ATE543899T1 - Hyaluronsäure produzierender mikroorganismus und reinigungsverfahren für hyaluronsäure - Google Patents

Hyaluronsäure produzierender mikroorganismus und reinigungsverfahren für hyaluronsäure

Info

Publication number
ATE543899T1
ATE543899T1 AT03788171T AT03788171T ATE543899T1 AT E543899 T1 ATE543899 T1 AT E543899T1 AT 03788171 T AT03788171 T AT 03788171T AT 03788171 T AT03788171 T AT 03788171T AT E543899 T1 ATE543899 T1 AT E543899T1
Authority
AT
Austria
Prior art keywords
hyaluronic acid
purification process
producing microorganism
acid producing
streptococcus
Prior art date
Application number
AT03788171T
Other languages
English (en)
Inventor
Hee-Yong Han
Seung-Hong Jang
Eul-Chae Kim
Jung-Kyung Park
Young-Jin Han
Chung Lee
Heung-Soon Park
Yun-Cheul Kim
Ho-Jin Park
Original Assignee
Kolon Life Science Inc
Vacctech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020020048916A external-priority patent/KR100829086B1/ko
Priority claimed from KR10-2002-0048915A external-priority patent/KR100472007B1/ko
Application filed by Kolon Life Science Inc, Vacctech Corp filed Critical Kolon Life Science Inc
Application granted granted Critical
Publication of ATE543899T1 publication Critical patent/ATE543899T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/885—Streptococcus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT03788171T 2002-08-19 2003-08-19 Hyaluronsäure produzierender mikroorganismus und reinigungsverfahren für hyaluronsäure ATE543899T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020020048916A KR100829086B1 (ko) 2002-08-19 2002-08-19 히아루론산 및 그의 염 정제방법
KR10-2002-0048915A KR100472007B1 (ko) 2002-08-19 2002-08-19 히아루론산 생산 균주 및 상기 균주를 이용한 히아루론산 생산방법
PCT/KR2003/001666 WO2004016771A1 (en) 2002-08-19 2003-08-19 Microorganism producing hyaluronic acid and purification method of hyaluronic acid

Publications (1)

Publication Number Publication Date
ATE543899T1 true ATE543899T1 (de) 2012-02-15

Family

ID=36584473

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03788171T ATE543899T1 (de) 2002-08-19 2003-08-19 Hyaluronsäure produzierender mikroorganismus und reinigungsverfahren für hyaluronsäure

Country Status (7)

Country Link
US (1) US7575914B2 (de)
EP (1) EP1543103B1 (de)
JP (1) JP4106361B2 (de)
CN (1) CN100342004C (de)
AT (1) ATE543899T1 (de)
AU (1) AU2003252566A1 (de)
WO (1) WO2004016771A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100577075B1 (ko) * 2004-06-16 2006-05-08 주식회사 티앤라이프시스템 칼슘염 및 인산염, 또는 인산칼슘염을 이용한 히아루론산정제방법
JP2006104461A (ja) * 2004-09-10 2006-04-20 Seikagaku Kogyo Co Ltd グリコサミノグリカン画分中の不純物の除去方法
EP2039777A4 (de) * 2006-06-07 2011-11-30 Kyowa Hakko Bio Co Ltd Verfahren zur aufreinigung von hyaluronsäuresalz
AU2007298454B2 (en) * 2006-07-06 2014-01-16 Reliance Life Sciences Pvt Ltd Efficient process for purification of high molecular weight hyaluronic acid
KR101509139B1 (ko) * 2006-11-23 2015-04-08 주식회사 엘지생명과학 히알루론산의 정제방법
EP2031053A1 (de) * 2007-08-31 2009-03-04 The University Of Queensland HA-Herstellung
KR101132114B1 (ko) * 2009-09-15 2012-04-05 일동제약주식회사 히알루론산의 분자량을 조절하는 방법
CN103936882A (zh) * 2013-01-21 2014-07-23 上海昊海生物科技股份有限公司 一种从透明质酸钠发酵液中快速制备透明质酸钠的方法
KR101598329B1 (ko) * 2013-03-20 2016-02-29 일동제약주식회사 히알루론산의 제조방법 및 상기 제조방법으로 제조된 히알루론산을 포함하는 유착방지용 조성물
IT201600079633A1 (it) * 2016-07-28 2018-01-28 Fidia Farm Spa Procedimento di preparazione e purificazione del sale sodico dell’acido ialuronico
CN108192936A (zh) * 2018-03-19 2018-06-22 山东焦点生物科技股份有限公司 一种透明质酸发酵的补料方法
PL3897902T3 (pl) 2018-12-19 2024-02-26 Glycom A/S Rozdzielanie oligosacharydów
CN110922505A (zh) * 2019-12-27 2020-03-27 华熙生物科技股份有限公司 一种滴眼剂用透明质酸的制备方法
CN110981992B (zh) * 2019-12-27 2021-08-13 华熙生物科技股份有限公司 一种注射剂用透明质酸的制备方法
CN114397399A (zh) * 2021-12-31 2022-04-26 华熙生物科技股份有限公司 测定透明质酸-季铵盐聚合物中季铵盐含量的方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5856692A (ja) 1981-09-26 1983-04-04 Shiseido Co Ltd ヒアルロン酸の製造方法
US4517295A (en) * 1983-02-18 1985-05-14 Diagnostic, Inc. Hyaluronic acid from bacterial culture
US4780414A (en) 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
US4784990A (en) * 1985-01-18 1988-11-15 Bio-Technology General Corporation High molecular weight sodium hyaluronate
JPS62257382A (ja) 1986-05-01 1987-11-09 Yakult Honsha Co Ltd 新規なストレプトコツカス・ズ−エピデミカス
US5023175A (en) * 1986-05-01 1991-06-11 Kabushiki Kaisha Yakult Honsha Novel production process of hyaluronic acid and bacterium strain therefor
JPS6312293A (ja) 1986-07-03 1988-01-19 Kyowa Hakko Kogyo Co Ltd ヒアルロン酸の精製法
JP2938880B2 (ja) 1988-10-12 1999-08-25 電気化学工業株式会社 ヒアルロン酸の精製法
JPH03271829A (ja) 1990-03-20 1991-12-03 Fujitsu Ltd 情報処理装置
JPH06199656A (ja) 1992-12-28 1994-07-19 Hoya Corp パイロジエンの除去方法
US5496726A (en) * 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
SE9401806D0 (sv) * 1994-05-26 1994-05-26 Pharmacia Ab Method and means for the production of hyaluronic acid
JPH0823992A (ja) 1994-07-13 1996-01-30 Nissei Kagaku Kogyo Kk ヒアルロン酸の製造方法
DE19548954A1 (de) 1995-12-28 1997-07-03 Knoell Hans Forschung Ev Biotechnologische Herstellung von Hyaluronat enthaltenden Kulturlösungen
KR0149793B1 (ko) 1995-12-29 1998-08-17 이능희 고분자량 히알우론산의 정제방법
KR19980080116A (ko) * 1997-03-27 1998-11-25 히라따 다다시 히알루론산 나트륨의 정제법
JPH1160608A (ja) 1997-08-19 1999-03-02 Chisso Corp 高純度ヒアルロン酸もしくはその塩の製造法
CA2225866A1 (en) 1997-12-24 1999-06-24 Hyal Pharmaceutical Corporation Purification of polysaccharides and ultra pure products resulting therefrom
JP3973312B2 (ja) 1999-01-01 2007-09-12 電気化学工業株式会社 発酵法によるヒアルロン酸の製造方法
JP2000189186A (ja) 1999-01-01 2000-07-11 Denki Kagaku Kogyo Kk 発酵法によるヒアルロン酸の製造方法
JP2001131503A (ja) 1999-11-04 2001-05-15 Oji Paper Co Ltd 感圧接着シート

Also Published As

Publication number Publication date
US7575914B2 (en) 2009-08-18
EP1543103B1 (de) 2012-02-01
US20060127987A1 (en) 2006-06-15
CN1675352A (zh) 2005-09-28
JP4106361B2 (ja) 2008-06-25
EP1543103A4 (de) 2006-05-10
WO2004016771A1 (en) 2004-02-26
EP1543103A1 (de) 2005-06-22
JP2005536204A (ja) 2005-12-02
AU2003252566A1 (en) 2004-03-03
AU2003252566A8 (en) 2004-03-03
CN100342004C (zh) 2007-10-10

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