ATE522531T1 - Indolylpyrrolidine zur behandlung von krebs - Google Patents
Indolylpyrrolidine zur behandlung von krebsInfo
- Publication number
- ATE522531T1 ATE522531T1 AT08771523T AT08771523T ATE522531T1 AT E522531 T1 ATE522531 T1 AT E522531T1 AT 08771523 T AT08771523 T AT 08771523T AT 08771523 T AT08771523 T AT 08771523T AT E522531 T1 ATE522531 T1 AT E522531T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- cancer
- pyrrolidine
- indolylpyrrolidine
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94582007P | 2007-06-22 | 2007-06-22 | |
PCT/US2008/067566 WO2009002807A2 (en) | 2007-06-22 | 2008-06-19 | Indolyl pyrrolidines for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE522531T1 true ATE522531T1 (de) | 2011-09-15 |
Family
ID=39767054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08771523T ATE522531T1 (de) | 2007-06-22 | 2008-06-19 | Indolylpyrrolidine zur behandlung von krebs |
Country Status (8)
Country | Link |
---|---|
US (1) | US8513292B2 (de) |
EP (2) | EP2392574B1 (de) |
JP (2) | JP5490688B2 (de) |
CN (1) | CN101801969B (de) |
AT (1) | ATE522531T1 (de) |
CA (2) | CA2912546A1 (de) |
TW (1) | TWI421251B (de) |
WO (1) | WO2009002807A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5425060B2 (ja) * | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
NZ628087A (en) | 2009-12-23 | 2016-02-26 | Arqule Inc | Purified pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
US8563567B2 (en) | 2009-12-30 | 2013-10-22 | Arqule, Inc. | Substituted heterocyclic compounds |
WO2012088491A2 (en) * | 2010-12-23 | 2012-06-28 | Arqule, Inc. | Pyrroloquinolinyl-pyrrolidine-2,5-dione compositions and methods for preparing and using same |
US9216998B2 (en) | 2012-02-15 | 2015-12-22 | Janssen Pharmaceutica Nv | Tricyclic indole derivatives useful endothelial lipase inhibitors |
CN103626762B (zh) * | 2012-08-24 | 2015-07-29 | 上海医药工业研究院 | 苯并吡啶氮杂卓类化合物及其应用 |
CN113845961B (zh) * | 2021-10-11 | 2022-08-12 | 山东三品新能源有限公司 | 一种齿轮用润滑油组合物及其制备方法 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US36736A (en) * | 1862-10-21 | Improvement in curry-combs | ||
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
USRE36736E (en) | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
MC2096A1 (fr) | 1989-02-23 | 1991-02-15 | Hoffmann La Roche | Pyrroles substitues |
GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
PT93947B (pt) | 1989-05-05 | 1996-11-29 | Goedecke Ag | Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem |
DE4005970A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
DE4005969A1 (de) | 1990-02-26 | 1991-08-29 | Boehringer Mannheim Gmbh | Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
US5591842A (en) * | 1991-11-29 | 1997-01-07 | Banyu Pharmaceutical Co., Ltd. | Indolopyrrolocarbazole derivatives |
EP0630241A1 (de) | 1992-03-20 | 1994-12-28 | The Wellcome Foundation Limited | Indolderivate mit antiviraler wirkung |
US5721230A (en) * | 1993-05-10 | 1998-02-24 | Hoffmann-La Roche Inc. | Substituted pyrroles |
US5545636A (en) * | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
EP1449529B1 (de) | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Proteinkinase C Inhibitoren |
US6524832B1 (en) | 1994-02-04 | 2003-02-25 | Arch Development Corporation | DNA damaging agents in combination with tyrosine kinase inhibitors |
WO1995030682A1 (fr) | 1994-05-09 | 1995-11-16 | Banyu Pharmaceutical Co., Ltd. | Derive d'indolopyrolocarbazole antitumoral |
US5591855A (en) * | 1994-10-14 | 1997-01-07 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
AU2217797A (en) | 1996-03-20 | 1997-10-10 | Eli Lilly And Company | Synthesis of indolylmaleimides |
PE91698A1 (es) * | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
PE91598A1 (es) | 1996-07-29 | 1998-12-24 | Hoffmann La Roche | Pirroles sustituidos |
EA001392B1 (ru) | 1996-08-23 | 2001-02-26 | Эли Лилли Энд Компани | Синтез бисиндолилмалеимидов |
SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
