ATE538105T1 - Substituierte tetrazolverbindungen und ihre verwendung - Google Patents
Substituierte tetrazolverbindungen und ihre verwendungInfo
- Publication number
- ATE538105T1 ATE538105T1 AT08837110T AT08837110T ATE538105T1 AT E538105 T1 ATE538105 T1 AT E538105T1 AT 08837110 T AT08837110 T AT 08837110T AT 08837110 T AT08837110 T AT 08837110T AT E538105 T1 ATE538105 T1 AT E538105T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- tetrazole compounds
- compounds
- substituted tetrazole
- methods
- Prior art date
Links
- -1 TETRAZOLE COMPOUNDS Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97960107P | 2007-10-12 | 2007-10-12 | |
| PCT/US2008/079755 WO2009049305A2 (en) | 2007-10-12 | 2008-10-14 | 5- (2-hydroxyphenyl) tetrazoles as hsp90 inhibitors against cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE538105T1 true ATE538105T1 (de) | 2012-01-15 |
Family
ID=40473811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08837110T ATE538105T1 (de) | 2007-10-12 | 2008-10-14 | Substituierte tetrazolverbindungen und ihre verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7932279B2 (https=) |
| EP (1) | EP2217580B1 (https=) |
| JP (1) | JP4792128B2 (https=) |
| CN (1) | CN101821247A (https=) |
| AT (1) | ATE538105T1 (https=) |
| CA (1) | CA2700893A1 (https=) |
| WO (1) | WO2009049305A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
| WO2014034868A1 (ja) | 2012-08-31 | 2014-03-06 | 株式会社エーピーアイ コーポレーション | ビアリール化合物の製造方法 |
| JP5881837B2 (ja) | 2012-09-26 | 2016-03-09 | 株式会社エーピーアイ コーポレーション | テトラゾール化合物の脱保護方法 |
| KR20180011843A (ko) | 2015-06-11 | 2018-02-02 | 바실리어 파마슈티카 인터내셔널 리미티드 | 유출-펌프 억제제 및 이의 치료적 용도 |
| CN105418527A (zh) * | 2015-12-28 | 2016-03-23 | 青岛友诚高新技术有限公司 | 一种具有抗乳腺导管癌活性的化合物及其制备方法、用途 |
| EP3909577A1 (en) * | 2020-05-13 | 2021-11-17 | Fundación Profesor Novoa Santos | Ubiquitin-ligase inhibitors for the treatment of cancer |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1486057A (en) * | 1975-06-09 | 1977-09-14 | Ici Ltd | Hydroxyphenyl tetrazoles and their use in the extraction of metals |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| UA74803C2 (uk) | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| US6975843B2 (en) | 2000-12-21 | 2005-12-13 | Telefonaktiebolaget L M Ericsson (Publ) | Method and an arrangement relating to telecommunications systems |
| US6962944B2 (en) | 2001-07-31 | 2005-11-08 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| US7074824B2 (en) | 2001-07-31 | 2006-07-11 | Arqule, Inc. | Pharmaceutical compositions containing beta-lapachone, or derivatives or analogs thereof, and methods of using same |
| JPWO2003030937A1 (ja) * | 2001-10-05 | 2005-01-20 | 小野薬品工業株式会社 | ミトコンドリアルベンゾジアゼピン受容体アンタゴニストからなるストレス疾患の治療剤 |
| GB0228417D0 (en) | 2002-12-05 | 2003-01-08 | Cancer Rec Tech Ltd | Pyrazole compounds |
| EA009919B1 (ru) | 2003-02-11 | 2008-04-28 | Вернэлис (Кембридж) Лимитед | Соединения изоксазола |
| MXPA05012377A (es) | 2003-05-15 | 2006-05-25 | Arqule Inc | Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38. |
| GB0315111D0 (en) * | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| GB0316546D0 (en) * | 2003-07-15 | 2003-08-20 | Novartis Ag | Process for the manufacture of organic compounds |
| MXPA06004657A (es) * | 2003-10-28 | 2006-06-27 | Pharmacia Corp | Combinaciones que comprenden un inhibidor de hsp90 y un inhibidor de fosfodiesterasa para tratar o prevenir la neoplasia. |
| JPWO2005063222A1 (ja) * | 2003-12-26 | 2007-07-19 | 協和醗酵工業株式会社 | Ｈｓｐ９０ファミリー蛋白質阻害剤 |
| FR2865736B1 (fr) | 2004-02-02 | 2006-07-14 | Synt Em | Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese |
| JP2005225787A (ja) | 2004-02-12 | 2005-08-25 | Nippon Kayaku Co Ltd | Ｈｓｐ９０阻害剤 |
| WO2006011052A1 (en) | 2004-07-23 | 2006-02-02 | Pharmacia & Upjohn Company Llc | Method for the racemization of 2-trifluoro-2h-chromene-3-carboxylic acids |
| AR050084A1 (es) | 2004-07-27 | 2006-09-27 | Novartis Ag | Derivados de bencimidazolona como inhibidores de hsp90 |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| JP2008517064A (ja) | 2004-10-19 | 2008-05-22 | アークル インコーポレイテッド | Ｐ３８ｍａｐキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成 |
| WO2006055760A1 (en) * | 2004-11-18 | 2006-05-26 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| DE102005007304A1 (de) | 2005-02-17 | 2006-08-24 | Merck Patent Gmbh | Triazolderivate |
| JP2006306755A (ja) | 2005-04-27 | 2006-11-09 | Nippon Kayaku Co Ltd | 新規なピラゾール誘導体とそれを有効成分とするｈｓｐ９０阻害剤 |
| JP2008540395A (ja) | 2005-05-03 | 2008-11-20 | ファイザー・インク | アミドレソルシノール化合物 |
| JP5178515B2 (ja) * | 2005-08-12 | 2013-04-10 | シンタ ファーマシューティカルズ コーポレーション | Ｈｓｐ９０活性を調節するピラゾール化合物 |
| WO2007094819A2 (en) | 2005-08-18 | 2007-08-23 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP1951679B1 (en) * | 2005-08-18 | 2015-02-18 | Synta Pharmaceuticals Corp. | Imidazole compounds that modulate hsp90 activity |
| EP2013218A2 (en) | 2006-04-17 | 2009-01-14 | Arqule, Inc. | Raf inhibitors and their uses |
-
2008
- 2008-10-14 US US12/251,093 patent/US7932279B2/en active Active
- 2008-10-14 EP EP08837110A patent/EP2217580B1/en not_active Not-in-force
- 2008-10-14 AT AT08837110T patent/ATE538105T1/de active
- 2008-10-14 CN CN200880111766A patent/CN101821247A/zh active Pending
- 2008-10-14 JP JP2010529145A patent/JP4792128B2/ja not_active Expired - Fee Related
- 2008-10-14 WO PCT/US2008/079755 patent/WO2009049305A2/en not_active Ceased
- 2008-10-14 CA CA2700893A patent/CA2700893A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7932279B2 (en) | 2011-04-26 |
| US20090130117A1 (en) | 2009-05-21 |
| JP2011500603A (ja) | 2011-01-06 |
| CN101821247A (zh) | 2010-09-01 |
| WO2009049305A2 (en) | 2009-04-16 |
| JP4792128B2 (ja) | 2011-10-12 |
| EP2217580B1 (en) | 2011-12-21 |
| CA2700893A1 (en) | 2009-04-16 |
| EP2217580A2 (en) | 2010-08-18 |
| WO2009049305A3 (en) | 2009-07-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009013815A (es) | Compuestos de quinazolinona y metodos de uso para los mismos. | |
| MX2007009649A (es) | Derivados de meleimida, composiciones farmaceuticas y metodos para el tratamiento del cancer. | |
| MX2011006959A (es) | Compuestos substituidos de 5,6-dihidro-6-fenilbenzo [f] isoquinolina-2-amina. | |
| MY157124A (en) | Substituted imidazopyridinyl-aminopyridine compounds | |
| PH12012501337A1 (en) | Substituted pyrrolo-aminopyrimidine compounds | |
| EA201290919A1 (ru) | Индазольные соединения и их применение | |
| EA200870415A1 (ru) | Хиназолины для ингибирования pdk 1 | |
| WO2011082266A3 (en) | Substituted heterocyclic compounds | |
| BRPI0915084B8 (pt) | composto, e, composição farmacêutica | |
| EA201001196A1 (ru) | Соединения 4-пиридинона и их применение для лечения рака | |
| EA201001639A1 (ru) | Композиции и способы их получения и применения | |
| PH12013502565A1 (en) | Substituted imidazopyridinyl-aminopyridine compounds | |
| WO2011082267A3 (en) | Substituted triazolo-pyrazine compounds | |
| DK1951729T3 (da) | Oxygenbundne pyrimidinderivater | |
| WO2009026446A3 (en) | Hdac inhibitors | |
| EA201070327A1 (ru) | Катехоламиновые производные и их пролекарства | |
| WO2011123678A3 (en) | Substituted benzo-pyrido-triazolo-diazepine compounds | |
| PH12012501556A1 (en) | Substituted naphthalenyl-pyrimidine compounds | |
| ATE538105T1 (de) | Substituierte tetrazolverbindungen und ihre verwendung | |
| GEP20125603B (en) | Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents | |
| ATE522531T1 (de) | Indolylpyrrolidine zur behandlung von krebs | |
| WO2012061342A3 (en) | Substituted benzo-imidazo-pyrido-diazepine compounds | |
| PH12015501980A1 (en) | Pyrroloquinolinyl-pyrrolidine-2,5-dione formulations and methods for preparing and using same | |
| MY140324A (en) | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer | |
| MY148385A (en) | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |