündungen des magen-darm-trakts sowie verfahren zur herstellung und verwendung davon
US9951363B2 (en) 2014-03-14 2018-04-24 The Research Foundation for the State University of New York College of Environmental Science and Forestry Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects
JP7055634B2 (ja) 2014-10-30 2022-04-18 ウオーターズ・テクノロジーズ・コーポレイシヨン 標識化グリコシルアミンの迅速調製およびそれを生成するグリコシル化生体分子の分析方法
CN111796039B (zh) 2014-11-13 2023-03-17 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
US11035832B2 (en) 2016-06-21 2021-06-15 Waters Technologies Corporation Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
CN109690297A (zh) * 2016-07-01 2019-04-26 沃特世科技公司 使用分子量截留过滤和过滤器上去糖基化从复杂基质快速制备标记的葡基胺的方法
CN108079315B (zh) * 2016-11-21 2021-09-24 厦门华绰生物医药科技有限公司 FBP aldolase在制备激活AMPK的药物中的用途
EP3330380A1 (de) * 2016-12-05 2018-06-06 Evonik Degussa GmbH Verfahren zur herstellung von l-methionin aus methional
CN107541540B (zh) * 2017-10-18 2021-07-20 南京财经大学 一种活性炭串联大孔树脂纯化菜籽肽的方法
SG11202012198QA (en) * 2018-07-12 2021-01-28 Codexis Inc Engineered phenylalanine ammonia lyase polypeptides
EP3875590A4 (de) * 2018-10-30 2023-02-15 Green Earth Institute Co., Ltd. Verfahren zur herstellung einer organischen verbindung und coryneformes bakterium
EP4031557A4 (de) * 2019-09-19 2023-11-01 The Regents of the University of California Verfahren zur herstellung von d-tryptophan und substituierten d-tryptophanen
CN114279952B (zh) * 2020-09-27 2024-03-12 瑞辰星生物技术（广州）有限公司 用于造纸系统控制有机污染物沉积的生物酶酶活力的测定方法
CN112280773B (zh) * 2020-11-06 2022-07-12 杭州濡湜生物科技有限公司 一种制备2-氨基-3-取代苯基-3-羟基丙酸的生物酶催化流式工艺
CN112301067B (zh) * 2020-11-06 2022-07-05 杭州濡湜生物科技有限公司 一种制备2-氨基-3-取代苯基-3-羟基丙酸的绿色环保工艺
CN113151551A (zh) * 2021-04-22 2021-07-23 山西农业大学 Caps分子标记在鉴定谷子株高性状的用途及引物和检测试剂盒
CN116987601B (zh) * 2023-09-27 2023-12-15 菏泽学院 一种微生物制剂及其在多环芳烃降解中的应用

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366558A (en) 1979-03-23 1994-11-22 Brink David L Method of treating biomass material
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US5087571A (en) 1984-06-22 1992-02-11 President And Fellows Of Harvard College Method for providing a cell culture from a transgenic non-human mammal
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3587814T2 (de) 1985-03-30 1994-11-10 Marc Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
US5780292A (en) 1987-04-29 1998-07-14 Alko Group Ltd. Production of phytate degrading enzymes in trichoderma
US4962028A (en) 1986-07-09 1990-10-09 Dna Plant Technology Corporation Plant promotors
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5015580A (en) 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5573933A (en) 1987-04-14 1996-11-12 Luminis Pty, Ltd. Transgenic pigs
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5217879A (en) 1989-01-12 1993-06-08 Washington University Infectious Sindbis virus vectors
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5589583A (en) 1990-01-11 1996-12-31 Monsanto Company Plant promoter
GB2240105B (en) 1990-01-19 1993-06-09 Technology Finance Corp Process for the production of 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl) indole
AU7791991A (en) 1990-04-24 1991-11-11 Stratagene Methods for phenotype creation from multiple gene populations
DE69133372T2 (de) 1990-06-15 2005-02-24 Scios Inc., Sunnyvale Transgenes, nicht-menschliches säugetier das die amyloidbildende pathologie der alzheimerschen krankheit zeigt
EP0558676B1 (de) 1990-11-23 2000-04-19 Plant Genetic Systems, N.V. Verfahren zur transformation monokotyler pflanzen
CA2098824A1 (en) 1990-12-20 1992-06-21 William D. Huse Optimization of binding proteins
US6110700A (en) 1991-03-11 2000-08-29 The General Hospital Corporation PRAD1 cyclin and its cDNA
US5922854A (en) 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
CA2075135A1 (en) 1991-08-02 1993-02-03 David E. Ellis Particle-mediated transformation of gymnosperms
US5632957A (en) 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
JPH05236997A (ja) 1992-02-28 1993-09-17 Hitachi Ltd ポリヌクレオチド捕捉用チップ
CA2127807A1 (en) 1992-11-20 1994-06-09 John Maliyakal Transgenic cotton plants producing heterologous bioplastic
WO1995008914A1 (en) 1993-09-30 1995-04-06 Agracetus, Inc. Transgenic cotton plants producing heterologous peroxidase
US6045996A (en) 1993-10-26 2000-04-04 Affymetrix, Inc. Hybridization assays on oligonucleotide arrays
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US6468742B2 (en) 1993-11-01 2002-10-22 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5834252A (en) 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5639940A (en) 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
NZ279676A (en) 1994-03-09 1998-04-27 Abbott Lab Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates
WO1995024488A1 (en) 1994-03-09 1995-09-14 Abbott Laboratories Transgenic animals producing oligosaccharides and glycoconjugates
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5750870A (en) 1994-06-17 1998-05-12 Agritope, Inc. Plant genetic transformation methods and transgenic plants
US5959171A (en) 1994-08-17 1999-09-28 Pharming B.V. Method for the production of biologically active polypeptides in a mammal's
WO1996006927A1 (en) 1994-09-01 1996-03-07 Merck & Co., Inc. Transgenic animal expressing a familial form of human amyloid precursor protein
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US5880327A (en) 1994-09-21 1999-03-09 American National Red Cross Transgenic mammals expressing human coagulation factor VIII
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
US6187992B1 (en) 1994-12-05 2001-02-13 Merck & Co., Inc. Transgenic mouse having a disrupted amyloid precursor protein gene
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US5633440A (en) 1994-12-20 1997-05-27 Dna Plant Technology Corporation P119 promoters and their uses
US5705369A (en) 1994-12-27 1998-01-06 Midwest Research Institute Prehydrolysis of lignocellulose
DE69617641T3 (de) 1995-01-26 2009-10-22 Novozymes A/S Xylanase beinhaltende futterzusätze für tiere
US5959098A (en) 1996-04-17 1999-09-28 Affymetrix, Inc. Substrate preparation process
US5795749A (en) 1995-04-05 1998-08-18 The Scripps Research Institution Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfucose, analogues and derivatives
EP0831854A4 (de) 1995-06-06 2001-01-24 Isis Pharmaceuticals Inc Oligonukleotide mit phosphorothioat-bindungen von hoher chiraler reinheit
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
US5958672A (en) 1995-07-18 1999-09-28 Diversa Corporation Protein activity screening of clones having DNA from uncultivated microorganisms
US6057103A (en) 1995-07-18 2000-05-02 Diversa Corporation Screening for novel bioactivities
US5962258A (en) 1995-08-23 1999-10-05 Diversa Corporation Carboxymethyl cellulase fromthermotoga maritima
WO1997016533A1 (en) 1995-10-31 1997-05-09 The Regents Of The University Of California Mammalian artificial chromosomes and methods of using same
US6740506B2 (en) 1995-12-07 2004-05-25 Diversa Corporation End selection in directed evolution
US20030215798A1 (en) 1997-06-16 2003-11-20 Diversa Corporation High throughput fluorescence-based screening for novel enzymes
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
US6358709B1 (en) 1995-12-07 2002-03-19 Diversa Corporation End selection in directed evolution
US5830696A (en) 1996-12-05 1998-11-03 Diversa Corporation Directed evolution of thermophilic enzymes
US5939250A (en) 1995-12-07 1999-08-17 Diversa Corporation Production of enzymes having desired activities by mutagenesis
US6361974B1 (en) 1995-12-07 2002-03-26 Diversa Corporation Exonuclease-mediated nucleic acid reassembly in directed evolution
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US6022963A (en) 1995-12-15 2000-02-08 Affymetrix, Inc. Synthesis of oligonucleotide arrays using photocleavable protecting groups
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
US6025155A (en) 1996-04-10 2000-02-15 Chromos Molecular Systems, Inc. Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes
US5697987A (en) 1996-05-10 1997-12-16 The Trustees Of Princeton University Alternative fuel
AU3568897A (en) 1996-06-07 1998-01-05 Eos Biotechnology, Inc. Immobilised linear oligonucleotide arrays
DE69835360T2 (de) 1997-01-17 2007-08-16 Maxygen, Inc., Redwood City EVOLUTION Prokaryotischer GANZER ZELLEN DURCH REKURSIVE SEQUENZREKOMBINATION
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
BR9808368A (pt) 1997-03-18 2000-05-23 Novo Nordisk As Processos para a construção de uma biblioteca de polinucleotideos homólogos recombinados, para a identificação um polipeptìdeo de interesse, e, para a produção de um polipeptìdeo de interesse.
EP0996718B1 (de) 1997-03-18 2008-12-24 Novozymes A/S Methode zur herstellung einer bibliothek mittels dna-shuffling
US5948653A (en) 1997-03-21 1999-09-07 Pati; Sushma Sequence alterations using homologous recombination
US6153410A (en) 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6333181B1 (en) 1997-04-07 2001-12-25 University Of Florida Research Foundation, Inc. Ethanol production from lignocellulose
US5916780A (en) 1997-06-09 1999-06-29 Iogen Corporation Pretreatment process for conversion of cellulose to fuel ethanol
US7019827B2 (en) 1997-06-16 2006-03-28 Diversa Corporation GigaMatrix holding tray having through-hole wells
AUPO758297A0 (en) 1997-06-27 1997-07-24 Rowe, James Baber Control of acidic gut syndrome
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
EP1012335A4 (de) 1997-08-15 2004-06-09 Hyseq Inc Erfahren und zusammensetzungen zur detektion oder quantifizierung von nukleinsäurespezies
CN1249418C (zh) 1997-09-11 2006-04-05 生物风险公司 一种生产目标物质的高密度阵列的方法及高密度阵列
US6465178B2 (en) 1997-09-30 2002-10-15 Surmodics, Inc. Target molecule attachment to surfaces
WO1999021979A1 (en) 1997-10-28 1999-05-06 Maxygen, Inc. Human papillomavirus vectors
EP1690868A1 (de) 1997-10-31 2006-08-16 Maxygen, Inc. Modifizierung des Virustropismus und des Wirtspektrums durch virale Genomdurchmischung
US6118044A (en) 1997-11-14 2000-09-12 Sankyo Company, Limited Transgenic animal allergy models and methods for their use
IL136574A0 (en) 1997-12-08 2001-06-14 California Inst Of Techn A method for forming a polynucleotide of desired properties
AU3289199A (en) 1998-02-11 1999-08-30 Maxygen, Inc. Antigen library immunization
AU3291099A (en) 1998-02-11 1999-08-30 Maxygen, Inc. Genetic vaccine vector engineering
WO1999051773A1 (en) 1998-04-03 1999-10-14 Phylos, Inc. Addressable protein arrays
US6156952A (en) 1998-04-09 2000-12-05 Constituent Institution Of The University Of Maryland System HIV transgenic animals and uses therefor
US6048695A (en) 1998-05-04 2000-04-11 Baylor College Of Medicine Chemically modified nucleic acids and methods for coupling nucleic acids to solid support
IL140100A0 (en) 1998-06-29 2002-02-10 Phylos Inc Methods of generating highly diverse libraries
FR2782323B1 (fr) 1998-08-12 2002-01-11 Proteus Procede de production in vitro de sequences polynucleotidiques recombinees, banques de sequences et sequences ainsi obtenues
GB2340755B (en) 1998-08-24 2002-09-25 Cannon Rubber Ltd Breast pump insert
US6277628B1 (en) 1998-10-02 2001-08-21 Incyte Genomics, Inc. Linear microarrays
US6277489B1 (en) 1998-12-04 2001-08-21 The Regents Of The University Of California Support for high performance affinity chromatography and other uses
US6368861B1 (en) 1999-01-19 2002-04-09 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
DE19910464A1 (de) 1999-03-10 2000-09-14 Bayer Ag Verfahren zur Herstellung von Cyclobutanon
US6221653B1 (en) 1999-04-27 2001-04-24 Agilent Technologies, Inc. Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids
DK1176981T3 (da) 1999-05-07 2006-04-10 Genentech Inc Behandling af autoimmune sygdomme med antagonister som binder til B celleoverflademarkörer
US6653151B2 (en) 1999-07-30 2003-11-25 Large Scale Proteomics Corporation Dry deposition of materials for microarrays using matrix displacement
US6409841B1 (en) 1999-11-02 2002-06-25 Waste Energy Integrated Systems, Llc. Process for the production of organic products from diverse biomass sources
US20010008765A1 (en) 1999-12-06 2001-07-19 Fuji Photo Film Co., Ltd. DNA chip and reactive solid carrier
ES2166316B1 (es) 2000-02-24 2003-02-16 Ct Investig Energeticas Ciemat Procedimiento de produccion de etanol a partir de biomasa lignocelulosica utilizando una nueva levadura termotolerante.
JP2001328984A (ja) 2000-05-19 2001-11-27 Kuraray Co Ltd メバロラクトンの製造方法
CA2413022A1 (en) 2000-06-14 2001-12-20 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
US6423145B1 (en) 2000-08-09 2002-07-23 Midwest Research Institute Dilute acid/metal salt hydrolysis of lignocellulosics
WO2002014261A2 (en) 2000-08-10 2002-02-21 Eli Lilly And Company 4-substituted d-glutamic acid derivatives for use as antibiotic
WO2002029032A2 (en) 2000-09-30 2002-04-11 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
JP2005501217A (ja) 2000-10-10 2005-01-13 ディベルサ コーポレーション 生体活性または生体分子のハイスループットスクリーニングまたはキャピラリーに基づくスクリーニング
US6309872B1 (en) 2000-11-01 2001-10-30 Novozymes Biotech, Inc Polypeptides having glucoamylase activity and nucleic acids encoding same
US7459172B2 (en) 2000-11-30 2008-12-02 Verenium Corporation Method of making a protein polymer and uses of the polymer
US20060019913A1 (en) 2001-05-18 2006-01-26 Sirna Therapeutics, Inc. RNA interference mediated inhibtion of protein tyrosine phosphatase-1B (PTP-1B) gene expression using short interfering nucleic acid (siNA)
DE02786364T1 (de) 2001-10-01 2005-01-13 Diversa Inc., San Diego Konstruktion ganzer zellen unter verwendung einer echtzeitanalyse des metabolischen flusses
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
CN100516043C (zh) 2002-04-23 2009-07-22 嘉吉有限公司 多肽和生物合成途径
EP2280068A1 (de) * 2002-08-26 2011-02-02 Ajinomoto Co., Inc. Neuartige Aldolase und Herstellungsverfahren für substituierte Alpha-Ketosäuren
WO2004027075A2 (en) * 2002-09-20 2004-04-01 Diversa Corporation Chemoenzymatic methods for the synthesis of statins and stain intermediates
US6776979B2 (en) 2002-12-30 2004-08-17 Marvin B. Frager Periodontal treatment compound and method of use
CN1890377B (zh) 2003-10-21 2013-06-05 嘉吉有限公司 生产莫纳甜和莫纳甜前体
JP4500977B2 (ja) 2003-11-05 2010-07-14 味の素株式会社 新規アミノ酸誘導体及び甘味剤
JP4604524B2 (ja) * 2004-03-16 2011-01-05 味の素株式会社 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法
US20060014260A1 (en) 2004-05-07 2006-01-19 Zhiliang Fan Lower cellulase requirements for biomass cellulose hydrolysis and fermentation
US20060030003A1 (en) 2004-05-12 2006-02-09 Simon Michael R Composition and method for introduction of RNA interference sequences into targeted cells and tissues
US7338763B2 (en) 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
CN100519756C (zh) * 2004-06-07 2009-07-29 味之素株式会社 新的醛缩酶及光学活性ihog及莫那亭的制备方法
AU2005252273B2 (en) 2004-06-07 2011-04-28 Arbutus Biopharma Corporation Lipid encapsulated interfering RNA
CA2506247C (en) * 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US20060019258A1 (en) 2004-07-20 2006-01-26 Illumina, Inc. Methods and compositions for detection of small interfering RNA and micro-RNA
US7923231B2 (en) 2004-12-17 2011-04-12 Cargill, Incorporated Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
US8076108B2 (en) * 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
SG11201510439PA (en) 2013-06-21 2016-01-28 Bio Rad Laboratories Microfluidic system with fluid pickups

Also Published As

Publication number Publication date
KR20090004918A (ko) 2009-01-12
KR101622894B1 (ko) 2016-05-19
EA019971B1 (ru) 2014-07-30
EA201301267A1 (ru) 2014-11-28
EP1999256A4 (de) 2009-06-03
JP5793486B2 (ja) 2015-10-14
US8546118B2 (en) 2013-10-01
CA2645225A1 (en) 2007-09-13
KR20160058194A (ko) 2016-05-24
EP3153580A3 (de) 2017-04-19
EP1999256B1 (de) 2012-03-07
AU2007223086A1 (en) 2007-09-13
JP2013063068A (ja) 2013-04-11
CN102690833A (zh) 2012-09-26
ES2383767T3 (es) 2012-06-26
CN101443446A (zh) 2009-05-27
EP3153580A2 (de) 2017-04-12
BRPI0708614A2 (pt) 2011-06-07
EP1999256A2 (de) 2008-12-10
EP2385108B1 (de) 2016-11-23
CN101443446B (zh) 2013-08-21
US9290755B2 (en) 2016-03-22
US20100095390A1 (en) 2010-04-15
JP5793487B2 (ja) 2015-10-14
BR122017003017B1 (pt) 2018-10-23
WO2007103989A2 (en) 2007-09-13
JP2009531025A (ja) 2009-09-03
AU2007223086B2 (en) 2013-09-26
CN105063072A (zh) 2015-11-18
KR101508249B1 (ko) 2015-04-10
WO2007103989A9 (en) 2007-11-29
CN102690833B (zh) 2015-09-09
MX2008011442A (es) 2008-11-18
EA029538B1 (ru) 2018-04-30
KR101744157B1 (ko) 2017-06-08
JP2013066469A (ja) 2013-04-18
WO2007103989A8 (en) 2009-07-23
KR20150020722A (ko) 2015-02-26
KR101588539B1 (ko) 2016-01-25
US20140053287A1 (en) 2014-02-20
KR20140023424A (ko) 2014-02-26
EP2388316A3 (de) 2012-03-14
US20160251643A1 (en) 2016-09-01
JP5733777B2 (ja) 2015-06-10
US9719079B2 (en) 2017-08-01
EP2385108A1 (de) 2011-11-09
EA200870329A1 (ru) 2009-06-30
EP2388316A2 (de) 2011-11-23

Similar Documents

Publication Publication Date Title
ATE548450T1 (de) Aldolasen, nukleinsäuren zu ihrer kodierung sowie verfahren zu ihrer herstellung und verwendung
MX2008011477A (es) Aldolasas, acidos nucleicos que las codifican y metodos para hacerlas y usarlas.
MY148096A (en) 4,5-diphenyl-pyrimidinyl-amino substituted carboxylic acids, method for the production and use thereof as medicaments
MY148483A (en) 4,5-diphenyl-pyrimidinyl-oxy or-mercapto substituted carboxylic acids, method for the production and use thereof as medicaments
DE602006004719D1 (de) Verfahren zur herstellung von cellulosesulfat mit verbesserten eigenschaften
NO20056010L (no) Biaryloksymetylaren-karboksylsyrer
EA201001445A1 (ru) ПОЛУЧЕНИЕ 6-АМИНОКАПРОНОВОЙ КИСЛОТЫ ИЗ α-КЕТОПИМЕЛИНОВОЙ КИСЛОТЫ
EP2256201A3 (de) Modulation der eIF4E expression
WO2010048552A3 (en) Methods of using oligomeric compounds comprising 2'-substituted nucleosides
MX2009004739A (es) Efectos biologicos mejorados de composiciones que comprenden acido rosmarinico.
DE502006006865D1 (de) Neue dehydrogenasen, deren derivate und ein verfahren zur herstellung von optisch aktiven alkanolen
WO2008102720A1 (ja) 光学活性３－アミノピペリジン又はその塩の製造方法
ATE453622T1 (de) Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren
WO2004055162A3 (en) Modulation of endothelial lipase expression
DE60045176D1 (de) Verfahren zur Herstellung von N-Acetylneuraminsäure
ATE318813T1 (de) Neue kristalline formen von meloxicam, deren herstellung und verfahren zu deren umwandlung ineinander
BRPI0416672A (pt) método de produção de uma composição granular contendo lecitina e composição granular contendo lecitina
WO2008081938A1 (ja) 耐熱性ビオチン結合性タンパク質の利用法、および当該タンパク質が結合した固体担体
WO2008019069A3 (en) Enzymatic aqueous acylation
ATE402265T1 (de) Verfahren zur herstellung von biologisch abbaubaren milchsäurepolymeren
WO2007096654A3 (en) Methods for production of dioic acids
BRPI0413329A (pt) plantas tendo caracterìsticas de crescimento modificado e método para produzir as mesmas
ATE476416T1 (de) Additionssalze von hemmern des angiotensin konvertierenden enzyms mit no abgebenden säuren, verfahren zu ihrer herstellung und die sie enthaltenden pharmazeutischen zusammensetzungen
WO2008053206A3 (en) Process for preparation of aldonic acids and derivatives thereof
DE60233307D1 (de) Verfahren zur herstellung optisch aktiver propoxyanilinderivate