US6153618A (en) | 1996-10-11 | 2000-11-28 | Chiron Corporation | Inhibitors of glycogen synthase 3 kinase |
US5859261A (en) * | 1997-03-20 | 1999-01-12 | Eli Lilly And Company | Synthesis of indolylmaleimides |
EP1120414A1 (de) | 1998-07-30 | 2001-08-01 | Japan Tobacco Inc. | Disubstituierte maleimidverbindungen und medizinische verwendung davon |
EP1152002A4 (de) | 1999-02-09 | 2002-04-17 | Sagami Chem Res | Pyrrolderivate und zelltod-inhibitoren |
EP1250334B1 (de) | 1999-12-16 | 2004-05-19 | Eli Lilly And Company | Medikamente geeignet zur Behandlung von proliferativen Erkrankungen |
US6867198B2 (en) * | 1999-12-16 | 2005-03-15 | Eli Lilly And Company | Agents and methods for the treatment of proliferative diseases |
EP1275646A4 (de) | 2000-03-30 | 2003-05-28 | Sagami Chem Res | Indolylpyrrol-derivate und zelltod-inhibitoren |
ES2288948T3 (es) | 2000-05-11 | 2008-02-01 | Consejo Superior De Investigaciones Cientificas | Inhibidores heterociclicos del glicogeno sintasa quinasa gsk-3. |
CA2452445C (en) | 2000-06-29 | 2011-02-15 | North Shore-Long Island Jewish Health System | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
US20050124800A1 (en) | 2002-01-23 | 2005-06-09 | Lindsey Suzanne J. | Mammalian migration inducting gene and methods for detection and inhibition of migrating tumor cells |
ATE346070T1 (de) | 2002-03-05 | 2006-12-15 | Lilly Co Eli | Purinderivate als kinaseinhibitoren |
US20070059697A1 (en) | 2003-04-15 | 2007-03-15 | Avalon Pharmaceuticals, Inc | Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods |
US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
SI1636593T1 (sl) | 2003-06-06 | 2009-08-31 | Genentech Inc | Moduliranje interakcije med beta-verigo HGF in c-met |
US20070020234A1 (en) | 2003-07-07 | 2007-01-25 | Vande Woude George F | Inhibition of tumor angiogenesis by combination of thrombospondin-1 and inhibitors of vascular endothelial growth factor |
EP2336178A1 (de) | 2003-12-11 | 2011-06-22 | Genentech, Inc. | Verfahren und Produkt um c-Met-Dimerisierung und -Aktivierung zu verhindern |
NZ560225A (en) * | 2005-02-09 | 2010-10-29 | Arqule Inc | Maleimide derivatives, pharmaceutical compositions and methods for treatment of cancer |
PL1863519T3 (pl) | 2005-03-31 | 2014-03-31 | Massachusetts Gen Hospital | Modulowanie aktywności HGF/HGFR do leczenia obrzęku wskutek niedrożności naczyń chłonnych |
JP5425060B2 (ja) * | 2007-06-22 | 2014-02-26 | アークル インコーポレイテッド | ピロリジノン、ピロリジン−2,5−ジオン、ピロリジンおよびチオスクシンイミド誘導体、癌の治療のための組成物および方法 |
-
2008
- 2008-06-19 CA CA2912546A patent/CA2912546A1/en not_active Abandoned
- 2008-06-19 CA CA2690782A patent/CA2690782C/en active Active
- 2008-06-19 US US12/664,345 patent/US8513292B2/en active Active
- 2008-06-19 EP EP11170218.9A patent/EP2392574B1/de active Active
- 2008-06-19 AT AT08771523T patent/ATE522531T1/de not_active IP Right Cessation
- 2008-06-19 WO PCT/US2008/067566 patent/WO2009002807A2/en active Application Filing
- 2008-06-19 EP EP08771523A patent/EP2173748B1/de active Active
- 2008-06-19 CN CN200880103519.5A patent/CN101801969B/zh active Active
- 2008-06-19 JP JP2010513422A patent/JP5490688B2/ja active Active
- 2008-06-20 TW TW097123155A patent/TWI421251B/zh active
-
2013
- 2013-08-12 JP JP2013167362A patent/JP5792239B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2013241458A (ja) | 2013-12-05 |
WO2009002807A2 (en) | 2008-12-31 |
CA2690782A1 (en) | 2008-12-31 |
EP2392574B1 (de) | 2013-12-18 |
EP2392574A1 (de) | 2011-12-07 |
EP2173748A2 (de) | 2010-04-14 |
CA2912546A1 (en) | 2008-12-31 |
CA2690782C (en) | 2016-02-02 |
CN101801969B (zh) | 2014-10-29 |
WO2009002807A3 (en) | 2009-07-30 |
EP2173748B1 (de) | 2011-08-31 |
US8513292B2 (en) | 2013-08-20 |
JP2010530884A (ja) | 2010-09-16 |
US20100183603A1 (en) | 2010-07-22 |
CN101801969A (zh) | 2010-08-11 |
TWI421251B (zh) | 2014-01-01 |
TW200918530A (en) | 2009-05-01 |
JP5490688B2 (ja) | 2014-05-14 |
JP5792239B2 (ja) | 2015-10-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |